Primary Site >> Colorectal Cancer

Gene >> ALOX15

Journal: Adv Exp Med Biol. 1997;400B:599-604.
Title: Regulation of 15-lipoxygenase expression by cytokines.
Author: Brinckmann, R|Kuhn, H
PMID: 9547609
Journal: Cancer Lett. 1997 Jun 24;116(2):213-23.
Title: Production of arachidonic acid metabolites by the colon adenocarcinoma cell line HT29 cl.19A and their effect on chloride secretion.
Author: Battu, S|Clement, G|Heyman, M|Wal, J M|Cook-Moreau, J|Desjeux, J F|Beneytout, J L
PMID: 9215866
Journal: J Biol Chem. 1998 Aug 21;273(34):21569-77.
Title: Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation.
Author: Kamitani, H|Geller, M|Eling, T
PMID: 9705287
Journal: Cancer Res. 1999 Jan 15;59(2):360-6.
Title: Expression of 15-lipoxygenase-1 in human colorectal cancer.
Author: Ikawa, H|Kamitani, H|Calvo, B F|Foley, J F|Eling, T E
PMID: 9927047
Journal: Carcinogenesis. 1999 Oct;20(10):1985-95.
Title: Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers.
Author: Shureiqi, I|Wojno, K J|Poore, J A|Reddy, R G|Moussalli, M J|Spindler, S A|Greenson, J K|Normolle, D|Hasan, A A|Lawrence, T S|Brenner, D E
PMID: 10506115
Journal: J Natl Cancer Inst. 2000 Jul 19;92(14):1136-42.
Title: 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Author: Shureiqi, I|Chen, D|Lee, J J|Yang, P|Newman, R A|Brenner, D E|Lotan, R|Fischer, S M|Lippman, S M
PMID: 10904086
Journal: Cancer Res. 2000 Dec 15;60(24):6846-50.
Title: 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Author: Shureiqi, I|Chen, D|Lotan, R|Yang, P|Newman, R A|Fischer, S M|Lippman, S M
PMID: 11156377
Journal: Cancer Res. 2001 Jun 15;61(12):4879-84.
Title: Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Author: Shureiqi, I|Xu, X|Chen, D|Lotan, R|Morris, J S|Fischer, S M|Lippman, S M
PMID: 11406566
Journal: Cancer Res. 2001 Sep 1;61(17):6307-12.
Title: Lipoxygenase modulation to reverse carcinogenesis.
Author: Shureiqi, I|Lippman, S M
PMID: 11522616
Journal: Biochem Pharmacol. 2001 Nov 1;62(9):1175-83.
Title: Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues.
Author: Hong, J|Smith, T J|Ho, C T|August, D A|Yang, C S
PMID: 11705450
Journal: Cancer Res. 2002 Feb 15;62(4):1178-83.
Title: GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells.
Author: Shureiqi, Imad|Jiang, Wei|Fischer, Susan M|Xu, Xiaochun|Chen, Dongning|Lee, J Jack|Lotan, Reuben|Lippman, Scott M
PMID: 11861401
Journal: J Biol Chem. 2002 Oct 25;277(43):40549-56. Epub 2002 Aug 19.
Title: Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Author: Hsi, Linda C|Wilson, Leigh C|Eling, Thomas E
PMID: 12189136
Journal: Int J Cancer. 2003 Dec 10;107(5):837-43.
Title: 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway.
Author: Chen, George G|Xu, Hu|Lee, Janet F Y|Subramaniam, Malayannan|Leung, Ka L|Wang, Su H|Chan, Ursula P F|Spelsberg, Thomas C
PMID: 14566836
Journal: Prostaglandins Leukot Essent Fatty Acids. 2003 May;68(5):323-30.
Title: Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells.
Author: Nixon, J B|Kamitani, H|Baek, S J|Eling, T E
PMID: 12711249
Journal: Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):111-22.
Title: 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Author: Yoshinaga, Masahiro|Buchanan, F Gregory|DuBois, Raymond N
PMID: 15165036
Journal: Ann Surg. 2005 Jun;241(6):941-6; discussion 946-7.
Title: Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.
Author: Heslin, Martin J|Hawkins, Ashley|Boedefeld, William|Arnoletti, J Pablo|Frolov, Andrey|Soong, Richie|Urist, Marshall M|Bland, Kirby I
PMID: 15912043
Journal: Cancer Res. 2005 Sep 15;65(18):8442-7.
Title: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Author: Deguchi, Atsuko|Xing, Steven W|Shureiqi, Imad|Yang, Peiying|Newman, Robert A|Lippman, Scott M|Feinmark, Steven J|Oehlen, Bert|Weinstein, I Bernard
PMID: 16166323
Journal: Mol Cancer Res. 2005 Sep;3(9):511-7.
