Primary Site >> Colorectal Cancer

Gene >> AXIN1

Journal: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3020-3.
Title: Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.
Author: Sakanaka, C|Weiss, J B|Williams, L T
PMID: 9501208
Journal: Curr Biol. 1998 May 7;8(10):573-81.
Title: Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Author: Hart, M J|de los Santos, R|Albert, I N|Rubinfeld, B|Polakis, P
PMID: 9601641
Journal: Genes Cells. 1998 Jun;3(6):395-403.
Title: Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
Author: Nakamura, T|Hamada, F|Ishidate, T|Anai, K|Kawahara, K|Toyoshima, K|Akiyama, T
PMID: 9734785
Journal: Curr Biol. 1999 Jan 28;9(2):105-8.
Title: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Author: van Es, J H|Kirkpatrick, C|van de Wetering, M|Molenaar, M|Miles, A|Kuipers, J|Destree, O|Peifer, M|Clevers, H
PMID: 10021369
Journal: EMBO J. 1999 May 4;18(9):2401-10.
Title: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
Author: Kitagawa, M|Hatakeyama, S|Shirane, M|Matsumoto, M|Ishida, N|Hattori, K|Nakamichi, I|Kikuchi, A|Nakayama, K|Nakayama, K
PMID: 10228155
Journal: Proc Natl Acad Sci U S A. 1999 May 11;96(10):5522-7.
Title: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.
Author: Shtutman, M|Zhurinsky, J|Simcha, I|Albanese, C|D'Amico, M|Pestell, R|Ben-Ze'ev, A
PMID: 10318916
Journal: Bioessays. 1999 Dec;21(12):1021-30.
Title: beta-catenin signaling and cancer.
Author: Morin, P J
PMID: 10580987
Journal: Nat Genet. 2000 Mar;24(3):245-50.
Title: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.
Author: Satoh, S|Daigo, Y|Furukawa, Y|Kato, T|Miwa, N|Nishiwaki, T|Kawasoe, T|Ishiguro, H|Fujita, M|Tokino, T|Sasaki, Y|Imaoka, S|Murata, M|Shimano, T|Yamaoka, Y|Nakamura, Y
PMID: 10700176
Journal: J Biol Chem. 2000 Mar 24;275(12):8369-74.
Title: Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin.
Author: Kawahara, K|Morishita, T|Nakamura, T|Hamada, F|Toyoshima, K|Akiyama, T
PMID: 10722668
Journal: Genes Chromosomes Cancer. 2000 Aug;28(4):443-53.
Title: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.
Author: Webster, M T|Rozycka, M|Sara, E|Davis, E|Smalley, M|Young, N|Dale, T C|Wooster, R
PMID: 10862053
Journal: J Biol Chem. 2000 Nov 3;275(44):34399-406.
Title: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.
Author: Hinoi, T|Yamamoto, H|Kishida, M|Takada, S|Kishida, S|Kikuchi, A
PMID: 10906131
Journal: Oncol Res. 2000;12(4):193-201.
Title: Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin.
Author: Vincan, E|Leet, C S|Reyes, N I|Dilley, R J|Thomas, R J|Phillips, W A
PMID: 11341469
Journal: Mol Carcinog. 2001 May;31(1):56-62.
Title: Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer.
Author: Uthoff, S M|Eichenberger, M R|McAuliffe, T L|Hamilton, C J|Galandiuk, S
PMID: 11398198
Journal: Oncogene. 2001 Aug 16;20(36):5062-6.
Title: Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney.
Author: Ishiguro, H|Tsunoda, T|Tanaka, T|Fujii, Y|Nakamura, Y|Furukawa, Y
PMID: 11526492
Journal: Cancer Res. 2001 Nov 1;61(21):7722-6.
Title: Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas.
Author: Fujita, M|Furukawa, Y|Tsunoda, T|Tanaka, T|Ogawa, M|Nakamura, Y
PMID: 11691783
Journal: Genes Chromosomes Cancer. 2002 Jan;33(1):73-81.
Title: Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability.
Author: Shimizu, Yosuke|Ikeda, Satoshi|Fujimori, Masahiko|Kodama, Shinya|Nakahara, Masahiro|Okajima, Masazumi|Asahara, Toshimasa
PMID: 11746989
Journal: Mol Cell Biol. 2002 Feb;22(4):1184-93.
Title: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Author: Lustig, Barbara|Jerchow, Boris|Sachs, Martin|Weiler, Sigrid|Pietsch, Torsten|Karsten, Uwe|van de Wetering, Marc|Clevers, Hans|Schlag, Peter M|Birchmeier, Walter|Behrens, Jurgen
PMID: 11809809
Journal: Am J Pathol. 2002 Feb;160(2):389-401.
Title: Beta-catenin--a linchpin in colorectal carcinogenesis?
Author: Wong, Newton Alexander Chiang Shuek|Pignatelli, Massimo
PMID: 11839557
Journal: Biol Chem. 2002 Feb;383(2):255-61.
Title: TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.
Author: Brantjes, Helen|Barker, Nick|van Es, Johan|Clevers, Hans
PMID: 11934263
Journal: Am J Pathol. 2002 Apr;160(4):1229-38.
