Primary Site >> Colorectal Cancer

Gene >> ALOX5

Journal: J Lab Clin Med. 1993 Nov;122(5):518-23.
Title: Altered eicosanoid levels in human colon cancer.
Author: Rigas, B|Goldman, I S|Levine, L
PMID: 8228569
Journal: Cancer Lett. 1997 Jun 24;116(2):213-23.
Title: Production of arachidonic acid metabolites by the colon adenocarcinoma cell line HT29 cl.19A and their effect on chloride secretion.
Author: Battu, S|Clement, G|Heyman, M|Wal, J M|Cook-Moreau, J|Desjeux, J F|Beneytout, J L
PMID: 9215866
Journal: Biochem Biophys Res Commun. 2000 Feb 24;268(3):778-83.
Title: Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation.
Author: Wachtershauser, A|Steinhilber, D|Loitsch, S M|Stein, J
PMID: 10679282
Journal: Arch Biochem Biophys. 2002 Feb 1;398(1):51-60.
Title: Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity.
Author: Kawajiri, Hiroo|Hsi, Linda C|Kamitani, Hideki|Ikawa, Hiroshi|Geller, Mark|Ward, Toni|Eling, Thomas E|Glasgow, Wayne C
PMID: 11811948
Journal: Carcinogenesis. 2002 Oct;23(10):1653-60.
Title: Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice.
Author: Kisley, Lori R|Barrett, Bradley S|Dwyer-Nield, Lori D|Bauer, Alison K|Thompson, David C|Malkinson, Alvin M
PMID: 12376474
Journal: Phytomedicine. 2002 Oct;9(7):654-8.
Title: Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophlebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro.
Author: Ingolfsdottir, K|Gudmundsdottir, G F|Ogmundsdottir, H M|Paulus, K|Haraldsdottir, S|Kristinsson, H|Bauer, R
PMID: 12487331
Journal: Gastroenterology. 2003 Jan;124(1):57-70.
Title: Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas.
Author: Ohd, John F|Nielsen, Christian Kamp|Campbell, Joan|Landberg, Goran|Lofberg, Helge|Sjolander, Anita
PMID: 12512030
Journal: J Pharmacol Exp Ther. 2004 Jan;308(1):66-72. Epub 2003 Oct 20.
Title: Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.
Author: Ye, Yi N|Liu, Edgar S L|Shin, Vivian Y|Wu, William K K|Luo, Jiing C|Cho, Chi H
PMID: 14569062
Journal: Carcinogenesis. 2004 Sep;25(9):1671-9.
Title: Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase.
Author: Hong, Jungil|Bose, Mousumi|Ju, Jihyeung|Ryu, Jae-Ha|Chen, Xiaoxin|Sang, Shengmin|Lee, Mao-Jung|Yang, Chung S
PMID: 15073046
Journal: J Pharmacol Exp Ther. 2004 Oct;311(1):123-30.
Title: The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Author: Ye, Yi N|Liu, Edgar S L|Shin, Vivian Y|Wu, William K K|Cho, Chi H
PMID: 15161935
Journal: Cancer Lett. 2004 Jul 8;210(1):41-6.
Title: Effect of LY293111 in combination with gemcitabine in colonic cancer.
Author: Hennig, Rene|Ding, Xian-Zhong|Tong, Wei-Gang|Witt, Richard C|Jovanovic, Borko D|Adrian, Thomas E
PMID: 15172119
Journal: Carcinogenesis. 2004 Dec;25(12):2467-72. Epub 2004 Aug 12.
Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Author: Goodman, Julie E|Bowman, Elise D|Chanock, Stephen J|Alberg, Anthony J|Harris, Curtis C
PMID: 15308583
Journal: Toxicology. 2004 Oct 15;203(1-3):179-88.
Title: Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking.
Author: Ye, Yi-Ni|Liu, Edgar Shiu-Lam|Shin, Vivian Yvonne|Wu, William Ka-Kei|Cho, Chi-Hin
PMID: 15363593
Journal: Eur J Pharmacol. 2005 Sep 5;519(1-2):52-7.
Title: A mechanistic study of colon cancer growth promoted by cigarette smoke extract.
Author: Ye, Yi N|Wu, William K K|Shin, Vivian Y|Cho, Chi H
PMID: 16125168
Journal: Cancer Res. 2005 Dec 15;65(24):11486-92.
