Primary Site >> Colorectal Cancer
Gene >> AXIN2
| 1. | |||||||||||
| Journal: | Curr Biol. 1999 Jan 28;9(2):105-8. | ||||||||||
| Title: | Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. | ||||||||||
| Author: | van Es, J H|Kirkpatrick, C|van de Wetering, M|Molenaar, M|Miles, A|Kuipers, J|Destree, O|Peifer, M|Clevers, H | ||||||||||
| PMID: | 10021369 | ||||||||||
| 2. | |||||||||||
| Journal: | Bioessays. 1999 Dec;21(12):1021-30. | ||||||||||
| Title: | beta-catenin signaling and cancer. | ||||||||||
| Author: | Morin, P J | ||||||||||
| PMID: | 10580987 | ||||||||||
| 3. | |||||||||||
| Journal: | Nat Genet. 2000 Oct;26(2):146-7. | ||||||||||
| Title: | Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. | ||||||||||
| Author: | Liu, W|Dong, X|Mai, M|Seelan, R S|Taniguchi, K|Krishnadath, K K|Halling, K C|Cunningham, J M|Boardman, L A|Qian, C|Christensen, E|Schmidt, S S|Roche, P C|Smith, D I|Thibodeau, S N | ||||||||||
| PMID: | 11017067 | ||||||||||
| 4. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14973-8. | ||||||||||
| Title: | Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. | ||||||||||
| Author: | Yan, D|Wiesmann, M|Rohan, M|Chan, V|Jefferson, A B|Guo, L|Sakamoto, D|Caothien, R H|Fuller, J H|Reinhard, C|Garcia, P D|Randazzo, F M|Escobedo, J|Fantl, W J|Williams, L T | ||||||||||
| PMID: | 11752446 | ||||||||||
| 5. | |||||||||||
| Journal: | Mol Cell Biol. 2002 Feb;22(4):1184-93. | ||||||||||
| Title: | Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. | ||||||||||
| Author: | Lustig, Barbara|Jerchow, Boris|Sachs, Martin|Weiler, Sigrid|Pietsch, Torsten|Karsten, Uwe|van de Wetering, Marc|Clevers, Hans|Schlag, Peter M|Birchmeier, Walter|Behrens, Jurgen | ||||||||||
| PMID: | 11809809 | ||||||||||
| 6. | |||||||||||
| Journal: | Biol Chem. 2002 Feb;383(2):255-61. | ||||||||||
| Title: | TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. | ||||||||||
| Author: | Brantjes, Helen|Barker, Nick|van Es, Johan|Clevers, Hans | ||||||||||
| PMID: | 11934263 | ||||||||||
| 7. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8683-8. Epub 2002 Jun 18. | ||||||||||
| Title: | Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. | ||||||||||
| Author: | Anderson, Christine B|Neufeld, Kristi L|White, Raymond L | ||||||||||
| PMID: | 12072559 | ||||||||||
| 8. | |||||||||||
| Journal: | Anticancer Res. 2002 Nov-Dec;22(6A):3409-14. | ||||||||||
| Title: | Overexpression of Wnt target genes in adenomas of familial adenomatous polyposis patients. | ||||||||||
| Author: | D'Orazio, Daniel|Muller, Patrick Y|Heinimann, Karl|Albrecht, Christiane|Bendik, Igor|Herzog, Urs|Tondelli, Peter|Bauerfeind, Peter|Muller, Hansjakob|Dobbie, Zuzana | ||||||||||
| PMID: | 12530096 | ||||||||||
| 9. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2004 Feb;39(2):138-42. | ||||||||||
| Title: | Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. | ||||||||||
| Author: | Domingo, Enric|Espin, Eloi|Armengol, Manel|Oliveira, Carla|Pinto, Mafalda|Duval, Alex|Brennetot, Caroline|Seruca, Raquel|Hamelin, Richard|Yamamoto, Hiroyuki|Schwartz, Simo Jr | ||||||||||
| PMID: | 14695993 | ||||||||||
| 10. | |||||||||||
| Journal: | Nat Genet. 2004 Apr;36(4):417-22. Epub 2004 Mar 14. | ||||||||||
| Title: | Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. | ||||||||||
| Author: | Suzuki, Hiromu|Watkins, D Neil|Jair, Kam-Wing|Schuebel, Kornel E|Markowitz, Sanford D|Chen, Wei Dong|Pretlow, Theresa P|Yang, Bin|Akiyama, Yoshimitsu|Van Engeland, Manon|Toyota, Minoru|Tokino, Takashi|Hinoda, Yuji|Imai, Kohzoh|Herman, James G|Baylin, Step | ||||||||||
