Primary Site >> Colorectal Cancer
Gene >> ATR
| 1. | |||||||||||
| Journal: | Carcinogenesis. 1999 Nov;20(11):2189-92. | ||||||||||
| Title: | A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes. | ||||||||||
| Author: | Mironov, N|Jansen, L A|Zhu, W B|Aguelon, A M|Reguer, G|Yamasaki, H | ||||||||||
| PMID: | 10545425 | ||||||||||
| 2. | |||||||||||
| Journal: | J Biol Chem. 2004 Sep 17;279(38):39584-92. Epub 2004 Jul 20. | ||||||||||
| Title: | ATM-dependent CHK2 activation induced by anticancer agent, irofulven. | ||||||||||
| Author: | Wang, Jian|Wiltshire, Timothy|Wang, Yutian|Mikell, Carmenza|Burks, Julian|Cunningham, Cynthia|Van Laar, Emily S|Waters, Stephen J|Reed, Eddie|Wang, Weixin | ||||||||||
| PMID: | 15269203 | ||||||||||
| 3. | |||||||||||
| Journal: | Mol Cancer Ther. 2004 Sep;3(9):1147-57. | ||||||||||
| Title: | CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. | ||||||||||
| Author: | Yan, Tao|Desai, Anand B|Jacobberger, James W|Sramkoski, R Michael|Loh, Tamalette|Kinsella, Timothy J | ||||||||||
| PMID: | 15367709 | ||||||||||
| 4. | |||||||||||
| Journal: | EMBO J. 2004 Aug 4;23(15):3164-74. Epub 2004 Jul 29. | ||||||||||
| Title: | ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. | ||||||||||
| Author: | Fang, Yanan|Tsao, Cheng-Chung|Goodman, Barbara K|Furumai, Ryohei|Tirado, Carlos A|Abraham, Robert T|Wang, Xiao-Fan | ||||||||||
| PMID: | 15282542 | ||||||||||
| 5. | |||||||||||
| Journal: | Oncogene. 2007 Apr 19;26(18):2535-42. Epub 2006 Oct 16. | ||||||||||
| Title: | Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. | ||||||||||
| Author: | Hurley, P J|Wilsker, D|Bunz, F | ||||||||||
| PMID: | 17043640 | ||||||||||
| 6. | |||||||||||
| Journal: | Gastroenterology. 2007 Jan;132(1):221-35. | ||||||||||
| Title: | 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. | ||||||||||
| Author: | Luciani, M Gloria|Campregher, Christoph|Fortune, John M|Kunkel, Thomas A|Gasche, Christoph | ||||||||||
| PMID: | 17241873 | ||||||||||
| 7. | |||||||||||
| Journal: | Cell Cycle. 2007 Nov 15;6(22):2760-7. Epub 2007 Aug 22. | ||||||||||
| Title: | The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses. | ||||||||||
| Author: | Conti, Chiara|Seiler, Jennifer A|Pommier, Yves | ||||||||||
| PMID: | 17986860 | ||||||||||
| 8. | |||||||||||
| Journal: | DNA Repair (Amst). 2008 Feb 1;7(2):239-52. | ||||||||||
| Title: | Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells. | ||||||||||
| Author: | Hill, Richard|Leidal, Andrew M|Madureira, Patricia A|Gillis, Laura D|Cochrane, Haley K|Waisman, David M|Chiu, Arthur|Lee, Patrick W K | ||||||||||
| PMID: | 18024214 | ||||||||||
| 9. | |||||||||||
| Journal: | Clin Cancer Res. 2008 Mar 15;14(6):1877-87. | ||||||||||
| Title: | Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. | ||||||||||
| Author: | Crescenzi, Elvira|Palumbo, Giuseppe|de Boer, Jasper|Brady, Hugh J M | ||||||||||
| PMID: | 18347191 | ||||||||||
| 10. | |||||||||||
| Journal: | Mol Pharmacol. 2008 Jul;74(1):173-83. | ||||||||||
| Title: | AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. | ||||||||||
