Primary Site >> Colorectal Cancer

Gene >> CDK1

Journal: Br J Cancer. 1995 Jun;71(6):1231-6.
Title: Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer.
Author: Yamamoto, H|Monden, T|Ikeda, K|Izawa, H|Fukuda, K|Fukunaga, M|Tomita, N|Shimano, T|Shiozaki, H|Monden, M
PMID: 7779716
Journal: Exp Cell Res. 1996 Jan 10;222(1):179-88.
Title: Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.
Author: Shiff, S J|Koutsos, M I|Qiao, L|Rigas, B
PMID: 8549662
Journal: Oncogene. 1996 Feb 15;12(4):893-901.
Title: The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.
Author: Goldberg, Y|Nassif, I I|Pittas, A|Tsai, L L|Dynlacht, B D|Rigas, B|Shiff, S J
PMID: 8632912
Journal: J Natl Cancer Inst. 1996 Jul 17;88(14):956-65.
Title: UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
Author: Wang, Q|Fan, S|Eastman, A|Worland, P J|Sausville, E A|O'Connor, P M
PMID: 8667426
Journal: Cancer Res. 1996 Oct 1;56(19):4430-7.
Title: Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Author: Goldwasser, F|Shimizu, T|Jackman, J|Hoki, Y|O'Connor, P M|Kohn, K W|Pommier, Y
PMID: 8813137
Journal: Exp Cell Res. 1996 Sep 15;227(2):190-6.
Title: Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Author: Shao, R G|Shimizu, T|Pommier, Y
PMID: 8831555
Journal: Nihon Rinsho. 1996 Apr;54(4):965-71.
Title: [RB gene expression in gastrointestinal tract].
Author: Monden, T|Yamamoto, H|Ikeda, K|Izawa, H|Tsujie, M|Ohnishi, T|Miyoshi, Y|Sekimoto, M|Tomita, N|Monden, M
PMID: 8920658
Journal: J Biol Chem. 1997 Aug 29;272(35):21681-4.
Title: Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34.
Author: Trzepacz, C|Lowy, A M|Kordich, J J|Groden, J
PMID: 9268294
Journal: Cancer Res. 1997 Sep 15;57(18):4029-35.
Title: Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Author: Shao, R G|Cao, C X|Shimizu, T|O'Connor, P M|Kohn, K W|Pommier, Y
PMID: 9307289
Journal: Clin Cancer Res. 1997 Dec;3(12 Pt 2):2696-702.
Title: Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.
Author: Weinstein, I B|Begemann, M|Zhou, P|Han, E K|Sgambato, A|Doki, Y|Arber, N|Ciaparrone, M|Yamamoto, H
PMID: 10068276
Journal: Mol Cell Biol. 1998 Jan;18(1):576-89.
Title: Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.
Author: Sancho, E|Vila, M R|Sanchez-Pulido, L|Lozano, J J|Paciucci, R|Nadal, M|Fox, M|Harvey, C|Bercovich, B|Loukili, N|Ciechanover, A|Lin, S L|Sanz, F|Estivill, X|Valencia, A|Thomson, T M
PMID: 9418904
Journal: Exp Cell Res. 1998 May 1;240(2):236-43.
Title: Elevated expression of the cdc25A protein phosphatase in colon cancer.
Author: Dixon, D|Moyana, T|King, M J
PMID: 9596996
Journal: Int J Oncol. 1998 Aug;13(2):233-9.
Title: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.
Author: Yamamoto, H|Monden, T|Miyoshi, H|Izawa, H|Ikeda, K|Tsujie, M|Ohnishi, T|Sekimoto, M|Tomita, N|Monden, M
PMID: 9664116
Journal: Int J Oncol. 1998 Sep;13(3):611-7.
Title: gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells.
Author: Jiang, W G|Bryce, R P|Horrobin, D F|Mansel, R E
PMID: 9683802
Journal: Int J Cancer. 1998 Aug 31;77(5):796-802.
Title: Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of HT29 human colon carcinoma cells.
Author: Dimanche-Boitrel, M T|Micheau, O|Hammann, A|Haugg, M|Eymin, B|Chauffert, B|Solary, E
PMID: 9688315
Journal: Cancer. 1999 Feb 1;85(3):546-53.
Title: Amplified CDK2 and cdc2 activities in primary colorectal carcinoma.
Author: Kim, J H|Kang, M J|Park, C U|Kwak, H J|Hwang, Y|Koh, G Y
PMID: 10091728
Journal: Anticancer Res. 1999 Jan-Feb;19(1B):741-8.
Title: Differential cyclin-dependent kinase expression and activation in human colon cancer.
Author: Salh, B|Bergman, D|Marotta, A|Pelech, S L
PMID: 10216486
Journal: Oncogene. 1999 Apr 29;18(17):2747-54.
Title: Induction of apoptosis and G2/M cell cycle arrest by DCC.
Author: Chen, Y Q|Hsieh, J T|Yao, F|Fang, B|Pong, R C|Cipriano, S C|Krepulat, F
PMID: 10348349
Journal: Nature. 1999 Oct 7;401(6753):616-20.
Title: 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Author: Chan, T A|Hermeking, H|Lengauer, C|Kinzler, K W|Vogelstein, B
PMID: 10524633
Journal: Proc Soc Exp Biol Med. 1999 Nov;222(2):150-6.
Title: Butyrate-induced G2/M block in Caco-2 colon cancer cells is associated with decreased p34cdc2 activity.
Author: Harrison, L E|Wang, Q M|Studzinski, G P
PMID: 10564539
Journal: Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1167-73.
Title: Assessment of biomarkers in paired primary and recurrent colorectal adenocarcinomas.
Author: Seong, J|Chung, E J|Kim, H|Kim, G E|Kim, N K|Sohn, S K|Min, J S|Suh, C O
PMID: 10613309
Journal: Mol Med. 1999 Nov;5(11):711-20.
Title: beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells.
Author: Huang, L|Pardee, A B
PMID: 10656873
Journal: Carcinogenesis. 2000 Feb;21(2):331-5.
Title: Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis.
Author: Chuang, S E|Kuo, M L|Hsu, C H|Chen, C R|Lin, J K|Lai, G M|Hsieh, C Y|Cheng, A L
PMID: 10657978
Journal: Curr Pharm Des. 2000 Mar;6(4):379-92.
Title: Cell cycle molecular targets in novel anticancer drug discovery.
Author: Buolamwini, J K
PMID: 10788588
Journal: Carcinogenesis. 2000 Jun;21(6):1129-34.
Title: Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation.
Author: Knowles, L M|Milner, J A
PMID: 10837000
Journal: Mol Carcinog. 2000 Jun;28(2):102-10.
Title: Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines.
Author: Wang, W|Heideman, L|Chung, C S|Pelling, J C|Koehler, K J|Birt, D F
PMID: 10900467
Journal: Anticancer Drugs. 2001 Jan;12(1):43-50.
Title: Inhibition of mitotic cyclin B and cdc2 kinase activity by selenomethionine in synchronized colon cancer cells.
Author: Chigbrow, M|Nelson, M
PMID: 11272285
Journal: Anticancer Res. 2001 Mar-Apr;21(2A):873-8.
Title: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells.
Author: Moragoda, L|Jaszewski, R|Majumdar, A P
PMID: 11396178
Journal: Int J Oncol. 2001 Sep;19(3):613-6.
Title: DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells.
Author: Jaiswal, A S|Narayan, S
PMID: 11494044
Journal: J Biol Chem. 2001 Nov 30;276(48):45201-6.
Title: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.
Author: Samuel, T|Weber, H O|Rauch, P|Verdoodt, B|Eppel, J T|McShea, A|Hermeking, H|Funk, J O
PMID: 11574543
Journal: FASEB J. 2001 Dec;15(14):2742-4. Epub 2001 Oct 15.
Title: COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib.
Author: Grosch, S|Tegeder, I|Niederberger, E|Brautigam, L|Geisslinger, G
PMID: 11606477
Journal: Neoplasia. 2001 Sep-Oct;3(5):428-36.
Title: A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts.
Author: Williams, C S|Sheng, H|Brockman, J A|Armandla, R|Shao, J|Washington, M K|Elkahloun, A G|DuBois, R N
PMID: 11687954
Journal: Clin Cancer Res. 2001 Nov;7(11):3336-42.
Title: The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways.
Author: Ding, Z|Parchment, R E|LoRusso, P M|Zhou, J Y|Li, J|Lawrence, T S|Sun, Y|Wu, G S
PMID: 11705845
Journal: Cancer Res. 2001 Nov 15;61(22):8290-7.
Title: Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation.
Author: Yan, T|Schupp, J E|Hwang, H S|Wagner, M W|Berry, S E|Strickfaden, S|Veigl, M L|Sedwick, W D|Boothman, D A|Kinsella, T J
PMID: 11719462
Journal: J Exp Clin Cancer Res. 2001 Dec;20(4):549-52.
Title: Cdk1/P34Cdc2 and P21waf expression in colorectal adenomas and carcinomas.
Author: Egilmez, R|Elagoz, S|Kanik, E A
PMID: 11876550
Journal: J Inorg Biochem. 2002 Jan 1;88(1):25-36.
Title: Antiproliferative activity of mixed-ligand dien-Cu(II) complexes with thiazole, thiazoline and imidazole derivatives.
Author: Bolos, C A|Papazisis, K T|Kortsaris, A H|Voyatzi, S|Zambouli, D|Kyriakidis, D A
PMID: 11750022
Journal: Int J Cancer. 2002 Jan 1;97(1):121-8.
Title: Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination.
Author: Lin, Hong|Liu, Xiang Y|Subramanian, Balanehru|Nakeff, Alexander|Valeriote, Fred|Chen, Ben D
PMID: 11774253
Journal: J Nutr. 2002 Feb;132(2):298-302.
Title: Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines.
Author: Wolter, Freya|Clausnitzer, Antje|Akoglu, Bora|Stein, Jurgen
PMID: 11823594
Journal: Cancer Res. 2002 Jun 1;62(11):3322-6.
