Primary Site >> Colorectal Cancer

Gene >> BAD

Journal: Br J Cancer. 1998 Oct;78(8):986-92.
Title: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins.
Author: Nita, M E|Nagawa, H|Tominaga, O|Tsuno, N|Fujii, S|Sasaki, S|Fu, C G|Takenoue, T|Tsuruo, T|Muto, T
PMID: 9792140
Journal: Br J Surg. 1999 Nov;86(11):1448-50.
Title: Surgery may be curative for patients with a localized perforation of rectal carcinoma.
Author: Kagda, F H|Nyam, D C|Ho, Y H|Eu, K W|Leong, A F|Seow-Choen, F
PMID: 10583294
Journal: Cancer Res. 2003 Feb 1;63(3):616-20.
Title: Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Author: Rice, Pamela L|Washington, Michele|Schleman, Shea|Beard, K Scott|Driggers, Linda J|Ahnen, Dennis J
PMID: 12566304
Journal: Clin Cancer Res. 2003 Mar;9(3):1171-8.
Title: Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.
Author: Cho, Yee Sook|Cho-Chung, Yoon S
PMID: 12631623
Journal: Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G919-28. Epub 2003 Jul
Title: 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis.
Author: Farah, Myriam|Parhar, Kuljit|Moussavi, Maryam|Eivemark, Sharlene|Salh, Baljinder
PMID: 12842827
Journal: Biochem J. 2003 Apr 1;371(Pt 1):115-24.
Title: The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage.
Author: Wikstrom, Katarina|Juhas, Maria|Sjolander, Anita
PMID: 12482325
Journal: Carcinogenesis. 2004 Aug;25(8):1371-6.
Title: Inactivating mutations of proapoptotic Bad gene in human colon cancers.
Author: Lee, Jong Woo|Soung, Young Hwa|Kim, Su Young|Nam, Suk Woo|Kim, Chang Jae|Cho, Yong Gu|Lee, Jong Heun|Kim, Hong Sug|Park, Won Sang|Kim, Sang Ho|Lee, Jung Young|Yoo, Nam Jin|Lee, Sug Hyung
PMID: 15033904
Journal: Cancer Res. 2005 Jan 15;65(2):613-21.
Title: Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.
Author: Xu, Rui-Hua|Pelicano, Helene|Zhou, Yan|Carew, Jennifer S|Feng, Li|Bhalla, Kapil N|Keating, Michael J|Huang, Peng
PMID: 15695406
Journal: Mol Carcinog. 2006 Jul;45(7):461-78.
Title: Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis.
Author: Chen, Jinn-Shiun|Lin, Shyr-Yi|Tso, Wei-Ling|Yeh, Geng-Chang|Lee, Wen-Sen|Tseng, How|Chen, Li-Ching|Ho, Yuan-Soon
PMID: 16649252
Journal: Int J Oncol. 2006 Nov;29(5):1279-86.
Title: Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells.
Author: H-Zadeh, Akram M|Collard, Tracey J|Malik, Karim|Hicks, Diane J|Paraskeva, Chris|Williams, Ann C
PMID: 17016662
Journal: Anticancer Res. 2007 Sep-Oct;27(5B):3601, 3603-8.
Title: Colorectal cancer treatment in elderly patients: results of a retrospective analysis addressed to the chiefs of medical oncology units in Italy.
Author: Pasetto, Lara Maria|Falci, Cristina|Basso, Umberto|Gasparini, Giampietro|D'Andrea, Mario|Bonginelli, Paola|Bajetta, Emilio|Platania, Marco|Alabisio, Oscar|Miraglia, Stefania|Bertona, Erica|Oniga, Francesco|Biason, Rita|Chetri, Maria Concetta|Fedele, Palma
PMID: 17972523
Journal: Exp Biol Med (Maywood). 2009 Mar;234(3):287-95.
Title: Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.
Author: Telang, Urvi|Brazeau, Daniel A|Morris, Marilyn E
PMID: 19144873
Journal: Proteomics. 2009 Jul;9(13):3535-48.
