Primary Site >> Colorectal Cancer
Gene >> AXIN2
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Ref: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. PMID: 10021369 Ref: beta-catenin signaling and cancer. PMID: 10580987 |
Ref: Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. PMID: 11017067 |
Ref: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. PMID: 11752446 |
Ref: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. PMID: 11809809 Ref: TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. PMID: 11934263 Ref: Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. PMID: 12072559 Ref: Overexpression of Wnt target genes in adenomas of familial adenomatous polyposis patients. PMID: 12530096 |
Ref: Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. PMID: 14695993 Ref: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. PMID: 15034581 Ref: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. PMID: 15042511 |
Ref: Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. PMID: 15735684 Ref: Germline mutations of AXIN2 are not associated with nonsyndromic colorectal cancer. PMID: 15841489 Ref: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. PMID: 16014379 Ref: Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. PMID: 16273202 |
Ref: Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. PMID: 15885887 Ref: Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. PMID: 16247484 Ref: Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. PMID: 16426922 Ref: Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. PMID: 16708370 Ref: Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis. PMID: 16764864 Ref: Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. PMID: 16815967 Ref: Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. PMID: 16820935 Ref: Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. PMID: 16941501 Ref: CIN By WNT: growth pathways, mitotic control and chromosomal instability in cancer. PMID: 16969101 Ref: Colorectal cancer and genetic alterations in the Wnt pathway. PMID: 17143297 |
Ref: Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. PMID: 17189293 Ref: Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. PMID: 17258725 Ref: [Mechanism study of antisense cyclin B1 in tumorigenesis inhibition using proteomic technique]. PMID: 17355788 Ref: [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer]. PMID: 17927870 |
Ref: Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. PMID: 18084253 Ref: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. PMID: 18384130 Ref: Individual tumorigenesis pathways of sporadic colorectal adenocarcinomas are associated with the biological behavior of tumors. PMID: 18422752 Ref: The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders. PMID: 18499550 Ref: Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. PMID: 18542073 Ref: Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. PMID: 18843029 |
Ref: AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts. PMID: 18683894 Ref: Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. PMID: 18790474 Ref: AXIS inhibition protein 2, orofacial clefts and a family history of cancer. PMID: 19119171 Ref: Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. PMID: 19454286 Ref: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. PMID: 19787250 |
Ref: Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. PMID: 19966865 Ref: Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. PMID: 20663899 Ref: Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers. PMID: 20696052 |
Ref: Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. PMID: 21199802 Ref: A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis. PMID: 21321609 Ref: Novelty of Axin 2 and lack of Axin 1 gene mutation in colorectal cancer: a study in Kashmiri population. PMID: 21541676 Ref: Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers. PMID: 22009536 |
Ref: A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. PMID: 21996741 Ref: Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. PMID: 22207181 Ref: Cell cycle control of Wnt/beta-catenin signalling by conductin/axin2 through CDC20. PMID: 22322943 Ref: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. PMID: 22440753 Ref: Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity. PMID: 22745173 Ref: The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway. PMID: 22935447 Ref: Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PMID: 23144924 |
Ref: In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-ODeltaN89beta-catenin system. PMID: 22469981 Ref: Increased growth of colorectal liver metastasis following partial hepatectomy. PMID: 23385555 Ref: Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells. PMID: 23393221 Ref: p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. PMID: 23624843 Ref: IDO1 metabolites activate beta-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. PMID: 23669411 Ref: Expression and localization of axin 2 in colorectal carcinoma and its clinical implication. PMID: 23702820 Ref: Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a gamma-secretase inhibitor, in a preclinical colorectal explant model. PMID: 23868008 Ref: Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. PMID: 23951239 Ref: Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription. PMID: 24060489 Ref: The prognostic significance of WNT pathway in surgically-treated colorectal cancer: beta-catenin expression predicts for disease-free survival. PMID: 24123033 |