Title: Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas.
Author: Zhai, Yali|Wu, Rong|Schwartz, Donald R|Darrah, Danielle|Reed, Heather|Kolligs, Frank T|Nieman, Marvin T|Fearon, Eric R|Cho, Kathleen R
PMID: 11943708
Journal: J Biol Chem. 2002 Jul 5;277(27):24258-64. Epub 2002 May 1.
Title: Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1.
Author: Henderson, Beric R|Galea, Melanie|Schuechner, Stefan|Leung, Louie
PMID: 11986304
Journal: Cancer Res. 2002 Jun 1;62(11):3322-6.
Title: Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin.
Author: Sekiya, Takashi|Nakamura, Tsutomu|Kazuki, Yasuhiro|Oshimura, Mitsuo|Kohu, Kazuyoshi|Tago, Ken-Ichi|Ohwada, Susumu|Akiyama, Tetsu
PMID: 12036951
Journal: Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8683-8. Epub 2002 Jun 18.
Title: Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.
Author: Anderson, Christine B|Neufeld, Kristi L|White, Raymond L
PMID: 12072559
Journal: Cancer Res. 2002 Oct 15;62(20):5651-6.
Title: Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis.
Author: Takahashi, Meiko|Fujita, Manabu|Furukawa, Yoichi|Hamamoto, Ryuji|Shimokawa, Takashi|Miwa, Nobutomo|Ogawa, Michio|Nakamura, Yusuke
PMID: 12384519
Journal: Digestion. 2002;66(3):131-44.
Title: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
Author: Kolligs, Frank T|Bommer, Guido|Goke, Burkhard
PMID: 12481159
Journal: Cancer Biol Ther. 2002 Nov-Dec;1(6):621-5.
Title: beta-Catenin signaling: therapeutic strategies in oncology.
Author: Li, Han|Pamukcu, Rifat|Thompson, W Joseph
PMID: 12642683
Journal: Oncogene. 2003 Jan 30;22(4):632-6.
Title: AXIN1 mutations but not deletions in cerebellar medulloblastomas.
Author: Baeza, Nathalie|Masuoka, Jun|Kleihues, Paul|Ohgaki, Hiroko
PMID: 12555076
Journal: Int J Cancer. 2003 Dec 10;107(5):696-9.
Title: Detection of point mutations of the Axin1 gene in colorectal cancers.
Author: Jin, Li-Hua|Shao, Qiu-Jie|Luo, Wen|Ye, Zhi-Yun|Li, Qing|Lin, Sheng-Cai
PMID: 14566817
Journal: Med Klin (Munich). 2003 Dec 15;98(12):776-82.
Title: [Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms].
Author: Friedrich, Anja|Kullmann, Frank
PMID: 14685680
Journal: Oncol Rep. 2004 Feb;11(2):341-8.
Title: Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features.
Author: Lin, Shyr-Yi|Yeh, Kun-Tu|Chen, Willian Tzu-Liang|Chen, Hung-Chang|Chen, Shou-Tung|Chiou, Hung-Yi|Chang, Jan-Gowth
PMID: 14719065
Journal: Oncogene. 2004 Jun 3;23(26):4577-83.
Title: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling.
Author: Taylor, Michael D|Zhang, Xiaoyun|Liu, Ling|Hui, Chi-Chung|Mainprize, Todd G|Scherer, Stephen W|Wainwright, Brandon|Hogg, David|Rutka, James T
PMID: 15077159
Journal: Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15992-7. Epub 2004 Nov 1.
Title: Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
Author: Fearnhead, Nicola S|Wilding, Jennifer L|Winney, Bruce|Tonks, Susan|Bartlett, Sylvia|Bicknell, David C|Tomlinson, Ian P M|Mortensen, Neil J McC|Bodmer, Walter F
PMID: 15520370
Journal: Cancer Res. 2004 Dec 1;64(23):8496-501.
Title: Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.
Author: Adachi, Shungo|Jigami, Takafumi|Yasui, Toshio|Nakano, Tetsuhiro|Ohwada, Susumu|Omori, Yoshihiro|Sugano, Sumio|Ohkawara, Bisei|Shibuya, Hiroshi|Nakamura, Tsutomu|Akiyama, Tetsu
PMID: 15574752
Journal: Cancer Res. 2005 Jan 1;65(1):166-76.
Title: Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors.
Author: Reichling, Tim|Goss, Kathleen Heppner|Carson, Daniel J|Holdcraft, Robert W|Ley-Ebert, Cathy|Witte, Dave|Aronow, Bruce J|Groden, Joanna
PMID: 15665292
Journal: Biochem Biophys Res Commun. 2005 Mar 4;328(1):227-34.
Title: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.
Author: Park, Chi Hoon|Chang, Joon Young|Hahm, Eun Ryeong|Park, Seyeon|Kim, Hyun-Kyung|Yang, Chul Hak
PMID: 15670774
Journal: Gastroenterology. 2005 Jun;128(7):1907-18.
Title: Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Author: Li, Jingnan|Mizukami, Yusuke|Zhang, Xiaobo|Jo, Won-Seok|Chung, Daniel C
PMID: 15940626
Journal: Anat Sci Int. 2005 Sep;80(3):121-31.
