Primary Site >> Colorectal Cancer

Gene >> ATOH1

Journal: Cancer Res. 2004 Sep 1;64(17):6050-7.
Title: Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells.
Author: Leow, Ching Ching|Romero, Maria S|Ross, Sarajane|Polakis, Paul|Gao, Wei-Qiang
PMID: 15342386
Journal: Ann N Y Acad Sci. 2005 Nov;1059:174-83.
Title: A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma.
Author: Leow, Ching Ching|Polakis, Paul|Gao, Wei-Qiang
PMID: 16382053
Journal: Clin Cancer Res. 2006 Sep 15;12(18):5403-10.
Title: HATH1 expression in mucinous cancers of the colorectum and related lesions.
Author: Park, Eun Taek|Oh, Hee Kyung|Gum, James R Jr|Crawley, Suzanne C|Kakar, Sanjay|Engel, Juan|Leow, Ching Ching|Gao, Wei-Qiang|Kim, Young S
PMID: 17000673
Journal: Gastroenterology. 2007 Jan;132(1):208-20.
Title: Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.
Author: Tsuchiya, Kiichiro|Nakamura, Tetsuya|Okamoto, Ryuichi|Kanai, Takanori|Watanabe, Mamoru
PMID: 17241872
Journal: Biochem Biophys Res Commun. 2008 Apr 18;368(4):923-9.
Title: Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.
Author: Aragaki, Mikayo|Tsuchiya, Kiichiro|Okamoto, Ryuichi|Yoshioka, Sanae|Nakamura, Tetsuya|Sakamoto, Naoya|Kanai, Takanori|Watanabe, Mamoru
PMID: 18275842
Journal: PLoS Biol. 2009 Feb 24;7(2):e39.
Title: Atonal homolog 1 is a tumor suppressor gene.
Author: Bossuyt, Wouter|Kazanjian, Avedis|De Geest, Natalie|Van Kelst, Sofie|De Hertogh, Gert|Geboes, Karel|Boivin, Greg P|Luciani, Judith|Fuks, Francois|Chuah, Marinee|VandenDriessche, Thierry|Marynen, Peter|Cools, Jan|Shroyer, Noah F|Hassan, Bassem A
PMID: 19243219
Journal: Cancer Res. 2009 Aug 1;69(15):6065-73.
Title: The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells.
Author: Pannequin, Julie|Bonnans, Caroline|Delaunay, Nathalie|Ryan, Joanne|Bourgaux, Jean-Francois|Joubert, Dominique|Hollande, Frederic
PMID: 19622776
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2010 May;30(5):1005-8.
Title: [Hath1 gene transfer inhibits the proliferation of colonic cancer cells in vitro].
Author: Zhu, Dai-hua|Gong, Jian-ping|Ren, Ke|Sun, Jian-ming|Wei, Si-dong
PMID: 20501407
Journal: Gastroenterology. 2010 Sep;139(3):918-28, 928.e1-6.
Title: Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells.
Author: Kazanjian, Avedis|Noah, Taeko|Brown, Douglas|Burkart, Jarred|Shroyer, Noah F
PMID: 20621629
Journal: Cancer Res. 2010 Feb 15;70(4):1469-78.
Title: NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer.
Author: Sikandar, Shaheen S|Pate, Kira T|Anderson, Scott|Dizon, Diana|Edwards, Robert A|Waterman, Marian L|Lipkin, Steven M
PMID: 20145124
Journal: Gut. 2011 Feb;60(2):166-76.
Title: Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis.
Author: Peignon, Gregory|Durand, Aurelie|Cacheux, Wulfran|Ayrault, Olivier|Terris, Benoit|Laurent-Puig, Pierre|Shroyer, Noah F|Van Seuningen, Isabelle|Honjo, Tasuku|Perret, Christine|Romagnolo, Beatrice
PMID: 21205878
Journal: Neoplasma. 2011;58(4):343-7.
Title: Gamma-secretase inhibitor, a potential target therapy for MUC2-positive colorectal carcinoma.
Author: Bu, X|Li, N|Tian, X|Huang, P
PMID: 21520992
Journal: Curr Colorectal Cancer Rep. 2011 Jun;7(2):121-127.
Title: NOTCH Signaling and ATOH1 in Colorectal Cancers.
Author: Kazanjian, Avedis|Shroyer, Noah F
PMID: 21980310
Journal: Asian Pac J Cancer Prev. 2012;13(12):6349-55.
Title: Hath1 inhibits proliferation of colon cancer cells probably through up-regulating expression of Muc2 and p27 and down-regulating expression of cyclin D1.
Author: Zhu, Dai-Hua|Niu, Bai-Lin|Du, Hui-Min|Ren, Ke|Sun, Jian-Ming|Gong, Jian-Ping
PMID: 23464457
Journal: Annu Rev Physiol. 2013;75:263-88.
Title: Notch in the intestine: regulation of homeostasis and pathogenesis.
Author: Noah, Taeko K|Shroyer, Noah F
PMID: 23190077
Journal: PLoS One. 2013;8(2):e55620.
Title: Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo.
Author: Becker, Svetlana|Oelschlaeger, Tobias A|Wullaert, Andy|Vlantis, Katerina|Pasparakis, Manolis|Wehkamp, Jan|Stange, Eduard F|Gersemann, Michael
PMID: 23418447
Journal: PLoS One. 2013;8(2):e55904.
Title: Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study.