| PMID: | 15034581 | ||||||||||
| 11. | |||||||||||
| Journal: | Am J Hum Genet. 2004 May;74(5):1043-50. Epub 2004 Mar 23. | ||||||||||
| Title: | Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. | ||||||||||
| Author: | Lammi, Laura|Arte, Sirpa|Somer, Mirja|Jarvinen, Heikki|Lahermo, Paivi|Thesleff, Irma|Pirinen, Sinikka|Nieminen, Pekka | ||||||||||
| PMID: | 15042511 | ||||||||||
| 12. | |||||||||||
| Journal: | Oncogene. 2005 Apr 21;24(18):3054-8. | ||||||||||
| Title: | Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. | ||||||||||
| Author: | He, Biao|Reguart, Noemi|You, Liang|Mazieres, Julien|Xu, Zhidong|Lee, Amie Y|Mikami, Iwao|McCormick, Frank|Jablons, David M | ||||||||||
| PMID: | 15735684 | ||||||||||
| 13. | |||||||||||
| Journal: | Hum Mutat. 2005 May;25(5):498-500. | ||||||||||
| Title: | Germline mutations of AXIN2 are not associated with nonsyndromic colorectal cancer. | ||||||||||
| Author: | Peterlongo, Paolo|Howe, Louise R|Radice, Paolo|Sala, Paola|Hong, Young-Joon|Hong, Seok-Il|Mitra, Nandita|Offit, Kenneth|Ellis, Nathan A | ||||||||||
| PMID: | 15841489 | ||||||||||
| 14. | |||||||||||
| Journal: | J Cell Sci. 2005 Jul 15;118(Pt 14):3117-29. | ||||||||||
| Title: | The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. | ||||||||||
| Author: | Weiske, Jorg|Huber, Otmar | ||||||||||
| PMID: | 16014379 | ||||||||||
| 15. | |||||||||||
| Journal: | Int J Oncol. 2005 Dec;27(6):1483-7. | ||||||||||
| Title: | Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. | ||||||||||
| Author: | Takahashi, Meiko|Nakamura, Yusuke|Obama, Kazutaka|Furukawa, Yoichi | ||||||||||
| PMID: | 16273202 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Lett. 2006 Feb 28;233(2):338-47. | ||||||||||
| Title: | Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. | ||||||||||
| Author: | Hughes, Thomas A|Brady, Hugh J M | ||||||||||
| PMID: | 15885887 | ||||||||||
| 17. | |||||||||||
| Journal: | Oncogene. 2006 Jan 5;25(1):139-46. | ||||||||||
| Title: | Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. | ||||||||||
| Author: | Koinuma, K|Yamashita, Y|Liu, W|Hatanaka, H|Kurashina, K|Wada, T|Takada, S|Kaneda, R|Choi, Y L|Fujiwara, S-I|Miyakura, Y|Nagai, H|Mano, H | ||||||||||
| PMID: | 16247484 | ||||||||||
| 18. | |||||||||||
| Journal: | Hum Pathol. 2006 Feb;37(2):212-7. | ||||||||||
| Title: | Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. | ||||||||||
| Author: | Chetty, Runjan|Serra, Stefano|Salahshor, Sima|Alsaad, Khaled|Shih, Warren|Blaszyk, Hagen|Woodgett, James R|Tsao, Ming-Sound | ||||||||||
| PMID: | 16426922 | ||||||||||
| 19. | |||||||||||
| Journal: | Int J Cancer. 2006 Oct 15;119(8):1837-42. | ||||||||||
| Title: | Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. | ||||||||||
| Author: | Suraweera, Nirosha|Robinson, James|Volikos, Emmanuoil|Guenther, Thomas|Talbot, Ian|Tomlinson, Ian|Silver, Andrew | ||||||||||
| PMID: | 16708370 | ||||||||||
| 20. | |||||||||||
| Journal: | FEBS Lett. 2006 Jun 26;580(15):3665-70. Epub 2006 Jun 5. | ||||||||||
| Title: | Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis. | ||||||||||
| Author: | Cho, Kwang-Hyun|Baek, Songjoon|Sung, Myong-Hee | ||||||||||
| PMID: | 16764864 | ||||||||||
| 21. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10747-52. Epub 2006 Jun 30. | ||||||||||
| Title: | Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. | ||||||||||
| Author: | Hadjihannas, Michel V|Bruckner, Martina|Jerchow, Boris|Birchmeier, Walter|Dietmaier, Wolfgang|Behrens, Jurgen | ||||||||||
| PMID: | 16815967 | ||||||||||
| 22. | |||||||||||
| Journal: | Int J Mol Med. 2006 Aug;18(2):279-84. | ||||||||||
