Primary Site >> Colorectal Cancer
Gene >> CDK1
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Ref: Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer. PMID: 7779716 |
Ref: Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. PMID: 8549662 Ref: The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins. PMID: 8632912 Ref: UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. PMID: 8667426 Ref: Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells. PMID: 8813137 Ref: Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. PMID: 8831555 Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 |
Ref: Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. PMID: 9268294 Ref: Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. PMID: 9307289 Ref: Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. PMID: 10068276 |
Ref: Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. PMID: 9418904 Ref: Elevated expression of the cdc25A protein phosphatase in colon cancer. PMID: 9596996 Ref: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells. PMID: 9664116 Ref: gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. PMID: 9683802 Ref: Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of HT29 human colon carcinoma cells. PMID: 9688315 |
Ref: Amplified CDK2 and cdc2 activities in primary colorectal carcinoma. PMID: 10091728 Ref: Differential cyclin-dependent kinase expression and activation in human colon cancer. PMID: 10216486 Ref: Induction of apoptosis and G2/M cell cycle arrest by DCC. PMID: 10348349 Ref: 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. PMID: 10524633 Ref: Butyrate-induced G2/M block in Caco-2 colon cancer cells is associated with decreased p34cdc2 activity. PMID: 10564539 Ref: Assessment of biomarkers in paired primary and recurrent colorectal adenocarcinomas. PMID: 10613309 Ref: beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells. PMID: 10656873 |
Ref: Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. PMID: 10657978 Ref: Cell cycle molecular targets in novel anticancer drug discovery. PMID: 10788588 Ref: Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation. PMID: 10837000 Ref: Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. PMID: 10900467 |
Ref: Inhibition of mitotic cyclin B and cdc2 kinase activity by selenomethionine in synchronized colon cancer cells. PMID: 11272285 Ref: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. PMID: 11396178 Ref: DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells. PMID: 11494044 Ref: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. PMID: 11574543 Ref: COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. PMID: 11606477 Ref: A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. PMID: 11687954 Ref: The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways. PMID: 11705845 Ref: Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation. PMID: 11719462 Ref: Cdk1/P34Cdc2 and P21waf expression in colorectal adenomas and carcinomas. PMID: 11876550 |
Ref: Antiproliferative activity of mixed-ligand dien-Cu(II) complexes with thiazole, thiazoline and imidazole derivatives. PMID: 11750022 Ref: Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination. PMID: 11774253 Ref: Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines. PMID: 11823594 Ref: Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. PMID: 12036951 Ref: Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells. PMID: 12119558 Ref: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. PMID: 12466962 Ref: [Potentiation of radiosensitivity by staurosporine associated with abrogation of G2 phase arrest]. PMID: 12579796 |
Ref: Influence of environmental pH on G2-phase arrest caused by ionizing radiation. PMID: 12492371 Ref: Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. PMID: 12663041 Ref: p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma. PMID: 12884029 Ref: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. PMID: 14614451 Ref: [Predictive molecular marker of distant metastasis in colorectal cancer]. PMID: 15027705 |
Ref: Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. PMID: 14578157 Ref: Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. PMID: 14627709 Ref: Establishment of a colonic adenoma cell line (GEKI-2): spectral karyotype analysis and functional characterization. PMID: 14648095 Ref: N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. PMID: 14728717 Ref: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. PMID: 14729633 Ref: Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line. PMID: 15001986 Ref: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. PMID: 15048074 Ref: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. PMID: 15073169 Ref: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells. PMID: 15169628 Ref: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines. PMID: 15204521 Ref: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines. PMID: 15206942 Ref: Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. PMID: 15231455 Ref: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). PMID: 15317660 Ref: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. PMID: 15326376 Ref: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells. PMID: 15342418 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 |
Ref: Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines. PMID: 15483186 Ref: Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells. PMID: 15513932 Ref: The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines. PMID: 15655409 Ref: Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. PMID: 15710357 Ref: Overexpression of RGC-32 in colon cancer and other tumors. PMID: 15713436 Ref: Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. PMID: 15860443 Ref: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest. PMID: 15870882 Ref: Proteomic analysis of differentially expressed proteins between metastatic and non-metastatic human colorectal carcinoma cell lines. PMID: 15947549 Ref: Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. PMID: 15958646 Ref: Oxaliplatin, a potent inhibitor of survivin, enhances paclitaxel-induced apoptosis and mitotic catastrophe in colon cancer cells. PMID: 16024531 Ref: Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. PMID: 16112579 Ref: Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. PMID: 16226712 Ref: Differential gene expression of sulindac-treated human breast epithelial cells. PMID: 16273229 Ref: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. PMID: 16317137 |