Title: Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin.
Author: Sekiya, Takashi|Nakamura, Tsutomu|Kazuki, Yasuhiro|Oshimura, Mitsuo|Kohu, Kazuyoshi|Tago, Ken-Ichi|Ohwada, Susumu|Akiyama, Tetsu
PMID: 12036951
Journal: Int J Mol Med. 2002 Aug;10(2):193-9.
Title: Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells.
Author: Delmas, Delmas|Passilly-Degrace, Patricia|Jannin, Brigitte|Cherkaoui Malki, Mustapha|Latruffe, Norbert
PMID: 12119558
Journal: Oncogene. 2002 Dec 5;21(55):8414-27.
Title: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells.
Author: Jaiswal, Aruna S|Marlow, Benjamin P|Gupta, Nirupama|Narayan, Satya
PMID: 12466962
Journal: Yao Xue Xue Bao. 2002 Jun;37(6):419-23.
Title: [Potentiation of radiosensitivity by staurosporine associated with abrogation of G2 phase arrest].
Author: Sun, Xin-chen|Wang, Jun-jie|Zhen, Yong-su|Shao, Rong-guang
PMID: 12579796
Journal: Radiat Res. 2003 Jan;159(1):86-93.
Title: Influence of environmental pH on G2-phase arrest caused by ionizing radiation.
Author: Park, Heon Joo|Lee, Sang Hwa|Chung, HyunSook|Rhee, Yun Hee|Lim, Byung Uk|Ha, Sung Whan|Griffin, Robert J|Lee, Hyung Sik|Song, Chang Won|Choi, Eun Kyung
PMID: 12492371
Journal: Biochem Pharmacol. 2003 Apr 1;65(7):1053-60.
Title: Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells.
Author: Liang, Yu-Chih|Tsai, Shu-Huei|Chen, Linda|Lin-Shiau, Shoei-Yn|Lin, Jen-Kun
PMID: 12663041
Journal: J Cancer Res Clin Oncol. 2003 Sep;129(9):498-502.
Title: p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma.
Author: Nozoe, T|Honda, M|Inutsuka, S|Korenaga, D
PMID: 12884029
Journal: Oncogene. 2003 Nov 13;22(51):8271-82.
Title: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Author: Agarwal, Chapla|Singh, Rana P|Dhanalakshmi, Sivanandhan|Tyagi, Anil K|Tecklenburg, Marianne|Sclafani, Robert A|Agarwal, Rajesh
PMID: 14614451
Journal: An R Acad Nac Med (Madr). 2003;120(3):545-55; discussion 555-7.
Title: [Predictive molecular marker of distant metastasis in colorectal cancer].
Author: Sanz Esponera, Julian
PMID: 15027705
Journal: Carcinogenesis. 2004 Feb;25(2):219-27.
Title: Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.
Author: Jackson, Steven J T|Singletary, Keith W
PMID: 14578157
Journal: J Biol Chem. 2004 Feb 6;279(6):5035-41.
Title: Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage.
Author: Yoon, Hong S|Yang, Vincent W
PMID: 14627709
Journal: Int J Colorectal Dis. 2004 Jan;19(1):12-7.
Title: Establishment of a colonic adenoma cell line (GEKI-2): spectral karyotype analysis and functional characterization.
Author: Menzel, Thomas|Melcher, Ralph|Koehler, Sigrid|Dusel, Gerda|Backhaus, Kerstin|Ott, German|Breithaupt, Wolfram|Al-Taie, Oliver|Schauber, Jurgen|Gostner, Andrea|Scheppach, Wolfgang|Luhrs, Hardi
PMID: 14648095
Journal: Mol Cancer. 2004 Jan 16;3:3.
Title: N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA.
Author: Jaiswal, Aruna S|Multani, Asha S|Pathak, Sen|Narayan, Satya
PMID: 14728717
Journal: Cancer Res. 2004 Jan 1;64(1):262-72.
Title: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Author: Whittaker, Steven R|Walton, Mike I|Garrett, Michelle D|Workman, Paul
PMID: 14729633
Journal: Oncogene. 2004 Mar 4;23(9):1737-44.
Title: Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line.
Author: Abal, Miguel|Bras-Goncalves, Rui|Judde, Jean-Gabriel|Fsihi, Hafida|De Cremoux, Patricia|Louvard, Daniel|Magdelenat, Henri|Robine, Sylvie|Poupon, Marie-France
PMID: 15001986
Journal: Oncogene. 2004 May 27;23(25):4353-61.
Title: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
Author: Castedo, Maria|Perfettini, Jean-Luc|Roumier, Thomas|Yakushijin, Kenichi|Horne, David|Medema, Rene|Kroemer, Guido
PMID: 15048074
Journal: J Biol Chem. 2004 Jun 11;279(24):25813-22. Epub 2004 Apr 8.
Title: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.
Author: Singh, Shivendra V|Herman-Antosiewicz, Anna|Singh, Ajita V|Lew, Karen L|Srivastava, Sanjay K|Kamath, Ravindra|Brown, Kevin D|Zhang, Lin|Baskaran, Rajasekaran
PMID: 15073169
Journal: Acta Pharmacol Sin. 2004 Jun;25(6):756-62.
Title: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Author: Shao, Rong-Guang|Cao, Chun-Xia|Pommier, Yves
PMID: 15169628
Journal: Int J Hyperthermia. 2004 Jun;20(4):405-19.
Title: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines.
Author: Atallah, D|Marsaud, V|Radanyi, C|Kornprobst, M|Rouzier, R|Elias, D|Renoir, J-M
PMID: 15204521
Journal: Eur J Biochem. 2004 Jul;271(13):2773-81.
Title: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines.
Author: Liu, Wai M|Scott, Katherine A|Shahin, Sipra|Propper, David J
PMID: 15206942
Journal: Nutr Cancer. 2004;48(2):198-206.
Title: Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.
Author: Parnaud, Geraldine|Li, PengFei|Cassar, Georges|Rouimi, Patrick|Tulliez, Jacques|Combaret, Lydie|Gamet-Payrastre, Laurence
PMID: 15231455
Journal: Am J Physiol Cell Physiol. 2004 Dec;287(6):C1541-6. Epub 2004 Aug 18.
Title: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Author: Goke, R|Barth, P|Schmidt, A|Samans, B|Lankat-Buttgereit, B
PMID: 15317660
Journal: Cell Cycle. 2004 Sep;3(9):1177-81. Epub 2004 Sep 13.
Title: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53.
Author: Carrassa, Laura|Broggini, Massimo|Erba, Eugenio|Damia, Giovanna
PMID: 15326376
Journal: Cancer Res. 2004 Sep 1;64(17):6296-303.
Title: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Author: Geller, James I|Szekely-Szucs, Kinga|Petak, Istvan|Doyle, Belinda|Houghton, Janet A
PMID: 15342418
Journal: Cancer Res. 2004 Dec 15;64(24):9086-92.
Title: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.
Author: Meng, Ling-Hua|Zhang, Hongliang|Hayward, Larry|Takemura, Haruyuki|Shao, Rong-Guang|Pommier, Yves
PMID: 15604277
Journal: Toxicol Sci. 2005 Jan;83(1):126-35.
Title: Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines.
Author: Neave, Antje S|Sarup, Sussi M|Seidelin, Michel|Duus, Fritz|Vang, Ole
PMID: 15483186
Journal: Carcinogenesis. 2005 Jan;26(1):109-17.
Title: Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells.
Author: Goulet, Anne-Christine|Chigbrow, Marianne|Frisk, Peter|Nelson, Mark A
PMID: 15513932
Journal: Anticancer Drugs. 2005 Feb;16(2):129-36.
Title: The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
Author: Heim, Martina|Scharifi, Mariam|Zisowsky, Jochen|Jaehde, Ulrich|Voliotis, Dimitris|Seeber, Siegfried|Strumberg, Dirk
PMID: 15655409
Journal: Biochem Pharmacol. 2005 Mar 1;69(5):801-9.
Title: Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells.
Author: Hyzy, Magdalena|Bozko, Przemyslaw|Konopa, Jerzy|Skladanowski, Andrzej
PMID: 15710357
Journal: Exp Mol Pathol. 2005 Apr;78(2):116-22.
Title: Overexpression of RGC-32 in colon cancer and other tumors.
Author: Fosbrink, Matthew|Cudrici, Cornelia|Niculescu, Florin|Badea, Tudor C|David, Stefan|Shamsuddin, Abulkalam|Shin, Moon L|Rus, Horea
PMID: 15713436
Journal: Nutr Cancer. 2005;51(2):207-17.
Title: Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries.
Author: Han, ChunHua|Ding, Haiming|Casto, Bruce|Stoner, Gary D|D'Ambrosio, Steven M
PMID: 15860443
Journal: Int J Oncol. 2005 Jun;26(6):1653-61.
Title: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest.
Author: Sato, Ken|Kitajima, Yoshihiko|Kohya, Naohiko|Miyoshi, Atsushi|Koga, Yasuo|Miyazaki, Kohji
PMID: 15870882
Journal: Eur J Gastroenterol Hepatol. 2005 Jul;17(7):725-32.
Title: Proteomic analysis of differentially expressed proteins between metastatic and non-metastatic human colorectal carcinoma cell lines.
Author: Ying-Tao, Zhang|Yi-Ping, Geng|Lu-Sheng, Si|Yi-Li, Wang
PMID: 15947549
Journal: Clin Cancer Res. 2005 Jun 15;11(12):4601-9.
Title: Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors.
Author: Park, Richard|Chang, Chih-Chuan|Liang, Yu-Chuan|Chung, Yousun|Henry, Ryan A|Lin, Elaine|Mold, David E|Huang, Ru Chih C
PMID: 15958646
Journal: Jpn J Clin Oncol. 2005 Aug;35(8):453-63.
Title: Oxaliplatin, a potent inhibitor of survivin, enhances paclitaxel-induced apoptosis and mitotic catastrophe in colon cancer cells.
