Primary Site >> Colorectal Cancer

Gene >> BMI1

Journal: Nat Cell Biol. 2009 Dec;11(12):1487-95.
Title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Author: Wellner, Ulrich|Schubert, Jorg|Burk, Ulrike C|Schmalhofer, Otto|Zhu, Feng|Sonntag, Annika|Waldvogel, Bettina|Vannier, Corinne|Darling, Douglas|zur Hausen, Axel|Brunton, Valerie G|Morton, Jennifer|Sansom, Owen|Schuler, Julia|Stemmler, Marc P|Herzberger, Ch
PMID: 19935649
Journal: Br J Cancer. 2009 Jul 21;101(2):320-6.
Title: Type I collagen inhibits differentiation and promotes a stem cell-like phenotype in human colorectal carcinoma cells.
Author: Kirkland, S C
PMID: 19568234
Journal: Med Oncol. 2010 Dec;27(4):1273-6.
Title: Polycomb group protein Bmi1 expression in colon cancers predicts the survival.
Author: Du, Jianjun|Li, Yongqi|Li, Jipeng|Zheng, Jianyong
PMID: 19957112
Journal: Biochem Biophys Res Commun. 2011 Jan 7;404(1):273-8.
Title: MicroRNA expression profile of colon cancer stem-like cells in HT29 adenocarcinoma cell line.
Author: Zhang, Huanle|Li, Weihua|Nan, Feifei|Ren, Fang|Wang, Hongxia|Xu, Yingchun|Zhang, Fengchun
PMID: 21130073
Journal: Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4382-7.
Title: Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells.
Author: Yeung, Trevor M|Gandhi, Shaan C|Bodmer, Walter F
PMID: 21368208
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Aug;14(8):623-6.
Title: [Mechanism of polycomb Bmi1-targeted therapy for colorectal cancer].
Author: Zhang, Hui|Ye, Ying-jiang|Cui, Zhi-rong|Wang, Shan
PMID: 21866458
Journal: J Biol Chem. 2012 Jan 20;287(4):2798-809.
Title: TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer.
Author: Lee, Chun-Chung|Chen, Wei-Shone|Chen, Chia-Chi|Chen, Li-Li|Lin, Yi-Shing|Fan, Chi-Shuan|Huang, Tze-Sing
PMID: 22130667
Journal: J Biol Chem. 2012 Feb 3;287(6):3760-8.
Title: Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer.
Author: Yu, Tianxin|Chen, Xi|Zhang, Wen|Colon, Deannon|Shi, Jiandang|Napier, Dana|Rychahou, Piotr|Lu, Wange|Lee, Eun Y|Weiss, Heidi L|Evers, B Mark|Liu, Chunming
PMID: 22170051
Journal: Cancer Res. 2012 Mar 1;72(5):1301-15.
Title: Oncogenicity of the developmental transcription factor Sox9.
Author: Matheu, Ander|Collado, Manuel|Wise, Clare|Manterola, Lorea|Cekaite, Lina|Tye, Angela J|Canamero, Marta|Bujanda, Luis|Schedl, Andreas|Cheah, Kathryn S E|Skotheim, Rolf I|Lothe, Ragnhild A|Lopez de Munain, Adolfo|Briscoe, James|Serrano, Manuel|Lovell-Badge,
PMID: 22246670
Journal: PLoS One. 2012;7(2):e32170.
Title: Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
Author: Zhu, Rong|Yang, Yongtao|Tian, Yin|Bai, Jianying|Zhang, Xin|Li, Xiaohuan|Peng, Zhihong|He, Yonghong|Chen, Lei|Pan, Qiong|Fang, Dianchun|Chen, Wensheng|Qian, Chen|Bian, Xiuwu|Wang, Rongquan
PMID: 22384170
Journal: Mol Cancer. 2012 Nov 23;11:87.
Title: IL-1beta promotes stemness and invasiveness of colon cancer cells through Zeb1 activation.
