Primary Site >> Colorectal Cancer
Gene >> ALOX5
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Ref: Altered eicosanoid levels in human colon cancer. PMID: 8228569 |
Ref: Production of arachidonic acid metabolites by the colon adenocarcinoma cell line HT29 cl.19A and their effect on chloride secretion. PMID: 9215866 |
Ref: Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation. PMID: 10679282 |
Ref: Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. PMID: 11811948 Ref: Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. PMID: 12376474 Ref: Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophlebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro. PMID: 12487331 |
Ref: Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. PMID: 12512030 |
Ref: Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. PMID: 14569062 Ref: Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. PMID: 15073046 Ref: The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. PMID: 15161935 Ref: Effect of LY293111 in combination with gemcitabine in colonic cancer. PMID: 15172119 Ref: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. PMID: 15308583 Ref: Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. PMID: 15363593 |
Ref: Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. PMID: 15637091 Ref: A mechanistic study of colon cancer growth promoted by cigarette smoke extract. PMID: 16125168 Ref: Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. PMID: 16185917 Ref: The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. PMID: 16357157 |
Ref: Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. PMID: 16537708 Ref: Expression of 5-lipoxygenase in human colorectal cancer. PMID: 17072961 Ref: Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. PMID: 17121918 |
Ref: 5-Lipoxygenase is coexpressed with Cox-2 in sporadic colorectal cancer: a correlation with advanced stage. PMID: 17762961 |
Ref: Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. PMID: 18927292 Ref: Correlative study of microvessel density and 5-lipoxygenase expression in human sporadic colorectal cancer. PMID: 18976020 Ref: Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. PMID: 19042113 |
Ref: Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. PMID: 20091083 Ref: Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. PMID: 20372792 |
Ref: Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention. PMID: 21885812 |
Ref: Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. PMID: 23013454 Ref: Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members. PMID: 23148666 Ref: Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention. PMID: 23293573 |
Ref: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. PMID: 22678777 Ref: Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia. PMID: 23404351 Ref: Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. PMID: 23517721 Ref: 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy. PMID: 23752617 Ref: [Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma]. PMID: 24062003 |
Ref: Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. PMID: 24295787 Ref: Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer. PMID: 24396479 Ref: ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. PMID: 24810758 Ref: Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer. PMID: 25013352 |
Ref: 5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-alpha secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells. PMID: 25642980 Ref: Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. PMID: 25886460 Ref: Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies. PMID: 26197788 Ref: Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PMID: 26216432 |
Ref: Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? PMID: 26549540 Ref: Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. PMID: 26707712 Ref: Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model. PMID: 26979937 Ref: The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. PMID: 26997150 Ref: Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice. PMID: 27016075 |
Ref: CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway. PMID: 28569429 |
Ref: Cysteinyl Leukotriene Receptor Antagonists Inhibit Migration, Invasion, and Expression of MMP-2/9 in Human Glioblastoma. PMID: 28600709 Ref: MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5. PMID: 28786533 Ref: Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells. PMID: 29909078 |