Author: Fujie, Yujiro|Yamamoto, Hirofumi|Ngan, Chew Yee|Takagi, Akimitsu|Hayashi, Taro|Suzuki, Rei|Ezumi, Koji|Takemasa, Ichiro|Ikeda, Masataka|Sekimoto, Mitsugu|Matsuura, Nariaki|Monden, Morito
PMID: 16024531
Journal: Bioorg Med Chem. 2005 Nov 1;13(21):6064-9.
Title: Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells.
Author: Matsumoto, Kenji|Akao, Yukihiro|Ohguchi, Kenji|Ito, Tetsuro|Tanaka, Toshiyuki|Iinuma, Munekazu|Nozawa, Yoshinori
PMID: 16112579
Journal: Biochem Biophys Res Commun. 2005 Dec 2;337(4):1176-84. Epub 2005 Oct 6.
Title: Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
Author: Niture, Suryakant K|Doneanu, Catalin E|Velu, Chinavenmeni S|Bailey, Nathan I|Srivenugopal, Kalkunte S
PMID: 16226712
Journal: Int J Oncol. 2005 Dec;27(6):1727-36.
Title: Differential gene expression of sulindac-treated human breast epithelial cells.
Author: Roy, D|Panda, A|Calaf, G M|Mitra, A
PMID: 16273229
Journal: J Nutr. 2005 Dec;135(12):2884-90.
Title: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells.
Author: Lu, Xianghua|Jung, Jae in|Cho, Han Jin|Lim, Do Young|Lee, Hyun Sook|Chun, Hyang Sook|Kwon, Dae Young|Park, Jung Han Yoon
PMID: 16317137
Journal: Nucleic Acids Res. 2006 Feb 2;34(3):880-92. Print 2006.
Title: Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
Author: Hiyama, Takashi|Katsura, Mari|Yoshihara, Takashi|Ishida, Mari|Kinomura, Aiko|Tonda, Tetsuji|Asahara, Toshimasa|Miyagawa, Kiyoshi
PMID: 16456034
Journal: Cancer Res. 2006 Apr 15;66(8):4299-308.
Title: Discovery and evaluation of dual CDK1 and CDK2 inhibitors.
Author: Payton, Marc|Chung, Grace|Yakowec, Peter|Wong, Andrew|Powers, Dave|Xiong, Ling|Zhang, Nancy|Leal, Juan|Bush, Tammy L|Santora, Vincent|Askew, Ben|Tasker, Andrew|Radinsky, Robert|Kendall, Richard|Coats, Steve
PMID: 16618755
Journal: Mol Carcinog. 2006 Jul;45(7):461-78.
Title: Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis.
Author: Chen, Jinn-Shiun|Lin, Shyr-Yi|Tso, Wei-Ling|Yeh, Geng-Chang|Lee, Wen-Sen|Tseng, How|Chen, Li-Ching|Ho, Yuan-Soon
PMID: 16649252
Journal: Int J Radiat Biol. 2006 Apr;82(4):277-83.
Title: Radiosensitization of tumor cells by modulation of ATM kinase.
Author: Choi, Eun Kyung|Ji, In Mi|Lee, So Ryung|Kook, Yeon Hee|Griffin, Robert J|Lim, Byung Uk|Kim, Jin-Seok|Lee, Doo Sung|Song, Chang Won|Park, Heon Joo
PMID: 16690595
Journal: Toxicology. 2006 Jun 1;223(1-2):136-43.
Title: Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line.
Author: Huan, Steven Kuan-Hua|Lee, Hao-Hsien|Liu, Der-Zen|Wu, Chien-Chih|Wang, Ching-Chiung
PMID: 16697099
Journal: Toxicology. 2006 Jun 15;223(3):235-47.
Title: Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes.
Author: Jeng, Jiiang-Huei|Kuo, Mark Yen-Ping|Lee, Po-Hsuen|Wang, Ying-Jan|Lee, Mon-Ying|Lee, Jang-Jaer|Lin, Bor-Ru|Tai, Tseng-Fang|Chang, Mei-Chi
PMID: 16737765
Journal: J Med Chem. 2006 Nov 2;49(22):6549-60.
Title: Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
Author: Chu, Xin-Jie|DePinto, Wanda|Bartkovitz, David|So, Sung-Sau|Vu, Binh T|Packman, Kathryn|Lukacs, Christine|Ding, Qingjie|Jiang, Nan|Wang, Ka|Goelzer, Petra|Yin, Xuefeng|Smith, Melissa A|Higgins, Brian X|Chen, Yingsi|Xiang, Qing|Moliterni, John|Kaplan, Geral
PMID: 17064073
Journal: Cancer Res. 2006 Nov 1;66(21):10349-56.
Title: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Author: Knock, Erin|Deng, Liyuan|Wu, Qing|Leclerc, Daniel|Wang, Xiao-ling|Rozen, Rima
PMID: 17079455
Journal: Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):223-33.
Title: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
Author: Lu, Pin-Hsuan|Kung, Fan-Lu|Kuo, Sheng-Chu|Chueh, Shih-Chieh|Guh, Jih-Hwa
PMID: 17102938
Journal: Oncogene. 2007 May 3;26(20):2914-24. Epub 2006 Oct 30.
Title: RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints.
Author: Mamidipudi, V|Dhillon, N K|Parman, T|Miller, L D|Lee, K C|Cartwright, C A
PMID: 17072338
Journal: J Biol Chem. 2007 Jan 12;282(2):871-8. Epub 2006 Nov 22.
Title: An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4.
Author: Yochum, Gregory S|Cleland, Ryan|McWeeney, Shannon|Goodman, Richard H
PMID: 17121828
Journal: Oncol Rep. 2007 Mar;17(3):597-603.
Title: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway.
Author: Liu, Xia|Bian, Chunjing|Ren, Kaihuan|Jin, Haixia|Li, Baowei|Shao, Rong-Guang
PMID: 17273739
Journal: Cancer Res. 2007 Jul 15;67(14):6987-94.
Title: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels.
Author: Nawrocki, Steffan T|Carew, Jennifer S|Douglas, Leslie|Cleveland, John L|Humphreys, Robin|Houghton, Janet A
PMID: 17638911
Journal: Cancer Res. 2007 Sep 1;67(17):8325-34.
Title: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Author: Bettayeb, Karima|Tirado, Oscar M|Marionneau-Lambot, Severine|Ferandin, Yoan|Lozach, Olivier|Morris, Jonathan C|Mateo-Lozano, Silvia|Drueckes, Peter|Schachtele, Christoph|Kubbutat, Michael H G|Liger, Francois|Marquet, Bernard|Joseph, Benoit|Echalier, Aude|
PMID: 17804748
Journal: Biomed Environ Sci. 2007 Dec;20(6):495-501.
Title: Tetrandrine: a potent abrogator of G2 checkpoint function in tumor cells and its mechanism.
Author: Sun, Xin-Chen|Cheng, Hong-Yan|Deng, Yu-Xia|Shao, Rong-Guang|Ma, Jun
PMID: 18348409
Journal: Carcinogenesis. 2008 Jan;29(1):139-46.
Title: Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines.
Author: Fini, Lucia|Hotchkiss, Erin|Fogliano, Vincenzo|Graziani, Giulia|Romano, Marco|De Vol, Edward B|Qin, Huanying|Selgrad, Michael|Boland, C Richard|Ricciardiello, Luigi
PMID: 17999988
Journal: Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G1025-32.
Title: Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2.
Author: Subramaniam, Dharmalingam|Natarajan, Gopalan|Ramalingam, Satish|Ramachandran, Ilangovan|May, Randal|Queimado, Lurdes|Houchen, Courtney W|Anant, Shrikant
PMID: 18292181
Journal: Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1235-44.
Title: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe.
Author: Natarajan, Gopalan|Ramalingam, Satish|Ramachandran, Ilangovan|May, Randal|Queimado, Lurdes|Houchen, Courtney W|Anant, Shrikant
PMID: 18325984
Journal: Oncogene. 2008 Sep 18;27(42):5567-77.
Title: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.
Author: Moran, D M|Gawlak, G|Jayaprakash, M S|Mayar, S|Maki, C G
PMID: 18504430
Journal: Tumour Biol. 2008;29(5):287-303.
Title: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs.
Author: Abaza, Mohamed-Salah I|Al-Saffar, Amal|Al-Sawan, Shorooq|Al-Attiyah, Rajaa
PMID: 18802399
Journal: Br J Pharmacol. 2008 Nov;155(5):641-54.
Title: Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis.
Author: Jada, S R|Matthews, C|Saad, M S|Hamzah, A S|Lajis, N H|Stevens, M F G|Stanslas, J
PMID: 18806812
Journal: Int J Mol Sci. 2008 Mar;9(3):355-70. Epub 2008 Mar 14.
Title: Anti-cancer effects of xanthones from pericarps of mangosteen.
Author: Akao, Yukihiro|Nakagawa, Yoshihito|Iinuma, Munekazu|Nozawa, Yoshinori
PMID: 19325754
Journal: Food Chem Toxicol. 2009 Jan;47(1):171-9.
Title: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways.
Author: Yang, Jai-Sing|Chen, Guang-Wei|Hsia, Te-Chun|Ho, Heng-Chien|Ho, Chin-Chin|Lin, Meng-Wei|Lin, Song-Shei|Yeh, Ru-Duan|Ip, Siu-Wan|Lu, Hsu-Fung|Chung, Jing-Gung
PMID: 19038304
Journal: Mol Cancer Ther. 2009 Feb;8(2):324-32.
Title: Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.
Author: Squires, Matthew S|Feltell, Ruth E|Wallis, Nicola G|Lewis, E Jonathan|Smith, Donna-Michelle|Cross, David M|Lyons, John F|Thompson, Neil T
PMID: 19174555
Journal: Eur J Cancer. 2009 May;45(8):1466-73.
Title: Cdc2 as prognostic marker in stage UICC II colon carcinomas.
