Literatures

Primary Site >> Colorectal Cancer

Gene >> AREG

1.
Journal:	Int J Cancer. 1988 Dec 15;42(6):895-901.
Title:	Autocrine secretion of a colorectum-derived growth factor by HT-29 human colon carcinoma cell line.
Author:	Culouscou, J M\|Garrouste, F\|Remacle-Bonnet, M\|Bettetini, D\|Marvaldi, J\|Pommier, G
PMID:	3263953

2.
Journal:	Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7792-6.
Title:	Differential expression of epidermal growth factor-related proteins in human colorectal tumors.
Author:	Ciardiello, F\|Kim, N\|Saeki, T\|Dono, R\|Persico, M G\|Plowman, G D\|Garrigues, J\|Radke, S\|Todaro, G J\|Salomon, D S
PMID:	1715580

3.
Journal:	Cancer Res. 1992 Jun 1;52(11):3224-7.
Title:	Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas.
Author:	Cook, P W\|Pittelkow, M R\|Keeble, W W\|Graves-Deal, R\|Coffey, R J Jr\|Shipley, G D
PMID:	1591731

4.
Journal:	Cancer Res. 1992 Jun 15;52(12):3467-73.
Title:	Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors.
Author:	Saeki, T\|Stromberg, K\|Qi, C F\|Gullick, W J\|Tahara, E\|Normanno, N\|Ciardiello, F\|Kenney, N\|Johnson, G R\|Salomon, D S
PMID:	1596904

5.
Journal:	J Cell Biol. 1992 Aug;118(3):741-51.
Title:	Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon.
Author:	Johnson, G R\|Saeki, T\|Gordon, A W\|Shoyab, M\|Salomon, D S\|Stromberg, K
PMID:	1639855

6.
Journal:	Growth Factors. 1992;7(3):195-205.
Title:	Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family.
Author:	Culouscou, J M\|Remacle-Bonnet, M\|Carlton, G W\|Plowman, G D\|Shoyab, M
PMID:	1333777

7.
Journal:	Int J Oncol. 1994 Apr;4(4):865-71.
Title:	Immunolocalization of criptoregulin and amphiregulin in rectal-cancer - correlation with prognosis.
Author:	Gagliardi, G\|Talbot, I\|Northover, J\|Warren, A\|Stamp, G\|Lalani, E\|Gullick, W\|Pignatelli, M
PMID:	21566994

8.
Journal:	Int J Cancer. 1995 Sep 15;62(6):762-6.
Title:	Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line.
Author:	Normanno, N\|Selvam, M P\|Bianco, C\|Damiano, V\|de Angelis, E\|Grassi, M\|Magliulo, G\|Tortora, G\|Salomon, D S\|Ciardiello, F
PMID:	7558427

9.
Journal:	Int J Cancer. 1995 Jul 4;62(1):48-57.
Title:	Two newly established cell lines derived from the same colonic adenocarcinoma exhibit differences in EGF-receptor ligand and adhesion molecule expression.
Author:	Solic, N\|Collins, J E\|Richter, A\|Holt, S J\|Campbell, I\|Alexander, P\|Davies, D E
PMID:	7601566

10.
Journal:	Exp Cell Res. 1995 Jul;219(1):8-14.
Title:	Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate.
Author:	Huang, F\|Sauma, S\|Yan, Z\|Friedman, E
PMID:	7628553

11.
Journal:	Int J Cancer. 1995 Jun 9;61(6):848-53.
Title:	Colon goblet cells lose proliferative response to TGF alpha as they differentiate.
Author:	Sauma, S\|Huang, F\|Winawer, S\|Friedman, E
PMID:	7790121

12.
Journal:	Dig Dis Sci. 1995 Mar;40(3):485-94.
Title:	Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease.
Author:	Alexander, R J\|Panja, A\|Kaplan-Liss, E\|Mayer, L\|Raicht, R F
PMID:	7895532

13.
Journal:	Clin Cancer Res. 1996 Mar;2(3):601-9.
Title:	Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides.
Author:	Normanno, N\|Bianco, C\|Damiano, V\|de Angelis, E\|Selvam, M P\|Grassi, M\|Magliulo, G\|Tortora, G\|Bianco, A R\|Mendelsohn, J\|Salomon, D S\|Ciardiello, F
PMID:	9816209

14.
Journal:	J Natl Cancer Inst. 1996 Dec 4;88(23):1770-6.
Title:	Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A.
Author:	Ciardiello, F\|Damiano, V\|Bianco, R\|Bianco, C\|Fontanini, G\|De Laurentiis, M\|De Placido, S\|Mendelsohn, J\|Bianco, A R\|Tortora, G
PMID:	8944008