Title: Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene.
Author: Senda, Takao|Shimomura, Atsushi|Iizuka-Kogo, Akiko
PMID: 16158975
Journal: Int J Oncol. 2005 Dec;27(6):1483-7.
Title: Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer.
Author: Takahashi, Meiko|Nakamura, Yusuke|Obama, Kazutaka|Furukawa, Yoichi
PMID: 16273202
Journal: Science. 2005 Dec 2;310(5753):1504-10.
Title: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.
Author: Castellone, Maria Domenica|Teramoto, Hidemi|Williams, Bart O|Druey, Kirk M|Gutkind, J Silvio
PMID: 16293724
Journal: BMC Genomics. 2006 Jun 13;7:148.
Title: Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression.
Author: Pospisil, Heike|Herrmann, Alexander|Butherus, Kristine|Pirson, Stefan|Reich, Jens G|Kemmner, Wolfgang
PMID: 16772034
Journal: Am J Gastroenterol. 2006 Dec;101(12):2810-7.
Title: Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression.
Author: Cao, Xia|Hong, Yi|Eu, Kong Weng|Loi, Carol|Cheah, Peh Yean
PMID: 17026565
Journal: Oncogene. 2006 Dec 4;25(57):7531-7.
Title: Colorectal cancer and genetic alterations in the Wnt pathway.
Author: Segditsas, S|Tomlinson, I
PMID: 17143297
Journal: Oncogene. 2007 Jul 12;26(32):4699-713. Epub 2007 Feb 5.
Title: Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.
Author: Nojima, M|Suzuki, H|Toyota, M|Watanabe, Y|Maruyama, R|Sasaki, S|Sasaki, Y|Mita, H|Nishikawa, N|Yamaguchi, K|Hirata, K|Itoh, F|Tokino, T|Mori, M|Imai, K|Shinomura, Y
PMID: 17297461
Journal: Proteins. 2007 Jun 1;67(4):941-9.
Title: Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues.
Author: Zhang, Na|Jiang, Yongjun|Zou, Jianwei|Zhuang, Shulin|Jin, Haixiao|Yu, Qingsen
PMID: 17380482
Journal: Science. 2007 May 18;316(5827):1043-6.
Title: Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
Author: Major, Michael B|Camp, Nathan D|Berndt, Jason D|Yi, Xianhua|Goldenberg, Seth J|Hubbert, Charlotte|Biechele, Travis L|Gingras, Anne-Claude|Zheng, Ning|Maccoss, Michael J|Angers, Stephane|Moon, Randall T
PMID: 17510365
Journal: Int J Cancer. 2007 Sep 15;121(6):1175-81.
Title: Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.
Author: Shi, Yihui|He, Biao|Kuchenbecker, Kristopher M|You, Liang|Xu, Zhidong|Mikami, Iwao|Yagui-Beltran, Adam|Clement, Genevieve|Lin, Yu-Ching|Okamoto, Junichi|Bravo, Dawn T|Jablons, David M
PMID: 17534895
Journal: Med Mol Morphol. 2007 Jun;40(2):68-81. Epub 2007 Jun 18.
Title: Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.
Author: Senda, Takao|Iizuka-Kogo, Akiko|Onouchi, Takanori|Shimomura, Atsushi
PMID: 17572842
Journal: Cell Signal. 2007 Sep;19(9):1973-85. Epub 2007 Jun 2.
Title: Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.
Author: Kurzik-Dumke, Ursula|Czaja, Joachim
PMID: 17588722
Journal: J Cell Sci. 2007 Oct 1;120(Pt 19):3327-35.
Title: Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.
Author: Aoki, Koji|Taketo, Makoto M
PMID: 17881494
Journal: Genes Cells. 2007 Dec;12(12):1339-45.
Title: Putative tumor suppressor EDD interacts with and up-regulates APC.
Author: Ohshima, Ryuichi|Ohta, Tomohiko|Wu, Wenwen|Koike, Ayaka|Iwatani, Tsuguo|Henderson, Michelle|Watts, Colin K W|Otsubo, Takehito
PMID: 18076571
Journal: Int J Mol Med. 2008 Jan;21(1):19-31.
Title: Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor.
Author: Kurzik-Dumke, Ursula|Horner, Manuela|Czaja, Joachim|Nicotra, Maria Rita|Simiantonaki, Nektaria|Koslowski, Michael|Natali, Pier Giorgio
PMID: 18097612
Journal: Genes Chromosomes Cancer. 2008 Jul;47(7):614-24.
Title: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma.
Author: Castiglia, Daniele|Bernardini, Silvia|Alvino, Ester|Pagani, Elena|De Luca, Naomi|Falcinelli, Sabrina|Pacchiarotti, Alberto|Bonmassar, Enzo|Zambruno, Giovanna|D'Atri, Stefania
PMID: 18384130
Journal: Oncol Res. 2008;17(1):1-9.
Title: Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer?
Author: Bordonaro, Michael|Lazarova, Darina L|Sartorelli, Alan C
PMID: 18488710
Journal: Curr Cancer Drug Targets. 2008 Sep;8(6):454-65.
Title: Importance of Wnt signaling in the tumor stroma microenvironment.