Title: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.
Author: Kim, Jong-Sik|Baek, Seung Joon|Bottone, Frank G Jr|Sali, Tina|Eling, Thomas E
PMID: 16179498
Journal: Mol Cancer Ther. 2005 Nov;4(11):1740-6.
Title: The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Author: Hsi, Linda C|Xi, Xiaopei|Wu, Yuanqing|Lippman, Scott M
PMID: 16275995
Journal: Cancer Res. 2005 Dec 15;65(24):11486-92.
Title: The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
Author: Shureiqi, Imad|Wu, Yuanqing|Chen, Dongning|Yang, Xiu L|Guan, Baoxiang|Morris, Jeffrey S|Yang, Peiying|Newman, Robert A|Broaddus, Russell|Hamilton, Stanley R|Lynch, Patrick|Levin, Bernard|Fischer, Susan M|Lippman, Scott M
PMID: 16357157
Journal: Oncogene. 2006 Feb 23;25(8):1225-41.
Title: Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity.
Author: Zuo, X|Wu, Y|Morris, J S|Stimmel, J B|Leesnitzer, L M|Fischer, S M|Lippman, S M|Shureiqi, I
PMID: 16288226
Journal: FASEB J. 2007 Mar;21(3):743-53. Epub 2006 Dec 13.
Title: The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
Author: Shureiqi, Imad|Zuo, Xiangsheng|Broaddus, Russell|Wu, Yuanqing|Guan, Baoxiang|Morris, Jeffrey S|Lippman, Scott M
PMID: 17167069
Journal: J Gastroenterol Hepatol. 2007 Dec;22(12):2324-9. Epub 2007 Jun 7.
Title: The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds.
Author: Yoshinaga, Masahiro|Murao, Hiroyuki|Kitamura, Yosuke|Koga, Koutaro|Tsuruta, Satoru|Igarashi, Hisato|Nakamura, Kazuhiko|Takayanagi, Ryoichi
PMID: 17559385
Journal: Histopathology. 2007 Oct;51(4):520-7. Epub 2007 Aug 17.
Title: Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer.
Author: Yuri, M|Sasahira, T|Nakai, K|Ishimaru, S|Ohmori, H|Kuniyasu, H
PMID: 17711445
Journal: FASEB J. 2008 Jun;22(6):1981-92.
Title: 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
Author: Zuo, Xiangsheng|Shen, Lanlan|Issa, Jean-Pierre|Moy, Ofir|Morris, Jeffrey S|Lippman, Scott M|Shureiqi, Imad
PMID: 18198215
Journal: J Biol Chem. 2008 Nov 14;283(46):31341-7.
Title: Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells.
Author: Zuo, Xiangsheng|Morris, Jeffrey S|Shureiqi, Imad
PMID: 18799463
Journal: Int J Cancer. 2008 Dec 15;123(12):2741-9.
Title: 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
Author: Zhu, Hong|Glasgow, Wayne|George, Margaret D|Chrysovergis, Kali|Olden, Kenneth|Roberts, John D|Eling, Thomas
PMID: 18785202
Journal: Bioorg Med Chem. 2008 Apr 15;16(8):4589-93.
Title: Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids.
Author: Russell, Wendy R|Scobbie, Lorraine|Duthie, Garry G|Chesson, Andrew
PMID: 18314336
Journal: Mol Ther. 2008 May;16(5):886-92.
Title: Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Author: Wu, Yuanqing|Fang, Bingliang|Yang, Xiulan Q|Wang, Li|Chen, Dongning|Krasnykh, Victor|Carter, Bing Z|Morris, Jeffrey S|Shureiqi, Imad
PMID: 18388920
Journal: Oncogene. 2009 Mar 26;28(12):1496-505.
Title: 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
Author: Zuo, X|Morris, J S|Broaddus, R|Shureiqi, I
PMID: 19198625
Journal: Curr Mol Med. 2009 Jun;9(5):565-79.
Title: Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer.
Author: Janakiram, Naveena B|Rao, Chinthalapally V
PMID: 19601807
Journal: Tumour Biol. 2009;30(4):185-99.
Title: 15-lipoxygenase-1 in colorectal cancer: a review.
Author: Bhattacharya, S|Mathew, G|Jayne, D G|Pelengaris, S|Khan, M
PMID: 19752603
Journal: Cancer Prev Res (Phila). 2010 Jul;3(7):829-38.
Title: Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis.
Author: Shureiqi, Imad|Chen, Dongning|Day, R Sue|Zuo, Xiangsheng|Hochman, Fredric Lyone|Ross, William A|Cole, Rhonda A|Moy, Ofie|Morris, Jeffrey S|Xiao, Lianchun|Newman, Robert A|Yang, Peiying|Lippman, Scott M
PMID: 20570882
Journal: J Cell Biochem. 2011 Sep;112(9):2490-501.