Title: The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
Author: Shureiqi, Imad|Wu, Yuanqing|Chen, Dongning|Yang, Xiu L|Guan, Baoxiang|Morris, Jeffrey S|Yang, Peiying|Newman, Robert A|Broaddus, Russell|Hamilton, Stanley R|Lynch, Patrick|Levin, Bernard|Fischer, Susan M|Lippman, Scott M
PMID: 16357157
Journal: Biochim Biophys Acta. 2005 Oct 1;1736(3):244-50.
Title: Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein.
Author: Kim, Jung-Hyun|Hubbard, Neil E|Ziboh, Vincent|Erickson, Kent L
PMID: 16185917
Journal: Carcinogenesis. 2005 Apr;26(4):827-34. Epub 2005 Jan 6.
Title: Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.
Author: Ye, Y N|Wu, W K K|Shin, V Y|Bruce, I C|Wong, B C Y|Cho, C H
PMID: 15637091
Journal: Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):502-8.
Title: Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps.
Author: Poole, Elizabeth M|Bigler, Jeannette|Whitton, John|Sibert, Justin G|Potter, John D|Ulrich, Cornelia M
PMID: 16537708
Journal: World J Gastroenterol. 2006 Oct 21;12(39):6355-60.
Title: Expression of 5-lipoxygenase in human colorectal cancer.
Author: Soumaoro, Labile Togba|Iida, Satoru|Uetake, Hiroyuki|Ishiguro, Megumi|Takagi, Yoko|Higuchi, Tetsuro|Yasuno, Masamichi|Enomoto, Masayuki|Sugihara, Kenichi
PMID: 17072961
Journal: Mol Cancer Ther. 2006 Nov;5(11):2716-26.
Title: Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.
Author: Cianchi, Fabio|Cortesini, Camillo|Magnelli, Lucia|Fanti, Elena|Papucci, Laura|Schiavone, Nicola|Messerini, Luca|Vannacci, Alfredo|Capaccioli, Sergio|Perna, Federico|Lulli, Matteo|Fabbroni, Valentina|Perigli, Giuliano|Bechi, Paolo|Masini, Emanuela
PMID: 17121918
Journal: Dis Colon Rectum. 2007 Oct;50(10):1576-84.
Title: 5-Lipoxygenase is coexpressed with Cox-2 in sporadic colorectal cancer: a correlation with advanced stage.
Author: Barresi, Valeria|Grosso, Maddalena|Vitarelli, Enrica|Tuccari, Giovanni|Barresi, Gaetano
PMID: 17762961
Journal: Clin Cancer Res. 2008 Oct 15;14(20):6525-30.
Title: Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.
Author: Melstrom, Laleh G|Bentrem, David J|Salabat, Mohammad R|Kennedy, Timothy J|Ding, Xian-Zhong|Strouch, Matthew|Rao, Sambasiva M|Witt, Richard C|Ternent, Charles A|Talamonti, Mark S|Bell, Richard H|Adrian, Thomas A
PMID: 18927292
Journal: Arch Pathol Lab Med. 2008 Nov;132(11):1807-12.
Title: Correlative study of microvessel density and 5-lipoxygenase expression in human sporadic colorectal cancer.
Author: Barresi, Valeria|Vitarelli, Enrica|Tuccari, Giovanni|Barresi, Gaetano
PMID: 18976020
Journal: Prostaglandins Leukot Essent Fatty Acids. 2008 Dec;79(6):223-31.
Title: Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells.
Author: Yudina, Yulyana|Parhamifar, Ladan|Bengtsson, Astrid M-L|Juhas, Maria|Sjolander, Anita
PMID: 19042113
Journal: Cell Mol Life Sci. 2010 Mar;67(5):797-806.
Title: Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.
Author: Steinbrink, Svenja D|Pergola, Carlo|Buhring, Ulrike|George, Sven|Metzner, Julia|Fischer, Astrid S|Hafner, Ann-Kathrin|Wisniewska, Joanna M|Geisslinger, Gerd|Werz, Oliver|Steinhilber, Dieter|Maier, Thorsten J
PMID: 20091083
Journal: Int J Oncol. 2010 May;36(5):1183-91.
Title: Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.
Author: Lepage, Clemence|Liagre, Bertrand|Cook-Moreau, Jeanne|Pinon, Aline|Beneytout, Jean-Louis
PMID: 20372792
Journal: Cancer Prev Res (Phila). 2011 Dec;4(12):2015-26.
Title: Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
Author: Mohammed, Altaf|Janakiram, Naveena B|Li, Qian|Choi, Chang-In|Zhang, Yuting|Steele, Vernon E|Rao, Chinthalapally V
PMID: 21885812
Journal: BMC Cancer. 2012 Nov 13;12:515.
