Primary Site >> Colorectal Cancer
Gene >> AREG
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Ref: Autocrine secretion of a colorectum-derived growth factor by HT-29 human colon carcinoma cell line. PMID: 3263953 |
Ref: Differential expression of epidermal growth factor-related proteins in human colorectal tumors. PMID: 1715580 |
Ref: Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. PMID: 1333777 Ref: Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. PMID: 1591731 Ref: Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors. PMID: 1596904 Ref: Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon. PMID: 1639855 |
Ref: Immunolocalization of criptoregulin and amphiregulin in rectal-cancer - correlation with prognosis. PMID: 21566994 |
Ref: Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line. PMID: 7558427 Ref: Two newly established cell lines derived from the same colonic adenocarcinoma exhibit differences in EGF-receptor ligand and adhesion molecule expression. PMID: 7601566 Ref: Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate. PMID: 7628553 Ref: Colon goblet cells lose proliferative response to TGF alpha as they differentiate. PMID: 7790121 Ref: Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease. PMID: 7895532 |
Ref: Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. PMID: 8944008 Ref: Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. PMID: 9816209 |
Ref: Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. PMID: 9012840 Ref: Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis. PMID: 9062390 Ref: Differential effects of EGF and amphiregulin on adhesion molecule expression and migration of colon carcinoma cells. PMID: 9260917 Ref: Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells. PMID: 9335455 |
Ref: Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications. PMID: 9563874 Ref: Extracellular matrix modulates expression of growth factors and growth-factor receptors in liver-colonizing colon-cancer cell lines. PMID: 9650567 Ref: Hepatocyte extracellular matrix modulates expression of growth factors and growth factor receptors in human colon cancer cells. PMID: 9828107 |
Ref: Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families. PMID: 10024674 Ref: Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. PMID: 10362109 Ref: Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability. PMID: 10618649 |
Ref: Hepatocyte-derived soluble factors regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability. PMID: 10867612 Ref: Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts. PMID: 11127817 |
Ref: Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options. PMID: 12790326 Ref: Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. PMID: 14500348 Ref: Reduced survival of rectal cancer patients with increased tumor epidermal growth factor receptor levels. PMID: 14530681 |
Ref: Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. PMID: 14742435 Ref: DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. PMID: 14996990 Ref: Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. PMID: 15067352 |
Ref: Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. PMID: 16213893 Ref: Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. PMID: 16361624 |
Ref: Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner. PMID: 16207795 Ref: Canonical WNT signaling pathway and human AREG. PMID: 16685431 |
Ref: Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. PMID: 18054559 |
Ref: Amphiregulin and epiregulin expression in neoplastic and inflammatory lesions in the colon. PMID: 18097582 Ref: [Predictive factors of response to anti-EGFR treatments in colorectal cancer]. PMID: 18230579 Ref: Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. PMID: 18413824 |
Ref: Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. PMID: 19229991 Ref: Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent. PMID: 19276250 Ref: Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. PMID: 19558693 Ref: Anti-EGFR therapy in colorectal cancer: how to choose the right patient. PMID: 19663767 Ref: Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. PMID: 19738126 Ref: Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. PMID: 19903783 |
Ref: Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes. PMID: 20570135 Ref: Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer. PMID: 20570921 Ref: Amphiregulin and epiregulin expression in colorectal carcinoma and the correlation with clinicopathological characteristics. PMID: 20631481 Ref: IGFBP-rP1, a potential molecule associated with colon cancer differentiation. PMID: 20977730 |
Ref: Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in >/= 2 line cetuximab-based therapy of colorectal cancer patients. PMID: 21283802 Ref: Amphiregulin exosomes increase cancer cell invasion. PMID: 21514161 |
Ref: Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon. PMID: 21948946 Ref: Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. PMID: 22409860 Ref: Amphiregulin is a prognostic factor in colorectal cancer. PMID: 22641668 Ref: Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. PMID: 22791816 Ref: Regulation of amphiregulin gene expression by beta-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PMID: 23285165 |
Ref: Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. PMID: 23010081 Ref: Pro-neoplastic effects of amphiregulin in colorectal carcinogenesis. PMID: 23263765 Ref: Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. PMID: 23374602 Ref: Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma. PMID: 23557862 Ref: Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. PMID: 23805328 Ref: [Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue]. PMID: 23885463 Ref: The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab. PMID: 24050852 Ref: Intermittent versus continuous erlotinib with concomitant modified "XELOX" (q3W) in first-line treatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha. PMID: 24114668 |
Ref: Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan. PMID: 23959273 Ref: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids. PMID: 24520077 Ref: EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. PMID: 24595598 Ref: TGFalpha and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells. PMID: 24916700 Ref: Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition. PMID: 25053989 Ref: Paracrine network: another step in the complexity of resistance to EGFR blockade? PMID: 25139340 |
Ref: EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer. PMID: 25026457 Ref: Warburg effect regulated by amphiregulin in the development of colorectal cancer. PMID: 25644309 Ref: Circulating hepatocyte growth factor is correlated with resistance to cetuximab in metastatic colorectal cancer. PMID: 25750328 Ref: Overcoming Resistance to Anti-EGFR Therapy in Colorectal Cancer. PMID: 25993166 Ref: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PMID: 26258407 Ref: Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer. PMID: 26569500 |
Ref: Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth. PMID: 26300003 Ref: Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer. PMID: 26867820 Ref: AREG and EREG as Predictive Biomarkers for RAS Wild-Type Colorectal Cancer Treated With Panitumumab: A Fresh Approach to an Old Puzzle. PMID: 26869404 Ref: Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer. PMID: 26935861 Ref: Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer. PMID: 27272216 Ref: PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. PMID: 27296289 Ref: Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients. PMID: 27344184 Ref: Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting. PMID: 27345057 Ref: Impact of tumour RAS/BRAF status in a first-line study of panitumumab + FOLFIRI in patients with metastatic colorectal cancer. PMID: 27764839 |
Ref: Development and validation of a panel of five proteins as blood biomarkers for early detection of colorectal cancer. PMID: 29184444 Ref: [Mechanism of cross talk between tissue factor/active coagulation factor VII and epidermal growth factor receptor signalings in colon cancer cells in culture]. PMID: 29263461 Ref: The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer. PMID: 29299357 |
Ref: Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer. PMID: 29075780 Ref: Cellular prion protein and gamma-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch. PMID: 29527422 Ref: Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells. PMID: 29682205 Ref: Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer. PMID: 30252132 |