15.
Journal:	Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):657-62.
Title:	Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.
Author:	Coffey, R J\|Hawkey, C J\|Damstrup, L\|Graves-Deal, R\|Daniel, V C\|Dempsey, P J\|Chinery, R\|Kirkland, S C\|DuBois, R N\|Jetton, T L\|Morrow, J D
PMID:	9012840

16.
Journal:	Clin Exp Metastasis. 1997 Mar;15(2):140-50.
Title:	Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis.
Author:	Singh, R K\|Tsan, R\|Radinsky, R
PMID:	9062390

17.
Journal:	Exp Cell Res. 1997 Aug 1;234(2):465-76.
Title:	Differential effects of EGF and amphiregulin on adhesion molecule expression and migration of colon carcinoma cells.
Author:	Solic, N\|Davies, D E
PMID:	9260917

18.
Journal:	Int J Cancer. 1997 Oct 9;73(2):277-82.
Title:	Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells.
Author:	De Luca, A\|Selvam, M P\|Sandomenico, C\|Pepe, S\|Bianco, A R\|Ciardiello, F\|Salomon, D S\|Normanno, N
PMID:	9335455

19.
Journal:	Clin Cancer Res. 1998 Apr;4(4):821-8.
Title:	Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.
Author:	Ciardiello, F\|Tortora, G
PMID:	9563874

20.
Journal:	Int J Cancer. 1998 Jul 17;77(2):295-301.
Title:	Extracellular matrix modulates expression of growth factors and growth-factor receptors in liver-colonizing colon-cancer cell lines.
Author:	Zvibel, I\|Halpern, Z\|Papa, M
PMID:	9650567

21.
Journal:	Exp Cell Res. 1998 Nov 25;245(1):123-31.
Title:	Hepatocyte extracellular matrix modulates expression of growth factors and growth factor receptors in human colon cancer cells.
Author:	Zvibel, I\|Brill, S\|Halpern, Z\|Papa, M
PMID:	9828107

22.
Journal:	Int J Oncol. 1999 Mar;14(3):437-40.
Title:	Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.
Author:	De Angelis, E\|Grassi, M\|Gullick, W J\|Johnson, G R\|Rossi, G B\|Tempesta, A\|De Angelis, F\|De Luca, A\|Salomon, D S\|Normanno, N
PMID:	10024674

23.
Journal:	Br J Cancer. 1999 Jun;80(7):1012-9.
Title:	Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis.
Author:	Damstrup, L\|Kuwada, S K\|Dempsey, P J\|Brown, C L\|Hawkey, C J\|Poulsen, H S\|Wiley, H S\|Coffey, R J Jr
PMID:	10362109

24.
Journal:	J Cell Biochem. 1999 Dec;76(2):332-40.
Title:	Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability.
Author:	Zvibel, I\|Brill, S\|Halpern, Z\|Papa, M
PMID:	10618649

25.
Journal:	Tumour Biol. 2000 Jul-Aug;21(4):187-96.
Title:	Hepatocyte-derived soluble factors regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability.
Author:	Zvibel, I\|Brill, S\|Papa, M\|Halpern, Z
PMID:	10867612

26.
Journal:	Oncogene. 2000 Nov 30;19(51):5863-71.
Title:	Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts.
Author:	De Luca, A\|Arra, C\|D'Antonio, A\|Casamassimi, A\|Losito, S\|Ferraro, P\|Ciardiello, F\|Salomon, D S\|Normanno, N
PMID:	11127817

27.
Journal:	Recent Results Cancer Res. 2003;162:115-32.
Title:	Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options.
Author:	Kopp, Reinhard\|Rothbauer, Elisabeth\|Ruge, Maximilian\|Arnholdt, Hans\|Spranger, Joachim\|Muders, M\|Pfeiffer, Doris G\|Schildberg, Friedrich Wilhelm\|Pfeiffer, Andreas
PMID:	12790326

28.
Journal:	Cancer Res. 2003 Sep 1;63(17):5218-23.
Title:	Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin.
Author:	Shao, Jinyi\|Lee, Sean B\|Guo, Huiping\|Evers, B Mark\|Sheng, Hongmiao
PMID:	14500348

