Primary Site >> Colorectal Cancer
Gene >> AKT2
| 1. | |||||||||||
| Journal: | Cancer Res. 2000 Nov 1;60(21):6201-7. | ||||||||||
| Title: | Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. | ||||||||||
| Author: | Izuishi, K|Kato, K|Ogura, T|Kinoshita, T|Esumi, H | ||||||||||
| PMID: | 11085546 | ||||||||||
| 2. | |||||||||||
| Journal: | Mol Pharmacol. 2005 Aug;68(2):477-86. | ||||||||||
| Title: | Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyri din-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxami | ||||||||||
| Author: | Bruzek, Laura M|Poynter, Jenny N|Kaufmann, Scott H|Adjei, Alex A | ||||||||||
| PMID: | 15901852 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Sci. 2005 Sep;96(9):620-6. | ||||||||||
| Title: | Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs. | ||||||||||
| Author: | Yanagihara, Miyako|Katano, Masayoshi|Takahashi-Sasaki, Noriko|Kimata, Kiyonori|Taira, Kazunari|Andoh, Toshiwo | ||||||||||
| PMID: | 16128748 | ||||||||||
| 4. | |||||||||||
| Journal: | Clin Cancer Res. 2005 Nov 1;11(21):7621-8. | ||||||||||
| Title: | X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. | ||||||||||
| Author: | Takeuchi, Hiroya|Kim, Joseph|Fujimoto, Akihide|Umetani, Naoyuki|Mori, Takuji|Bilchik, Anton|Turner, Rod|Tran, Andy|Kuo, Christine|Hoon, Dave S B | ||||||||||
| PMID: | 16278380 | ||||||||||
| 5. | |||||||||||
| Journal: | Ann Surg. 2006 Jun;243(6):833-42; discussion 843-4. | ||||||||||
| Title: | Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. | ||||||||||
| Author: | Rychahou, Piotr G|Jackson, Lindsey N|Silva, Scott R|Rajaraman, Srinivasan|Evers, B Mark | ||||||||||
| PMID: | 16772787 | ||||||||||
| 6. | |||||||||||
| Journal: | Genome Biol. 2007;8(7):R131. | ||||||||||
| Title: | Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. | ||||||||||
| Author: | Kaiser, Sergio|Park, Young-Kyu|Franklin, Jeffrey L|Halberg, Richard B|Yu, Ming|Jessen, Walter J|Freudenberg, Johannes|Chen, Xiaodi|Haigis, Kevin|Jegga, Anil G|Kong, Sue|Sakthivel, Bhuvaneswari|Xu, Huan|Reichling, Timothy|Azhar, Mohammad|Boivin, Gregory P| | ||||||||||
| PMID: | 17615082 | ||||||||||
| 7. | |||||||||||
| Journal: | Br J Cancer. 2008 Oct 21;99(8):1265-8. | ||||||||||
| Title: | A novel AKT3 mutation in melanoma tumours and cell lines. | ||||||||||
| Author: | Davies, M A|Stemke-Hale, K|Tellez, C|Calderone, T L|Deng, W|Prieto, V G|Lazar, A J F|Gershenwald, J E|Mills, G B | ||||||||||
| PMID: | 18813315 | ||||||||||
| 8. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20315-20. | ||||||||||
| Title: | Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. | ||||||||||
| Author: | Rychahou, Piotr G|Kang, JungHee|Gulhati, Pat|Doan, Hung Q|Chen, L Andy|Xiao, Shu-Yuan|Chung, Dai H|Evers, B Mark | ||||||||||
| PMID: | 19075230 | ||||||||||
| 9. | |||||||||||
| Journal: | Biochem Pharmacol. 2009 Sep 15;78(6):561-72. | ||||||||||
| Title: | Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs. | ||||||||||
| Author: | Lincova, Eva|Hampl, Ales|Pernicova, Zuzana|Starsichova, Andrea|Krcmar, Pavel|Machala, Miroslav|Kozubik, Alois|Soucek, Karel | ||||||||||
| PMID: | 19433066 | ||||||||||
| 10. | |||||||||||
| Journal: | J Am Coll Surg. 2010 May;210(5):767-76, 776-8. | ||||||||||
