Primary Site >> Colorectal Cancer
Gene >> AXIN1
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Ref: Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. PMID: 9501208 Ref: Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. PMID: 9601641 Ref: Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. PMID: 9734785 |
Ref: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. PMID: 10021369 Ref: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. PMID: 10228155 Ref: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. PMID: 10318916 Ref: beta-catenin signaling and cancer. PMID: 10580987 |
Ref: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. PMID: 10700176 Ref: Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin. PMID: 10722668 Ref: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. PMID: 10862053 Ref: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin. PMID: 10906131 Ref: Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin. PMID: 11341469 |
Ref: Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer. PMID: 11398198 Ref: Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. PMID: 11526492 Ref: Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. PMID: 11691783 |
Ref: Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability. PMID: 11746989 Ref: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. PMID: 11809809 Ref: Beta-catenin--a linchpin in colorectal carcinogenesis? PMID: 11839557 Ref: TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. PMID: 11934263 Ref: Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas. PMID: 11943708 Ref: Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1. PMID: 11986304 Ref: Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. PMID: 12036951 Ref: Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. PMID: 12072559 Ref: Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. PMID: 12384519 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 Ref: beta-Catenin signaling: therapeutic strategies in oncology. PMID: 12642683 |
Ref: AXIN1 mutations but not deletions in cerebellar medulloblastomas. PMID: 12555076 Ref: Detection of point mutations of the Axin1 gene in colorectal cancers. PMID: 14566817 Ref: [Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms]. PMID: 14685680 |
Ref: Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. PMID: 14719065 Ref: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. PMID: 15077159 Ref: Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. PMID: 15520370 Ref: Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. PMID: 15574752 |
Ref: Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors. PMID: 15665292 Ref: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. PMID: 15670774 Ref: Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. PMID: 15940626 Ref: Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. PMID: 16158975 Ref: Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. PMID: 16273202 Ref: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. PMID: 16293724 |
Ref: Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression. PMID: 16772034 Ref: Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression. PMID: 17026565 Ref: Colorectal cancer and genetic alterations in the Wnt pathway. PMID: 17143297 |
Ref: Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. PMID: 17297461 Ref: Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues. PMID: 17380482 Ref: Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. PMID: 17510365 Ref: Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. PMID: 17534895 Ref: Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. PMID: 17572842 Ref: Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. PMID: 17588722 Ref: Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. PMID: 17881494 Ref: Putative tumor suppressor EDD interacts with and up-regulates APC. PMID: 18076571 |
Ref: Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor. PMID: 18097612 Ref: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. PMID: 18384130 Ref: Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer? PMID: 18488710 Ref: Importance of Wnt signaling in the tumor stroma microenvironment. PMID: 18781892 Ref: Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. PMID: 18819930 |
Ref: A novel monoclonal antibody specific to DIXDC1 protein. PMID: 19519246 Ref: DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation. PMID: 19572978 Ref: Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. PMID: 19850932 Ref: Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PMID: 19956716 |
Ref: Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. PMID: 19966865 Ref: MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. PMID: 20128690 Ref: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. PMID: 20691072 Ref: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha. PMID: 20890287 Ref: Independent interactions of phosphorylated beta-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. PMID: 21152425 Ref: Screening for common copy-number variants in cancer genes. PMID: 21156252 |
Ref: Diversity of axin in signaling pathways and its relation to colorectal cancer. PMID: 21053101 Ref: Novelty of Axin 2 and lack of Axin 1 gene mutation in colorectal cancer: a study in Kashmiri population. PMID: 21541676 |
