Primary Site >> Colorectal Cancer

Gene >> ASCL2

Journal: Gut. 2010 Sep;59(9):1236-44.
Title: Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
Author: Stange, D E|Engel, F|Longerich, T|Koo, B K|Koch, M|Delhomme, N|Aigner, M|Toedt, G|Schirmacher, P|Lichter, P|Weitz, J|Radlwimmer, B
PMID: 20479215
Journal: Cancer Res. 2010 Jun 1;70(11):4644-54.
Title: Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.
Author: Dessein, Anne-Frederique|Stechly, Laurence|Jonckheere, Nicolas|Dumont, Patrick|Monte, Didier|Leteurtre, Emmanuelle|Truant, Stephanie|Pruvot, Francois-Rene|Figeac, Martin|Hebbar, Mohamed|Lecellier, Charles-Henri|Lesuffleur, Thecla|Dessein, Rodrigue|Grard,
PMID: 20460542
Journal: Gut. 2011 Nov;60(11):1606-7; author reply 1607.
Title: Ascl2 and 11p15.5 amplification in colorectal cancer.
Author: Jubb, Adrian M|Hoeflich, Klaus P|Haverty, Peter M|Wang, Jennifer|Koeppen, Hartmut
PMID: 21106550
Journal: Br J Cancer. 2011 Aug 9;105(4):552-61.
Title: Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.
Author: Birkenkamp-Demtroder, K|Maghnouj, A|Mansilla, F|Thorsen, K|Andersen, C L|Oster, B|Hahn, S|Orntoft, T F
PMID: 21772334
Journal: Cell Stem Cell. 2011 Nov 4;9(5):476-85.
Title: Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
Author: de Sousa E Melo, Felipe|Colak, Selcuk|Buikhuisen, Joyce|Koster, Jan|Cameron, Kate|de Jong, Joan H|Tuynman, Jurriaan B|Prasetyanti, Pramudita R|Fessler, Evelyn|van den Bergh, Saskia P|Rodermond, Hans|Dekker, Evelien|van der Loos, Chris M|Pals, Steven T|van
PMID: 22056143
Journal: Br J Cancer. 2011 Aug 9;105(4):552-61.
Title: Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.
Author: Birkenkamp-Demtroder, K|Maghnouj, A|Mansilla, F|Thorsen, K|Andersen, C L|Oster, B|Hahn, S|Orntoft, T F
PMID: 23085750
Journal: Gut. 2012 Oct;61(10):1435-8.
Title: Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.
Author: Reed, Karen R|Tunster, Simon J|Young, Madeleine|Carrico, Adam|John, Rosalind M|Clarke, Alan R
PMID: 22138533
Journal: PLoS One. 2012;7(2):e32170.
Title: Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
Author: Zhu, Rong|Yang, Yongtao|Tian, Yin|Bai, Jianying|Zhang, Xin|Li, Xiaohuan|Peng, Zhihong|He, Yonghong|Chen, Lei|Pan, Qiong|Fang, Dianchun|Chen, Wensheng|Qian, Chen|Bian, Xiuwu|Wang, Rongquan
PMID: 22384170
Journal: Oncogene. 2013 Feb 14;32(7):883-93.
Title: In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-ODeltaN89beta-catenin system.
Author: Jarde, T|Evans, R J|McQuillan, K L|Parry, L|Feng, G J|Alvares, B|Clarke, A R|Dale, T C
PMID: 22469981
Journal: Gut. 2013 Jul;62(7):1012-23.
Title: In situ validation of an intestinal stem cell signature in colorectal cancer.
Author: Ziskin, Jennifer L|Dunlap, Debra|Yaylaoglu, Murat|Fodor, Imola K|Forrest, William F|Patel, Rajesh|Ge, Nianfeng|Hutchins, Gordon G|Pine, James K|Quirke, Philip|Koeppen, Hartmut|Jubb, Adrian M
PMID: 22637696
Journal: BMC Genomics. 2014 Jan 28;15:74.
Title: Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling.
Author: Herbst, Andreas|Jurinovic, Vindi|Krebs, Stefan|Thieme, Susanne E|Blum, Helmut|Goke, Burkhard|Kolligs, Frank T
PMID: 24467841
Journal: Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4886-91.
Title: Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer.
Author: Jagle, Sabine|Ronsch, Kerstin|Timme, Sylvia|Andrlova, Hana|Bertrand, Miriam|Jager, Marcel|Proske, Amelie|Schrempp, Monika|Yousaf, Afsheen|Michoel, Tom|Zeiser, Robert|Werner, Martin|Lassmann, Silke|Hecht, Andreas
PMID: 24707046
Journal: J Biol Chem. 2014 Dec 26;289(52):36101-15.
Title: MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells.
Author: Tian, Yin|Pan, Qiong|Shang, Yangyang|Zhu, Rong|Ye, Jun|Liu, Yun|Zhong, Xiaoli|Li, Shanshan|He, Yonghong|Chen, Lei|Zhao, Jingjing|Chen, Wensheng|Peng, Zhihong|Wang, Rongquan
PMID: 25371200
Journal: Mol Oncol. 2015 Feb;9(2):335-54.