| Author: | Caporali, Simona|Levati, Lauretta|Starace, Giuseppe|Ragone, Gianluca|Bonmassar, Enzo|Alvino, Ester|D'Atri, Stefania | ||||||||||
| PMID: | 18413665 | ||||||||||
| 11. | |||||||||||
| Journal: | J Biol Chem. 2008 Aug 1;283(31):21382-93. | ||||||||||
| Title: | Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. | ||||||||||
| Author: | Wagner, Mark W|Li, Long Shan|Morales, Julio C|Galindo, Cristi L|Garner, Harold R|Bornmann, William G|Boothman, David A | ||||||||||
| PMID: | 18480061 | ||||||||||
| 12. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2008 Nov 21;376(3):509-13. | ||||||||||
| Title: | Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. | ||||||||||
| Author: | Iwabuchi, Kuniyoshi|Matsui, Tadashi|Hashimoto, Mitsumasa|Matsumoto, Yoshihisa|Kurihara, Takayuki|Date, Takayasu | ||||||||||
| PMID: | 18804090 | ||||||||||
| 13. | |||||||||||
| Journal: | Biochim Biophys Acta. 2009 May;1790(5):339-46. | ||||||||||
| Title: | Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression. | ||||||||||
| Author: | Kumamoto-Yonezawa, Yuko|Sasaki, Ryohei|Ota, Yosuke|Suzuki, Yoko|Fukushima, Shoji|Hada, Takahiko|Uryu, Keisuke|Sugimura, Kazuro|Yoshida, Hiromi|Mizushina, Yoshiyuki | ||||||||||
| PMID: | 19364474 | ||||||||||
| 14. | |||||||||||
| Journal: | Mol Biol Cell. 2009 Sep;20(17):3801-9. | ||||||||||
| Title: | Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. | ||||||||||
| Author: | Jardim, Melanie J|Wang, Qinhong|Furumai, Ryohei|Wakeman, Timothy|Goodman, Barbara K|Wang, Xiao-Fan | ||||||||||
| PMID: | 19570909 | ||||||||||
| 15. | |||||||||||
| Journal: | Int J Cancer. 2009 Jun 15;124(12):2797-803. | ||||||||||
| Title: | Ascochlorin activates p53 in a manner distinct from DNA damaging agents. | ||||||||||
| Author: | Jeong, Ji-Hak|Nakajima, Hiroo|Magae, Junji|Furukawa, Chiharu|Taki, Keiko|Otsuka, Kensuke|Tomita, Masanori|Lee, In-Seon|Kim, Cheorl-Ho|Chang, Hyeun-Wook|Min, Kwan-Sik|Park, Kwang-Kyun|Park, Kwan-Kyu|Chang, Young-Chae | ||||||||||
| PMID: | 19253369 | ||||||||||
| 16. | |||||||||||
| Journal: | Oncol Rep. 2010 Jul;24(1):37-46. | ||||||||||
| Title: | Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. | ||||||||||
| Author: | Dibra, H K|Brown, J E|Hooley, P|Nicholl, I D | ||||||||||
| PMID: | 20514442 | ||||||||||
| 17. | |||||||||||
| Journal: | Oncogene. 2011 Jun 2;30(22):2526-33. | ||||||||||
| Title: | ATR mediates cisplatin resistance in a p53 genotype-specific manner. | ||||||||||
| Author: | Sangster-Guity, N|Conrad, B H|Papadopoulos, N|Bunz, F | ||||||||||
| PMID: | 21258400 | ||||||||||
| 18. | |||||||||||
| Journal: | Stem Cells. 2011 Mar;29(3):418-29. | ||||||||||
| Title: | Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction. | ||||||||||
| Author: | Gallmeier, Eike|Hermann, Patrick C|Mueller, Maria-Theresa|Machado, Juan G|Ziesch, Andreas|De Toni, Enrico N|Palagyi, Andreas|Eisen, Christian|Ellwart, Joachim W|Rivera, Jose|Rubio-Viqueira, Belen|Hidalgo, Manuel|Bunz, Fred|Goke, Burkhard|Heeschen, Christo | ||||||||||
| PMID: | 21308861 | ||||||||||
| 19. | |||||||||||
| Journal: | Int J Biochem Cell Biol. 2011 Sep;43(9):1354-64. | ||||||||||