29.
Journal:	Dis Colon Rectum. 2003 Oct;46(10):1391-9.
Title:	Reduced survival of rectal cancer patients with increased tumor epidermal growth factor receptor levels.
Author:	Kopp, Reinhard\|Rothbauer, Elisabeth\|Mueller, Elisabeth\|Schildberg, Friedrich Wilhelm\|Jauch, Karl-Walter\|Pfeiffer, Andreas
PMID:	14530681

30.
Journal:	J Biol Chem. 2004 Apr 2;279(14):14287-93. Epub 2004 Jan 23.
Title:	Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells.
Author:	Shao, Jinyi\|Evers, B Mark\|Sheng, Hongmiao
PMID:	14742435

31.
Journal:	Physiol Genomics. 2004 Apr 13;17(2):122-9.
Title:	DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line.
Author:	Wood, Richard J\|Tchack, Laurie\|Angelo, Giana\|Pratt, Richard E\|Sonna, Larry A
PMID:	14996990

32.
Journal:	Int J Oncol. 2004 May;24(5):1279-88.
Title:	Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil.
Author:	de Angelis, Paula M\|Fjell, Bjorg\|Kravik, Katherine L\|Haug, Terje\|Tunheim, Siv H\|Reichelt, Wenche\|Beigi, Marzieh\|Clausen, Ole Petter\|Galteland, Eivind\|Stokke, Trond
PMID:	15067352

33.
Journal:	Surgery. 2005 Sep;138(3):415-21.
Title:	Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.
Author:	Merchant, Nipun B\|Rogers, Christopher M\|Trivedi, Bakula\|Morrow, Jason\|Coffey, Robert J
PMID:	16213893

34.
Journal:	J Clin Oncol. 2005 Dec 20;23(36):9265-74.
Title:	Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.
Author:	Rothenberg, Mace L\|LaFleur, Bonnie\|Levy, Donna E\|Washington, Mary Kay\|Morgan-Meadows, Sherry L\|Ramanathan, Ramesh K\|Berlin, Jordan D\|Benson, Al B 3rd\|Coffey, Robert J
PMID:	16361624

35.
Journal:	Am J Physiol Cell Physiol. 2006 Feb;290(2):C592-600. Epub 2005 Oct 5.
Title:	Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner.
Author:	O'Reilly, Susan M\|Leonard, Martin O\|Kieran, Niamh\|Comerford, Katrina M\|Cummins, Eoin\|Pouliot, Marc\|Lee, Sean B\|Taylor, Cormac T
PMID:	16207795

36.
Journal:	Int J Mol Med. 2006 Jun;17(6):1163-6.
Title:	Canonical WNT signaling pathway and human AREG.
Author:	Katoh, Yuriko\|Katoh, Masaru
PMID:	16685431

37.
Journal:	Gastroenterology. 2007 Dec;133(6):1869-81. Epub 2007 Sep 14.
Title:	Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.
Author:	Fukata, Masayuki\|Chen, Anli\|Vamadevan, Arunan S\|Cohen, Jason\|Breglio, Keith\|Krishnareddy, Suneeta\|Hsu, David\|Xu, Ruliang\|Harpaz, Noam\|Dannenberg, Andrew J\|Subbaramaiah, Kotha\|Cooper, Harry S\|Itzkowitz, Steven H\|Abreu, Maria T
PMID:	18054559

38.
Journal:	Oncol Rep. 2008 Jan;19(1):105-10.
Title:	Amphiregulin and epiregulin expression in neoplastic and inflammatory lesions in the colon.
Author:	Nishimura, Takashi\|Andoh, Akira\|Inatomi, Osamu\|Shioya, Makoto\|Yagi, Yuhki\|Tsujikawa, Tomoyuki\|Fujiyama, Yoshihide
PMID:	18097582

39.
Journal:	Bull Cancer. 2008 Jan;95(1):133-40.
Title:	[Predictive factors of response to anti-EGFR treatments in colorectal cancer].
Author:	Lievre, Astrid\|Laurent-Puig, Pierre
PMID:	18230579

40.
Journal:	Clin Cancer Res. 2008 Apr 15;14(8):2351-6.
Title:	Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer.
Author:	Yamada, Michiyo\|Ichikawa, Yasushi\|Yamagishi, Shigeru\|Momiyama, Nobuyoshi\|Ota, Mitsuyoshi\|Fujii, Syoichi\|Tanaka, Kuniya\|Togo, Shinji\|Ohki, Shigeo\|Shimada, Hiroshi
PMID:	18413824

