Primary Site >> Colorectal Cancer
Gene >> ALOX15
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Ref: Production of arachidonic acid metabolites by the colon adenocarcinoma cell line HT29 cl.19A and their effect on chloride secretion. PMID: 9215866 Ref: Regulation of 15-lipoxygenase expression by cytokines. PMID: 9547609 |
Ref: Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation. PMID: 9705287 |
Ref: Expression of 15-lipoxygenase-1 in human colorectal cancer. PMID: 9927047 Ref: Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers. PMID: 10506115 |
Ref: 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. PMID: 10904086 Ref: 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. PMID: 11156377 |
Ref: Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. PMID: 11406566 Ref: Lipoxygenase modulation to reverse carcinogenesis. PMID: 11522616 Ref: Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. PMID: 11705450 |
Ref: GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells. PMID: 11861401 Ref: Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. PMID: 12189136 |
Ref: Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. PMID: 12711249 Ref: 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. PMID: 14566836 |
Ref: 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. PMID: 15165036 |
Ref: Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer. PMID: 15912043 Ref: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. PMID: 16166323 Ref: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. PMID: 16179498 Ref: The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. PMID: 16275995 Ref: The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. PMID: 16357157 |
Ref: Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. PMID: 16288226 |
Ref: The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. PMID: 17167069 Ref: The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds. PMID: 17559385 Ref: Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. PMID: 17711445 |
Ref: 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. PMID: 18198215 Ref: Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids. PMID: 18314336 Ref: Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer. PMID: 18388920 Ref: 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. PMID: 18785202 Ref: Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. PMID: 18799463 |
Ref: 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. PMID: 19198625 Ref: Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer. PMID: 19601807 Ref: 15-lipoxygenase-1 in colorectal cancer: a review. PMID: 19752603 |
Ref: Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis. PMID: 20570882 |
Ref: 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma. PMID: 21544861 Ref: Silencing IL-13Ralpha2 promotes glioblastoma cell death via endogenous signaling. PMID: 21596889 Ref: Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion. PMID: 21881028 Ref: 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in? PMID: 22037943 |
Ref: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. PMID: 22678777 Ref: Eicosanoid profiling in colon cancer: emergence of a pattern. PMID: 22960430 Ref: Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia. PMID: 23404351 |
Ref: 15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1alpha expression in human colon cancer cells. PMID: 24634093 |
Ref: 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models. PMID: 25576922 Ref: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. PMID: 25713055 Ref: Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies. PMID: 26197788 |
Ref: Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer. PMID: 27320813 Ref: Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue. PMID: 27546520 |
Ref: ALOX15 as a suppressor of inflammation and cancer: Lost in the link. PMID: 28089732 Ref: Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study. PMID: 28214365 |