Title: Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members.
Author: Pringels, Sarah|Van Damme, Nancy|De Craene, Bram|Pattyn, Piet|Ceelen, Wim|Peeters, Marc|Grooten, Johan
PMID: 23148666
Journal: Curr Colorectal Cancer Rep. 2012 Dec;8(4):316-324.
Title: Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.
Author: Rao, Chinthalapally V|Janakiram, Naveena B|Mohammed, Altaf
PMID: 23293573
Journal: World J Surg Oncol. 2012 Sep 26;10:200.
Title: Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells.
Author: Ganesh, Radhakrishnan|Marks, Daniel J B|Sales, Kevin|Winslet, Marc C|Seifalian, Alexander M
PMID: 23013454
Journal: Genes Nutr. 2013 Jan;8(1):115-26.
Title: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer.
Author: Habermann, Nina|Ulrich, Cornelia M|Lundgreen, Abbie|Makar, Karen W|Poole, Elizabeth M|Caan, Bette|Kulmacz, Richard|Whitton, John|Galbraith, Rachel|Potter, John D|Slattery, Martha L
PMID: 22678777
Journal: Genes Chromosomes Cancer. 2013 May;52(5):437-49.
Title: Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Author: Kleinstein, Sarah E|Heath, Laura|Makar, Karen W|Poole, Elizabeth M|Seufert, Brenna L|Slattery, Martha L|Xiao, Liren|Duggan, David J|Hsu, Li|Curtin, Karen|Koepl, Lisel|Muehling, Jill|Taverna, Darin|Caan, Bette J|Carlson, Christopher S|Potter, John D|Ulrich
PMID: 23404351
Journal: Bioorg Med Chem. 2013 May 1;21(9):2551-9.
Title: Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Author: Misra, Suniti|Ghatak, Shibnath|Patil, Neha|Dandawate, Prasad|Ambike, Vinita|Adsule, Shreelekha|Unni, Deepak|Venkateswara Swamy, K|Padhye, Subhash
PMID: 23517721
Journal: Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):709-19.
Title: 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy.
Author: Bishayee, Kausik|Khuda-Bukhsh, Anisur Rahman
PMID: 23752617
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Sep;16(9):895-7.
Title: [Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma].
Author: Li, Yue-chun|Wang, Dong-xia|Li, Cai-shi|Ye, Zhen-peng|Wu, Zhi-ming|Chen, Jian-hua
PMID: 24062003
Journal: Bioorg Med Chem Lett. 2014 Jan 1;24(1):317-24.
Title: Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
Author: Ghatak, Shibnath|Vyas, Alok|Misra, Suniti|O'Brien, Paul|Zambre, Ajit|Fresco, Victor M|Markwald, Roger R|Swamy, K Venkateshwara|Afrasiabi, Zahra|Choudhury, Amitava|Khetmalas, Madhukar|Padhye, Subhash
PMID: 24295787
Journal: Oncol Lett. 2014 Feb;7(2):513-518.
Title: Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer.
Author: Pimenta, Celia Aparecida Marques|Latini, Flavia Roche Moreira|DE Lima, Jacqueline Miranda|DA Silva, Tiago Donizetti|Felipe, Aledson Vitor|DE Lima Pazine, Vanessa Maria|Forones, Nora Manoukian
PMID: 24396479
Journal: PLoS One. 2014 May 8;9(5):e96418.
Title: ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid.
Author: Zhang, Haiyuan|Lei, Yunlong|Yuan, Ping|Li, Lingjun|Luo, Chao|Gao, Rui|Tian, Jun|Feng, Zuohua|Nice, Edouard C|Sun, Jun
PMID: 24810758
Journal: Med Chem Res. 2014 Aug 1;23(8):3836-3851.
Title: Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.
Author: Misra, Suniti|Ghatak, Shibnath|Vyas, Alok|O'Brien, Paul|Markwald, Roger R|Khetmalas, Madhukar|Hascall, Vincent C|McCarthy, James B|Karamanos, Nikos K|Tammi, Markku I|Tammi, Raija H|Prestwitch, Glenn D|Padhye, Subhash
PMID: 25013352
Journal: Anticancer Agents Med Chem. 2015;15(8):1066-77.
Title: 5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-alpha secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells.
Author: Yarla, Nagendra Sastry|Azad, Rajaram|Basha, Mahaboob|Rajack, Abdul|Kaladhar, D S V G K|Allam, Bharat Kumar|Pragada, Rajeswara Rao|Singh, Krishna Nand|K, Sunanda Kumari|Pallu, Reddanna|Parimi, Umadevi|Bishayee, Anupam|Duddukuri, Govinda Rao
PMID: 25642980
Journal: Physiol Rep. 2015 Jul;3(7). pii: 3/7/e12417.