41.
Journal:	Inflamm Bowel Dis. 2009 Jul;15(7):997-1006.
Title:	Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors.
Author:	Fukata, Masayuki\|Hernandez, Yasmin\|Conduah, Daisy\|Cohen, Jason\|Chen, Anli\|Breglio, Keith\|Goo, Tyralee\|Hsu, David\|Xu, Ruliang\|Abreu, Maria T
PMID:	19229991

42.
Journal:	Clin Cancer Res. 2009 Apr 1;15(7):2397-405.
Title:	Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent.
Author:	Mutsaers, Anthony J\|Francia, Giulio\|Man, Shan\|Lee, Christina R\|Ebos, John M L\|Wu, Yan\|Witte, Larry\|Berry, Scott\|Moore, Malcolm\|Kerbel, Robert S
PMID:	19276250

43.
Journal:	BMC Cancer. 2009 Jun 26;9:207.
Title:	Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer.
Author:	Doherty, Glen A\|Byrne, Sinead M\|Molloy, Eamonn S\|Malhotra, Vikrum\|Austin, Sandra C\|Kay, Elaine W\|Murray, Frank E\|Fitzgerald, Desmond J
PMID:	19558693

44.
Journal:	Curr Drug Targets. 2009 Oct;10(10):1033-40.
Title:	Anti-EGFR therapy in colorectal cancer: how to choose the right patient.
Author:	Meriggi, F\|Di Biasi, B\|Abeni, C\|Zaniboni, A
PMID:	19663767

45.
Journal:	J Clin Oncol. 2009 Oct 20;27(30):5068-74.
Title:	Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab.
Author:	Jacobs, Bart\|De Roock, Wendy\|Piessevaux, Hubert\|Van Oirbeek, Robin\|Biesmans, Bart\|De Schutter, Jef\|Fieuws, Steffen\|Vandesompele, Jo\|Peeters, Marc\|Van Laethem, Jean-Luc\|Humblet, Yves\|Penault-Llorca, Frederique\|De Hertogh, Gert\|Laurent-Puig, Pierre\|Van Cuts
PMID:	19738126

46.
Journal:	Clin Cancer Res. 2009 Nov 15;15(22):6780-9.
Title:	Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.
Author:	Dougherty, Urszula\|Cerasi, Dario\|Taylor, Ieva\|Kocherginsky, Masha\|Tekin, Ummuhan\|Badal, Shamiram\|Aluri, Lata\|Sehdev, Amikar\|Cerda, Sonia\|Mustafi, Reba\|Delgado, Jorge\|Joseph, Loren\|Zhu, Hongyan\|Hart, John\|Threadgill, David\|Fichera, Alessandro\|Bissonnette,
PMID:	19903783

47.
Journal:	Eur J Cancer. 2010 Jul;46(11):2119-26.
Title:	Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes.
Author:	Watanabe, Toshiaki\|Kobunai, Takashi\|Yamamoto, Yoko\|Kanazawa, Takamitsu\|Konishi, Tsuyoshi\|Tanaka, Toshiaki\|Matsuda, Keiji\|Ishihara, Soichiro\|Nozawa, Keijiro\|Eshima, Kiyoshi\|Muto, Tetsuichiro\|Nagawa, Hirokazu
PMID:	20570135

48.
Journal:	Mol Cancer. 2010 Oct 26;9:281.
Title:	IGFBP-rP1, a potential molecule associated with colon cancer differentiation.
Author:	Ruan, Wenjing\|Zhu, Shuzhen\|Wang, Haibing\|Xu, Fangying\|Deng, Hong\|Ma, Yu\|Lai, Maode
PMID:	20977730

49.
Journal:	Clin Cancer Res. 2010 Jul 1;16(13):3378-89.
Title:	Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer.
Author:	Kyula, Joan N\|Van Schaeybroeck, Sandra\|Doherty, Joanne\|Fenning, Catherine S\|Longley, Daniel B\|Johnston, Patrick G
PMID:	20570921

50.
Journal:	Onkologie. 2010;33(7):353-8.
Title:	Amphiregulin and epiregulin expression in colorectal carcinoma and the correlation with clinicopathological characteristics.
Author:	Li, Xiao-Dong\|Miao, Su-Yu\|Wang, Guo-Liang\|Yang, Li\|Shu, Yong-Qian\|Yin, Yong-Mei
PMID:	20631481