Title: Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer.
Author: Pirnia, Farzaneh|Pawlak, Michael|Thallinger, Gerhard G|Gierke, Berthold|Templin, Markus F|Kappeler, Andi|Betticher, Daniel C|Gloor, Beat|Borner, Markus M
PMID: 19609961
Journal: J Med Food. 2009 Oct;12(5):952-8.
Title: trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis.
Author: Cho, Han Jin|Kwon, Gyoo Taik|Park, Jung Han Yoon
PMID: 19857056
Journal: Oncol Res. 2009;18(1):1-8.
Title: The anticancer effects of sodium selenite and selenomethionine on human colorectal carcinoma cell lines in nude mice.
Author: Yang, Yang|Huang, Fang|Ren, Yun|Xing, Lu|Wu, Ying|Li, Zhushi|Pan, Huazhen|Xu, Caimin
PMID: 19911698
Journal: Int J Cancer. 2010 Jul 15;127(2):474-84.
Title: Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability.
Author: Li, Ying-Yi|Wang, Ying-Ying|Taniguchi, Tsuyoshi|Kawakami, Takahiro|Baba, Tomohisa|Ishibashi, Hiroyuki|Mukaida, Naofumi
PMID: 19921695
Journal: PLoS One. 2011 Feb 15;6(2):e16916.
Title: ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer.
Author: Gan, Lihong|Chen, Shujie|Zhong, Jing|Wang, Xian|Lam, Emily K Y|Liu, Xin|Zhang, Jianbin|Zhou, Tianhua|Yu, Jun|Si, Jianmin|Wang, Liangjing|Jin, Hongchuan
PMID: 21347233
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Oct;14(10):803-6.
Title: [Study of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic and inflammatory gene expressions in colon cancer cell line].
Author: Yu, Hong-bin|Zhu, Wei|Dai, Chuang
PMID: 22030783
Journal: Anticancer Drugs. 2012 Aug;23(7):675-82.
Title: Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.
Author: Sasaki, Kazuhito|Tsuno, Nelson H|Sunami, Eiji|Kawai, Kazushige|Hongo, Kumiko|Hiyoshi, Masaya|Kaneko, Manabu|Murono, Koji|Tada, Noriko|Nirei, Takako|Takahashi, Koki|Kitayama, Joji
PMID: 22561420
Journal: Int J Biochem Cell Biol. 2012 Aug;44(8):1214-22.
Title: Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis.
Author: Lim, Min-Jin|Ahn, Ji-Yeon|Han, Youngsoo|Yu, Chi-Ho|Kim, Mi-Hyoung|Lee, Sae-Lo-Oom|Lim, Dae-Seog|Song, Jie-Young
PMID: 22564437
Journal: Oncol Rep. 2013 Mar;29(3):1245-51.
Title: T-18, a stemonamide synthetic intermediate inhibits Pim kinase activity and induces cell apoptosis, acting as a potent anticancer drug.
Author: Wang, Zhen|Li, Xing-Min|Shang, Kun|Zhang, Peng|Wang, Chao-Fu|Xin, Yu-Hu|Zhou, Lu|Li, Ying-Yi
PMID: 23314349
Journal: PLoS One. 2013;8(3):e58055.
Title: Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.
Author: Dey, Sumit Kumar|Bose, Dipayan|Hazra, Abhijit|Naskar, Subhendu|Nandy, Abhishek|Munda, Rudra Narayan|Das, Subhadip|Chatterjee, Nabanita|Mondal, Nirup Bikash|Banerjee, Sukdeb|Saha, Krishna Das
PMID: 23472133
Journal: Eur J Cancer Prev. 2013 May;22(3):215-28.
Title: Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy.
Author: Saini, Manpreet Kaur|Vaish, Vivek|Sanyal, Sankar Nath
PMID: 23514809
Journal: Biochim Biophys Acta. 2013 Nov;1830(11):5142-56.
Title: Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation.
Author: Piplani, Honit|Rana, Chandan|Vaish, Vivek|Vaiphei, Kim|Sanyal, S N
PMID: 23872169
Journal: Mol Med Rep. 2013 Dec;8(6):1767-72.