Author: Li, Yijing|Wang, Lei|Pappan, Loretta|Galliher-Beckley, Amy|Shi, Jishu
PMID: 23174018
Journal: Mol Med. 2013 Feb 8;18:1491-8.
Title: MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene.
Author: He, Xinqi|Dong, Yujuan|Wu, Chung Wah|Zhao, Zengren|Ng, Simon S M|Chan, Francis K L|Sung, Joseph J Y|Yu, Jun
PMID: 23255074
Journal: PLoS One. 2013 Nov 28;8(11):e81839.
Title: Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer.
Author: Sugihara, Hidetaka|Ishimoto, Takatsugu|Watanabe, Masayuki|Sawayama, Hiroshi|Iwatsuki, Masaaki|Baba, Yoshifumi|Komohara, Yoshihiro|Takeya, Motohiro|Baba, Hideo
PMID: 24312366
Journal: Cell Biol Int. 2013 May;37(5):406-14.
Title: Intestinal stem cells - types and markers.
Author: Zhang, Zhigang|Huang, Jian
PMID: 23471862
Journal: Gut. 2013 Jul;62(7):1012-23.
Title: In situ validation of an intestinal stem cell signature in colorectal cancer.
Author: Ziskin, Jennifer L|Dunlap, Debra|Yaylaoglu, Murat|Fodor, Imola K|Forrest, William F|Patel, Rajesh|Ge, Nianfeng|Hutchins, Gordon G|Pine, James K|Quirke, Philip|Koeppen, Hartmut|Jubb, Adrian M
PMID: 22637696
Journal: Oncogene. 2014 Jul 10;33(28):3742-7.
Title: Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer.
Author: Maynard, M A|Ferretti, R|Hilgendorf, K I|Perret, C|Whyte, P|Lees, J A
PMID: 23955081
Journal: Oncogenesis. 2014 Jun 9;3:e105.
Title: Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway.
Author: Lu, R|Wu, S|Zhang, Y-G|Xia, Y|Liu, X|Zheng, Y|Chen, H|Schaefer, K L|Zhou, Z|Bissonnette, M|Li, L|Sun, J
PMID: 24911876
Journal: Mol Clin Oncol. 2014 Sep;2(5):817-820.
Title: Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients.
Author: Pun, Jason Chun-Sang|Chan, Joyce Yee-Jing|Chun, Bobby Ka-Ming|Ng, Ka-Wai|Tsui, Samuel Yung-Kin|Wan, Timothy Ming-Hun|Lo, Oswens|Poon, Jensen Tung-Chung|Ng, Lui|Pang, Roberta
PMID: 25054051
Journal: Cancer Res. 2014 Nov 1;74(21):6119-28.
Title: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer.
Author: Sakurai, Toshiharu|Kashida, Hiroshi|Watanabe, Tomohiro|Hagiwara, Satoru|Mizushima, Tsunekazu|Iijima, Hideki|Nishida, Naoshi|Higashitsuji, Hiroaki|Fujita, Jun|Kudo, Masatoshi
PMID: 25187386
Journal: PLoS One. 2014 Sep 22;9(9):e108265.
Title: Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer.
Author: Benard, Anne|Goossens-Beumer, Ines J|van Hoesel, Anneke Q|Horati, Hamed|Putter, Hein|Zeestraten, Eliane C M|van de Velde, Cornelis J H|Kuppen, Peter J K
PMID: 25243792
Journal: PLoS One. 2015 Jul 17;10(7):e0132977.
Title: Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.
Author: Alberti, Loredana|Losi, Lorena|Leyvraz, Serge|Benhattar, Jean
PMID: 26185996
Journal: Curr Pharmacol Rep. 2015 Aug 1;1(4):217-222.
Title: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.
Author: Sureban, Sripathi M|Qu, Dongfeng|Houchen, Courtney W
PMID: 26366338
Journal: Oncotarget. 2015 Sep 8;6(26):22179-90.
Title: Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels.
Author: Lim, Byungho|Mun, Jihyeob|Kim, Jeong-Hwan|Kim, Chan Wook|Roh, Seon Ae|Cho, Dong-Hyung|Kim, Yong Sung|Kim, Seon-Young|Kim, Jin Cheon
PMID: 26109429
Journal: Cell Stem Cell. 2015 Jun 4;16(6):627-38.