51.
Journal:	PLoS One. 2011 Jan 20;6(1):e15980.
Title:	Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in >/= 2 line cetuximab-based therapy of colorectal cancer patients.
Author:	Saridaki, Zacharenia\|Tzardi, Maria\|Papadaki, Chara\|Sfakianaki, Maria\|Pega, Fraga\|Kalikaki, Aristea\|Tsakalaki, Eleftheria\|Trypaki, Maria\|Messaritakis, Ippokratis\|Stathopoulos, Efstathios\|Mavroudis, Dimitris\|Georgoulias, Vassilis\|Souglakos, John
PMID:	21283802

52.
Journal:	Curr Biol. 2011 May 10;21(9):779-86.
Title:	Amphiregulin exosomes increase cancer cell invasion.
Author:	Higginbotham, James N\|Demory Beckler, Michelle\|Gephart, Jonathan D\|Franklin, Jeffrey L\|Bogatcheva, Galina\|Kremers, Gert-Jan\|Piston, David W\|Ayers, Gregory D\|McConnell, Russell E\|Tyska, Matthew J\|Coffey, Robert J
PMID:	21514161

53.
Journal:	Gut. 2012 Jul;61(7):1041-9.
Title:	Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon.
Author:	IJssennagger, Noortje\|Rijnierse, Anneke\|de Wit, Nicole\|Jonker-Termont, Denise\|Dekker, Jan\|Muller, Michael\|van der Meer, Roelof
PMID:	21948946

54.
Journal:	BMC Cancer. 2012 Mar 13;12:88.
Title:	Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases.
Author:	Kuramochi, Hidekazu\|Nakajima, Go\|Kaneko, Yuka\|Nakamura, Ayako\|Inoue, Yuji\|Yamamoto, Masakazu\|Hayashi, Kazuhiko
PMID:	22409860

55.
Journal:	Anticancer Res. 2012 Jun;32(6):2315-21.
Title:	Amphiregulin is a prognostic factor in colorectal cancer.
Author:	Ohchi, Takafumi\|Akagi, Yoshito\|Kinugasa, Tetsushi\|Kakuma, Tatsuyuki\|Kawahara, Akihiro\|Sasatomi, Teruo\|Gotanda, Yukito\|Yamaguchi, Keizo\|Tanaka, Natsuki\|Ishibashi, Yoshiaki\|Miyamoto, Shingo\|Kage, Masayoshi\|Shirouzu, Kazuo
PMID:	22641668

56.
Journal:	Carcinogenesis. 2012 Oct;33(10):1930-9.
Title:	Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.
Author:	Mustafi, Reba\|Dougherty, Urszula\|Shah, Hardik\|Dehghan, Hooman\|Gliksberg, Ariel\|Wu, Jiang\|Zhu, Hongyan\|Joseph, Loren\|Hart, John\|Dive, Caroline\|Fichera, Alessandro\|Threadgill, David\|Bissonnette, Marc
PMID:	22791816

57.
Journal:	PLoS One. 2012;7(12):e52711.
Title:	Regulation of amphiregulin gene expression by beta-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system.
Author:	Latasa, Maria U\|Salis, Fabiana\|Urtasun, Raquel\|Garcia-Irigoyen, Oihane\|Elizalde, Maria\|Uriarte, Iker\|Santamaria, Monica\|Feo, Francesco\|Pascale, Rosa M\|Prieto, Jesus\|Berasain, Carmen\|Avila, Matias A
PMID:	23285165

58.
Journal:	J Gastrointest Cancer. 2013 Jun;44(2):211-21.
Title:	Pro-neoplastic effects of amphiregulin in colorectal carcinogenesis.
Author:	Guzman, Michael J\|Shao, Jinyi\|Sheng, Hongmiao
PMID:	23263765

59.
Journal:	Cancer. 2013 Dec 1;119(23):4145-53.
Title:	Intermittent versus continuous erlotinib with concomitant modified "XELOX" (q3W) in first-line treatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha.
Author:	Ma, Brigette B Y\|Chan, Stephen L\|Ho, Wing M\|Lau, Wilson\|Mo, Frankie\|Hui, Edwin P\|Chan, Charles\|Poon, Annette\|Dattatray, Rasalkar D\|Wong, S C Cesar\|To, Ka F\|King, Ann D\|Ahuja, Anil\|Chan, Anthony T C
PMID:	24114668

60.
Journal:	Clin Colorectal Cancer. 2013 Dec;12(4):267-274.e2.
Title:	The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.
Author:	Strimpakos, Alexios\|Pentheroudakis, George\|Kotoula, Vassiliki\|De Roock, Wendy\|Kouvatseas, George\|Papakostas, Pavlos\|Makatsoris, Thomas\|Papamichael, Demetris\|Andreadou, Anna\|Sgouros, Joseph\|Zizi-Sermpetzoglou, Adamantia\|Kominea, Athina\|Televantou, Despina\|
PMID:	24050852