Title: Soy soluble polysaccharide induces apoptosis in HCT116 human colon cancer cells via reactive oxygen species generation.
Author: Ko, Yu-Jin|Jeong, Jin-Woo|Choi, Yung-Hyun|Ryu, Chung-Ho
PMID: 24126443
Journal: Chem Res Toxicol. 2013 Nov 18;26(11):1683-91.
Title: N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
Author: Liu, Ling-Yu|Huang, Wei-Jan|Lin, Ren-Jye|Lin, Shyr-Yi|Liang, Yu-Chih
PMID: 24127835
Journal: Acta Pharmacol Sin. 2013 Dec;34(12):1535-44.
Title: A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway.
Author: Wang, Hai-jun|Liu, Yu|Fan, Li-qiao|Han, Cai-li|Jiang, Ye|Cheng, Shu-jie|Li, Yong
PMID: 24241351
Journal: Biosci Rep. 2014 Dec 12;34(6):e00161.
Title: Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.
Author: Yu, Xiaojun|Zheng, Bo'an|Chai, Rui
PMID: 25370813
Journal: Oncol Rep. 2014 Sep;32(3):1124-32.
Title: S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells.
Author: Tong, Dandan|Qu, Hui|Meng, Xiangning|Jiang, Yang|Liu, Duanyang|Ye, Shengqian|Chen, He|Jin, Yan|Fu, Songbin|Geng, Jingshu
PMID: 24970681
Journal: Curr Cancer Drug Targets. 2014;14(2):156-66.
Title: Anticancer effect of a curcumin derivative B63: ROS production and mitochondrial dysfunction.
Author: Zheng, Adi|Li, Hao|Wang, Xun|Feng, Zhihui|Xu, Jie|Cao, Ke|Zhou, Bo|Wu, Jing|Liu, Jiankang
PMID: 24274397
Journal: BMC Cancer. 2014 Mar 6;14:160.
Title: Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.
Author: Park, Ji-Won|Kim, Seung Cheol|Kim, Won Ki|Hong, Jun Pyu|Kim, Kyung-Hee|Yeo, Hyun Yang|Lee, Jae Yong|Kim, M Sun|Kim, Jong Heon|Yang, Se Young|Kim, Dae Yong|Oh, Jae Hwan|Cho, Jae Youl|Yoo, Byong Chul
PMID: 24602180
Journal: Tumour Biol. 2015 Feb;36(2):633-41.
Title: GRP78 mediates the therapeutic efficacy of curcumin on colon cancer.
Author: Chang, Yu-Jia|Huang, Chien-Yu|Hung, Chin-Sheng|Chen, Wei-Yu|Wei, Po-Li
PMID: 25277658
Journal: Int J Mol Med. 2015 Apr;35(4):1081-7.
Title: BAD-mediated apoptotic pathway is associated with human cancer development.
Author: Stickles, Xiaomang B|Marchion, Douglas C|Bicaku, Elona|Al Sawah, Entidhar|Abbasi, Forough|Xiong, Yin|Bou Zgheib, Nadim|Boac, Bernadette M|Orr, Brian C|Judson, Patricia L|Berry, Amy|Hakam, Ardeshir|Wenham, Robert M|Apte, Sachin M|Berglund, Anders E|Lancast
PMID: 25653146
Journal: Eur J Med Chem. 2015 Sep 18;102:93-105.
Title: Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29).
Author: Chakraborty, Biswajit|Dutta, Debasmita|Mukherjee, Sanjukta|Das, Supriya|Maiti, Nakul C|Das, Padma|Chowdhury, Chinmay
PMID: 26248310
Journal: Gastroenterol Hepatol Bed Bench. 2015 Summer;8(3):215-24.
Title: Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer.
Author: Zamanian-Azodi, Mona|Rezaei-Tavirani, Mostafa|Rahmati-Rad, Sara|Hasanzadeh, Hadi|Rezaei Tavirani, Majid|Seyyedi, Samaneh Sadat
PMID: 26328044
Journal: PLoS One. 2015 Nov 25;10(11):e0142928.