Author: Souaze, Frederique|Bou-Hanna, Chantal|Kandel, Christine|Leclair, Francois|Devalliere, Julie|Charreau, Beatrice|Bezieau, Stephane|Mosnier, Jean-Francois|Laboisse, Christian L
PMID: 23409082
Journal: Gastroenterology. 2013 May;144(5):1012-1023.e6.
Title: SPDEF functions as a colorectal tumor suppressor by inhibiting beta-catenin activity.
Author: Noah, Taeko K|Lo, Yuan-Hung|Price, Allison|Chen, Gang|King, Eileen|Washington, Mary-Kay|Aronow, Bruce J|Shroyer, Noah F
PMID: 23376423
Journal: Biochem Biophys Res Commun. 2013 Mar 1;432(1):175-81.
Title: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.
Author: Kano, Yoshihito|Tsuchiya, Kiichiro|Zheng, Xiu|Horita, Nobukatsu|Fukushima, Keita|Hibiya, Shuji|Yamauchi, Yuhki|Nishimura, Tatsunori|Hinohara, Kunihiko|Gotoh, Noriko|Suzuki, Shinji|Okamoto, Ryuichi|Nakamura, Tetsuya|Watanabe, Mamoru
PMID: 23333391
Journal: Oncogene. 2015 Jul 23;34(30):3935-3945.
Title: Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling.
Author: Mo, Pingli|Zhou, Qiling|Guan, Lei|Wang, Yi|Wang, Wei|Miao, Mengmeng|Tong, Zhangwei|Li, Ming|Majaz, Sidra|Liu, Yonghong|Su, Guoqiang|Xu, Jianming|Yu, Chundong
PMID: 25263446
Journal: Cancer Sci. 2015 Aug;106(8):1000-7.
Title: Atonal homolog 1 protein stabilized by tumor necrosis factor alpha induces high malignant potential in colon cancer cell line.
Author: Fukushima, Keita|Tsuchiya, Kiichiro|Kano, Yoshihito|Horita, Nobukatsu|Hibiya, Shuji|Hayashi, Ryohei|Kitagaki, Keisuke|Negi, Mariko|Itoh, Eisaku|Akashi, Takumi|Eishi, Yoshinobu|Oshima, Shigeru|Nagaishi, Takashi|Okamoto, Ryuichi|Nakamura, Tetsuya|Watanabe,
PMID: 26017781
Journal: Genes Cancer. 2016 May;7(5-6):154-168.
Title: MUC4 is negatively regulated through the Wnt/beta-catenin pathway via the Notch effector Hath1 in colorectal cancer.
Author: Pai, Priya|Rachagani, Satyanarayana|Dhawan, Punita|Sheinin, Yuri M|Macha, Muzafar A|Qazi, Asif Khurshid|Chugh, Seema|Ponnusamy, Moorthy P|Mallya, Kavita|Pothuraju, Ramesh|Batra, Surinder K
PMID: 27551331
Journal: Cell Rep. 2016 Sep 20;16(12):3297-3310.
Title: Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKClambda/iota.
Author: Nakanishi, Yuki|Reina-Campos, Miguel|Nakanishi, Naoko|Llado, Victoria|Elmen, Lisa|Peterson, Scott|Campos, Alex|De, Surya K|Leitges, Michael|Ikeuchi, Hiroki|Pellecchia, Maurizio|Blumberg, Richard S|Diaz-Meco, Maria T|Moscat, Jorge
PMID: 27653691
Journal: Cancer Biol Ther. 2017 Apr 3;18(4):257-267.
Title: Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer.
Author: Saxena, Arpit|Fayad, Raja|Kaur, Kamaljeet|Truman, Samantha|Greer, Julian|Carson, James A|Chanda, Anindya
PMID: 28045589
Journal: BMC Cancer. 2017 Jan 13;17(1):50.
Title: Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms.
Author: Badenes, Marina|Trindade, Alexandre|Pissarra, Hugo|Lopes-da-Costa, Luis|Duarte, Antonio
PMID: 28086833
Journal: Anticancer Drugs. 2017 Jun;28(5):531-539.
Title: Metformin depresses overactivated Notch1/Hes1 signaling in colorectal cancer patients with type 2 diabetes mellitus.
Author: Yang, Bin|Huang, Can-Ze|Yu, Tao|Zhou, Sheng-Ning|Liu, Qi|Liu, Gao-Jie|Chen, Shuang|Han, Fang-Hai
PMID: 28177944
Journal: Oncol Rep. 2018 Apr;39(4):1930-1938.
Title: Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Author: Park, Joo-Hung|Lee, Jeong-Min|Lee, Eun-Jin|Kim, Da-Jeong|Hwang, Won-Bhin
PMID: 29436668
Journal: Int J Mol Sci. 2018 May 22;19(5). pii: ijms19051541.
Title: SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma.
Author: Shen, Ping|Yang, Shu|Sun, Haimei|Li, Guilan|Wu, Bo|Ji, Fengqing|Sun, Tingyi|Zhou, Deshan
PMID: 29786668
Journal: Biochem Biophys Res Commun. 2018 Sep 12. pii: S0006-291X(18)31972-7.
Title: MicroRNA-613 promotes colon cancer cell proliferation, invasion and migration by targeting ATOH1.
Author: Yang, Xuanxuan|Zhang, Luo|Song, Xing|He, Wenting|Zhang, Dachuan|Lu, Qicheng|Wu, Jun|Wu, Changping|Jiang, Jingting
PMID: 30219232