Author: Meyer, Alexander|Merkel, Susanne|Bruckl, Wolfgang|Schellerer, Vera|Schildberg, Claus|Campean, Valentina|Hohenberger, Werner|Croner, Roland S
PMID: 19223178
Journal: Pancreas. 2009 Jul;38(5):551-7.
Title: Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells.
Author: Wang, Hong|Stephens, Bret|Von Hoff, Daniel D|Han, Haiyong
PMID: 19276868
Journal: Int J Radiat Biol. 2009 Feb;85(2):167-74.
Title: 1-Methylxanthine enhances the radiosensitivity of tumor cells.
Author: Youn, Hyewon|Hee Kook, Yeon|Oh, Eun-Taex|Jeong, Seong-Yun|Kim, Chulhee|Kyung Choi, Eun|Uk Lim, Byung|Park, Heon Joo
PMID: 19280470
Journal: Int J Oncol. 2009 Apr;34(4):1061-8.
Title: Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression.
Author: Furuya, Momoko|Tsuji, Naoki|Kobayashi, Daisuke|Watanabe, Naoki
PMID: 19287963
Journal: Hell J Nucl Med. 2009 Jan-Apr;12(1):2-4.
Title: The impact of gene expression on 18F-FDG kinetics; a new chapter for diagnostic nuclear medicine.
Author: Strauss, Ludwig G|Dimitrakopoulou-Strauss, Antonia
PMID: 19330172
Journal: Int J Oncol. 2009 May;34(5):1181-9.
Title: Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.
Author: Nakamura, Junya|Aoyagi, Sayaka|Nanchi, Isamu|Nakatsuka, Shin-Ichi|Hirata, Erika|Shibata, Shohei|Fukuda, Mari|Yamamoto, Yumiko|Fukuda, Ikuyo|Tatsumi, Naoya|Ueda, Tazu|Fujiki, Fumihiro|Nomura, Masaya|Nishida, Sumiyuki|Shirakata, Toshiaki|Hosen, Naoki|Tsuboi
PMID: 19360331
Journal: Cancer Prev Res (Phila). 2009 Jun;2(6):581-9.
Title: 3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin.
Author: Bhatnagar, Namrata|Li, Xia|Chen, Yue|Zhou, Xudong|Garrett, Scott H|Guo, Bin
PMID: 19470789
Journal: BMC Gastroenterol. 2009 May 29;9:39.
Title: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.
Author: Choi, Hyun Ju|Lim, Do Young|Park, Jung Han Yoon
PMID: 19480695
Journal: Cancer Biol Ther. 2009 Aug;8(16):1559-66. Epub 2009 Aug 8.
Title: Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.
Author: Pan, Yu|Ren, Kai-Huan|He, Hong-Wei|Shao, Rong-Guang
PMID: 19502782
Journal: Biochim Biophys Acta. 2009 Oct;1794(10):1433-40.
Title: Comparative proteomic analysis of colon cancer cells in response to oxaliplatin treatment.
Author: Yao, Yi|Jia, Xiao-Yuan|Tian, Hong-Yu|Jiang, Yu-Xiang|Xu, Gen-Jun|Qian, Qi-Jun|Zhao, Fu-Kun
PMID: 19520192
Journal: Int J Cancer. 2009 Oct 15;125(8):1965-74.
Title: Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.
Author: Chintharlapalli, Sudhakar|Papineni, Sabitha|Abdelrahim, Maen|Abudayyeh, Ala|Jutooru, Indira|Chadalapaka, Gayathri|Wu, Fei|Mertens-Talcott, Susanne|Vanderlaag, Kathy|Cho, Sung Dae|Smith, Roger 3rd|Safe, Stephen
PMID: 19582879
Journal: Toxicol In Vitro. 2009 Dec;23(8):1497-503.
Title: Antiproliferative and cytotoxic effects of sodium selenite in human colon cancer cells.
Author: Kralova, Vera|Brigulova, Katerina|Cervinka, Miroslav|Rudolf, Emil
PMID: 19602434
Journal: Chem Biol Interact. 2009 Dec 10;182(2-3):173-82.
Title: Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells.
Author: Chiu, Shu-Jun|Lee, Yi-Jang|Hsu, Tzu-Sheng|Chen, Wen-Shu
PMID: 19735649
Journal: Bioorg Med Chem. 2009 Dec 1;17(23):8040-7.
Title: Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies.
Author: Ortin, Irene|Gonzalez, Juan Francisco|Cuesta, Elena de la|Manguan-Garcia, Cristina|Perona, Rosario|Avendano, Carmen
PMID: 19875300
Journal: J Pharmacol Sci. 2009 Nov;111(3):276-84.
Title: Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells.
Author: Kang, You-Jin|Park, Kwang-Kyun|Chung, Won-Yoon|Hwang, Jae-Kwan|Lee, Sang Kook
PMID: 19926935
Journal: Int J Cancer. 2010 Apr 15;126(8):1838-49.
Title: Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells.
Author: Patsos, Georgios|Germann, Anja|Gebert, Johannes|Dihlmann, Susanne
PMID: 19795419
Journal: Food Chem Toxicol. 2010 Jan;48(1):277-83.
Title: c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells.
Author: Lee, Se-Jung|Moon, Gi-Seong|Jung, Kyung-Hwan|Kim, Wun-Jae|Moon, Sung-Kwon
PMID: 19833164
Journal: Exp Mol Pathol. 2010 Feb;88(1):67-76.
Title: Epigenetic modifications induced by RGC-32 in colon cancer.
Author: Vlaicu, Sonia I|Tegla, Cosmin A|Cudrici, Cornelia D|Fosbrink, Matthew|Nguyen, Vingh|Azimzadeh, Philippe|Rus, Violeta|Chen, Hegang|Mircea, Petru A|Shamsuddin, Abulkalam|Rus, Horea
PMID: 19883641
Journal: Mol Cancer Ther. 2010 Jan;9(1):89-100.
Title: The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.
Author: Walton, Michael I|Eve, Paul D|Hayes, Angela|Valenti, Melanie|De Haven Brandon, Alexis|Box, Gary|Boxall, Kathy J|Aherne, G Wynne|Eccles, Suzanne A|Raynaud, Florence I|Williams, David H|Reader, John C|Collins, Ian|Garrett, Michelle D
PMID: 20053762
Journal: Cancer Biol Ther. 2010 Apr 1;9(7):514-22. Epub 2010 Apr 1.
Title: MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.
Author: Hirai, Hiroshi|Arai, Tsuyoshi|Okada, Megumu|Nishibata, Toshihide|Kobayashi, Makiko|Sakai, Naoko|Imagaki, Kazuhide|Ohtani, Junko|Sakai, Takumi|Yoshizumi, Takashi|Mizuarai, Shinji|Iwasawa, Yoshikazu|Kotani, Hidehito
PMID: 20107315
Journal: Phytother Res. 2010 Dec;24(12):1870-6.
Title: Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression.
Author: Lee, Se-Jung|Park, Keerang|Ha, Sang-Do|Kim, Wun-Jae|Moon, Sung-Kwon
PMID: 20564491
Journal: Nutr Cancer. 2010;62(5):611-21.
Title: DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells.
Author: Slagsvold, Jens E|Pettersen, Caroline H H|Storvold, Gro L|Follestad, Turid|Krokan, Hans E|Schonberg, Svanhild A
PMID: 20574922
Journal: J Biochem. 2010 Sep;148(3):319-26.
Title: Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity.
Author: Zeng, Zhao-Lei|Wu, Ming-Wei|Sun, Jian|Sun, Yue-Li|Cai, Yu-Chen|Huang, Yi-Jun|Xian, Li-Jian
PMID: 20576619
Journal: Oncol Rep. 2010 Aug;24(2):449-55.
Title: Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway.
Author: Chen, Nian-Gu|Chen, Kuan-Tin|Lu, Chi-Cheng|Lan, Yu-Hsuan|Lai, Cheng-Hung|Chung, Yang-Tsung|Yang, Jai-Sing|Lin, Yung-Chang
PMID: 20596632
Journal: PLoS One. 2010 Aug 23;5(8):e12341.
Title: Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.
Author: Nantajit, Danupon|Fan, Ming|Duru, Nadire|Wen, Yunfei|Reed, John C|Li, Jian Jian
PMID: 20808790
Journal: PLoS One. 2010 Oct 1;5(10). pii: e13054.
Title: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.
Author: Shi, Ting|Mazumdar, Tapati|Devecchio, Jennifer|Duan, Zhong-Hui|Agyeman, Akwasi|Aziz, Mohammad|Houghton, Janet A
PMID: 20957031
Journal: PLoS One. 2010 Nov 30;5(11):e14143.
Title: Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers.
Author: Kruewel, Thomas|Schenone, Silvia|Radi, Marco|Maga, Giovanni|Rohrbeck, Astrid|Botta, Maurizio|Borlak, Juergen
PMID: 21152443
Journal:
Title: ML264: An Antitumor Agent that Potently and Selectively Inhibits Kruppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression
Author: Bialkowska, Agnieszka|Crisp, Melissa|Madoux, Franck|Spicer, Tim|Knapinska, Ania|Mercer, Becky|Bannister, Thomas D.|He, Yuanjun|Chowdhury, Sarwat|Cameron, Michael|Yang, Vincent W.|Hodder, Peter
PMID: 23762940
Journal:
Title: Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry
Author: Simanski, Scott|Madoux, Franck|Rahaim, Ronald J.|Chase, Peter|Schurer, Stephan|Cameron, Michael|Mercer, Becky A.|Hodder, Peter|Roush, William R.|Ayad, Nagi G.
PMID: 23762957
Journal: Invest New Drugs. 2011 Aug;29(4):627-36.
Title: Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.
Author: Fu, Jia-Ning|Li, Jing|Tan, Qiang|Yin, Han-Wei|Xiong, Kun|Wang, Tian-Yu|Ren, Xiao-Yuan|Zeng, Hui-Hui
PMID: 20195699
Journal: Int J Cancer. 2011 Feb 15;128(4):847-56.
Title: G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer.