| Title: | Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. | ||||||||||
| Author: | Kanzaki, Hirotaka|Ouchida, Mamoru|Hanafusa, Hiroko|Yano, Masaaki|Suzuki, Hiromitsu|Aoe, Motoi|Imai, Kazue|Shimizu, Nobuyoshi|Nakachi, Kei|Shimizu, Kenji | ||||||||||
| PMID: | 16820935 | ||||||||||
| 23. | |||||||||||
| Journal: | Hum Mutat. 2006 Oct;27(10):1064. | ||||||||||
| Title: | Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. | ||||||||||
| Author: | Lejeune, Sophie|Guillemot, Francois|Triboulet, Jean-Pierre|Cattan, Stephane|Mouton, Christine|Porchet, Nicole|Manouvrier, Sylvie|Buisine, Marie-Pierre | ||||||||||
| PMID: | 16941501 | ||||||||||
| 24. | |||||||||||
| Journal: | Cell Cycle. 2006 Sep;5(18):2077-81. Epub 2006 Sep 15. | ||||||||||
| Title: | CIN By WNT: growth pathways, mitotic control and chromosomal instability in cancer. | ||||||||||
| Author: | Hadjihannas, Michel V|Behrens, Jurgen | ||||||||||
| PMID: | 16969101 | ||||||||||
| 25. | |||||||||||
| Journal: | Oncogene. 2006 Dec 4;25(57):7531-7. | ||||||||||
| Title: | Colorectal cancer and genetic alterations in the Wnt pathway. | ||||||||||
| Author: | Segditsas, S|Tomlinson, I | ||||||||||
| PMID: | 17143297 | ||||||||||
| 26. | |||||||||||
| Journal: | Hum Mol Genet. 2007 Jan 15;16(2):199-209. Epub 2006 Dec 22. | ||||||||||
| Title: | Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. | ||||||||||
| Author: | Schneikert, Jean|Grohmann, Annette|Behrens, Jurgen | ||||||||||
| PMID: | 17189293 | ||||||||||
| 27. | |||||||||||
| Journal: | Gastroenterology. 2007 Feb;132(2):527-30. Epub 2006 Nov 29. | ||||||||||
| Title: | Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. | ||||||||||
| Author: | Will, Olivia|Carvajal-Carmona, Luis G|Gorman, Patricia|Howarth, Kimberley M|Jones, Angela M|Polanco-Echeverry, Guadalupe M|Chinaleong, Jo-Anne|Gunther, Thomas|Silver, Andrew|Clark, Susan K|Tomlinson, Ian | ||||||||||
| PMID: | 17258725 | ||||||||||
| 28. | |||||||||||
| Journal: | Ai Zheng. 2007 Mar;26(3):264-9. | ||||||||||
| Title: | [Mechanism study of antisense cyclin B1 in tumorigenesis inhibition using proteomic technique]. | ||||||||||
| Author: | Yang, Tao|Zhang, Ling|Yan, Fei|Tong, Ai-Ping|Liu, Xin-Yu|Liu, Huan-Yi|Huang, Can-Hua | ||||||||||
| PMID: | 17355788 | ||||||||||
| 29. | |||||||||||
| Journal: | Ai Zheng. 2007 Oct;26(10):1041-6. | ||||||||||
| Title: | [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer]. | ||||||||||
| Author: | Wang, Feng-Wei|Wen, Ling|Zhu, Si-Wei|Yao, Qiang|Cai, Yu-Mei|Ma, Gang | ||||||||||
| PMID: | 17927870 | ||||||||||
| 30. | |||||||||||
| Journal: | Mod Pathol. 2008 Mar;21(3):271-81. Epub 2007 Dec 14. | ||||||||||
| Title: | Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. | ||||||||||
| Author: | Salahshor, Sima|Naidoo, Richard|Serra, Stefano|Shih, Warren|Tsao, Ming-Sound|Chetty, Runjan|Woodgett, James R | ||||||||||
| PMID: | 18084253 | ||||||||||
| 31. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2008 Jul;47(7):614-24. | ||||||||||
| Title: | Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. | ||||||||||
| Author: | Castiglia, Daniele|Bernardini, Silvia|Alvino, Ester|Pagani, Elena|De Luca, Naomi|Falcinelli, Sabrina|Pacchiarotti, Alberto|Bonmassar, Enzo|Zambruno, Giovanna|D'Atri, Stefania | ||||||||||
| PMID: | 18384130 | ||||||||||
| 32. | |||||||||||
| Journal: | Cancer Sci. 2008 Jul;99(7):1348-54. | ||||||||||
| Title: | Individual tumorigenesis pathways of sporadic colorectal adenocarcinomas are associated with the biological behavior of tumors. | ||||||||||