Author: Macheda, Maria L|Stacker, Steven A
PMID: 18781892
Journal: Mol Cancer Res. 2008 Sep;6(9):1421-30.
Title: Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.
Author: Guo, Lizheng|Zhong, Diansheng|Lau, Stephen|Liu, Xiuju|Dong, Xue-Yuan|Sun, Xiaodong|Yang, Vincent W|Vertino, Paula M|Moreno, Carlos S|Varma, Vijay|Dong, Jin-Tang|Zhou, Wei
PMID: 18819930
Journal: Hybridoma (Larchmt). 2009 Jun;28(3):183-8.
Title: A novel monoclonal antibody specific to DIXDC1 protein.
Author: Liu, Tantan|Wang, Lei|Chen, Qi|Zheng, Li|Zhu, Hongguang
PMID: 19519246
Journal: Cancer Sci. 2009 Oct;100(10):1801-8.
Title: DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation.
Author: Wang, Lei|Cao, Xi-Xi|Chen, Qi|Zhu, Teng-Fang|Zhu, Hong-Guang|Zheng, Li
PMID: 19572978
Journal: J Biol Chem. 2009 Dec 18;284(51):35308-13.
Title: Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade.
Author: Ng, Ser Sue|Mahmoudi, Tokameh|Danenberg, Esther|Bejaoui, Ines|de Lau, Wim|Korswagen, Hendrik C|Schutte, Mieke|Clevers, Hans
PMID: 19850932
Journal: PLoS One. 2009 Nov 24;4(11):e7982.
Title: Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.
Author: Guo, Jianhui|Cagatay, Tolga|Zhou, Guangjin|Chan, Chih-Chiang|Blythe, Shelby|Suyama, Kaye|Zheng, Li|Pan, Kaifeng|Qian, Chiping|Hamelin, Richard|Thibodeau, Stephen N|Klein, Peter S|Wharton, Keith A|Liu, Wanguo
PMID: 19956716
Journal: Oncogene. 2010 Mar 18;29(11):1663-71.
Title: Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients.
Author: Kohler, E M|Brauburger, K|Behrens, J|Schneikert, J
PMID: 19966865
Journal: Biol Chem. 2010 Feb-Mar;391(2-3):171-80.
Title: MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.
Author: Sue Ng, Ser|Mahmoudi, Tokameh|Li, Vivian S W|Hatzis, Pantelis|Boersema, Paul J|Mohammed, Shabaz|Heck, Albert J|Clevers, Hans
PMID: 20128690
Journal: Mol Cancer. 2010 Aug 6;9:212.
Title: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres.
Author: Kanwar, Shailender S|Yu, Yingjie|Nautiyal, Jyoti|Patel, Bhaumik B|Majumdar, Adhip P N
PMID: 20691072
Journal: Nat Chem Biol. 2010 Nov;6(11):829-36.
Title: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha.
Author: Thorne, Curtis A|Hanson, Alison J|Schneider, Judsen|Tahinci, Emilios|Orton, Darren|Cselenyi, Christopher S|Jernigan, Kristin K|Meyers, Kelly C|Hang, Brian I|Waterson, Alex G|Kim, Kwangho|Melancon, Bruce|Ghidu, Victor P|Sulikowski, Gary A|LaFleur, Bonnie|S
PMID: 20890287
Journal: PLoS One. 2010 Nov 30;5(11):e14127.
Title: Independent interactions of phosphorylated beta-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions.
Author: Faux, Maree C|Coates, Janine L|Kershaw, Nadia J|Layton, Meredith J|Burgess, Antony W
PMID: 21152425
Journal: Cancer Genet Cytogenet. 2010 Dec;203(2):316-23.
Title: Screening for common copy-number variants in cancer genes.
Author: Tyson, Jess|Majerus, Tamsin M O|Walker, Susan|Armour, John A L
PMID: 21156252
Journal: Med Oncol. 2011 Dec;28 Suppl 1:S259-67.
Title: Diversity of axin in signaling pathways and its relation to colorectal cancer.
Author: Parveen, Nighat|Hussain, Mahboob Ul|Pandith, Arshad A|Mudassar, Syed
PMID: 21053101
Journal: Mol Cell Biochem. 2011 Sep;355(1-2):149-55.
Title: Novelty of Axin 2 and lack of Axin 1 gene mutation in colorectal cancer: a study in Kashmiri population.
Author: Khan, Nighat P|Pandith, Arshad A|Hussain, Mahboob Ul|Yousuf, Adfar|Khan, Mosin S|Wani, Khursheed A|Mudassar, Syed
PMID: 21541676
Journal: Gastroenterology. 2012 Feb;142(2):219-32.
Title: Dysregulation of Wnt/beta-catenin signaling in gastrointestinal cancers.
Author: White, Bryan D|Chien, Andy J|Dawson, David W
PMID: 22155636
Journal: Mol Biol Rep. 2012 May;39(5):6171-8.
Title: Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran.
Author: Naghibalhossaini, Fakhraddin|Zamani, Mozhdeh|Mokarram, Pooneh|Khalili, Islam|Rasti, Mozhgan|Mostafavi-Pour, Zohreh
PMID: 22207181
Journal: PLoS One. 2012;7(2):e31882.