Author: Tang, Yong|Chen, Yakun|Jiang, Hongmei|Robbins, Gregory T|Nie, Daotai
PMID: 20979106
Journal: Carcinogenesis. 2011 Apr;32(4):629-35.
Title: 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.
Author: Lee, Dong Eun|Lee, Ki Won|Jung, Sung Keun|Lee, Eun Jung|Hwang, Jung A|Lim, Tae-Gyu|Kim, Bo Yeon|Bode, Ann M|Lee, Hyong Joo|Dong, Zigang
PMID: 21258042
Journal: Int J Oncol. 2011 Apr;38(4):1067-73.
Title: Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways.
Author: Huang, Wen-Wen|Ko, Shih-Wei|Tsai, Huei-Yann|Chung, Jing-Gung|Chiang, Jo-Hua|Chen, Kuan-Tin|Chen, Yen-Chen|Chen, Hung-Yi|Chen, Yuh-Fung|Yang, Jai-Sing
PMID: 21271215
Journal: Cell Res. 2011 May;21(5):730-40.
Title: A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis.
Author: Wang, Wei|Liu, Haiyang|Wang, Sheng|Hao, Xiaojiang|Li, Lin
PMID: 21321609
Journal: Cancer Biother Radiopharm. 2011 Feb;26(1):97-104.
Title: Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53.
Author: Hu, Bing|Shen, Ke-Ping|An, Hong-Mei|Wu, Yang|Du, Qin
PMID: 21348775
Journal: Cancer Lett. 2011 Sep 1;308(1):62-70.
Title: RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-kappaB in colon carcinoma HCT116 cells.
Author: Zhang, Hao|Zhang, Shenghua|He, Hongwei|Zhao, Wuli|Ren, Kaihuan|Chen, Jianhua|Shao, Rong-guang
PMID: 21570766
Journal: Apoptosis. 2011 Aug;16(8):856-67.
Title: Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.
Author: Gan, Fei-Fei|Nagle, Amrita A|Ang, Xiaohui|Ho, Olivia Huixian|Tan, Sock-Hoon|Yang, Hong|Chui, Wai-Keung|Chew, Eng-Hui
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Journal: Bioorg Med Chem Lett. 2011 Sep 15;21(18):5633-7.
Title: Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Author: Zhang, Lin|Fan, Junhua|Chong, Jer-Hong|Cesena, Angela|Tam, Betty Y Y|Gilson, Charles|Boykin, Christina|Wang, Deping|Aivazian, Dikran|Marcotte, Doug|Xiao, Guangqing|Le Brazidec, Jean-Yves|Piao, Jinhua|Lundgren, Karen|Hong, Kevin|Vu, Khang|Nguyen, Khanh|Gan
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Journal: Exp Ther Med. 2011 Mar;2(2):301-307.
Title: Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro.
Author: Strey, Christoph W|Schamell, Lea|Oppermann, Elsie|Haferkamp, Axel|Bechstein, Wolf O|Blaheta, Roman A
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Journal: Br J Cancer. 2012 Jan 3;106(1):133-40.
Title: Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer.
Author: Zeestraten, E C M|Maak, M|Shibayama, M|Schuster, T|Nitsche, U|Matsushima, T|Nakayama, S|Gohda, K|Friess, H|van de Velde, C J H|Ishihara, H|Rosenberg, R|Kuppen, P J K|Janssen, K-P
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Journal: Hepatology. 2012 Sep;56(3):982-93.
Title: S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.
Author: Tomasi, Maria Lauda|Tomasi, Ivan|Ramani, Komal|Pascale, Rosa Maria|Xu, Jun|Giordano, Pasquale|Mato, Jose M|Lu, Shelly C
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Journal: J Nutr Metab. 2012;2012:351796.
Title: Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats.
Author: Rondini, Elizabeth A|Bennink, Maurice R
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Journal: Int J Oncol. 2012 Jul;41(1):76-82.
Title: Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.
Author: Hong, Yong Sang|Hong, Seung-Woo|Kim, Seung-Mi|Jin, Dong-Hoon|Shin, Jae-Sik|Yoon, Dok Hyun|Kim, Kyu-Pyo|Lee, Jae-Lyun|Heo, Dae Seog|Lee, Jung Shin|Kim, Tae Won
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Journal: Int J Oncol. 2012 Jul;41(1):325-30.
Title: Nitric oxide-donating aspirin induces G2/M phase cell cycle arrest in human cancer cells by regulating phase transition proteins.
Author: Gao, Li|Williams, Jennie L
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Journal: PLoS One. 2012;7(4):e36006.
Title: Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells.
Author: Tseng, Ho-Hsing|Chuah, Qiu-Yu|Yang, Pei-Ming|Chen, Chiung-Tong|Chao, Jung-Chi|Lin, Ming-Der|Chiu, Shu-Jun
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Journal: Evid Based Complement Alternat Med. 2012;2012:326096.
Title: 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest.
Author: Lin, Ching-Bin|Lin, Chun-Che|Tsay, Gregory J
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Journal: J Biol Chem. 2012 Nov 9;287(46):39193-204.
Title: Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins.
Author: Sakurikar, Nandini|Eichhorn, Joshua M|Chambers, Timothy C
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Journal: Mol Med Rep. 2012 Dec;6(6):1243-8.
Title: Effects of SASH1 on melanoma cell proliferation and apoptosis in vitro.
Author: Lin, Sheyu|Zhang, Junyu|Xu, Jiawei|Wang, Honglian|Sang, Qing|Xing, Qinghe|He, Lin
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Journal: Int J Oncol. 2012 Dec;41(6):2057-64.
Title: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells.
Author: Hwang, Hye Jung|Kang, Yong Jung|Hossain, Mohammad Akbar|Kim, Dong Hwan|Jang, Jung Yoon|Lee, Sun Hwa|Yoon, Jeong-Hyun|Moon, Hyung Ryong|Kim, Hyung Sik|Chung, Hae Young|Kim, Nam Deuk
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Journal: Int J Food Sci Nutr. 2013 Feb;64(1):36-43.
Title: The inhibitory effects and mechanisms of rhamnogalacturonan I pectin from potato on HT-29 colon cancer cell proliferation and cell cycle progression.
Author: Cheng, Hairong|Zhang, Zhongyu|Leng, Jiayi|Liu, Dan|Hao, Miao|Gao, Xiaoge|Tai, Guihua|Zhou, Yifa
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Journal: Oncol Lett. 2013 Jan;5(1):305-310.
Title: Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro.
Author: Oh, Se-Mi|Kim, Jinhee|Lee, Jun|Yi, Jin-Mu|Oh, Dal-Seok|Bang, Ok-Sun|Kim, No Soo
PMID: 23255939
Journal: Cancer Sci. 2013 Aug;104(8):1062-6.
Title: HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways.
Author: Zhao, Yu|Wu, Zhonghua|Zhang, Yuting|Zhu, Li
PMID: 23600770
Journal: Int J Oncol. 2013 Jul;43(1):289-96.
Title: Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells.
Author: Zhang, Zhiyu|Wang, Chong-Zhi|Du, Guang-Jian|Qi, Lian-Wen|Calway, Tyler|He, Tong-Chuan|Du, Wei|Yuan, Chun-Su
PMID: 23686257
Journal: PLoS One. 2013 Jun 14;8(6):e65683.
Title: ToP: a trend-of-disease-progression procedure works well for identifying cancer genes from multi-state cohort gene expression data for human colorectal cancer.
Author: Chung, Feng-Hsiang|Lee, Henry Hsin-Chung|Lee, Hoong-Chien
PMID: 23799036
Journal: J Proteome Res. 2013 Sep 6;12(9):4136-51.
Title: TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells.
Author: Hekmat, Omid|Munk, Stephanie|Fogh, Louise|Yadav, Rachita|Francavilla, Chiara|Horn, Heiko|Wurtz, Sidse Ornbjerg|Schrohl, Anne-Sofie|Damsgaard, Britt|Romer, Maria Unni|Belling, Kirstine C|Jensen, Niels Frank|Gromova, Irina|Bekker-Jensen, Dorte B|Moreira, Jo
PMID: 23909892
Journal: PLoS One. 2013 Aug 29;8(8):e73219.
Title: The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9.
Author: Iizumi, Yosuke|Oishi, Masakatsu|Taniguchi, Tomoyuki|Goi, Wakana|Sowa, Yoshihiro|Sakai, Toshiyuki
PMID: 24009741
Journal: PLoS One. 2013 Oct 3;8(10):e74140.
Title: Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis.
Author: Leiszter, Katalin|Galamb, Orsolya|Sipos, Ferenc|Krenacs, Tibor|Veres, Gabor|Wichmann, Barnabas|Kalmar, Alexandra|Patai, Arpad V|Toth, Kinga|Valcz, Gabor|Molnar, Bela|Tulassay, Zsolt
PMID: 24098334
Journal: Cell Prolif. 2013 Dec;46(6):665-76.
Title: Higher anti-tumour efficacy of platinum(IV) complex LA-12 is associated with its ability to bypass M-phase entry block induced in oxaliplatin-treated human colon cancer cells.
Author: Vondalova Blanarova, O|Jelinkova, I|Hyrslova Vaculova, A|Sova, P|Hofmanova, J|Kozubik, A
PMID: 24118195
Journal: Chem Res Toxicol. 2013 Nov 18;26(11):1683-91.
Title: N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
Author: Liu, Ling-Yu|Huang, Wei-Jan|Lin, Ren-Jye|Lin, Shyr-Yi|Liang, Yu-Chih
PMID: 24127835
Journal: J Cancer Prev. 2013 Sep;18(3):257-63.
Title: Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells.
Author: Cho, Han Jin|Park, Jung Han Yoon
PMID: 25337553
Journal: J Nat Med. 2014 Jan;68(1):53-62.
Title: Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo.
Author: Cai, Yuchen|Xia, Qing|Luo, Rongzhen|Huang, Peiyu|Sun, Yueli|Shi, Yanxia|Jiang, Wenqi
PMID: 23604974
Journal: Mitochondrion. 2014 May;16:55-64.