| Author: | Kim, Jin C|Cho, Young K|Roh, Seon A|Yu, Chang S|Gong, Gyungyub|Jang, Se J|Kim, Seon Y|Kim, Yong S | ||||||||||
| PMID: | 18422752 | ||||||||||
| 33. | |||||||||||
| Journal: | Eur J Med Genet. 2008 Jul-Aug;51(4):273-91. | ||||||||||
| Title: | The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders. | ||||||||||
| Author: | Bailleul-Forestier, Isabelle|Molla, Muriel|Verloes, Alain|Berdal, Ariane | ||||||||||
| PMID: | 18499550 | ||||||||||
| 34. | |||||||||||
| Journal: | Br J Cancer. 2008 Jul 8;99(1):136-42. | ||||||||||
| Title: | Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. | ||||||||||
| Author: | Belshaw, N J|Elliott, G O|Foxall, R J|Dainty, J R|Pal, N|Coupe, A|Garg, D|Bradburn, D M|Mathers, J C|Johnson, I T | ||||||||||
| PMID: | 18542073 | ||||||||||
| 35. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2835-45. | ||||||||||
| Title: | Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. | ||||||||||
| Author: | Galamb, Orsolya|Sipos, Ferenc|Solymosi, Norbert|Spisak, Sandor|Krenacs, Tibor|Toth, Kinga|Tulassay, Zsolt|Molnar, Bela | ||||||||||
| PMID: | 18843029 | ||||||||||
| 36. | |||||||||||
| Journal: | Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):169-73. | ||||||||||
| Title: | AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts. | ||||||||||
| Author: | Letra, Ariadne|Menezes, Renato|Granjeiro, Jose M|Vieira, Alexandre R | ||||||||||
| PMID: | 18683894 | ||||||||||
| 37. | |||||||||||
| Journal: | Arch Oral Biol. 2009 Jan;54(1):45-9. | ||||||||||
| Title: | Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. | ||||||||||
| Author: | Callahan, N|Modesto, A|Meira, R|Seymen, F|Patir, A|Vieira, A R | ||||||||||
| PMID: | 18790474 | ||||||||||
| 38. | |||||||||||
| Journal: | J Am Dent Assoc. 2009 Jan;140(1):80-4. | ||||||||||
| Title: | AXIS inhibition protein 2, orofacial clefts and a family history of cancer. | ||||||||||
| Author: | Menezes, Renato|Marazita, Mary Louise|Goldstein McHenry, Toby|Cooper, Margaret E|Bardi, Kathleen|Brandon, Carla|Letra, Ariadne|Martin, Rick A|Vieira, Alexandre Rezende | ||||||||||
| PMID: | 19119171 | ||||||||||
| 39. | |||||||||||
| Journal: | Gastroenterology. 2009 Sep;137(3):902-13, 913.e1-11. | ||||||||||
| Title: | Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. | ||||||||||
| Author: | Samuel, Michael S|Suzuki, Hiromu|Buchert, Michael|Putoczki, Tracy L|Tebbutt, Niall C|Lundgren-May, Therese|Christou, Aliki|Inglese, Melissa|Toyota, Minoru|Heath, Joan K|Ward, Robyn L|Waring, Paul M|Ernst, Matthias | ||||||||||
| PMID: | 19454286 | ||||||||||
| 40. | |||||||||||
| Journal: | Int J Oncol. 2009 Nov;35(5):977-82. | ||||||||||
| Title: | Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. | ||||||||||
| Author: | Kawaguchi, Makiko|Banno, Kouji|Yanokura, Megumi|Kobayashi, Yusuke|Kishimi, Arisa|Ogawa, Seiji|Kisu, Iori|Nomura, Hiroyuki|Hirasawa, Akira|Susumu, Nobuyuki|Aoki, Daisuke | ||||||||||
| PMID: | 19787250 | ||||||||||
| 41. | |||||||||||
| Journal: | Oncogene. 2010 Mar 18;29(11):1663-71. | ||||||||||
| Title: | Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. | ||||||||||
| Author: | Kohler, E M|Brauburger, K|Behrens, J|Schneikert, J | ||||||||||
| PMID: | 19966865 | ||||||||||
| 42. | |||||||||||
| Journal: | Cancer Res. 2010 Aug 15;70(16):6629-38. | ||||||||||
| Title: | Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. | ||||||||||
| Author: | Metcalfe, Ciara|Ibrahim, Ashraf E K|Graeb, Michael|de la Roche, Marc|Schwarz-Romond, Thomas|Fiedler, Marc|Winton, Douglas J|Corfield, Anthony|Bienz, Mariann | ||||||||||
| PMID: | 20663899 | ||||||||||
| 43. | |||||||||||