Title: Wnt signalling pathway parameters for mammalian cells.
Author: Tan, Chin Wee|Gardiner, Bruce S|Hirokawa, Yumiko|Layton, Meredith J|Smith, David W|Burgess, Antony W
PMID: 22363759
Journal: Cell. 2012 Jun 8;149(6):1245-56.
Title: Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex.
Author: Li, Vivian S W|Ng, Ser Sue|Boersema, Paul J|Low, Teck Y|Karthaus, Wouter R|Gerlach, Jan P|Mohammed, Shabaz|Heck, Albert J R|Maurice, Madelon M|Mahmoudi, Tokameh|Clevers, Hans
PMID: 22682247
Journal: PLoS One. 2012;7(11):e48670.
Title: Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.
Author: Bao, Renyue|Christova, Tania|Song, Siyuan|Angers, Stephane|Yan, Xiaojun|Attisano, Liliana
PMID: 23144924
Journal: Turk Patoloji Derg. 2013;29(2):87-93.
Title: Relationship between beta-catenin expression and prognostic parameters of colorectal carcinomas.
Author: Peker, Kemal|Basoglu, Mahmut|Gursan, Nesrin
PMID: 23661344
Journal: Dig Dis Sci. 2013 Sep;58(9):2507-17.
Title: Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.
Author: Sadik, Nermin Abdel Hamid|Shaker, Olfat Gamil
PMID: 23722564
Journal: PLoS Comput Biol. 2013;9(9):e1003217.
Title: Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells.
Author: Barua, Dipak|Hlavacek, William S
PMID: 24086117
Journal: J Med Chem. 2013 Dec 27;56(24):10003-15.
Title: Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
Author: Hua, Zihao|Bregman, Howard|Buchanan, John L|Chakka, Nagasree|Guzman-Perez, Angel|Gunaydin, Hakan|Huang, Xin|Gu, Yan|Berry, Virginia|Liu, Jingzhou|Teffera, Yohannes|Huang, Liyue|Egge, Bryan|Emkey, Renee|Mullady, Erin L|Schneider, Steve|Andrews, Paul S|Acqu
PMID: 24294969
Journal: ACS Med Chem Lett. 2013 Oct 21;4(12):1218-23.
Title: Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors.
Author: Huang, Hongbing|Guzman-Perez, Angel|Acquaviva, Lisa|Berry, Virginia|Bregman, Howard|Dovey, Jennifer|Gunaydin, Hakan|Huang, Xin|Huang, Liyue|Saffran, Doug|Serafino, Randy|Schneider, Steve|Wilson, Cindy|DiMauro, Erin F
PMID: 24900633
Journal: Cancer Res. 2014 Mar 1;74(5):1495-505.
Title: LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.
Author: de la Roche, Marc|Ibrahim, Ashraf E K|Mieszczanek, Juliusz|Bienz, Mariann
PMID: 24419084
Journal: PLoS One. 2014 Apr 10;9(4):e94413.
Title: different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.
Author: Schneikert, Jean|Ruppert, Jan Gustav|Behrens, Jurgen|Wenzel, Eva Maria
PMID: 24722208
Journal: J Cell Sci. 2014 Jul 15;127(Pt 14):3116-30.
Title: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4.
Author: Jin, Runsen|Liu, Wensheng|Menezes, Sharleen|Yue, Fei|Zheng, Minhua|Kovacevic, Zaklina|Richardson, Des R
PMID: 24829151
Journal: Oncol Lett. 2014 Jun;7(6):2185-2191.
Title: FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma.
Author: Zhu, Jianjun|Deng, Shishan|Duan, Jie|Xie, Xingguo|Xu, Shiquan|Ran, Maocheng|Dai, Xiaosi|Pu, Yu|Zhang, Xiaoming
PMID: 24932313
Journal: PLoS One. 2014 Sep 15;9(9):e106881.
Title: Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts.
Author: Hustoft, Hanne Kolsrud|Vehus, Tore|Brandtzaeg, Ole Kristian|Krauss, Stefan|Greibrokk, Tyge|Wilson, Steven Ray|Lundanes, Elsa
PMID: 25222838
Journal: Cancer Lett. 2014 Dec 1;355(1):1-8.
Title: AXIN1 and AXIN2 variants in gastrointestinal cancers.
Author: Mazzoni, Serina M|Fearon, Eric R
PMID: 25236910
Journal: Tumour Biol. 2015 Mar;36(3):1701-10.
Title: MicroRNA-93 suppress colorectal cancer development via Wnt/beta-catenin pathway downregulating.
Author: Tang, Qingchao|Zou, Zhaoxia|Zou, Chendan|Zhang, Qian|Huang, Rui|Guan, Xu|Li, Qiang|Han, Zhongjing|Wang, Dayong|Wei, Huiyan|Gao, Xu|Wang, Xishan
PMID: 25371073
Journal: Int J Cancer. 2015 Oct 1;137(7):1560-73.
Title: Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling.