Title: Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status.
Author: LeJeune, Timothy M|Tsui, Hei Yin|Parsons, Laura B|Miller, Gerald E|Whitted, Crystal|Lynch, Kayla E|Ramsauer, Robert E|Patel, Jasmine U|Wyatt, Jarrett E|Street, Doris S|Adams, Carolyn B|McPherson, Brian|Tsui, Hei Man|Evans, Julie A|Livesay, Christopher|Tor
PMID: 26606169
Journal: Gastroenterol Res Pract. 2015;2015:457193.
Title: Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways.
Author: Wang, Jie|Chen, Chao|Wang, Shiying|Zhang, Yong|Yin, Peihao|Gao, Zhongxiang|Xu, Jie|Feng, Dianxu|Zuo, Qinsong|Zhao, Ronghua|Chen, Teng
PMID: 26770191
Journal: Mol Med Rep. 2016 Mar;13(3):2583-9.
Title: The hypoxia-mimetic agent CoCl(2) induces chemotherapy resistance in LOVO colorectal cancer cells.
Author: Yang, Guanglei|Xu, Shuqing|Peng, Lintao|Li, Hui|Zhao, Yan|Hu, Yanfang
PMID: 26846577
Journal: Pharmacogn Mag. 2016 Jan-Mar;12(45):25-30.
Title: Luffa echinata Roxb. Induced Apoptosis in Human Colon Cancer Cell (SW-480) in the Caspase-dependent Manner and Through a Mitochondrial Apoptosis Pathway.
Author: Shang, Li-Hua|Yu, Yan|Che, De-Hai|Pan, Bo|Jin, Shi|Zou, Xiao-Long
PMID: 27019558
Journal: Tumour Biol. 2016 Oct;37(10):13225-13235.
Title: Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells.
Author: Chai, Rui|Yu, Xiaojun|Tu, Shiliang|Zheng, Bo'an
PMID: 27456362
Journal: BMC Complement Altern Med. 2016 Oct 1;16(1):384.
Title: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action.
Author: Abaza, Mohamed Salah I|Afzal, Mohammad|Al-Attiyah, Raja'a J|Guleri, Radhika
PMID: 27716288
Journal: Rev Med Suisse. 2016 Oct 12;12(534):1703-1707.
Title: [Clostridium septicum aortitis : case report and update on infectious aortitis].
Author: Rouiller, Stephanie|Abbet, Philippe|Daniel, Danzer|Nicolas, Troillet
PMID: 28686395
Journal: Gut Liver. 2017 Mar 15;11(2):243-252.
Title: Acai Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice.
Author: Choi, Yoon Jin|Choi, Yoon Jeong|Kim, Nayoung|Nam, Ryoung Hee|Lee, Seonmin|Lee, Hye Seung|Lee, Ha-Na|Surh, Young-Joon|Lee, Dong Ho
PMID: 27965474
Journal: Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):926-934.
Title: Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Author: Sheng, Nengquan|Yan, Li|You, Weiqiang|Tan, Gewen|Gong, Jianfeng|Chen, Hongqi|Yang, Yi|Hu, Landian|Wang, Zhigang
PMID: 28981607
Journal: Life Sci. 2017 Sep 15;185:63-72.
Title: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway.
Author: Peng, Ying|Qiu, Ling|Xu, Dong|Zhang, Li|Yu, Huixin|Ding, Yuedi|Deng, Lili|Lin, Jianguo
PMID: 28751160
Journal: Gene. 2017 Sep 5;627:255-262.
Title: ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma.
Author: Xie, Wenjun|Wu, Meijuan|Fu, Tianhong|Li, Xiaohong|Wang, Zhaoming|Hu, Yongxian|Zhu, Liyan|Zhang, Gu
PMID: 28629825
Journal: Nutr Res. 2017 May;41:36-46.
Title: Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines.