Title: Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells.
Author: Tailor, Dhanir|Hahm, Eun-Ryeong|Kale, Raosaheb K|Singh, Shivendra V|Singh, Rana P
PMID: 24177748
Journal: Int J Oncol. 2014 Jan;44(1):256-64.
Title: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-kappaB in HCT116 human colon cancer cells.
Author: Kim, Mi Kyeong|Kang, Yong Jung|Kim, Dong Hwan|Hossain, Mohammad Akbar|Jang, Jung Yoon|Lee, Sun Hwa|Yoon, Jeong-Hyun|Chun, Pusoon|Moon, Hyung Ryong|Kim, Hyung Sik|Chung, Hae Young|Kim, Nam Deuk
PMID: 24190633
Journal: Apoptosis. 2014 Mar;19(3):451-66.
Title: Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells.
Author: Bhattacharya, Sujoy|Ray, Ramesh M|Johnson, Leonard R
PMID: 24242917
Journal: Genes Nutr. 2014 Jan;9(1):359.
Title: The fermented non-digestible fraction of common bean (Phaseolus vulgaris L.) triggers cell cycle arrest and apoptosis in human colon adenocarcinoma cells.
Author: Cruz-Bravo, R K|Guevara-Gonzalez, R G|Ramos-Gomez, M|Oomah, B D|Wiersma, P|Campos-Vega, R|Loarca-Pina, G
PMID: 24293398
Journal: J Biol Chem. 2014 Feb 28;289(9):5997-6005.
Title: A colon cancer-derived mutant of Kruppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3beta (GSK3beta) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7alpha (FBW7alpha).
Author: Bialkowska, Agnieszka B|Liu, Yang|Nandan, Mandayam O|Yang, Vincent W
PMID: 24398687
Journal: Dev Biol. 2014 Mar 15;387(2):191-202.
Title: Inducible intestine-specific deletion of Kruppel-like factor 5 is characterized by a regenerative response in adult mouse colon.
Author: Nandan, Mandayam O|Ghaleb, Amr M|Liu, Yang|Bialkowska, Agnieszka B|McConnell, Beth B|Shroyer, Kenneth R|Robine, Sylvie|Yang, Vincent W
PMID: 24440658
Journal: Int J Oncol. 2014 May;44(5):1599-606.
Title: Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells.
Author: Lee, Yujin|Sung, Bokyung|Kang, Yong Jung|Kim, Dong Hwan|Jang, Jung-Yoon|Hwang, Seong Yeon|Kim, Minjung|Lim, Hyun Sook|Yoon, Jeong-Hyun|Chung, Hae Young|Kim, Nam Deuk
PMID: 24626522
Journal: Cell Death Dis. 2014 Apr 24;5:e1198.
Title: Therapeutic ROS targeting of GADD45gamma in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E.
Author: Hsu, Y-C|Huang, T-Y|Chen, M-J
PMID: 24763055
Journal: Chem Biol Interact. 2014 Aug 5;219:1-8.
Title: Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer.
Author: Kim, Hyeon Jin|Park, Jung Han Yoon|Kim, Jin-Kyung
PMID: 24858077
Journal: Cancer Biol Ther. 2014 Sep;15(9):1268-79.
Title: Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer.
Author: Fang, Yifeng|Yu, Hong|Liang, Xiao|Xu, Junfen|Cai, Xiujun
PMID: 24971465
Journal: Cancer Lett. 2014 Dec 28;355(2):297-309.
Title: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo.
Author: Xia, Yong|Lei, Qian|Zhu, Yongxia|Ye, Tinghong|Wang, Ningyu|Li, Guobo|Shi, Xuanhong|Liu, Yantong|Shao, Bin|Yin, Tao|Zhao, Lifeng|Wu, Wenshuang|Song, Xuejiao|Xiong, Ying|Wei, Yuquan|Yu, Luoting
PMID: 25301449
Journal: BMC Cancer. 2014 Dec 15;14:951.
Title: High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients.
Author: Sung, Wen-Wei|Lin, Yueh-Min|Wu, Pei-Ru|Yen, Hsu-Heng|Lai, Hung-Wen|Su, Tzu-Cheng|Huang, Ren-Hung|Wen, Chun-Kai|Chen, Chia-Yu|Chen, Chih-Jung|Yeh, Kun-Tu
PMID: 25511643
Journal: Leukemia. 2015 Jan;29(1):27-37.
Title: Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies.
Author: Weisberg, Ellen|Nonami, Atsushi|Chen, Zhao|Liu, Feiyang|Zhang, Jianming|Sattler, Martin|Nelson, Erik|Cowens, Kristen|Christie, Amanda L|Mitsiades, Constantine|Wong, Kwok-Kin|Liu, Qingsong|Gray, Nathanael|Griffin, James D
PMID: 24791855
Journal: Int J Cancer. 2015 Jun 15;136(12):2961-6.
Title: Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
Author: Lodhia, Kunal A|Gao, Shan|Aleksic, Tamara|Esashi, Fumiko|Macaulay, Valentine M
PMID: 25388513
Journal: Cancer Chemother Pharmacol. 2015 Feb;75(2):411-20.
Title: Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.
Author: Khattar, Vinayak|Fried, Joshua|Xu, Bo|Thottassery, Jaideep V
PMID: 25544127
Journal: Oncol Rep. 2015 Mar;33(3):1131-40.
Title: Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.
Author: Jikihara, Hiroshi|Qi, Guangying|Nozoe, Koichiro|Hirokawa, Mayumi|Sato, Hiromi|Sugihara, Yuka|Shimamoto, Fumio
PMID: 25573280
Journal: Biochem Biophys Res Commun. 2015 Jun 12;461(4):605-11.
Title: Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
Author: Chung, Hye Jin|Park, Kyeong Ryang|Lee, Hyo Jeong|Lee, Jongkook|Kim, Jeong-Hyun|Kim, Yong-Chul|Han, Sun-Young
PMID: 25912878
Journal: Nucleic Acids Res. 2015 Jul 27;43(13):6257-69.
Title: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells.
Author: Shi, Zhongcheng|Chiang, Chi-I|Labhart, Paul|Zhao, Yanling|Yang, Jianhua|Mistretta, Toni-Ann|Henning, Susan J|Maity, Sankar N|Mori-Akiyama, Yuko
PMID: 26040697
Journal: Am J Chin Med. 2015;43(4):743-56.
Title: Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk.
Author: Qi, Lian-Wen|Zhang, Zhiyu|Zhang, Chun-Feng|Anderson, Samantha|Liu, Qun|Yuan, Chun-Su|Wang, Chong-Zhi
PMID: 26119958
Journal: Mol Cancer Ther. 2015 Sep;14(9):2090-102.
Title: CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.
Author: Liu, Rui|Fan, Ming|Candas, Demet|Qin, Lili|Zhang, Xiaodi|Eldridge, Angela|Zou, June X|Zhang, Tieqiao|Juma, Shuaib|Jin, Cuihong|Li, Robert F|Perks, Julian|Sun, Lun-Quan|Vaughan, Andrew T M|Hai, Chun-Xu|Gius, David R|Li, Jian Jian
PMID: 26141949
Journal: Int J Mol Sci. 2015 Aug 17;16(8):19401-18.
Title: Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.
Author: Lan, Qiusheng|Li, Shoufeng|Lai, Wei|Xu, Heyang|Zhang, Yang|Zeng, Yujie|Lan, Wenjian|Chu, Zhonghua
PMID: 26287184
Journal: Biomed Pharmacother. 2015 Aug;74:117-23.
Title: Effect of RTKN on progression and metastasis of colon cancer in vitro.
Author: Qu, Guo-Qiang|Lu, Yun-Min|Liu, Yuan-Fei|Liu, Yuan|Chen, Wei-Xiong|Liao, Xiao-Hong|Kong, Wu-Ming
PMID: 26349972
Journal: Neoplasia. 2015 Sep;17(9):704-715.
Title: Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.
Author: Bilsland, Alan E|Pugliese, Angelo|Liu, Yu|Revie, John|Burns, Sharon|McCormick, Carol|Cairney, Claire J|Bower, Justin|Drysdale, Martin|Narita, Masashi|Sadaie, Mahito|Keith, W Nicol
PMID: 26476078
Journal: J Exp Clin Cancer Res. 2015 Nov 21;34:142.
Title: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Author: Jagadish, Nirmala|Parashar, Deepak|Gupta, Namita|Agarwal, Sumit|Purohit, Sapna|Kumar, Vikash|Sharma, Aditi|Fatima, Rukhsar|Topno, Amos Prashant|Shaha, Chandrima|Suri, Anil
PMID: 26590805
Journal: J Nat Prod. 2015 Dec 24;78(12):2983-93.
Title: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
Author: Jung, Cholomi|Hong, Ji-Young|Bae, Song Yi|Kang, Sam Sik|Park, Hyen Joo|Lee, Sang Kook
PMID: 26595875
Journal: Cell Death Discov. 2015;1.
Title: p53 Configures the G2/M Arrest Response of Nucleostemin-Deficient Cells.
Author: Huang, Guanqun|Meng, Lingjun|Tsai, Robert Y L
PMID: 26835157
Journal: Cell Discov. 2015;1.
Title: Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.
Author: Lin, Zhenghong|Tan, Can|Qiu, Quan|Kong, Sinyi|Yang, Heeyoung|Zhao, Fang|Liu, Zhaojian|Li, Jinping|Kong, Qingfei|Gao, Beixue|Barrett, Terry|Yang, Guang-Yu|Zhang, Jianing|Fang, Deyu
PMID: 27030811
Journal: Oncotarget. 2016 Jan 5;7(1):622-37.
Title: Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer.
Author: Thorenoor, Nithyananda|Faltejskova-Vychytilova, Petra|Hombach, Sonja|Mlcochova, Jitka|Kretz, Markus|Svoboda, Marek|Slaby, Ondrej
PMID: 26506418
Journal: Oncol Rep. 2016 Mar;35(3):1807-15.