| Journal: | BMC Cancer. 2010 Aug 9;10:413. | ||||||||||
| Title: | Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers. | ||||||||||
| Author: | Scheel, Silvio K|Porzner, Marc|Pfeiffer, Sabine|Ormanns, Steffen|Kirchner, Thomas|Jung, Andreas | ||||||||||
| PMID: | 20696052 | ||||||||||
| 44. | |||||||||||
| Journal: | Cancer Res. 2011 Jan 1;71(1):197-205. | ||||||||||
| Title: | Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. | ||||||||||
| Author: | Waaler, Jo|Machon, Ondrej|von Kries, Jens Peter|Wilson, Steven Ray|Lundenes, Elsa|Wedlich, Doris|Gradl, Dietmar|Paulsen, Jan Erik|Machonova, Olga|Dembinski, Jennifer L|Dinh, Huyen|Krauss, Stefan | ||||||||||
| PMID: | 21199802 | ||||||||||
| 45. | |||||||||||
| Journal: | Cell Res. 2011 May;21(5):730-40. | ||||||||||
| Title: | A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis. | ||||||||||
| Author: | Wang, Wei|Liu, Haiyang|Wang, Sheng|Hao, Xiaojiang|Li, Lin | ||||||||||
| PMID: | 21321609 | ||||||||||
| 46. | |||||||||||
| Journal: | Mol Cell Biochem. 2011 Sep;355(1-2):149-55. | ||||||||||
| Title: | Novelty of Axin 2 and lack of Axin 1 gene mutation in colorectal cancer: a study in Kashmiri population. | ||||||||||
| Author: | Khan, Nighat P|Pandith, Arshad A|Hussain, Mahboob Ul|Yousuf, Adfar|Khan, Mosin S|Wani, Khursheed A|Mudassar, Syed | ||||||||||
| PMID: | 21541676 | ||||||||||
| 47. | |||||||||||
| Journal: | Cancer Res. 2011 Dec 15;71(24):7628-39. | ||||||||||
| Title: | Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers. | ||||||||||
| Author: | Song, Siyuan|Christova, Tania|Perusini, Stephen|Alizadeh, Solmaz|Bao, Ren-Yue|Miller, Bryan W|Hurren, Rose|Jitkova, Yulia|Gronda, Marcela|Isaac, Methvin|Joseph, Babu|Subramaniam, Ratheesh|Aman, Ahmed|Chau, Anh|Hogge, Donna E|Weir, Scott J|Kasper, James|Sc | ||||||||||
| PMID: | 22009536 | ||||||||||
| 48. | |||||||||||
| Journal: | Oncogene. 2012 May 10;31(19):2423-37. | ||||||||||
| Title: | A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. | ||||||||||
| Author: | Zeineldin, M|Cunningham, J|McGuinness, W|Alltizer, P|Cowley, B|Blanchat, B|Xu, W|Pinson, D|Neufeld, K L | ||||||||||
| PMID: | 21996741 | ||||||||||
| 49. | |||||||||||
| Journal: | Mol Biol Rep. 2012 May;39(5):6171-8. | ||||||||||
| Title: | Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. | ||||||||||
| Author: | Naghibalhossaini, Fakhraddin|Zamani, Mozhdeh|Mokarram, Pooneh|Khalili, Islam|Rasti, Mozhgan|Mostafavi-Pour, Zohreh | ||||||||||
| PMID: | 22207181 | ||||||||||
| 50. | |||||||||||
| Journal: | EMBO Rep. 2012 Apr;13(4):347-54. | ||||||||||
| Title: | Cell cycle control of Wnt/beta-catenin signalling by conductin/axin2 through CDC20. | ||||||||||
| Author: | Hadjihannas, Michel V|Bernkopf, Dominic B|Bruckner, Martina|Behrens, Jurgen | ||||||||||
| PMID: | 22322943 | ||||||||||
| 51. | |||||||||||
| Journal: | Cancer Res. 2012 Jun 1;72(11):2822-32. | ||||||||||
| Title: | A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. | ||||||||||
| Author: | Waaler, Jo|Machon, Ondrej|Tumova, Lucie|Dinh, Huyen|Korinek, Vladimir|Wilson, Steven Ray|Paulsen, Jan Erik|Pedersen, Nina Marie|Eide, Tor J|Machonova, Olga|Gradl, Dietmar|Voronkov, Andrey|von Kries, Jens Peter|Krauss, Stefan | ||||||||||
| PMID: | 22440753 | ||||||||||
| 52. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11312-7. | ||||||||||
| Title: | Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity. | ||||||||||
| Author: | Wu, Zhao-Qiu|Brabletz, Thomas|Fearon, Eric|Willis, Amanda L|Hu, Casey Yuexian|Li, Xiao-Yan|Weiss, Stephen J | ||||||||||
| PMID: | 22745173 | ||||||||||
| 53. | |||||||||||