Title: Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.
Author: Asfaha, Samuel|Hayakawa, Yoku|Muley, Ashlesha|Stokes, Sarah|Graham, Trevor A|Ericksen, Russell E|Westphalen, Christoph B|von Burstin, Johannes|Mastracci, Teresa L|Worthley, Daniel L|Guha, Chandhan|Quante, Michael|Rustgi, Anil K|Wang, Timothy C
PMID: 26046762
Journal: Clin Colorectal Cancer. 2015 Jun;14(2):63-71.
Title: Clinical implications of intestinal stem cell markers in colorectal cancer.
Author: Espersen, Maiken Lise Marcker|Olsen, Jesper|Linnemann, Dorte|Hogdall, Estrid|Troelsen, Jesper T
PMID: 25657049
Journal: Carcinogenesis. 2015 Mar;36(3):355-67.
Title: Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer.
Author: Toden, Shusuke|Okugawa, Yoshinaga|Jascur, Thomas|Wodarz, Dominik|Komarova, Natalia L|Buhrmann, Constanze|Shakibaei, Mehdi|Boland, C Richard|Goel, Ajay
PMID: 25653233
Journal: Cell Death Dis. 2015 Jan 8;6:e1583.
Title: Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p.
Author: Ma, M-Z|Chu, B-F|Zhang, Y|Weng, M-Z|Qin, Y-Y|Gong, W|Quan, Z-W
PMID: 25569100
Journal: Inflamm Bowel Dis. 2015 Jan;21(1):31-9.
Title: Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease.
Author: Adachi, Teppei|Sakurai, Toshiharu|Kashida, Hiroshi|Mine, Hiromasa|Hagiwara, Satoru|Matsui, Shigenaga|Yoshida, Koji|Nishida, Naoshi|Watanabe, Tomohiro|Itoh, Katsuhiko|Fujita, Jun|Kudo, Masatoshi
PMID: 25437815
Journal: Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1550-8.
Title: The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation.
Author: Jones, Matthew F|Hara, Toshifumi|Francis, Princy|Li, Xiao Ling|Bilke, Sven|Zhu, Yuelin|Pineda, Marbin|Subramanian, Murugan|Bodmer, Walter F|Lal, Ashish
PMID: 25775580
Journal: APMIS. 2016 Jul;124(7):541-6.
Title: The prognostic value of polycomb group protein B-cell-specific moloney murine leukemia virus insertion site 1 in stage II colon cancer patients.
Author: Espersen, Maiken L M|Linnemann, Dorte|Christensen, Ib J|Alamili, Mahdi|Troelsen, Jesper T|Hogdall, Estrid
PMID: 27102362
Journal: PLoS One. 2016 Nov 15;11(11):e0166282.
Title: Bacterially-Associated Transcriptional Remodelling in a Distinct Genomic Subtype of Colorectal Cancer Provides a Plausible Molecular Basis for Disease Development.
Author: Lennard, Katie S|Goosen, Ryan W|Blackburn, Jonathan M
PMID: 27846243
Journal: Physiol Rep. 2016 Aug;4(16). pii: 4/16/e12906.
Title: BMI1 is downregulated by the natural compound curcumin, but not by bisdemethoxycurcumin and dimethoxycurcumin.
Author: Adeyeni, Temitope A|Khatwani, Natasha|San, KayKay|Ezekiel, Uthayashanker R
PMID: 27550987
Journal: Saudi J Gastroenterol. 2016 Jul-Aug;22(4):288-93.
Title: Significance of BMI1 and FSCN1 expression in colorectal cancer.
Author: Alajez, Nehad M
PMID: 27488323
Journal: Cancer Biol Ther. 2016 Aug 2;17(8):813-23.
Title: Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer.
Author: Huynh, Nhi|Shulkes, Arthur|Baldwin, Graham|He, Hong
PMID: 27260988
Journal: J Exp Clin Cancer Res. 2016 May 25;35:84.