Title: Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade.
Author: Zhang, Binhao|Leng, Chao|Wu, Chao|Zhang, Zhanguo|Dou, Lei|Luo, Xin|Zhang, Bixiang|Chen, Xiaoping
PMID: 26647806
Journal: Int J Oncol. 2016 Apr;48(4):1628-38.
Title: Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway.
Author: Chen, Jingwen|Wei, Ye|Feng, Qingyang|Ren, Li|He, Guodong|Chang, Wenju|Zhu, Dexiang|Yi, Tuo|Lin, Qi|Tang, Wentao|Xu, Jianmin|Qin, Xinyu
PMID: 26847263
Journal: Mol Nutr Food Res. 2016 May;60(5):1068-78.
Title: Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization.
Author: Byun, Sanguine|Shin, Seung Ho|Park, Jiman|Lim, Semi|Lee, Eunjung|Lee, Chaeyoon|Sung, Dongeun|Farrand, Lee|Lee, Seoung Rak|Kim, Ki Hyun|Dong, Zigang|Lee, Sam W|Lee, Ki Won
PMID: 26918318
Journal: J Gastroenterol. 2016 Oct;51(10):971-84.
Title: Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.
Author: Belharazem, Djeda|Magdeburg, Julia|Berton, Ann-Kristin|Beissbarth, Li|Sauer, Christian|Sticht, Carsten|Marx, Alexander|Hofheinz, Ralf|Post, Stefan|Kienle, Peter|Strobel, Philipp
PMID: 26984550
Journal: Oncol Rep. 2016 Jun;35(6):3363-70.
Title: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.
Author: Liu, Jiming|Li, Qiang|Liu, Zhilong|Lin, Liuming|Zhang, Xiangqiang|Cao, Mingrong|Jiang, Jianwei
PMID: 27004568
Journal: PLoS One. 2016 Jul 6;11(7):e0158844.
Title: Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses.
Author: Lin, Peng-Chan|Yang, Yi-Fang|Tyan, Yu-Chang|Hsiao, Eric S L|Chu, Po-Chen|Lee, Chung-Ta|Lee, Jenq-Chang|Chen, Yi-Ming Arthur|Liao, Pao-Chi
PMID: 27383761
Journal: Cell Metab. 2016 Sep 13;24(3):447-461.
Title: Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.
Author: Xue, Xiang|Ramakrishnan, Sadeesh K|Weisz, Kevin|Triner, Daniel|Xie, Liwei|Attili, Durga|Pant, Asha|Gyorffy, Balazs|Zhan, Mingkun|Carter-Su, Christin|Hardiman, Karin M|Wang, Thomas D|Dame, Michael K|Varani, James|Brenner, Dean|Fearon, Eric R|Shah, Yatrik M
PMID: 27546461
Journal: Cancer Lett. 2016 Dec 28;383(2):295-308.
Title: Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Author: Wen, Chuangyu|Chen, Junxiong|Zhang, Di|Wang, Huihui|Che, Jia|Qin, Qiyuan|He, Lu|Cai, Zerong|Lin, Mengmeng|Lou, Qiong|Huang, Lanlan|Chen, Daici|Iwamoto, Aikichi|Ren, Donglin|Wang, Lei|Lan, Ping|Wang, Jianping|Liu, Huanliang|Yang, Xiangling
PMID: 27713084
Journal: BMC Complement Altern Med. 2016 Oct 1;16(1):384.
Title: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action.
Author: Abaza, Mohamed Salah I|Afzal, Mohammad|Al-Attiyah, Raja'a J|Guleri, Radhika
PMID: 27716288
Journal: J Cancer Prev. 2016 Dec;21(4):249-256.
Title: Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells.
Author: Oh, You Na|Jin, Soojung|Park, Hyun-Jin|Kwon, Hyun Ju|Kim, Byung Woo
PMID: 28053959
Journal: Oncol Lett. 2016 Dec;12(6):5092-5098.
Title: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis.
Author: Yan, Ming|Song, Maomin|Bai, Rixing|Cheng, Shi|Yan, Wenmao
PMID: 28105216
Journal: Mol Carcinog. 2017 Jan;56(1):18-35.
Title: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression.
Author: Zakraoui, Ons|Marcinkiewicz, Cezary|Aloui, Zohra|Othman, Houcemeddine|Grepin, Renaud|Haoues, Meriam|Essafi, Makram|Srairi-Abid, Najet|Gasmi, Ammar|Karoui, Habib|Pages, Gilles|Essafi-Benkhadir, Khadija
PMID: 26824338
Journal: Clin Cancer Res. 2017 Jan 1;23(1):104-115.
Title: BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression.
Author: Barras, David|Missiaglia, Edoardo|Wirapati, Pratyaksha|Sieber, Oliver M|Jorissen, Robert N|Love, Chris|Molloy, Peter L|Jones, Ian T|McLaughlin, Stephen|Gibbs, Peter|Guinney, Justin|Simon, Iris M|Roth, Arnaud D|Bosman, Fred T|Tejpar, Sabine|Delorenzi, Maur
PMID: 27354468
Journal: Eur J Pharmacol. 2017 Feb 5;796:139-148.
Title: MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells.
Author: Liang, Baoxia|Liu, Ziyi|Cao, Yingnan|Zhu, Cuige|Zuo, Yinglin|Huang, Lei|Wen, Gesi|Shang, Nana|Chen, Yu|Yue, Xin|Du, Jun|Li, Baojian|Zhou, Binhua|Bu, Xianzhang
PMID: 28024945
Journal: PLoS One. 2017 Jan 9;12(1):e0168989.
Title: CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.
Author: Huang, Wen-Shih|Kuo, Yi-Hung|Kuo, Hsing-Chun|Hsieh, Meng-Chiao|Huang, Cheng-Yi|Lee, Ko-Chao|Lee, Kam-Fai|Shen, Chien-Heng|Tung, Shui-Yi|Teng, Chih-Chuan
PMID: 28068431
Journal: Oncotarget. 2017 Mar 28;8(13):21229-21240.
Title: TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma.
Author: Maddalena, Francesca|Simeon, Vittorio|Vita, Giulia|Bochicchio, Annamaria|Possidente, Luciana|Sisinni, Lorenza|Lettini, Giacomo|Condelli, Valentina|Matassa, Danilo Swann|Li Bergolis, Valeria|Fersini, Alberto|Romito, Sante|Aieta, Michele|Ambrosi, Antonio|Es
PMID: 28177905
Journal: Oncotarget. 2017 Mar 14;8(11):18106-18117.
Title: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction.
Author: Tsai, Chun-Hao|Hung, Amos C|Chen, Yuan-Yin|Chiu, Ya-Wen|Hsieh, Pei-Wen|Lee, Yi-Chen|Su, Yu-Han|Chang, Po-Chih|Hu, Stephen Chu-Sung|Yuan, Shyng-Shiou F
PMID: 28178649
Journal: Biomed Pharmacother. 2017 May;89:152-161.
Title: Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-kappaB pathway.
Author: Wang, Shi-Bin|Tao, Zhenzhou|Li, Ping
PMID: 28222396
Journal: Nanotechnology. 2017 Mar 7;28(13):135103.
Title: Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells.
Author: Hsu, H J|Huang, R F|Kao, T H|Inbaraj, B S|Chen, B H
PMID: 28266352
Journal: Onco Targets Ther. 2017 Mar 16;10:1613-1624.
Title: CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Author: Qin, Chunzhi|Ren, Li|Ji, Meiling|Lv, Shixu|Wei, Ye|Zhu, Dexiang|Lin, Qi|Xu, Pingping|Chang, Wenju|Xu, Jianmin
PMID: 28352193
Journal: PLoS One. 2017 Mar 29;12(3):e0174591.
Title: Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells.
Author: Nagappan, Arulkumar|Lee, Won Sup|Yun, Jeong Won|Lu, Jing Nan|Chang, Seong-Hwan|Jeong, Jae-Hoon|Kim, Gon Sup|Jung, Jin-Myung|Hong, Soon Chan
PMID: 28355296
Journal: Tumour Biol. 2017 Apr;39(4):1010428317697572.
Title: Long non-coding RNA colon cancer-associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression.
Author: Dou, Chunqing|Sun, Liyuan|Jin, Xin|Han, Mingming|Zhang, Bao|Li, Tao
PMID: 28381168
Journal: Toxicol Appl Pharmacol. 2017 Jul 1;326:25-33.
Title: Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy.
Author: Ji, Shuai|Tang, Shunan|Li, Kai|Li, Ziwei|Liang, Wenfei|Qiao, Xue|Wang, Qi|Yu, Siwang|Ye, Min
PMID: 28416456
Journal: Proc Natl Acad Sci U S A. 2017 May 16;114(20):5201-5206.
Title: Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm.
Author: Chen, Nan-Peng|Uddin, Borhan|Hardt, Robert|Ding, Wen|Panic, Marko|Lucibello, Ilaria|Kammerer, Patricia|Ruppert, Thomas|Schiebel, Elmar
PMID: 28465438
Journal: Cell Cycle. 2017 Jun 18;16(12):1193-1200.
Title: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.
Author: Zhang, Jun|Zhou, Lanlan|Zhao, Shuai|Dicker, David T|El-Deiry, Wafik S
PMID: 28486050
Journal: BMC Genomics. 2017 May 9;18(1):361.
Title: Associating transcriptional modules with colon cancer survival through weighted gene co-expression network analysis.
Author: Liu, Rong|Zhang, Wei|Liu, Zhao-Qian|Zhou, Hong-Hao
PMID: 28486948
Journal: Mar Drugs. 2017 Jul 20;15(7). pii: md15070221.
Title: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling.
Author: Tarhouni-Jabberi, Safa|Zakraoui, Ons|Ioannou, Efstathia|Riahi-Chebbi, Ichrak|Haoues, Meriam|Roussis, Vassilios|Kharrat, Riadh|Essafi-Benkhadir, Khadija
PMID: 28726723
Journal: Oncol Rep. 2017 Sep;38(3):1783-1789.