61.
Journal:	Harefuah. 2013 Jun;152(6):326-9, 369.
Title:	[Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue].
Author:	Levi, Yosef\|Barshack, Iris\|Avivi, Kamila\|Bar-ILan, Dalia\|Gutman, Mordechai\|Aderka, Dan\|Berger, Raanan\|Yacobi, Rinat
PMID:	23885463

62.
Journal:	PLoS One. 2013 Jun 21;8(6):e67819.
Title:	Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Author:	Xie, Yan\|Matsumoto, Hitoshi\|Nalbantoglu, Ilke\|Kerr, Thomas A\|Luo, Jianyang\|Rubin, Deborah C\|Kennedy, Susan\|Davidson, Nicholas O
PMID:	23805328

63.
Journal:	Biochim Biophys Acta. 2013 Nov;1834(11):2372-9.
Title:	Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma.
Author:	Bernhard, Oliver K\|Greening, David W\|Barnes, Thomas W\|Ji, Hong\|Simpson, Richard J
PMID:	23557862

64.
Journal:	BMC Cancer. 2013 Feb 2;13:49.
Title:	Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes.
Author:	Pentheroudakis, George\|Kotoula, Vassiliki\|De Roock, Wendy\|Kouvatseas, George\|Papakostas, Pavlos\|Makatsoris, Thomas\|Papamichael, Demetris\|Xanthakis, Ioannis\|Sgouros, Joseph\|Televantou, Despina\|Kafiri, Georgia\|Tsamandas, Athanassios C\|Razis, Evangelia\|Galan
PMID:	23374602

65.
Journal:	Cancer Lett. 2013 Jan 1;328(1):73-82.
Title:	Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR.
Author:	Benelli, Roberto\|Vene, Roberta\|Minghelli, Simona\|Carlone, Sebastiano\|Gatteschi, Beatrice\|Ferrari, Nicoletta
PMID:	23010081

66.
Journal:	Clin Cancer Res. 2014 Dec 15;20(24):6227-9.
Title:	Paracrine network: another step in the complexity of resistance to EGFR blockade?
Author:	Salazar, Ramon\|Capella, Gabriel\|Tabernero, Josep
PMID:	25139340

67.
Journal:	Genes Cancer. 2014 Mar;5(3-4):113-26.
Title:	Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition.
Author:	Edgar, Kyle A\|Crocker, Lisa\|Cheng, Eric\|Wagle, Marie-Claire\|Wongchenko, Matthew\|Yan, Yibing\|Wilson, Timothy R\|Dompe, Nicholas\|Neve, Richard M\|Belvin, Marcia\|Sampath, Deepak\|Friedman, Lori S\|Wallin, Jeffrey J
PMID:	25053989

68.
Journal:	Clin Cancer Res. 2014 Dec 15;20(24):6429-38.
Title:	TGFalpha and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells.
Author:	Hobor, Sebastijan\|Van Emburgh, Beth O\|Crowley, Emily\|Misale, Sandra\|Di Nicolantonio, Federica\|Bardelli, Alberto
PMID:	24916700

69.
Journal:	Cancer Res. 2014 Apr 1;74(7):2062-72.
Title:	Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids.
Author:	Nagathihalli, Nagaraj S\|Beesetty, Yugandhar\|Lee, Wooin\|Washington, M Kay\|Chen, Xi\|Lockhart, A Craig\|Merchant, Nipun B
PMID:	24520077

70.
Journal:	Pharmacogenomics J. 2014 Jun;14(3):256-62.
Title:	Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan.
Author:	Sebio, A\|Paez, D\|Salazar, J\|Berenguer-Llergo, A\|Pare-Brunet, L\|Lasa, A\|Del Rio, E\|Tobena, M\|Martin-Richard, M\|Baiget, M\|Barnadas, A
PMID:	23959273

71.
Journal:	J Cancer Res Clin Oncol. 2014 May;140(5):737-48.
Title:	EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab.
Author:	Razis, Evangelia\|Pentheroudakis, George\|Rigakos, George\|Bobos, Mattheos\|Kouvatseas, George\|Tzaida, Olympia\|Makatsoris, Thomas\|Papakostas, Pavlos\|Bai, Maria\|Goussia, Anna\|Samantas, Epaminontas\|Papamichael, Demetrios\|Romanidou, Ourania\|Efstratiou, Ioannis\|T
PMID:	24595598