Title: 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
Author: Cimen, I|Astarci, E|Banerjee, S
PMID: 21544861
Journal: Mol Cancer Ther. 2011 Jul;10(7):1149-60.
Title: Silencing IL-13Ralpha2 promotes glioblastoma cell death via endogenous signaling.
Author: Hsi, Linda C|Kundu, Suman|Palomo, Juan|Xu, Bo|Ficco, Ryan|Vogelbaum, Michael A|Cathcart, Martha K
PMID: 21596889
Journal: Cancer Prev Res (Phila). 2011 Dec;4(12):1961-72.
Title: Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Author: Moussalli, Micheline J|Wu, Yuanqing|Zuo, Xiangsheng|Yang, Xiu L|Wistuba, Ignacio Ivan|Raso, Maria G|Morris, Jeffrey S|Bowser, Jessica L|Minna, John D|Lotan, Reuben|Shureiqi, Imad
PMID: 21881028
Journal: Cancer Metastasis Rev. 2011 Dec;30(3-4):481-91.
Title: 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
Author: Il Lee, Sun|Zuo, Xiangsheng|Shureiqi, Imad
PMID: 22037943
Journal: Genes Nutr. 2013 Jan;8(1):115-26.
Title: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer.
Author: Habermann, Nina|Ulrich, Cornelia M|Lundgreen, Abbie|Makar, Karen W|Poole, Elizabeth M|Caan, Bette|Kulmacz, Richard|Whitton, John|Galbraith, Rachel|Potter, John D|Slattery, Martha L
PMID: 22678777
Journal: Genes Chromosomes Cancer. 2013 May;52(5):437-49.
Title: Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Author: Kleinstein, Sarah E|Heath, Laura|Makar, Karen W|Poole, Elizabeth M|Seufert, Brenna L|Slattery, Martha L|Xiao, Liren|Duggan, David J|Hsu, Li|Curtin, Karen|Koepl, Lisel|Muehling, Jill|Taverna, Darin|Caan, Bette J|Carlson, Christopher S|Potter, John D|Ulrich
PMID: 23404351
Journal: Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:139-43.
Title: Eicosanoid profiling in colon cancer: emergence of a pattern.
Author: Zuo, Xiangsheng|Shureiqi, Imad
PMID: 22960430
Journal: Cancer Med. 2014 Jun;3(3):472-84.
Title: 15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1alpha expression in human colon cancer cells.
Author: Wu, Yuanqing|Mao, Fei|Zuo, Xiangsheng|Moussalli, Micheline J|Elias, Elias|Xu, Weiguo|Shureiqi, Imad
PMID: 24634093
Journal: Oncotarget. 2015 Feb 20;6(5):2879-88.
Title: 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
Author: Chang, Jian|Jiang, Li|Wang, Yinqiu|Yao, Bing|Yang, Shilin|Zhang, Bixiang|Zhang, Ming-Zhi
PMID: 25576922
Journal: FASEB J. 2015 Jun;29(6):2359-70.
Title: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Author: Mao, Fei|Xu, Min|Zuo, Xiangsheng|Yu, Jiang|Xu, Weiguo|Moussalli, Micheline J|Elias, Elias|Li, Haiyan S|Watowich, Stephanie S|Shureiqi, Imad
PMID: 25713055
Journal: Daru. 2015 Jul 22;23:36.
Title: Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies.
Author: Aliabadi, Alireza|Mohammadi-Farani, Ahmad|Hosseinzadeh, Zeinab|Nadri, Hamid|Moradi, Alireza|Ahmadi, Farahnaz
PMID: 26197788
Journal: Cell Prolif. 2016 Aug;49(4):448-59.
Title: Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Author: Tuncer, S|Tuncay Cagatay, S|Keskus, A G|Colakoglu, M|Konu, O|Banerjee, S
PMID: 27320813
Journal: Sci Rep. 2016 Aug 22;6:31826.
Title: Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue.
Author: Li, Ming|Gao, Fei|Xia, Yudong|Tang, Yi|Zhao, Wei|Jin, Congcong|Luo, Huijuan|Wang, Junwen|Li, Qingshu|Wang, Yalan
PMID: 27546520
Journal: Prostaglandins Other Lipid Mediat. 2017 Sep;132:77-83.
Title: ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Author: Tian, Rui|Zuo, Xiangsheng|Jaoude, Jonathan|Mao, Fei|Colby, Jennifer|Shureiqi, Imad
PMID: 28089732
Journal: Colorectal Dis. 2017 May;19(5):O115-O125.
Title: Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study.
Author: Alonso, S|Mayol, X|Nonell, L|Salvans, S|Pascual, M|Pera, M
PMID: 28214365