Title: Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
Author: Cabral, Marisol|Martin-Venegas, Raquel|Moreno, Juan J
PMID: 26216432
Journal: Daru. 2015 Jul 22;23:36.
Title: Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies.
Author: Aliabadi, Alireza|Mohammadi-Farani, Ahmad|Hosseinzadeh, Zeinab|Nadri, Hamid|Moradi, Alireza|Ahmadi, Farahnaz
PMID: 26197788
Journal: PLoS One. 2015 Apr 17;10(4):e0123256.
Title: Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes.
Author: Zhang, Chengcheng|Yu, Haining|Ni, Xiaofeng|Shen, Shengrong|Das, Undurti N
PMID: 25886460
Journal: Pharmacol Ther. 2016 Jan;157:43-64.
Title: Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
Author: Roos, Jessica|Grosch, Sabine|Werz, Oliver|Schroder, Peter|Ziegler, Slava|Fulda, Simone|Paulus, Patrick|Urbschat, Anja|Kuhn, Benjamin|Maucher, Isabelle|Fettel, Jasmin|Vorup-Jensen, Thomas|Piesche, Matthias|Matrone, Carmela|Steinhilber, Dieter|Parnham, Mich
PMID: 26549540
Journal: Oncol Rep. 2016 Mar;35(3):1680-8.
Title: Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
Author: Che, Xiao-Hang|Chen, Chun-Lin|Ye, Xiao-Lei|Weng, Guo-Bin|Guo, Xian-Zhi|Yu, Wen-Ying|Tao, Jin|Chen, Yi-Chen|Chen, Xiaodong
PMID: 26707712
Journal: Carcinogenesis. 2016 May;37(5):491-9.
Title: Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model.
Author: Savari, Sayeh|Chandrashekar, Naveen Kumar|Osman, Janina|Douglas, Desiree|Bellamkonda, Kishan|Jonsson, Gunilla|Juhas, Maria|Greicius, Gedas|Pettersson, Sven|Sjolander, Anita
PMID: 26979937
Journal: Curr Med Chem. 2016;23(11):1131-8.
Title: The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
Author: Shen, J|Li, W X|Xiao, Z G|Zhang, L|Li, M X|Li, L F|Hu, W|Lu, L|Boudreau, F|Cho, C H
PMID: 26997150
Journal: Free Radic Biol Med. 2016 Jun;95:190-9.
Title: Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice.
Author: Jang, Yumi|Park, Na-Young|Rostgaard-Hansen, Agnetha Linn|Huang, Jianjie|Jiang, Qing
PMID: 27016075
Journal: ChemMedChem. 2017 Jul 6;12(13):1081-1086.
Title: CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway.
Author: Kuhnert, Robert|Sarosi, Menyhart-Botond|George, Sven|Lonnecke, Peter|Hofmann, Bettina|Steinhilber, Dieter|Murganic, Blagoje|Mijatovic, Sanja|Maksimovic-Ivanic, Danijela|Hey-Hawkins, Evamarie
PMID: 28569429
Journal: Cell Mol Neurobiol. 2018 Mar;38(2):559-573.
Title: Cysteinyl Leukotriene Receptor Antagonists Inhibit Migration, Invasion, and Expression of MMP-2/9 in Human Glioblastoma.
Author: Piromkraipak, Pannaree|Sangpairoj, Kant|Tirakotai, Wuttipong|Chaithirayanon, Kulathida|Unchern, Supeenun|Supavilai, Porntip|Power, Christopher|Vivithanaporn, Pornpun
PMID: 28600709
Journal: J Cell Biochem. 2018 Feb;119(2):1755-1766.
Title: MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Author: Wang, Dongxia|Li, Yuechun|Zhang, Chun|Li, Xianming|Yu, Jinming
PMID: 28786533
Journal: Biochem Pharmacol. 2018 Sep;155:48-60.
Title: Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells.
Author: Kuhn, Benjamin|Brat, Camilla|Fettel, Jasmin|Hellmuth, Nadine|Maucher, Isabelle V|Bulut, Ufuk|Hock, Katharina J|Grimmer, Jennifer|Manolikakes, Georg|Ruhl, Michael|Kuhn, Alessa|Zacharowski, Kai|Matrone, Carmela|Urbschat, Anja|Roos, Jessica|Steinhilber, Diet
PMID: 29909078