72.
Journal:	Pharmacogenomics J. 2015 Feb;15(1):77-83.
Title:	EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer.
Author:	Sebio, A\|Salazar, J\|Paez, D\|Berenguer-Llergo, A\|Del Rio, E\|Tobena, M\|Martin-Richard, M\|Sullivan, I\|Targarona, E\|Balart, J\|Baiget, M\|Barnadas, A
PMID:	25026457

73.
Journal:	Cancer Med. 2015 Apr;4(4):575-87.
Title:	Warburg effect regulated by amphiregulin in the development of colorectal cancer.
Author:	Nam, Sung Ouk\|Yotsumoto, Fusanori\|Miyata, Kohei\|Fukagawa, Satoshi\|Yamada, Hiromi\|Kuroki, Masahide\|Miyamoto, Shingo
PMID:	25644309

74.
Journal:	Anticancer Res. 2015 Mar;35(3):1683-9.
Title:	Circulating hepatocyte growth factor is correlated with resistance to cetuximab in metastatic colorectal cancer.
Author:	Yonesaka, Kimio\|Satoh, Taroh\|Ueda, Shinya\|Yoshida, Takeshi\|Takeda, Masayuki\|Shimizu, Toshio\|Okamoto, Isamu\|Nishio, Kazuto\|Tamura, Takao\|Nakagawa, Kazuhiko
PMID:	25750328

75.
Journal:	Am Soc Clin Oncol Educ Book. 2015:e149-56.
Title:	Overcoming Resistance to Anti-EGFR Therapy in Colorectal Cancer.
Author:	Dienstmann, Rodrigo\|Salazar, Ramon\|Tabernero, Josep
PMID:	25993166

76.
Journal:	PLoS One. 2015 Aug 10;10(8):e0134948.
Title:	Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
Author:	Chung, Seyung\|Dwabe, Sami\|Elshimali, Yayha\|Sukhija, Hemlata\|Aroh, Clement\|Vadgama, Jaydutt V
PMID:	26258407

77.
Journal:	PLoS One. 2015 Nov 16;10(11):e0143132.
Title:	Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer.
Author:	Yonesaka, Kimio\|Takegawa, Naoki\|Satoh, Taroh\|Ueda, Hiroto\|Yoshida, Takeshi\|Takeda, Masayuki\|Shimizu, Toshio\|Chiba, Yasutaka\|Okamoto, Isamu\|Nishio, Kazuto\|Tamura, Takao\|Nakagawa, Kazuhiko
PMID:	26569500

78.
Journal:	Mol Med Rep. 2016 Apr;13(4):3514-20.
Title:	Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer.
Author:	Nagaoka, Tomoko\|Kitaura, Kazutaka\|Miyata, Yukinaga\|Kumagai, Kenichi\|Kaneda, Goro\|Kanazawa, Hideki\|Suzuki, Satsuki\|Hamada, Yoshiki\|Suzuki, Ryuji
PMID:	26935861

79.
Journal:	Br J Cancer. 2016 Nov 8;115(10):1215-1222.
Title:	Impact of tumour RAS/BRAF status in a first-line study of panitumumab + FOLFIRI in patients with metastatic colorectal cancer.
Author:	Karthaus, Meinolf\|Hofheinz, Ralf-Dieter\|Mineur, Laurent\|Letocha, Henry\|Greil, Richard\|Thaler, Josef\|Fernebro, Eva\|Oliner, Kelly S\|Boedigheimer, Michael\|Twomey, Brian\|Zhang, Ying\|Demonty, Gaston\|Kohne, Claus-Henning
PMID:	27764839

80.
Journal:	J Extracell Vesicles. 2016 Jun 24;5:29254.
Title:	Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting.
Author:	Higginbotham, James N\|Zhang, Qin\|Jeppesen, Dennis K\|Scott, Andrew M\|Manning, H Charles\|Ochieng, Josiah\|Franklin, Jeffrey L\|Coffey, Robert J
PMID:	27345057

81.
Journal:	Oncotarget. 2016 Aug 23;7(34):55890-55899.
Title:	Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients.
Author:	Jing, Chen\|Jin, Yang Han\|You, Zhai\|Qiong, Qian\|Jun, Zhou
PMID:	27344184