Title: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.
Author: Ronsch, Kerstin|Jagle, Sabine|Rose, Katja|Seidl, Maximilian|Baumgartner, Francis|Freihen, Vivien|Yousaf, Afsheen|Metzger, Eric|Lassmann, Silke|Schule, Roland|Zeiser, Robert|Michoel, Tom|Hecht, Andreas
PMID: 25277775
Journal: Curr Pharmacol Rep. 2015 Aug 1;1(4):217-222.
Title: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.
Author: Sureban, Sripathi M|Qu, Dongfeng|Houchen, Courtney W
PMID: 26366338
Journal: Oncotarget. 2015 Oct 13;6(31):30993-1006.
Title: Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation.
Author: Shang, Yangyang|Pan, Qiong|Chen, Lei|Ye, Jun|Zhong, Xiaoli|Li, Xiaohuan|Meng, Linkuan|Guo, Jin|Tian, Yin|He, Yonghong|Chen, Wensheng|Peng, Zhihong|Wang, Rongquan
PMID: 26307678
Journal: J Pathol. 2015 Aug;236(4):467-78.
Title: SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
Author: Zhou, Zhi-hang|Rao, Jun|Yang, Jing|Wu, Feng|Tan, Juan|Xu, Sen-lin|Ding, Yanqing|Zhan, Na|Hu, Xu-gang|Cui, You-hong|Zhang, Xia|Dong, Weiguo|Liu, Xin-dong|Bian, Xiu-wu
PMID: 25866254
Journal: Histopathology. 2016 Mar;68(4):567-77.
Title: Distribution of intestinal stem cell markers in colorectal precancerous lesions.
Author: Jang, Bo Gun|Kim, Hye Sung|Kim, Kyung Ju|Rhee, Ye-Young|Kim, Woo Ho|Kang, Gyeong Hoon
PMID: 26212207
Journal: Cell Rep. 2016 Jun 21;15(12):2588-96.
Title: A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate.
Author: Giakountis, Antonis|Moulos, Panagiotis|Zarkou, Vasiliki|Oikonomou, Christina|Harokopos, Vaggelis|Hatzigeorgiou, Artemis G|Reczko, Martin|Hatzis, Pantelis
PMID: 27292638
Journal: Mol Oncol. 2016 Oct;10(8):1266-82.
Title: SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism.
Author: Christensen, Lise Lotte|True, Kirsten|Hamilton, Mark P|Nielsen, Morten M|Damas, Nkerorema D|Damgaard, Christian K|Ongen, Halit|Dermitzakis, Emmanouil|Bramsen, Jesper B|Pedersen, Jakob S|Lund, Anders H|Vang, Soren|Stribolt, Katrine|Madsen, Mogens R|Laurber
PMID: 27396952
Journal: Mol Clin Oncol. 2017 Jan;6(1):7-18.
Title: Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
Author: Wang, Chih-Yang|Shahi, Payam|Huang, John Ting Wei|Phan, Nam Nhut|Sun, Zhengda|Lin, Yen-Chang|Lai, Ming-Derg|Werb, Zena
PMID: 28123722
Journal: Oncogenesis. 2017 Apr 3;6(4):e308.
Title: Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer.
Author: Kandimalla, R|Linnekamp, J F|van Hooff, S|Castells, A|Llor, X|Andreu, M|Jover, R|Goel, A|Medema, J P
PMID: 28368388
Journal: Cell Rep. 2018 Feb 6;22(6):1600-1614.
Title: Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.
Author: Oost, Koen C|van Voorthuijsen, Lisa|Fumagalli, Arianna|Lindeboom, Rik G H|Sprangers, Joep|Omerzu, Manja|Rodriguez-Colman, Maria J|Heinz, Maria C|Verlaan-Klink, Ingrid|Maurice, Madelon M|Burgering, Boudewijn M T|van Rheenen, Jacco|Vermeulen, Michiel|Snippe
PMID: 29425513
Journal: Cancer Lett. 2018 Jun 28;424:9-18.
Title: The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
Author: Basu, Sayon|Gavert, Nancy|Brabletz, Thomas|Ben-Ze'ev, Avri
PMID: 29551399
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: Cell Cycle. 2018;17(8):1014-1025.
Title: R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells.
Author: Ye, Jun|Liu, Shanxi|Shang, Yangyang|Chen, Haoyuan|Wang, Rongquan
PMID: 29886802
Journal: Stem Cell Reports. 2018 Aug 14;11(2):410-424.
Title: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells.
Author: Strubberg, Ashlee M|Veronese Paniagua, Daniel A|Zhao, Tingting|Dublin, Leeran|Pritchard, Thomas|Bayguinov, Peter O|Fitzpatrick, James A J|Madison, Blair B
PMID: 30017821