Ref: Dysregulation of Wnt/beta-catenin signaling in gastrointestinal cancers. PMID: 22155636 Ref: Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. PMID: 22207181 Ref: Wnt signalling pathway parameters for mammalian cells. PMID: 22363759 Ref: Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex. PMID: 22682247 Ref: Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PMID: 23144924 |
Ref: Relationship between beta-catenin expression and prognostic parameters of colorectal carcinomas. PMID: 23661344 Ref: Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. PMID: 23722564 Ref: Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells. PMID: 24086117 Ref: Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. PMID: 24294969 Ref: Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors. PMID: 24900633 |
Ref: LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. PMID: 24419084 Ref: different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli. PMID: 24722208 Ref: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4. PMID: 24829151 Ref: FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma. PMID: 24932313 Ref: Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts. PMID: 25222838 Ref: AXIN1 and AXIN2 variants in gastrointestinal cancers. PMID: 25236910 |
Ref: MicroRNA-93 suppress colorectal cancer development via Wnt/beta-catenin pathway downregulating. PMID: 25371073 Ref: Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling. PMID: 25810027 Ref: Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes. PMID: 26124443 Ref: A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization. PMID: 26189498 Ref: 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/beta-catenin/MMP-7 signaling pathway. PMID: 26214021 Ref: [beta-Catenin: Structure, Function and Role in Malignant Transformation of Epithelial Cells]. PMID: 26710532 Ref: Novel beta-carbolines against colorectal cancer cell growth via inhibition of Wnt/beta-catenin signaling. PMID: 27551464 |
Ref: A High-Content Imaging Screen for Cellular Regulators of beta-Catenin Protein Abundance. PMID: 26656867 Ref: Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. PMID: 26820603 Ref: LGALS3 and AXIN1 gene variants playing role in the Wnt/ beta-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer. PMID: 26894286 Ref: Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of beta-Catenin Degradation-Competent Axin Puncta. PMID: 26930278 Ref: Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells. PMID: 27068260 Ref: Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. PMID: 27090353 Ref: The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila. PMID: 27190037 Ref: The Discovery and Characterization of K-756, a Novel Wnt/beta-Catenin Pathway Inhibitor Targeting Tankyrase. PMID: 27196752 Ref: AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/beta-Catenin Signaling. PMID: 27262173 Ref: The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma. PMID: 27462886 Ref: Simultaneous destabilization of beta-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer. PMID: 27470214 Ref: Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity. PMID: 27482906 Ref: Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of beta-Catenin Signaling. PMID: 27851986 Ref: Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer PMID: 28032729 |
Ref: Vitamin D receptor is a novel transcriptional regulator for Axin1. PMID: 27601169 Ref: Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions. PMID: 28100566 Ref: Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and beta-Catenin Degradation. PMID: 28107521 Ref: APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. PMID: 28179481 Ref: A kinetic model to study the regulation of beta-catenin, APC, and Axin in the human colonic crypt. PMID: 28271271 Ref: Targeting Tankyrase to Fight WNT-dependent Tumours. PMID: 28371398 Ref: Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction. PMID: 28418862 Ref: Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. PMID: 28659575 Ref: Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. PMID: 28683851 Ref: Coexpression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway. PMID: 28731177 Ref: Investigating MicroRNA and transcription factor co-regulatory networks in colorectal cancer. PMID: 28865443 Ref: Regulation of Wnt/beta-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding. PMID: 28910490 Ref: SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/beta-Catenin complex. PMID: 28970068 Ref: Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/beta-Catenin Pathways via miR-130a. PMID: 29225578 |
Ref: Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach. PMID: 28770488 Ref: The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Profiling. PMID: 29505855 Ref: [Expression of AXIN and MACC1 in Gastric Carcinoma and Its Clinical Significance]. PMID: 29737091 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: YAP-dependent ubiquitination and degradation of beta-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer. PMID: 29789528 Ref: Interaction between Wnt/beta-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of beta-catenin and RAS by targeting the Wnt/beta-catenin pathway. PMID: 29872723 Ref: The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/beta-catenin pathway via ubiquitination of Axin1. PMID: 29932918 Ref: miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4. PMID: 30072583 Ref: Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. PMID: 30097126 Ref: RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. PMID: 30238564 Ref: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling. PMID: 30257989 |