Ref: Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. PMID: 16456034 Ref: Discovery and evaluation of dual CDK1 and CDK2 inhibitors. PMID: 16618755 Ref: Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis. PMID: 16649252 Ref: Radiosensitization of tumor cells by modulation of ATM kinase. PMID: 16690595 Ref: Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. PMID: 16697099 Ref: Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes. PMID: 16737765 Ref: Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. PMID: 17064073 Ref: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. PMID: 17079455 Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 |
Ref: RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints. PMID: 17072338 Ref: An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. PMID: 17121828 Ref: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. PMID: 17273739 Ref: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. PMID: 17638911 Ref: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. PMID: 17804748 Ref: Tetrandrine: a potent abrogator of G2 checkpoint function in tumor cells and its mechanism. PMID: 18348409 |
Ref: Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. PMID: 17999988 Ref: Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. PMID: 18292181 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. PMID: 18504430 Ref: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. PMID: 18802399 Ref: Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis. PMID: 18806812 Ref: Anti-cancer effects of xanthones from pericarps of mangosteen. PMID: 19325754 |
Ref: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. PMID: 19038304 Ref: Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. PMID: 19174555 Ref: Cdc2 as prognostic marker in stage UICC II colon carcinomas. PMID: 19223178 Ref: Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells. PMID: 19276868 Ref: 1-Methylxanthine enhances the radiosensitivity of tumor cells. PMID: 19280470 Ref: Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression. PMID: 19287963 Ref: The impact of gene expression on 18F-FDG kinetics; a new chapter for diagnostic nuclear medicine. PMID: 19330172 Ref: Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle. PMID: 19360331 Ref: 3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. PMID: 19470789 Ref: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. PMID: 19480695 Ref: Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis. PMID: 19502782 Ref: Comparative proteomic analysis of colon cancer cells in response to oxaliplatin treatment. PMID: 19520192 Ref: Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. PMID: 19582879 Ref: Antiproliferative and cytotoxic effects of sodium selenite in human colon cancer cells. PMID: 19602434 Ref: Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells. PMID: 19735649 Ref: Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies. PMID: 19875300 Ref: Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. PMID: 19926935 |
Ref: Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. PMID: 19795419 Ref: c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. PMID: 19833164 Ref: Epigenetic modifications induced by RGC-32 in colon cancer. PMID: 19883641 Ref: The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. PMID: 20053762 Ref: MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil. PMID: 20107315 Ref: Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression. PMID: 20564491 Ref: DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells. PMID: 20574922 Ref: Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. PMID: 20576619 Ref: Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway. PMID: 20596632 Ref: Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PMID: 20808790 Ref: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PMID: 20957031 Ref: Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PMID: 21152443 Ref: ML264: An Antitumor Agent that Potently and Selectively Inhibits Kruppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression PMID: 23762940 Ref: Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry PMID: 23762957 |
Ref: Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest. PMID: 20195699 Ref: G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer. PMID: 20979106 Ref: 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. PMID: 21258042 Ref: Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. PMID: 21271215 Ref: A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis. PMID: 21321609 Ref: Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53. PMID: 21348775 Ref: RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-kappaB in colon carcinoma HCT116 cells. PMID: 21570766 Ref: Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. PMID: 21598039 Ref: Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I). PMID: 21798738 Ref: Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro. PMID: 22977502 |
Ref: Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer. PMID: 22108518 Ref: S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers. PMID: 22407595 Ref: Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats. PMID: 22496968 Ref: Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. PMID: 22552540 Ref: Nitric oxide-donating aspirin induces G2/M phase cell cycle arrest in human cancer cells by regulating phase transition proteins. PMID: 22552812 Ref: Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells. PMID: 22563433 Ref: 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest. PMID: 22719783 Ref: Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. PMID: 22965228 Ref: Effects of SASH1 on melanoma cell proliferation and apoptosis in vitro. PMID: 23023727 Ref: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. PMID: 23064444 |