| Journal: | Biochem Pharmacol. 2012 Nov 1;84(9):1143-53. | ||||||||||
| Title: | The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway. | ||||||||||
| Author: | Chen, Hui-Jye|Hsu, Le-Shiang|Shia, Yu-Ting|Lin, Meng-Wei|Lin, Chung-Ming | ||||||||||
| PMID: | 22935447 | ||||||||||
| 54. | |||||||||||
| Journal: | PLoS One. 2012;7(11):e48670. | ||||||||||
| Title: | Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. | ||||||||||
| Author: | Bao, Renyue|Christova, Tania|Song, Siyuan|Angers, Stephane|Yan, Xiaojun|Attisano, Liliana | ||||||||||
| PMID: | 23144924 | ||||||||||
| 55. | |||||||||||
| Journal: | Oncogene. 2013 Feb 14;32(7):883-93. | ||||||||||
| Title: | In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-ODeltaN89beta-catenin system. | ||||||||||
| Author: | Jarde, T|Evans, R J|McQuillan, K L|Parry, L|Feng, G J|Alvares, B|Clarke, A R|Dale, T C | ||||||||||
| PMID: | 22469981 | ||||||||||
| 56. | |||||||||||
| Journal: | Clin Exp Metastasis. 2013 Jun;30(5):681-93. | ||||||||||
| Title: | Increased growth of colorectal liver metastasis following partial hepatectomy. | ||||||||||
| Author: | Krause, P|Flikweert, H|Monin, M|Seif Amir Hosseini, A|Helms, G|Cantanhede, G|Ghadimi, B M|Koenig, S | ||||||||||
| PMID: | 23385555 | ||||||||||
| 57. | |||||||||||
| Journal: | Carcinogenesis. 2013 Jun;34(6):1361-9. | ||||||||||
| Title: | Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells. | ||||||||||
| Author: | Olsen, Anders Kruger|Coskun, Mehmet|Bzorek, Michael|Kristensen, Michael Holmsgaard|Danielsen, Erik Thomas|Jorgensen, Steffen|Olsen, Jorgen|Engel, Ulla|Holck, Susanne|Troelsen, Jesper Thorvald | ||||||||||
| PMID: | 23393221 | ||||||||||
| 58. | |||||||||||
| Journal: | Cell Cycle. 2013 May 15;12(10):1578-87. | ||||||||||
| Title: | p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. | ||||||||||
| Author: | Kim, Nam Hee|Cha, Yong Hoon|Kang, Shi Eun|Lee, Yoonmi|Lee, Inhan|Cha, So Young|Ryu, Joo Kyung|Na, Jung Min|Park, Changbum|Yoon, Ho-Geun|Park, Gyeong-Ju|Yook, Jong In|Kim, Hyun Sil | ||||||||||
| PMID: | 23624843 | ||||||||||
| 59. | |||||||||||
| Journal: | Gastroenterology. 2013 Aug;145(2):416-25.e1-4. | ||||||||||
| Title: | IDO1 metabolites activate beta-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. | ||||||||||
| Author: | Thaker, Ameet I|Rao, M Suprada|Bishnupuri, Kumar S|Kerr, Thomas A|Foster, Lynne|Marinshaw, Jeffrey M|Newberry, Rodney D|Stenson, William F|Ciorba, Matthew A | ||||||||||
| PMID: | 23669411 | ||||||||||
| 60. | |||||||||||
| Journal: | Int J Colorectal Dis. 2013 Nov;28(11):1469-78. | ||||||||||
| Title: | Expression and localization of axin 2 in colorectal carcinoma and its clinical implication. | ||||||||||
| Author: | Schaal, Ute|Grenz, Sandra|Merkel, Susanne|Rau, Tilman T|Hadjihannas, Michel V|Kremmer, Elisabeth|Chudasama, Priya|Croner, Roland S|Behrens, Jurgen|Sturzl, Michael|Naschberger, Elisabeth | ||||||||||
| PMID: | 23702820 | ||||||||||
| 61. | |||||||||||
| Journal: | Br J Cancer. 2013 Aug 6;109(3):667-75. | ||||||||||
| Title: | Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a gamma-secretase inhibitor, in a preclinical colorectal explant model. | ||||||||||
| Author: | Arcaroli, J J|Quackenbush, K S|Purkey, A|Powell, R W|Pitts, T M|Bagby, S|Tan, A C|Cross, B|McPhillips, K|Song, E-K|Tai, W M|Winn, R A|Bikkavilli, K|Vanscoyk, M|Eckhardt, S G|Messersmith, W A | ||||||||||
| PMID: | 23868008 | ||||||||||
| 62. | |||||||||||
| Journal: | PLoS One. 2013 Aug 12;8(8):e71755. | ||||||||||
| Title: | Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. | ||||||||||