Author: Saber, Amir|Alipour, Beitollah|Faghfoori, Zeinab|Mousavi Jam, Ali|Yari Khosroushahi, Ahmad
PMID: 28477945
Journal: Patient Educ Couns. 2017 Apr;100(4):655-666.
Title: Breaking bad news to patients with cancer: A randomized control trial of a brief communication skills training module incorporating the stories and preferences of actual patients.
Author: Gorniewicz, James|Floyd, Michael|Krishnan, Koyamangalath|Bishop, Thomas W|Tudiver, Fred|Lang, Forrest
PMID: 27876220
Journal: Int J Mol Med. 2018 Mar;41(3):1397-1408.
Title: shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1.
Author: Huang, You-Sheng|Jie, Na|Zhang, Yi-Xin|Zou, Ke-Jian|Weng, Yang
PMID: 29286138
Journal: Hum Pathol. 2018 Apr;74:54-63.
Title: Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain?
Author: Huhns, Maja|Krohn, Saskia|Murua Escobar, Hugo|Prall, Friedrich
PMID: 29307628
Journal: Phytother Res. 2018 Jun;32(6):1108-1118.
Title: Drug-like dietary vanilloids induce anticancer activity through proliferation inhibition and regulation of bcl-related apoptotic proteins.
Author: Mai, Chun-Wai|Kang, Yew-Beng|Nadarajah, Vishna Devi|Hamzah, Ahmad Sazali|Pichika, Mallikarjuna Rao
PMID: 29464796
Journal: Proc Natl Acad Sci U S A. 2018 May 29;115(22):5774-5779.
Title: Spatial mutation patterns as markers of early colorectal tumor cell mobility.
Author: Ryser, Marc D|Min, Byung-Hoon|Siegmund, Kimberly D|Shibata, Darryl
PMID: 29760052
Journal: Oncol Rep. 2018 Aug;40(2):813-822.
Title: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells.
Author: Zheng, Long-Zhi|Chen, Si-Zeng
PMID: 29845259
Journal: Oncol Lett. 2018 May;15(5):8019-8026.
Title: Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells.
Author: Dai, Xiao-Yu|Zhou, Bao-Feng|Xie, Yang-Yang|Lou, Jie|Li, Ke-Qiang
PMID: 29849804
Journal: Med Sci Monit. 2018 Jun 3;24:3710-3719.
Title: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells.
Author: Meng, Ling-Qi|Wang, Yue|Luo, Ying-Hua|Piao, Xian-Ji|Liu, Chang|Wang, Yue|Zhang, Yi|Wang, Jia-Ru|Wang, Hao|Xu, Wan-Ting|Liu, Yang|Wu, Yi-Qin|Sun, Hu-Nan|Han, Ying-Hao|Jin, Mei-Hua|Shen, Gui-Nan|Fang, Nan-Zhu|Jin, Cheng-Hao
PMID: 29860266
Journal: Life Sci. 2018 Sep 15;209:43-51.
Title: Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation.
Author: Liang, Hung-Hua|Huang, Chien-Yu|Chou, Ching-Wen|Makondi, Precious Takondwa|Huang, Ming-Te|Wei, Po-Li|Chang, Yu-Jia
PMID: 30056019
Journal: IET Nanobiotechnol. 2018 Sep;12(6):727-732.
Title: Evaluation of potential anti-cancer activity of cationic liposomal nanoformulated Lycopodium clavatum in colon cancer cells.
Author: Paramita, Pragyan|Subramaniam, Vimala Devi|Murugesan, Ramachandran|Gopinath, Madhumala|Ramachandran, Ilangovan|Ramalingam, Satish|Sun, Xiao Feng|Banerjee, Antara|Marotta, Francesco|Pathak, Surajit
PMID: 30104445
Journal: Zhonghua Yi Xue Za Zhi. 2018 Sep 25;98(36):2899-2904.
Title: [Expression of stem cell markers CD44 and Lgr5 in colorectal cancer and its relationship with lymph node and liver metastasis].
Author: Wang, X F|Zhang, X L|Xu, L P|Shi, G G|Zheng, H Y|Sun, B C
PMID: 30293346