Author: Takahashi, Kohta|Hosono, Masahiro|Sato, Ikuro|Hata, Keiko|Wada, Tadashi|Yamaguchi, Kazunori|Nitta, Kazuo|Shima, Hiroshi|Miyagi, Taeko
PMID: 25810027
Journal: Mol Cancer Res. 2015 Nov;13(11):1487-501.
Title: Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.
Author: Thorvaldsen, Tor Espen|Pedersen, Nina Marie|Wenzel, Eva M|Schultz, Sebastian W|Brech, Andreas|Liestol, Knut|Waaler, Jo|Krauss, Stefan|Stenmark, Harald
PMID: 26124443
Journal: Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10931-4.
Title: A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization.
Author: Wang, Yuanxiang|Chou, Danny Hung-Chieh
PMID: 26189498
Journal: Oncotarget. 2015 Sep 22;6(28):25975-87.
Title: 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/beta-catenin/MMP-7 signaling pathway.
Author: Sui, Hua|Xu, Hanchen|Ji, Qing|Liu, Xuan|Zhou, Lihong|Song, Haiyan|Zhou, Xiqiu|Xu, Yangxian|Chen, Zhesheng|Cai, Jianfeng|Ji, Guang|Li, Qi
PMID: 26214021
Journal: Vestn Ross Akad Med Nauk. 2015;(4):475-83.
Title: [beta-Catenin: Structure, Function and Role in Malignant Transformation of Epithelial Cells].
Author: Isaeva, A V|Zima, A P|Shabalova, I P|Ryazantseva, N V|Vasil'eva, O A|Kasoayn, K T|Saprina, T V|Latypova, V N|Berezkina, I S|Novitskii, V V
PMID: 26710532
Journal: Cell Death Discov. 2015 Oct 5;1:15033.
Title: Novel beta-carbolines against colorectal cancer cell growth via inhibition of Wnt/beta-catenin signaling.
Author: Li, X|Bai, B|Liu, L|Ma, P|Kong, L|Yan, J|Zhang, J|Ye, Z|Zhou, H|Mao, B|Zhu, H|Li, Y
PMID: 27551464
Journal: J Biomol Screen. 2016 Mar;21(3):260-8.
Title: A High-Content Imaging Screen for Cellular Regulators of beta-Catenin Protein Abundance.
Author: Zeng, Xin|Montoute, Monica|Bee, Tiger W|Lin, Hong|Kallal, Lorena A|Liu, Yan|Agarwal, Pankaj|Wang, Dayuan|Lu, Quinn|Morrow, Dwight|Pope, Andrew J|Wu, Zining
PMID: 26656867
Journal: Int J Oncol. 2016 Apr;48(4):1333-40.
Title: Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway.
Author: Wu, Xuefang|Luo, Feng|Li, Jinbang|Zhong, Xueyun|Liu, Kunping
PMID: 26820603
Journal: Bosn J Basic Med Sci. 2016 Feb 4;16(2):108-13.
Title: LGALS3 and AXIN1 gene variants playing role in the Wnt/ beta-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer.
Author: Korkmaz, Gurbet|Horozoglu, Cem|Arikan, Soykan|Gural, Zeynep|Saglam, Esra Kaytan|Turan, Saime|Ozkan, Nazli Ezgi|Kahraman, Ozlem Timirci|Yenilmez, Ezgi Nurdan|Duzkoylu, Yigit|Dogan, Mehmet Baki|Zeybek, Umit|Ergen, Arzu|Yaylim, Ilhan
PMID: 26894286
Journal: PLoS One. 2016 Mar 1;11(3):e0150484.
Title: Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of beta-Catenin Degradation-Competent Axin Puncta.
Author: Martino-Echarri, Estefania|Brocardo, Mariana G|Mills, Kate M|Henderson, Beric R
PMID: 26930278
Journal: Biomol Ther (Seoul). 2016 Jul 1;24(4):380-6.
Title: Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells.
Author: Eo, Hyun Ji|Park, Gwang Hun|Jeong, Jin Boo
PMID: 27068260
Journal: Eur J Oral Sci. 2016 Jun;124(3):228-33.
Title: Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis.
Author: Yue, Haitang|Liang, Jia|Yang, Kai|Hua, Bo|Bian, Zhuan
PMID: 27090353
Journal: Development. 2016 May 15;143(10):1710-20.
Title: The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.
Author: Wang, Zhenghan|Tian, Ai|Benchabane, Hassina|Tacchelly-Benites, Ofelia|Yang, Eungi|Nojima, Hisashi|Ahmed, Yashi
PMID: 27190037
Journal: Mol Cancer Ther. 2016 Jul;15(7):1525-34.
Title: The Discovery and Characterization of K-756, a Novel Wnt/beta-Catenin Pathway Inhibitor Targeting Tankyrase.
Author: Okada-Iwasaki, Ryoko|Takahashi, Yuichi|Watanabe, Yasuo|Ishida, Hiroshi|Saito, Jun-Ichi|Nakai, Ryuichiro|Asai, Akira
PMID: 27196752
Journal: Cancer Res. 2016 Aug 1;76(15):4559-68.
Title: AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/beta-Catenin Signaling.