| Author: | Dominguez-Valentin, Mev|Therkildsen, Christina|Veerla, Srinivas|Jonsson, Mats|Bernstein, Inge|Borg, Ake|Nilbert, Mef | ||||||||||
| PMID: | 23951239 | ||||||||||
| 63. | |||||||||||
| Journal: | Bioorg Med Chem Lett. 2013 Nov 1;23(21):5814-20. | ||||||||||
| Title: | Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription. | ||||||||||
| Author: | Zeller, Jorg|Turbiak, Anjanette J|Powelson, Ian A|Lee, Surin|Sun, Duxin|Showalter, H D Hollis|Fearon, Eric R | ||||||||||
| PMID: | 24060489 | ||||||||||
| 64. | |||||||||||
| Journal: | Anticancer Res. 2013 Oct;33(10):4573-84. | ||||||||||
| Title: | The prognostic significance of WNT pathway in surgically-treated colorectal cancer: beta-catenin expression predicts for disease-free survival. | ||||||||||
| Author: | Kamposioras, Konstantinos|Konstantara, Athina|Kotoula, Vassiliki|Lakis, Sotiris|Kouvatseas, George|Akriviadis, Evangelos|Vrettou, Eleni|Dionysopoulos, Dimitrios|Krikelis, Dimitrios|Papadopoulou, Kyriaki|Charalambous, Elpida|Chrisafi, Sofia|Konstantaras, C | ||||||||||
| PMID: | 24123033 | ||||||||||
| 65. | |||||||||||
| Journal: | Pharmacogenomics J. 2014 Apr;14(2):142-50. | ||||||||||
| Title: | Association of common gene variants in the WNT/beta-catenin pathway with colon cancer recurrence. | ||||||||||
| Author: | Paez, D|Gerger, A|Zhang, W|Yang, D|Labonte, M J|Benhanim, L|Kahn, M|Lenz, F|Lenz, C|Ning, Y|Wakatsuki, T|Loupakis, F|Lenz, H-J | ||||||||||
| PMID: | 23817222 | ||||||||||
| 66. | |||||||||||
| Journal: | FEBS J. 2014 Feb;281(3):787-801. | ||||||||||
| Title: | Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-beta-catenin signalling. | ||||||||||
| Author: | Brauburger, Katharina|Akyildiz, Senem|Ruppert, Jan G|Graeb, Michael|Bernkopf, Dominic B|Hadjihannas, Michel V|Behrens, Jurgen | ||||||||||
| PMID: | 24251807 | ||||||||||
| 67. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2014 Jan 3;443(1):217-22. | ||||||||||
| Title: | Nuclear AXIN2 represses MYC gene expression. | ||||||||||
| Author: | Rennoll, Sherri A|Konsavage, Wesley M Jr|Yochum, Gregory S | ||||||||||
| PMID: | 24299953 | ||||||||||
| 68. | |||||||||||
| Journal: | Carcinogenesis. 2014 Mar;35(3):606-12. | ||||||||||
| Title: | Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells. | ||||||||||
| Author: | Fan, Yang-Yi|Davidson, Laurie A|Callaway, Evelyn S|Goldsby, Jennifer S|Chapkin, Robert S | ||||||||||
| PMID: | 24336194 | ||||||||||
| 69. | |||||||||||
| Journal: | BMC Genomics. 2014 Jan 28;15:74. | ||||||||||
| Title: | Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling. | ||||||||||
| Author: | Herbst, Andreas|Jurinovic, Vindi|Krebs, Stefan|Thieme, Susanne E|Blum, Helmut|Goke, Burkhard|Kolligs, Frank T | ||||||||||
| PMID: | 24467841 | ||||||||||
| 70. | |||||||||||
| Journal: | Clin Cancer Res. 2014 Mar 15;20(6):1687-97. | ||||||||||
| Title: | A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients. | ||||||||||
| Author: | Szkandera, Joanna|Pichler, Martin|Absenger, Gudrun|Stotz, Michael|Weissmueller, Melanie|Samonigg, Hellmut|Asslaber, Martin|Lax, Sigurd|Leitner, Gerhard|Winder, Thomas|Renner, Wilfried|Gerger, Armin | ||||||||||
| PMID: | 24470513 | ||||||||||
| 71. | |||||||||||
| Journal: | Carcinogenesis. 2014 May;35(5):1185-92. | ||||||||||
| Title: | Involvement of CDX2 in the cross talk between TNF-alpha and Wnt signaling pathway in the colon cancer cell line Caco-2. | ||||||||||
| Author: | Coskun, Mehmet|Olsen, Anders Kruger|Bzorek, Michael|Holck, Susanne|Engel, Ulla Hojholt|Nielsen, Ole Haagen|Troelsen, Jesper Thorvald | ||||||||||
| PMID: | 24501326 | ||||||||||
| 72. | |||||||||||