| Title: | Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. | ||||||||||
| Author: | Brocardo, Mariana G|Borowiec, James A|Henderson, Beric R | ||||||||||
| PMID: | 21664290 | ||||||||||
| 20. | |||||||||||
| Journal: | PLoS One. 2011;6(12):e28862. | ||||||||||
| Title: | Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. | ||||||||||
| Author: | Geng, Liyi|Huehls, Amelia M|Wagner, Jill M|Huntoon, Catherine J|Karnitz, Larry M | ||||||||||
| PMID: | 22194930 | ||||||||||
| 21. | |||||||||||
| Journal: | Exp Ther Med. 2011 May;2(3):393-397. | ||||||||||
| Title: | Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. | ||||||||||
| Author: | Suzuki, Norihiko|Nakagawa, Fumio|Nukatsuka, Mamoru|Fukushima, Masakazu | ||||||||||
| PMID: | 22977515 | ||||||||||
| 22. | |||||||||||
| Journal: | Life Sci. 2012 Dec 17;91(25-26):1336-44. | ||||||||||
| Title: | Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells. | ||||||||||
| Author: | Vijayakurup, Vinod|Carmela, Spatafora|Carmelo, Daquino|Corrado, Tringali|Srinivas, Priya|Gopala, Srinivas | ||||||||||
| PMID: | 23123449 | ||||||||||
| 23. | |||||||||||
| Journal: | Cell Signal. 2012 Jan;24(1):316-24. | ||||||||||
| Title: | The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. | ||||||||||
| Author: | Lo, Pang-Kuo|Lee, Ji Shin|Sukumar, Saraswati | ||||||||||
| PMID: | 21964066 | ||||||||||
| 24. | |||||||||||
| Journal: | DNA Cell Biol. 2012 Jan;31(1):15-29. | ||||||||||
| Title: | Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines. | ||||||||||
| Author: | Kim, Young-Mee|Pyo, Hongryull | ||||||||||
| PMID: | 21830942 | ||||||||||
| 25. | |||||||||||
| Journal: | Int J Oncol. 2012 Jul;41(1):76-82. | ||||||||||
| Title: | Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. | ||||||||||
| Author: | Hong, Yong Sang|Hong, Seung-Woo|Kim, Seung-Mi|Jin, Dong-Hoon|Shin, Jae-Sik|Yoon, Dok Hyun|Kim, Kyu-Pyo|Lee, Jae-Lyun|Heo, Dae Seog|Lee, Jung Shin|Kim, Tae Won | ||||||||||
| PMID: | 22552540 | ||||||||||
| 26. | |||||||||||
| Journal: | J Med Chem. 2013 Mar 14;56(5):2125-38. | ||||||||||
| Title: | Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-y l}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. | ||||||||||
| Author: | Foote, Kevin M|Blades, Kevin|Cronin, Anna|Fillery, Shaun|Guichard, Sylvie S|Hassall, Lorraine|Hickson, Ian|Jacq, Xavier|Jewsbury, Philip J|McGuire, Thomas M|Nissink, J Willem M|Odedra, Rajesh|Page, Ken|Perkins, Paula|Suleman, Abid|Tam, Kin|Thommes, Pia|Br | ||||||||||
| PMID: | 23394205 | ||||||||||
| 27. | |||||||||||
| Journal: | Cancer Sci. 2013 Aug;104(8):1062-6. | ||||||||||
| Title: | HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways. | ||||||||||
| Author: | Zhao, Yu|Wu, Zhonghua|Zhang, Yuting|Zhu, Li | ||||||||||
| PMID: | 23600770 | ||||||||||
| 28. | |||||||||||
| Journal: | Epigenetics. 2013 Jun;8(6):612-23. | ||||||||||
| Title: | HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. | ||||||||||
| Author: | Rajendran, Praveen|Kidane, Ariam I|Yu, Tian-Wei|Dashwood, Wan-Mohaiza|Bisson, William H|Lohr, Christiane V|Ho, Emily|Williams, David E|Dashwood, Roderick H | ||||||||||