Author: Yum, Min Kyu|Kang, Jong-Seol|Lee, Al-Eum|Jo, Young-Woo|Seo, Ji-Yun|Kim, Hyun-A|Kim, Yoon-Young|Seong, Jinwoo|Lee, Eun Byul|Kim, Ji-Hoon|Han, Jung Min|Kim, Sunghoon|Kong, Young-Yun
PMID: 27262173
Journal: Einstein (Sao Paulo). 2016 Apr-Jun;14(2):135-42.
Title: The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma.
Author: Bourroul, Guilherme Muniz|Fragoso, Helio Jose|Gomes, Jose Walter Feitosa|Bourroul, Vivian Sati Oba|Oshima, Celina Tizuko Fujiyama|Gomes, Thiago Simao|Saba, Gabriela Tognini|Palma, Rogerio Tadeu|Waisberg, Jaques
PMID: 27462886
Journal: BMB Rep. 2016 Sep;49(9):455-6.
Title: Simultaneous destabilization of beta-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer.
Author: Cha, Pu-Hyeon|Choi, Kang-Yell
PMID: 27470214
Journal: PLoS One. 2016 Aug 2;11(8):e0160507.
Title: Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.
Author: Pedersen, Nina Marie|Thorvaldsen, Tor Espen|Schultz, Sebastian Wolfgang|Wenzel, Eva Maria|Stenmark, Harald
PMID: 27482906
Journal: Neoplasia. 2016 Dec;18(12):711-723.
Title: Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of beta-Catenin Signaling.
Author: Wang, Wenhui|Xu, Lei|Liu, Pengyu|Jairam, Kiran|Yin, Yuebang|Chen, Kan|Sprengers, Dave|Peppelenbosch, Maikel P|Pan, Qiuwei|Smits, Ron
PMID: 27851986
Journal: Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4991-4998.
Title: Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer
Author: Ahmed, Hanaa H|Aglan, Hadeer A|Zaazaa, Asmaa M|Shalby, Aziza B|El Toumy, Sayed A
PMID: 28032729
Journal: J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):430-437.
Title: Vitamin D receptor is a novel transcriptional regulator for Axin1.
Author: Jin, Dapeng|Zhang, Yong-Guo|Wu, Shaoping|Lu, Rong|Lin, Zhijie|Zheng, Yuanyuan|Chen, Honglei|Cs-Szabo, Gabriella|Sun, Jun
PMID: 27601169
Journal: EMBO Mol Med. 2017 Mar;9(3):293-303.
Title: Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
Author: Picco, Gabriele|Petti, Consalvo|Centonze, Alessia|Torchiaro, Erica|Crisafulli, Giovanni|Novara, Luca|Acquaviva, Andrea|Bardelli, Alberto|Medico, Enzo
PMID: 28100566
Journal: PLoS One. 2017 Jan 20;12(1):e0170508.
Title: Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and beta-Catenin Degradation.
Author: Thorvaldsen, Tor Espen|Pedersen, Nina Marie|Wenzel, Eva Maria|Stenmark, Harald
PMID: 28107521
Journal: Mol Cancer Ther. 2017 Apr;16(4):752-762.
Title: APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
Author: Tanaka, Noritaka|Mashima, Tetsuo|Mizutani, Anna|Sato, Ayana|Aoyama, Aki|Gong, Bo|Yoshida, Haruka|Muramatsu, Yukiko|Nakata, Kento|Matsuura, Masaaki|Katayama, Ryohei|Nagayama, Satoshi|Fujita, Naoya|Sugimoto, Yoshikazu|Seimiya, Hiroyuki
PMID: 28179481
Journal: J Math Biol. 2017 Nov;75(5):1171-1202.
Title: A kinetic model to study the regulation of beta-catenin, APC, and Axin in the human colonic crypt.
Author: Emerick, Brooks|Schleiniger, Gilberto|Boman, Bruce M
PMID: 28271271
Journal: Basic Clin Pharmacol Toxicol. 2017 Aug;121(2):81-88.
Title: Targeting Tankyrase to Fight WNT-dependent Tumours.
Author: Thorvaldsen, Tor Espen
PMID: 28371398
Journal: Oncotarget. 2017 May 9;8(19):31842-31855.
Title: Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction.
Author: Ahn, Sung Yong|Kim, Nam Hee|Lee, Kyungro|Cha, Yong Hoon|Yang, Ji Hye|Cha, So Young|Cho, Eunae Sandra|Lee, Yoonmi|Cha, Jeong Seok|Cho, Hyun Soo|Jeon, Yoon|Yuk, Young-Su|Cho, Suebean|No, Kyoung Tai|Kim, Hyun Sil|Lee, Ho|Choi, Jiwon|Yook, Jong In
PMID: 28418862
Journal: Nat Commun. 2017 Jun 28;8(1):40.
Title: Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Author: Kang, Dong Hoon|Lee, Doo Jae|Lee, Sunmi|Lee, So-Young|Jun, Yukyung|Kim, Yerin|Kim, Youngeun|Lee, Ju-Seog|Lee, Dae-Kee|Lee, Sanghyuk|Jho, Eek-Hoon|Yu, Dae-Yeul|Kang, Sang Won
PMID: 28659575
Journal: BMB Rep. 2017 Aug;50(8):391-392.