| Journal: | Hered Cancer Clin Pract. 2014 Mar 10;12(1):7. | ||||||||||
| Title: | Colorectal cancer and self-reported tooth agenesis. | ||||||||||
| Author: | Lindor, Noralane M|Win, Aung Ko|Gallinger, Steven|Daftary, Darshana|Thibodeau, Stephen N|Silva, Renato|Letra, Ariadne | ||||||||||
| PMID: | 24607150 | ||||||||||
| 73. | |||||||||||
| Journal: | Eur J Med Genet. 2014 Apr;57(5):235-9. | ||||||||||
| Title: | Is there a link between ovarian cancer and tooth agenesis? | ||||||||||
| Author: | Bonds, John|Pollan-White, Sarah|Xiang, Lilin|Mues, Gabriele|D'Souza, Rena | ||||||||||
| PMID: | 24631698 | ||||||||||
| 74. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2014 Apr 18;446(4):1120-5. | ||||||||||
| Title: | Targeted repression of AXIN2 and MYC gene expression using designer TALEs. | ||||||||||
| Author: | Rennoll, Sherri A|Scott, Samantha A|Yochum, Gregory S | ||||||||||
| PMID: | 24667606 | ||||||||||
| 75. | |||||||||||
| Journal: | PLoS One. 2014 Apr 10;9(4):e94413. | ||||||||||
| Title: | different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli. | ||||||||||
| Author: | Schneikert, Jean|Ruppert, Jan Gustav|Behrens, Jurgen|Wenzel, Eva Maria | ||||||||||
| PMID: | 24722208 | ||||||||||
| 76. | |||||||||||
| Journal: | Nat Prod Bioprospect. 2014 Jun;4(3):135-40. | ||||||||||
| Title: | Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors. | ||||||||||
| Author: | Zhang, Jing|Kong, Ling-Mei|Zhan, Rui|Ye, Zhen-Nan|Pu, Jian-Xin|Sun, Han-Dong|Li, Yan | ||||||||||
| PMID: | 24955294 | ||||||||||
| 77. | |||||||||||
| Journal: | BMC Cancer. 2014 Jun 25;14:466. | ||||||||||
| Title: | DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability. | ||||||||||
| Author: | Muto, Yuta|Maeda, Takafumi|Suzuki, Koichi|Kato, Takaharu|Watanabe, Fumiaki|Kamiyama, Hidenori|Saito, Masaaki|Koizumi, Kei|Miyaki, Yuichiro|Konishi, Fumio|Alonso, Sergio|Perucho, Manuel|Rikiyama, Toshiki | ||||||||||
| PMID: | 24964857 | ||||||||||
| 78. | |||||||||||
| Journal: | Cancer Lett. 2014 Dec 1;355(1):1-8. | ||||||||||
| Title: | AXIN1 and AXIN2 variants in gastrointestinal cancers. | ||||||||||
| Author: | Mazzoni, Serina M|Fearon, Eric R | ||||||||||
| PMID: | 25236910 | ||||||||||
| 79. | |||||||||||
| Journal: | Mod Pathol. 2015 Jan;28(1):146-58. | ||||||||||
| Title: | Distinct WNT/beta-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum. | ||||||||||
| Author: | Murakami, Takashi|Mitomi, Hiroyuki|Saito, Tsuyoshi|Takahashi, Michiko|Sakamoto, Naoto|Fukui, Naoshi|Yao, Takashi|Watanabe, Sumio | ||||||||||
| PMID: | 24925057 | ||||||||||
| 80. | |||||||||||
| Journal: | Oncogene. 2015 Sep 17;34(38):4914-27. | ||||||||||
| Title: | Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. | ||||||||||
| Author: | Lemieux, E|Cagnol, S|Beaudry, K|Carrier, J|Rivard, N | ||||||||||
| PMID: | 25500543 | ||||||||||
| 81. | |||||||||||
| Journal: | Fam Cancer. 2015 Jun;14(2):325-31. | ||||||||||
| Title: | The roles of AXIN2 in tumorigenesis and epigenetic regulation. | ||||||||||
| Author: | Li, Shuang|Wang, Chunpeng|Liu, Xiaodong|Hua, Shucheng|Liu, Xin | ||||||||||
| PMID: | 25504512 | ||||||||||
| 82. | |||||||||||
| Journal: | Tumour Biol. 2015 May;36(5):3301-8. | ||||||||||
| Title: | LYTAK1, a novel TAK1 inhibitor, suppresses KRAS mutant colorectal cancer cell growth in vitro and in vivo. | ||||||||||
| Author: | Zhou, Jundong|Zheng, Bing|Ji, Jiansong|Shen, Fei|Min, Han|Liu, Biao|Wu, Jinchang|Zhang, Shuyu | ||||||||||
| PMID: | 25524577 | ||||||||||
| 83. | |||||||||||
| Journal: | Carcinogenesis. 2015 Mar;36(3):318-26. | ||||||||||
| Title: | |||||||||||