Ref: Association of common gene variants in the WNT/beta-catenin pathway with colon cancer recurrence. PMID: 23817222 Ref: Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-beta-catenin signalling. PMID: 24251807 Ref: Nuclear AXIN2 represses MYC gene expression. PMID: 24299953 Ref: Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells. PMID: 24336194 Ref: Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling. PMID: 24467841 Ref: A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients. PMID: 24470513 Ref: Involvement of CDX2 in the cross talk between TNF-alpha and Wnt signaling pathway in the colon cancer cell line Caco-2. PMID: 24501326 Ref: Colorectal cancer and self-reported tooth agenesis. PMID: 24607150 Ref: Is there a link between ovarian cancer and tooth agenesis? PMID: 24631698 Ref: Targeted repression of AXIN2 and MYC gene expression using designer TALEs. PMID: 24667606 Ref: different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli. PMID: 24722208 Ref: Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors. PMID: 24955294 Ref: DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability. PMID: 24964857 Ref: AXIN1 and AXIN2 variants in gastrointestinal cancers. PMID: 25236910 |
Ref: Distinct WNT/beta-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum. PMID: 24925057 Ref: Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. PMID: 25500543 Ref: The roles of AXIN2 in tumorigenesis and epigenetic regulation. PMID: 25504512 Ref: LYTAK1, a novel TAK1 inhibitor, suppresses KRAS mutant colorectal cancer cell growth in vitro and in vivo. PMID: 25524577 Ref: A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/beta-catenin signaling. PMID: 25600769 Ref: Wnt ligand-dependent activation of the negative feedback regulator Nkd1. PMID: 25904337 Ref: An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function. PMID: 26025668 Ref: Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption. PMID: 26085034 Ref: Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/beta-catenin signalling. PMID: 26468775 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 |
Ref: In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases. PMID: 26031752 Ref: Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base. PMID: 26648507 Ref: Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-beta-catenin axis. PMID: 26910375 Ref: Topoisomerase IIalpha mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. PMID: 26947016 Ref: The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. PMID: 27070088 Ref: Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. PMID: 27090353 Ref: Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. PMID: 27207671 Ref: AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients. PMID: 27228364 Ref: Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). PMID: 27234654 Ref: Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. PMID: 27245242 Ref: Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity. PMID: 27482906 Ref: LDB1 overexpression is a negative prognostic factor in colorectal cancer. PMID: 27713177 Ref: Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells. PMID: 27784965 |
Ref: Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing. PMID: 27696107 Ref: Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and beta-Catenin Degradation. PMID: 28107521 Ref: APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. PMID: 28179481 Ref: Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. PMID: 28255344 Ref: Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. PMID: 28368388 Ref: Assessing the clinical utility of Wnt pathway markers in colorectal cancer. PMID: 28534366 Ref: omega-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. PMID: 28672272 Ref: Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 28714374 |
Ref: Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells. PMID: 28887754 Ref: miR-3120-5p promotes colon cancer stem cell stemness and invasiveness through targeting Axin2. PMID: 29307822 Ref: XPNPEP3 is a novel transcriptional target of canonical Wnt/beta-catenin signaling. PMID: 29383790 Ref: Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. PMID: 29534875 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer. PMID: 29869456 Ref: Tooth agenesis: A susceptible indicator for colorectal cancer? PMID: 29893310 Ref: Prognostic Significance of EPHB2 Expression in Colorectal Cancer Progression. PMID: 30016858 Ref: miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4. PMID: 30072583 Ref: Pimozide suppresses colorectal cancer via inhibition of Wnt/beta-catenin signaling pathway. PMID: 30107167 Ref: Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice. PMID: 30204842 Ref: Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/beta-Catenin Signaling Pathway. PMID: 30231258 Ref: RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. PMID: 30238564 Ref: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling. PMID: 30257989 Ref: Sulforaphane inhibits growth and blocks Wnt/beta-catenin signaling of colorectal cancer cells. PMID: 30338040 Ref: MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/beta-catenin signaling axis. PMID: 30338942 Ref: NUP153 overexpression suppresses the proliferation of colorectal cancer by negatively regulating Wnt/beta-catenin signaling pathway and predicts good prognosis. PMID: 30347601 |