Title: Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
Author: Kang, Dong Hoon|Lee, Joanna H S|Kang, Sang Won
PMID: 28683851
Journal: Mol Med Rep. 2017 Oct;16(4):3783-3790.
Title: Coexpression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway.
Author: Xu, Meili|Liu, Xianling|Xu, Yan|Zhu, Shicong|Gao, Yawen
PMID: 28731177
Journal: BMC Bioinformatics. 2017 Sep 2;18(1):388.
Title: Investigating MicroRNA and transcription factor co-regulatory networks in colorectal cancer.
Author: Wang, Hao|Luo, Jiamao|Liu, Chun|Niu, Huilin|Wang, Jing|Liu, Qi|Zhao, Zhongming|Xu, Hua|Ding, Yanqing|Sun, Jingchun|Zhang, Qingling
PMID: 28865443
Journal: Br J Pharmacol. 2017 Dec;174(24):4611-4636.
Title: Regulation of Wnt/beta-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.
Author: Mariotti, Laura|Pollock, Katie|Guettler, Sebastian
PMID: 28910490
Journal: Biochem Biophys Res Commun. 2017 Nov 25;493(3):1342-1348.
Title: SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/beta-Catenin complex.
Author: Ohashi, Wakana|Yamamine, Naoki|Imura, Johji|Hattori, Yuichi
PMID: 28970068
Journal: Front Pharmacol. 2017 Nov 24;8:877.
Title: Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/beta-Catenin Pathways via miR-130a.
Author: Dou, Huiqiang|Shen, Renhui|Tao, Jianxin|Huang, Longchang|Shi, Haoze|Chen, Hang|Wang, Yixin|Wang, Tong
PMID: 29225578
Journal: Cell Biochem Biophys. 2018 Jun;76(1-2):173-185.
Title: Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach.
Author: Khan, Imran|Ansari, Irfan A|Singh, Pratichi|Dass, J Febin Prabhu|Khan, Fahad
PMID: 28770488
Journal: Genomics Proteomics Bioinformatics. 2018 Feb;16(1):73-84.
Title: The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Profiling.
Author: Luna Coronell, Johana A|Sergelen, Khulan|Hofer, Philipp|Gyurjan, Istvan|Brezina, Stefanie|Hettegger, Peter|Leeb, Gernot|Mach, Karl|Gsur, Andrea|Weinhausel, Andreas
PMID: 29505855
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Jan;49(1):59-64.
Title: [Expression of AXIN and MACC1 in Gastric Carcinoma and Its Clinical Significance].
Author: Zhu, Bo|Wang, Dan-Na|Gong, Xiao-Meng|Yu, Lan|Wu, Shi-Wu|Tao, Yi-Sheng
PMID: 29737091
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: Cell Death Dis. 2018 May 22;9(6):591.
Title: YAP-dependent ubiquitination and degradation of beta-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer.
Author: Chen, Chen|Zhu, Dongrong|Zhang, Hao|Han, Chao|Xue, Guimin|Zhu, Tianyu|Luo, Jianguang|Kong, Lingyi
PMID: 29789528
Journal: NPJ Precis Oncol. 2018 Feb 20;2(1):5.
Title: Interaction between Wnt/beta-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of beta-catenin and RAS by targeting the Wnt/beta-catenin pathway.
Author: Jeong, Woo-Jeong|Ro, Eun Ji|Choi, Kang-Yell
PMID: 29872723
Journal: Biochem Biophys Res Commun. 2018 Sep 5;503(2):991-997.
Title: The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/beta-catenin pathway via ubiquitination of Axin1.
Author: Shen, Jiangli|Yu, Zhaohui|Li, Na
PMID: 29932918
Journal: Mol Cancer Res. 2018 Aug 2. pii: 1541-7786.MCR-18-0115.
Title: miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4.
Author: Prossomariti, Anna|Piazzi, Giulia|D'Angelo, Leonarda|Miccoli, Sara|Turchetti, Daniela|Alquati, Chiara|Montagna, Claudio|Bazzoli, Franco|Ricciardiello, Luigi
PMID: 30072583
Journal: Phytomedicine. 2018 Jul 15;46:85-92.
Title: Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells.
Author: Shi, Xianpeng|Zhu, Man|Kang, Yuan|Yang, Tianfeng|Chen, Xia|Zhang, Yanmin
PMID: 30097126
Journal: Cancer Sci. 2018 Sep 20.
Title: RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Author: Mizutani, Anna|Yashiroda, Yoko|Muramatsu, Yukiko|Yoshida, Haruka|Chikada, Tsubasa|Tsumura, Takeshi|Okue, Masayuki|Shirai, Fumiyuki|Fukami, Takahiro|Yoshida, Minoru|Seimiya, Hiroyuki
PMID: 30238564
Journal: Mol Cancer Res. 2018 Sep 26. pii: 1541-7786.MCR-18-0054.
Title: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling.
Author: Wang, Wenhui|Li, Shan|Liu, Pengyu|Sideras, Kostandinos|van de Werken, Harmen J G|van der Heide, Marieke|Cao, Wanlu|Lavrijsen, Marla|Peppelenbosch, Maikel P|Bruno, Marco|Pan, Qiuwei|Smits, Ron
PMID: 30257989