Primary Site >> Colorectal Cancer
Gene >> ASCL2
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Ref: Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells. PMID: 20460542 Ref: Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. PMID: 20479215 |
Ref: Ascl2 and 11p15.5 amplification in colorectal cancer. PMID: 21106550 Ref: Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells. PMID: 21772334 Ref: Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. PMID: 22056143 Ref: Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells. PMID: 23085750 |
Ref: Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. PMID: 22138533 Ref: Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PMID: 22384170 |
Ref: In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-ODeltaN89beta-catenin system. PMID: 22469981 Ref: In situ validation of an intestinal stem cell signature in colorectal cancer. PMID: 22637696 |
Ref: Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling. PMID: 24467841 Ref: Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. PMID: 24707046 Ref: MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells. PMID: 25371200 |
Ref: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775 Ref: SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis. PMID: 25866254 Ref: Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation. PMID: 26307678 Ref: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. PMID: 26366338 |
Ref: Distribution of intestinal stem cell markers in colorectal precancerous lesions. PMID: 26212207 Ref: A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate. PMID: 27292638 Ref: SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism. PMID: 27396952 |
Ref: Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients. PMID: 28123722 Ref: Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. PMID: 28368388 |
Ref: Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene. PMID: 29425513 Ref: The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression. PMID: 29551399 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells. PMID: 29886802 Ref: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. PMID: 30017821 |