Title: Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication.
Author: Kaufhold, Samantha|Garban, Hermes|Bonavida, Benjamin
PMID: 27225481
Journal: Oncotarget. 2016 May 10;7(19):27232-42.
Title: Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer.
Author: Scholch, Sebastian|Garcia, Sebastian A|Iwata, Naoki|Niemietz, Thomas|Betzler, Alexander M|Nanduri, Lahiri K|Bork, Ulrich|Kahlert, Christoph|Thepkaysone, May-Linn|Swiersy, Anka|Buchler, Markus W|Reissfelder, Christoph|Weitz, Jurgen|Rahbari, Nuh N
PMID: 27029058
Journal: Oncotarget. 2016 Mar 29;7(13):16158-71.
Title: Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer.
Author: Toden, Shusuke|Tran, Hanh-My|Tovar-Camargo, Oscar A|Okugawa, Yoshinaga|Goel, Ajay
PMID: 26930714
Journal: Oncotarget. 2016 Feb 9;7(6):7307-17.
Title: IL-32theta inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer.
Author: Bak, Yesol|Kwon, Taeho|Bak, In Seon|Hong, Jintae|Yu, Dae-Yeul|Yoon, Do-Young
PMID: 26824417
Journal: Tumour Biol. 2016 Jan;37(1):7-21.
Title: Cancer stem cells in human digestive tract malignancies.
Author: Rassouli, Fatemeh B|Matin, Maryam M|Saeinasab, Morvarid
PMID: 26446457
Journal: Hum Pathol. 2017 Apr;62:56-65.
Title: Prognostic significance of stromal GREM1 expression in colorectal cancer.
Author: Jang, Bo Gun|Kim, Hye Sung|Chang, Weon Young|Bae, Jeong Mo|Oh, Hyeon Jeong|Wen, Xianyu|Jeong, Seorin|Cho, Nam Yun|Kim, Woo Ho|Kang, Gyeong Hoon
PMID: 28041973
Journal: Genes Cancer. 2017 Jul;8(7-8):673-681.
Title: Deregulated expression of microRNA-200b/c and SUZ12, a Polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells.
Author: San, KayKay|Horita, Megan|Ganapathy, Aravinda|Chinnadurai, G|Ezekiel, Uthayashanker R
PMID: 28966728
Journal: J Nat Prod. 2017 Jun 23;80(6):1853-1859.
Title: Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata.
Author: Kaneta, Yui|Arai, Midori A|Ishikawa, Naoki|Toume, Kazufumi|Koyano, Takashi|Kowithayakorn, Thaworn|Chiba, Tetsuhiro|Iwama, Atsushi|Ishibashi, Masami
PMID: 28598616
Journal: Cell Cycle. 2017 Jul 3;16(13):1243-1251.
Title: NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.
Author: Karki, Rajendra|Malireddi, R K Subbarao|Zhu, Qifan|Kanneganti, Thirumala-Devi
PMID: 28598238
Journal: Mol Carcinog. 2017 Oct;56(10):2267-2278.
Title: Fas signaling induces stemness properties in colorectal cancer by regulation of Bmi1.
Author: Chen, Jiaxuan|Wang, Yadong|Zhuo, Linghao|Liu, Zhizhong|Liu, Tao|Li, Wenjing|Cai, Yidong|Zheng, Haoxuan
PMID: 28543447
Journal: Sci Rep. 2017 Feb 8;7:41838.
Title: Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion.
Author: Yanai, Hirotsugu|Atsumi, Naho|Tanaka, Toshihiro|Nakamura, Naohiro|Komai, Yoshihiro|Omachi, Taichi|Tanaka, Kiyomichi|Ishigaki, Kazuhiko|Saiga, Kazuho|Ohsugi, Haruyuki|Tokuyama, Yoko|Imahashi, Yuki|Ohe, Shuichi|Hisha, Hiroko|Yoshida, Naoko|Kumano, Keiki|Kon
PMID: 28176811
Journal: Mol Cancer. 2017 Feb 1;16(1):30.
