Primary Site >> Colorectal Cancer
Gene >> ATR
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Ref: A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes. PMID: 10545425 |
Ref: ATM-dependent CHK2 activation induced by anticancer agent, irofulven. PMID: 15269203 Ref: ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. PMID: 15282542 Ref: CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. PMID: 15367709 |
Ref: Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. PMID: 17043640 Ref: 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. PMID: 17241873 Ref: The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses. PMID: 17986860 |
Ref: Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells. PMID: 18024214 Ref: Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. PMID: 18347191 Ref: AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. PMID: 18413665 Ref: Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. PMID: 18480061 Ref: Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. PMID: 18804090 |
Ref: Ascochlorin activates p53 in a manner distinct from DNA damaging agents. PMID: 19253369 Ref: Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression. PMID: 19364474 Ref: Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. PMID: 19570909 |
Ref: Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. PMID: 20514442 |
Ref: ATR mediates cisplatin resistance in a p53 genotype-specific manner. PMID: 21258400 Ref: Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction. PMID: 21308861 Ref: Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. PMID: 21664290 Ref: Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PMID: 22194930 Ref: Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. PMID: 22977515 |
Ref: Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines. PMID: 21830942 Ref: The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. PMID: 21964066 Ref: Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. PMID: 22552540 Ref: Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells. PMID: 23123449 |
Ref: Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-y l}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. PMID: 23394205 Ref: HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways. PMID: 23600770 Ref: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. PMID: 23770684 Ref: 2-deprenyl-rheediaxanthone B isolated from Metaxya rostrata induces active cell death in colorectal tumor cells. PMID: 23776538 |
Ref: DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. PMID: 26243310 Ref: Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan. PMID: 26257651 |
Ref: A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers. PMID: 26755646 Ref: Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells. PMID: 26824423 Ref: The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. PMID: 26843428 Ref: Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples. PMID: 27086589 |
Ref: INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis. PMID: 29383140 |
Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PMID: 29870526 Ref: Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population. PMID: 29928473 Ref: Geminin ablation in vivo enhances tumorigenesis through increased genomic instability. PMID: 29952003 Ref: Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. PMID: 29963241 Ref: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. PMID: 30214601 Ref: Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. PMID: 30304680 Ref: pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. PMID: 30385821 |