| PMID: | 23770684 | ||||||||||
| 29. | |||||||||||
| Journal: | PLoS One. 2013 Jun 11;8(6):e65745. | ||||||||||
| Title: | 2-deprenyl-rheediaxanthone B isolated from Metaxya rostrata induces active cell death in colorectal tumor cells. | ||||||||||
| Author: | Kainz, Kerstin P|Krenn, Liselotte|Erdem, Zeynep|Kaehlig, Hanspeter|Zehl, Martin|Bursch, Wilfried|Berger, Walter|Marian, Brigitte | ||||||||||
| PMID: | 23776538 | ||||||||||
| 30. | |||||||||||
| Journal: | Carcinogenesis. 2015 Oct;36(10):1235-44. | ||||||||||
| Title: | DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. | ||||||||||
| Author: | Fahrer, Jorg|Frisch, Janina|Nagel, Georg|Kraus, Alexander|Dorsam, Bastian|Thomas, Adam D|Reissig, Sonja|Waisman, Ari|Kaina, Bernd | ||||||||||
| PMID: | 26243310 | ||||||||||
| 31. | |||||||||||
| Journal: | Front Pharmacol. 2015 Jul 22;6:147. | ||||||||||
| Title: | Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan. | ||||||||||
| Author: | Abu-Sanad, Atlal|Wang, Yunzhe|Hasheminasab, Fatemeh|Panasci, Justin|Noe, Alycia|Rosca, Lorena|Davidson, David|Amrein, Lilian|Sharif-Askari, Bahram|Aloyz, Raquel|Panasci, Lawrence | ||||||||||
| PMID: | 26257651 | ||||||||||
| 32. | |||||||||||
| Journal: | Nucleic Acids Res. 2016 May 5;44(8):3695-712. | ||||||||||
| Title: | The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. | ||||||||||
| Author: | Zhang, Xin|Trepanier, Veronique|Beaujois, Remy|Viranaicken, Wildriss|Drobetsky, Elliot|DesGroseillers, Luc | ||||||||||
| PMID: | 26843428 | ||||||||||
| 33. | |||||||||||
| Journal: | J Extracell Vesicles. 2016 Apr 15;5:25355. | ||||||||||
| Title: | Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples. | ||||||||||
| Author: | Belov, Larissa|Matic, Kieran J|Hallal, Susannah|Best, O Giles|Mulligan, Stephen P|Christopherson, Richard I | ||||||||||
| PMID: | 27086589 | ||||||||||
| 34. | |||||||||||
| Journal: | Oncotarget. 2016 Mar 1;7(9):10578-93. | ||||||||||
| Title: | Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells. | ||||||||||
| Author: | Chang, Elizabeth T|Parekh, Palak R|Yang, Qingyuan|Nguyen, Duc M|Carrier, France | ||||||||||
| PMID: | 26824423 | ||||||||||
| 35. | |||||||||||
| Journal: | Oncotarget. 2016 Feb 9;7(6):7080-95. | ||||||||||
| Title: | A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers. | ||||||||||
| Author: | Hocke, Sandra|Guo, Yang|Job, Albert|Orth, Michael|Ziesch, Andreas|Lauber, Kirsten|De Toni, Enrico N|Gress, Thomas M|Herbst, Andreas|Goke, Burkhard|Gallmeier, Eike | ||||||||||
| PMID: | 26755646 | ||||||||||
| 36. | |||||||||||
| Journal: | Oncotarget. 2017 Dec 6;8(70):115041-115053. | ||||||||||
| Title: | INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis. | ||||||||||
| Author: | Lee, Shin-Ai|Lee, Han-Sae|Hur, Shin-Kyoung|Kang, Sang Won|Oh, Goo Taeg|Lee, Daekee|Kwon, Jongbum | ||||||||||
| PMID: | 29383140 | ||||||||||
| 37. | |||||||||||
| Journal: | Cancer. 2018 Mar 1;124(5):1070-1082. | ||||||||||
| Title: | A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. | ||||||||||