Title: MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells.
Author: Hwang, Na Lam|Kang, Yong Jung|Sung, Bokyung|Hwang, Seong Yeon|Jang, Jung Yoon|Oh, Hye Jin|Ahn, Yu Ra|Kim, Do Hyun|Kim, Su Jeong|Ullah, Sultan|Hossain, Mohammad Akbar|Moon, Hyung Ryong|Chung, Hae Young|Kim, Nam Deuk
PMID: 28731136
Journal: Molecules. 2017 Aug 17;22(8). pii: molecules22081361.
Title: Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells.
Author: Suh, Sung-Suk|Kim, Tai Kyoung|Kim, Jung Eun|Hong, Ju-Mi|Nguyen, Trang Thu Thi|Han, Se Jong|Youn, Ui Joung|Yim, Joung Han|Kim, Il-Chan
PMID: 28817102
Journal: Int J Oncol. 2017 Oct;51(4):1331-1342.
Title: Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of bMyb and miRNA34a expression.
Author: Lee, Yu-Jin|Kang, Yeong-Rim|Lee, So Young|Jin, Yena|Han, Dong Cho|Kwon, Byoung-Mog
PMID: 28902363
Journal: J Inorg Biochem. 2017 Dec;177:27-38.
Title: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells.
Author: Dandash, Fatima|Leger, David Yannick|Fidanzi-Dugas, Chloe|Nasri, Soumaya|Bregier, Frederique|Granet, Robert|Karam, Walid|Diab-Assaf, Mona|Sol, Vincent|Liagre, Bertrand
PMID: 28923355
Journal: Oncotarget. 2017 May 11;8(42):71618-71629.
Title: CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway.
Author: Gan, Wei|Zhao, Hua|Li, Tiegang|Liu, Kuijie|Huang, Jiangsheng
PMID: 29069733
Journal: Int J Oncol. 2017 Dec;51(6):1661-1673.
Title: Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.
Author: Dachineni, Rakesh|Kumar, D Ramesh|Callegari, Eduardo|Kesharwani, Siddharth S|Sankaranarayanan, Ranjini|Seefeldt, Teresa|Tummala, Hemachand|Bhat, G Jayarama
PMID: 29075787
Journal: Oncol Rep. 2017 Dec;38(6):3489-3496.
Title: Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance.
Author: Chang, Weiping|Yu, Zhaoxiang|Tian, Ming|Lin, Xiaobo
PMID: 29130100
Journal: Oncotarget. 2017 Sep 15;8(47):82968-82980.
Title: RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis.
Author: Wu, Xin-Lin|Yang, Zhi-Wen|He, Li|Dong, Pei-De|Hou, Ming-Xing|Meng, Xing-Kai|Zhao, Hai-Ping|Wang, Zhao-Yang|Wang, Feng|Baoluri|Wurenqimuge|Agudamu|Jia, Yong-Feng|Shi, Lin
PMID: 29137316
Journal: Breast Cancer. 2018 Mar;25(2):224-232.
Title: UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer.
Author: He, Jing|Chen, Yuanping|Cai, Lu|Li, Zelei|Guo, Xiaoqing
PMID: 29196913
Journal: Mol Cancer Res. 2018 Mar;16(3):378-389.
Title: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.
Author: Zhang, Peng|Kawakami, Hisato|Liu, Weizhen|Zeng, Xiangyu|Strebhardt, Klaus|Tao, Kaixiong|Huang, Shengbing|Sinicrope, Frank A
PMID: 29233910
Journal: Oncol Lett. 2018 Feb;15(2):1985-1992.
Title: Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin.
Author: Zhou, Mo|Zheng, Jinkai|Bi, Jinfeng|Wu, Xinye|Lyu, Jian|Gao, Kun
PMID: 29399200
Journal: Anticancer Agents Med Chem. 2018;18(4):565-572.
Title: Riluzole Inhibits Proliferation, Migration and Cell Cycle Progression and Induces Apoptosis in Tumor Cells of Various Origins.
Author: Lemieszek, Marta Kinga|Stepulak, Andrzej|Sawa-Wejksza, Katarzyna|Czerwonka, Arkadiusz|Ikonomidou, Chrysanthy|Rzeski, Wojciech
PMID: 29493465
Journal: Med Sci Monit. 2018 Mar 9;24:1424-1433.
Title: Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Author: Liu, Shasha|Liu, Bingrong
PMID: 29519997
Journal: Mol Cancer Ther. 2018 Jun;17(6):1156-1166.
Title: ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.
Author: Patel, Hetal|Periyasamy, Manikandan|Sava, Georgina P|Bondke, Alexander|Slafer, Brian W|Kroll, Sebastian H B|Barbazanges, Marion|Starkey, Richard|Ottaviani, Silvia|Harrod, Alison|Aboagye, Eric O|Buluwela, Laki|Fuchter, Matthew J|Barrett, Anthony G M|Coombe
PMID: 29545334
Journal: Future Sci OA. 2018 Jan 24;4(3):FSO278.
Title: Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer.
Author: Asghari, Matin|Abazari, Mohammad Foad|Bokharaei, Hanieh|Aleagha, Maryam Nouri|Poortahmasebi, Vahdat|Askari, Hassan|Torabinejad, Sepehr|Ardalan, Abbas|Negaresh, Navid|Ataei, Atousa|Pazooki, Parisa|Poorebrahim, Mansour
PMID: 29568567
Journal: Cancer Cell Int. 2018 Mar 27;18:48.
Title: Effects of secreted frizzled-related protein 1 on proliferation, migration, invasion, and apoptosis of colorectal cancer cells.
Author: Wang, Zhongchuan|Li, Rujia|He, Yongshan|Huang, Shiyong
PMID: 29610564
Journal: Oncol Rep. 2018 Jun;39(6):2829-2836.
Title: Protein kinase, membraneassociated tyrosine/threonine 1 is associated with the progression of colorectal cancer.
Author: Jeong, Dongjun|Kim, Hyeongjoo|Kim, Doyeon|Ban, Seona|Oh, Seunghyun|Ji, Sanghee|Kang, Donghuyn|Lee, Hyunyong|Ahn, Tae Sung|Kim, Han Jo|Bae, Sang Byung|Lee, Moon Soo|Kim, Chang-Jin|Kwon, Hyog Young|Baek, Moo-Jun
PMID: 29658598
Journal: Chem Biol Interact. 2018 Jun 1;289:9-14.
Title: miR-223-RhoB signaling pathway regulates the proliferation and apoptosis of colon adenocarcinoma.
Author: Wei, Li-Juan|Li, Jun-An|Bai, Dong-Mei|Song, Ying
PMID: 29660302
Journal: Tumour Biol. 2018 Apr;40(4):1010428318770957.
Title: Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells.
Author: Spagnoletti, Girolamo|Li Bergolis, Valeria|Piscazzi, Annamaria|Giannelli, Francesca|Condelli, Valentina|Sisinni, Lorenza|Bove, Giuseppe|Storto, Giovanni|Landriscina, Matteo
PMID: 29663854
Journal: Eur J Med Chem. 2018 May 25;152:31-52.
Title: Structural-based design, synthesis, and antitumor activity of novel alloxazine analogues with potential selective kinase inhibition.
Author: Malki, Waleed H|Gouda, Ahmed M|Ali, Hamdy E A|Al-Rousan, Rabaa|Samaha, Doaa|Abdalla, Ashraf N|Bustamante, Juan|Abd Elmageed, Zakaria Y|Ali, Hamed I
PMID: 29684708
Journal: Indian J Med Res. 2018 Feb;147(2):158-168.
Title: C-glycosyl flavone from Urginea indica inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines.
Author: Bevara, Ganesh Babu|Naveen Kumar, A D|Koteshwaramma, K Laxmi|Badana, Anil|Kumari, Seema|Malla, Rama Rao
PMID: 29806604
Journal: Med Sci Monit. 2018 Jun 3;24:3710-3719.
Title: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells.
Author: Meng, Ling-Qi|Wang, Yue|Luo, Ying-Hua|Piao, Xian-Ji|Liu, Chang|Wang, Yue|Zhang, Yi|Wang, Jia-Ru|Wang, Hao|Xu, Wan-Ting|Liu, Yang|Wu, Yi-Qin|Sun, Hu-Nan|Han, Ying-Hao|Jin, Mei-Hua|Shen, Gui-Nan|Fang, Nan-Zhu|Jin, Cheng-Hao
PMID: 29860266
Journal: Bioorg Med Chem. 2018 Aug 7;26(14):3899-3908.
Title: Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells.
Author: He, Liu-Jun|Yang, Dong-Lin|Li, Shi-Qiang|Zhang, Ya-Jun|Tang, Yan|Lei, Jie|Frett, Brendan|Lin, Hui-Kuan|Li, Hong-Yu|Chen, Zhong-Zhu|Xu, Zhi-Gang
PMID: 29921474
Journal: Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6760-E6769.
Title: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Author: Zhou, Jiuli|Zeng, Yongji|Cui, Lian|Chen, Xingcheng|Stauffer, Seth|Wang, Zhan|Yu, Fang|Lele, Subodh M|Talmon, Geoffrey A|Black, Adrian R|Chen, Yuanhong|Dong, Jixin
PMID: 29967145
Journal: Int J Oncol. 2018 Oct;53(4):1667-1680.
Title: Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells.
Author: Wang, Yaqi|Yang, Lifeng|Zhang, Jing|Zhou, Menglong|Shen, Lijun|Deng, Weijuan|Liang, Liping|Hu, Ran|Yang, Wang|Yao, Ye|Zhang, Hui|Zhang, Zhen
PMID: 30085332
Journal: Biomed Res Int. 2018 Sep 27;2018:2548378.
Title: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells.
Author: Sun, Dongdong|Shen, Weixing|Zhang, Feng|Fan, Huisen|Tan, Jiani|Li, Liu|Xu, Changliang|Zhang, Haibin|Yang, Ye|Cheng, Haibo
PMID: 30363706