82.
Journal:	BMC Cancer. 2016 Jun 13;16:366.
Title:	PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study.
Author:	Kuramochi, Hidekazu\|Nakamura, Ayako\|Nakajima, Go\|Kaneko, Yuka\|Araida, Tatsuo\|Yamamoto, Masakazu\|Hayashi, Kazuhiko
PMID:	27296289

83.
Journal:	Br J Cancer. 2016 Jun 14;114(12):1352-61.
Title:	Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer.
Author:	Lee, Michael S\|McGuffey, Elizabeth J\|Morris, Jeffrey S\|Manyam, Ganiraju\|Baladandayuthapani, Veerabahdran\|Wei, Wei\|Morris, Van K\|Overman, Michael J\|Maru, Dipen M\|Jiang, Zhi-Qin\|Hamilton, Stanley R\|Kopetz, Scott
PMID:	27272216

84.
Journal:	JAMA Oncol. 2016 Feb 11. pii: 2490539.
Title:	AREG and EREG as Predictive Biomarkers for RAS Wild-Type Colorectal Cancer Treated With Panitumumab: A Fresh Approach to an Old Puzzle.
Author:	Smyth, Elizabeth C\|Khan, Khurum\|Cunningham, David
PMID:	26869404

85.
Journal:	JAMA Oncol. 2016 Feb 11. pii: 2490542.
Title:	Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer.
Author:	Seligmann, Jenny F\|Elliott, Faye\|Richman, Susan D\|Jacobs, Bart\|Hemmings, Gemma\|Brown, Sarah\|Barrett, Jennifer H\|Tejpar, Sabine\|Quirke, Philip\|Seymour, Matthew T
PMID:	26867820

86.
Journal:	Oncogene. 2016 May 19;35(20):2602-14.
Title:	Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
Author:	Schumacher, Y\|Aparicio, T\|Ourabah, S\|Baraille, F\|Martin, A\|Wind, P\|Dentin, R\|Postic, C\|Guilmeau, S
PMID:	26300003

87.
Journal:	Clin Epidemiol. 2017 Oct 31;9:517-526.
Title:	Development and validation of a panel of five proteins as blood biomarkers for early detection of colorectal cancer.
Author:	Chen, Hongda\|Qian, Jing\|Werner, Simone\|Cuk, Katarina\|Knebel, Phillip\|Brenner, Hermann
PMID:	29184444

88.
Journal:	Beijing Da Xue Xue Bao Yi Xue Ban. 2017 Dec 18;49(6):931-936.
Title:	[Mechanism of cross talk between tissue factor/active coagulation factor VII and epidermal growth factor receptor signalings in colon cancer cells in culture].
Author:	Chen, H K\|Dai, Y\|Wu, T\|Wang, X\|Wan, Y L\|Tang, J Q
PMID:	29263461

89.
Journal:	J Gastrointest Oncol. 2017 Dec;8(6):980-984.
Title:	The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer.
Author:	Chayangsu, Chawalit\|Khunsri, Siriporn\|Sriuranpong, Virote\|Tanasanvimon, Suebpong
PMID:	29299357

90.
Journal:	JAMA Oncol. 2018 Apr 1;4(4):564-568.
Title:	Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer.
Author:	Seligmann, Jenny F\|Hatch, Ace J\|Richman, Susan D\|Elliott, Faye\|Jacobs, Bart\|Brown, Sarah\|Hurwitz, Herbert\|Barrett, Jennifer H\|Quirke, Philip\|Nixon, Andrew B\|Seymour, Matthew T
PMID:	29075780

91.
Journal:	PeerJ. 2018 Mar 6;6:e4506.
Title:	Cellular prion protein and gamma-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch.
Author:	Ong, Sing-Hui\|Goh, Kai-Wey\|Chieng, Cornelius Kwang-Lee\|Say, Yee-How
PMID:	29527422

92.
Journal:	Oncotarget. 2018 Mar 30;9(24):17066-17077.
Title:	Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells.
Author:	Scheers, Nathalie M\|Pereira, Dora I A\|Faria, Nuno\|Powell, Jonathan J
PMID:	29682205

93.
Journal:	Int J Cancer. 2018 Sep 25.
Title:	Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer.
Author:	Bormann, Felix\|Stinzing, Sebastian\|Tierling, Sascha\|Morkel, Markus\|Rivera Markelova, Maria\|Walter, Jorn\|Weichert, Wilko\|Rossner, Florian\|Kuhn, Natalia\|Perner, Juliane\|Dietz, Johanna\|Ispasanie, Sylvia\|Dietel, Manfred\|Schafer, Reinhold\|Heinemann, Volker\|Ser
PMID:	30252132