Ref: The inhibitory effects and mechanisms of rhamnogalacturonan I pectin from potato on HT-29 colon cancer cell proliferation and cell cycle progression. PMID: 22694196 Ref: Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro. PMID: 23255939 Ref: HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways. PMID: 23600770 Ref: Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. PMID: 23686257 Ref: ToP: a trend-of-disease-progression procedure works well for identifying cancer genes from multi-state cohort gene expression data for human colorectal cancer. PMID: 23799036 Ref: TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells. PMID: 23909892 Ref: The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9. PMID: 24009741 Ref: Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis. PMID: 24098334 Ref: Higher anti-tumour efficacy of platinum(IV) complex LA-12 is associated with its ability to bypass M-phase entry block induced in oxaliplatin-treated human colon cancer cells. PMID: 24118195 Ref: N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo. PMID: 24127835 Ref: Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. PMID: 25337553 |
Ref: Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. PMID: 23604974 Ref: Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells. PMID: 24177748 Ref: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-kappaB in HCT116 human colon cancer cells. PMID: 24190633 Ref: Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. PMID: 24242917 Ref: The fermented non-digestible fraction of common bean (Phaseolus vulgaris L.) triggers cell cycle arrest and apoptosis in human colon adenocarcinoma cells. PMID: 24293398 Ref: A colon cancer-derived mutant of Kruppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3beta (GSK3beta) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7alpha (FBW7alpha). PMID: 24398687 Ref: Inducible intestine-specific deletion of Kruppel-like factor 5 is characterized by a regenerative response in adult mouse colon. PMID: 24440658 Ref: Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. PMID: 24626522 Ref: Therapeutic ROS targeting of GADD45gamma in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E. PMID: 24763055 Ref: Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer. PMID: 24858077 Ref: Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer. PMID: 24971465 Ref: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. PMID: 25301449 Ref: High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients. PMID: 25511643 |
Ref: Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. PMID: 24791855 Ref: Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition. PMID: 25388513 Ref: Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells. PMID: 25544127 Ref: Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. PMID: 25573280 Ref: Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells. PMID: 25912878 Ref: Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. PMID: 26040697 Ref: Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk. PMID: 26119958 Ref: CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. PMID: 26141949 Ref: Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. PMID: 26287184 Ref: Effect of RTKN on progression and metastasis of colon cancer in vitro. PMID: 26349972 Ref: Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks. PMID: 26476078 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 Ref: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. PMID: 26595875 Ref: p53 Configures the G2/M Arrest Response of Nucleostemin-Deficient Cells. PMID: 26835157 Ref: Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. PMID: 27030811 |
Ref: Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. PMID: 26506418 Ref: Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade. PMID: 26647806 Ref: Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway. PMID: 26847263 Ref: Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization. PMID: 26918318 Ref: Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. PMID: 26984550 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses. PMID: 27383761 Ref: Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. PMID: 27546461 Ref: Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells. PMID: 27713084 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 Ref: Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells. PMID: 28053959 Ref: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis. PMID: 28105216 |
Ref: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. PMID: 26824338 Ref: BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression. PMID: 27354468 Ref: MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells. PMID: 28024945 Ref: CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PMID: 28068431 Ref: TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma. PMID: 28177905 Ref: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. PMID: 28178649 Ref: Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-kappaB pathway. PMID: 28222396 Ref: Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells. PMID: 28266352 Ref: CDKL1 promotes tumor proliferation and invasion in colorectal cancer. PMID: 28352193 Ref: Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells. PMID: 28355296 Ref: Long non-coding RNA colon cancer-associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression. PMID: 28381168 Ref: Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy. PMID: 28416456 Ref: Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. PMID: 28465438 Ref: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia. PMID: 28486050 Ref: Associating transcriptional modules with colon cancer survival through weighted gene co-expression network analysis. PMID: 28486948 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells. PMID: 28731136 Ref: Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells. PMID: 28817102 Ref: Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of bMyb and miRNA34a expression. PMID: 28902363 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway. PMID: 29069733 Ref: Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer. PMID: 29075787 Ref: Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance. PMID: 29130100 Ref: RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis. PMID: 29137316 |
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