Title: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
Author: Chandrakesan, Parthasarathy|Yao, Jiannan|Qu, Dongfeng|May, Randal|Weygant, Nathaniel|Ge, Yang|Ali, Naushad|Sureban, Sripathi M|Gude, Modhi|Vega, Kenneth|Bannerman-Menson, Eddie|Xia, Lijun|Bronze, Michael|An, Guangyu|Houchen, Courtney W
PMID: 28148261
Journal: Gastroenterology. 2018 Mar;154(4):948-964.e8.
Title: Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.
Author: Sharma, Deepika|Malik, Ankit|Guy, Clifford S|Karki, Rajendra|Vogel, Peter|Kanneganti, Thirumala-Devi
PMID: 29203393
Journal: BMC Biol. 2018 Jan 10;16(1):3.
Title: A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer.
Author: Penarando, Jon|Lopez-Sanchez, Laura M|Mena, Rafael|Guil-Luna, Silvia|Conde, Francisco|Hernandez, Vanessa|Toledano, Marta|Gudino, Victoria|Raponi, Michela|Billard, Caroline|Villar, Carlos|Diaz, Cesar|Gomez-Barbadillo, Jose|De la Haba-Rodriguez, Juan|Myant,
PMID: 29329541
Journal: Biochem Biophys Res Commun. 2018 Feb 5;496(2):468-474.
Title: BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX.
Author: Yu, Feiyue|Zhou, Chuanyi|Zeng, Hui|Liu, Yabing|Li, Shangfu
PMID: 29337063
Journal: Cancer Res. 2018 Apr 1;78(7):1751-1765.
Title: miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer.
Author: Yan, Ting-Ting|Ren, Lin-Lin|Shen, Chao-Qin|Wang, Zhen-Hua|Yu, Ya-Nan|Liang, Qian|Tang, Jia-Yin|Chen, Ying-Xuan|Sun, Dan-Feng|Zgodzinski, Witold|Majewski, Marek|Radwan, Piotr|Kryczek, Ilona|Zhong, Ming|Chen, Jinxian|Liu, Qiang|Zou, Weiping|Chen, Hao-Yan|Ho
PMID: 29374066
Journal: Oncotarget. 2017 Dec 19;9(2):2367-2383.
Title: Modified miR-15a has therapeutic potential for improving treatment of advanced stage colorectal cancer through inhibition of BCL2, BMI1, YAP1 and DCLK1.
Author: Fesler, Andrew|Liu, Hua|Ju, Jingfang
PMID: 29416778
Journal: Cancer Res. 2018 Jun 15;78(12):3163-3175.
Title: Deptor Is a Novel Target of Wnt/beta-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.
Author: Wang, Qingding|Zhou, Yuning|Rychahou, Piotr|Harris, Jennifer W|Zaytseva, Yekaterina Y|Liu, Jinpeng|Wang, Chi|Weiss, Heidi L|Liu, Chunming|Lee, Eun Y|Evers, B Mark
PMID: 29666061
Journal: Cell Physiol Biochem. 2018;47(1):368-377.
Title: The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells.
Author: Zacharopoulou, Nefeli|Tsapara, Anna|Kallergi, Galatea|Schmid, Evi|Alkahtani, Saad|Alarifi, Saud|Tsichlis, Philip N|Kampranis, Sotirios C|Stournaras, Christos
PMID: 29772566
Journal: Cell Cycle. 2018;17(8):1014-1025.
Title: R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells.
Author: Ye, Jun|Liu, Shanxi|Shang, Yangyang|Chen, Haoyuan|Wang, Rongquan
PMID: 29886802
Journal: J Cell Biochem. 2018 Sep 1.
Title: Anticancer effects of miR-200c in colorectal cancer through BMI1.
Author: Karimi Mazraehshah, Mitra|Tavangar, Seyed Mohammad|Saidijam, Massoud|Amini, Razieh|Bahreini, Fatemeh|Karimi Dermani, Fatemeh|Najafi, Rezvan
PMID: 30171714