| Author: | Tricoli, James V|Boardman, Lisa A|Patidar, Rajesh|Sindiri, Sivasish|Jang, Jin S|Walsh, William D|McGregor, Paul M 3rd|Camalier, Corinne E|Mehaffey, Michele G|Furman, Wayne L|Bahrami, Armita|Williams, P Mickey|Lih, Chih-Jian|Conley, Barbara A|Khan, Javed | ||||||||||
| PMID: | 29194591 | ||||||||||
| 38. | |||||||||||
| Journal: | PLoS One. 2018 Jun 5;13(6):e0197154. | ||||||||||
| Title: | The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. | ||||||||||
| Author: | Aljarbou, Ftoon|Almousa, Nourah|Bazzi, Mohammad|Aldaihan, Sooad|Alanazi, Mohammed|Alharbi, Othman|Almadi, Majid|Aljebreen, Abdulrahman M|Azzam, Nahla Ali|Arafa, Maha|Aldbass, Abeer|Shaik, Jilani|Alasirri, Shaheerah|Warsy, Arjumand|Alamri, Abdullah|Parine, | ||||||||||
| PMID: | 29870526 | ||||||||||
| 39. | |||||||||||
| Journal: | Oncotarget. 2018 Jan 23;9(42):26616-26624. | ||||||||||
| Title: | Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population. | ||||||||||
| Author: | Wang, Shijia|Zhang, Yue|Chen, Min|Wang, Yong|Feng, Yifei|Xu, Ziwei|Zhang, Dongsheng|Sun, Yueming|Fu, Zan | ||||||||||
| PMID: | 29928473 | ||||||||||
| 40. | |||||||||||
| Journal: | J Pathol. 2018 Oct;246(2):134-140. | ||||||||||
| Title: | Geminin ablation in vivo enhances tumorigenesis through increased genomic instability. | ||||||||||
| Author: | Champeris Tsaniras, Spyridon|Villiou, Maria|Giannou, Anastassios D|Nikou, Sofia|Petropoulos, Michalis|Pateras, Ioannis S|Tserou, Paraskevi|Karousi, Foteini|Lalioti, Maria-Eleni|Gorgoulis, Vassilis G|Patmanidi, Alexandra L|Stathopoulos, Georgios T|Bravou, | ||||||||||
| PMID: | 29952003 | ||||||||||
| 41. | |||||||||||
| Journal: | Oncotarget. 2018 Jun 12;9(45):27835-27850. | ||||||||||
| Title: | Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. | ||||||||||
| Author: | Rauch, Anke|Carlstedt, Annemarie|Emmerich, Claudia|Mustafa, Al-Hassan M|Goder, Anja|Knauer, Shirley K|Linnebacher, Michael|Heinzel, Thorsten|Kramer, Oliver H | ||||||||||
| PMID: | 29963241 | ||||||||||
| 42. | |||||||||||
| Journal: | Oncol Lett. 2018 Oct;16(4):4671-4678. | ||||||||||
| Title: | Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. | ||||||||||
| Author: | Yao, Jingyun|Xiao, Jianbo|Wei, Xing|Lu, Yanhua | ||||||||||
| PMID: | 30214601 | ||||||||||
| 43. | |||||||||||
| Journal: | Cell Rep. 2018 Oct 9;25(2):398-412.e6. | ||||||||||
| Title: | Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. | ||||||||||
| Author: | Wang, Dan|Zhao, Rui|Qu, Yuan-Yuan|Mei, Xin-Yu|Zhang, Xuan|Zhou, Qian|Li, Yang|Yang, Shao-Bo|Zuo, Zhi-Gui|Chen, Yi-Ming|Lin, Yan|Xu, Wei|Chen, Chao|Zhao, Shi-Min|Zhao, Jian-Yuan | ||||||||||
| PMID: | 30304680 | ||||||||||
| 44. | |||||||||||
| Journal: | Br J Cancer. 2018 Nov 2. pii: 10.1038/s41416-018-0286-4. | ||||||||||
| Title: | pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. | ||||||||||
| Author: | Jones, Gemma N|Rooney, Claire|Griffin, Nicola|Roudier, Martine|Young, Lucy A|Garcia-Trinidad, Antonio|Hughes, Gareth D|Whiteaker, Jeffrey R|Wilson, Zena|Odedra, Rajesh|Zhao, Lei|Ivey, Richard G|Howat, William J|Harrington, Elizabeth A|Barrett, J Carl|Ramo | ||||||||||
| PMID: | 30385821 | ||||||||||