| Title: | Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. | ||||||||||
| Author: | Johnson, Sara M|Gulhati, Pat|Rampy, Bill A|Han, Yimei|Rychahou, Piotr G|Doan, Hung Q|Weiss, Heidi L|Evers, B Mark | ||||||||||
| PMID: | 20421047 | ||||||||||
| 11. | |||||||||||
| Journal: | Radiat Environ Biophys. 2010 Aug;49(3):427-35. | ||||||||||
| Title: | Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions. | ||||||||||
| Author: | Goetze, Kristina|Scholz, Michael|Taucher-Scholz, Gisela|Mueller-Klieser, Wolfgang | ||||||||||
| PMID: | 20535615 | ||||||||||
| 12. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2598-603. | ||||||||||
| Title: | Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. | ||||||||||
| Author: | Ericson, Kajsa|Gan, Christine|Cheong, Ian|Rago, Carlo|Samuels, Yardena|Velculescu, Victor E|Kinzler, Kenneth W|Huso, David L|Vogelstein, Bert|Papadopoulos, Nickolas | ||||||||||
| PMID: | 20133737 | ||||||||||
| 13. | |||||||||||
| Journal: | Am J Physiol Cell Physiol. 2011 Mar;300(3):C657-70. | ||||||||||
| Title: | Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. | ||||||||||
| Author: | Wang, Shouye|Basson, Marc D | ||||||||||
| PMID: | 21209368 | ||||||||||
| 14. | |||||||||||
| Journal: | Cancer Lett. 2011 May 1;304(1):52-9. | ||||||||||
| Title: | miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. | ||||||||||
| Author: | Li, Jian|Chen, Yuxiang|Zhao, Jingfeng|Kong, Fangren|Zhang, Yangde | ||||||||||
| PMID: | 21354697 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer. 2011 Apr 1;117(7):1399-408. | ||||||||||
| Title: | Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. | ||||||||||
| Author: | Baba, Yoshifumi|Nosho, Katsuhiko|Shima, Kaori|Hayashi, Marika|Meyerhardt, Jeffrey A|Chan, Andrew T|Giovannucci, Edward|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 21425139 | ||||||||||
| 16. | |||||||||||
| Journal: | Biomol Concepts. 2011 Apr 1;2(1-2):1-11. | ||||||||||
| Title: | Functional specificity of Akt isoforms in cancer progression. | ||||||||||
| Author: | Fortier, Anne-Marie|Asselin, Eric|Cadrin, Monique | ||||||||||
| PMID: | 25962016 | ||||||||||
| 17. | |||||||||||
| Journal: | Cell Death Dis. 2013 Mar 28;4:e563. | ||||||||||
| Title: | Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin alpha6beta4-dependent Akt, GSK-3beta, and HSF-1 in mesenchymal stem cells. | ||||||||||
| Author: | Son, T W|Yun, S P|Yong, M S|Seo, B N|Ryu, J M|Youn, H Y|Oh, Y M|Han, H J | ||||||||||
| PMID: | 23538444 | ||||||||||
| 18. | |||||||||||
| Journal: | Cell Signal. 2013 Aug;25(8):1711-9. | ||||||||||
| Title: | Cell survival and metastasis regulation by Akt signaling in colorectal cancer. | ||||||||||
| Author: | Agarwal, Ekta|Brattain, Michael G|Chowdhury, Sanjib | ||||||||||
| PMID: | 23603750 | ||||||||||
| 19. | |||||||||||
| Journal: | Tumour Biol. 2014 Apr;35(4):3525-34. | ||||||||||
| Title: | The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. | ||||||||||
| Author: | Sahlberg, Sara Haggblad|Gustafsson, Ann-Sofie|Pendekanti, Prathyusha N|Glimelius, Bengt|Stenerlow, Bo | ||||||||||
| PMID: | 24338765 | ||||||||||
| 20. | |||||||||||
| Journal: | Theranostics. 2014 Sep 19;4(12):1193-208. | ||||||||||
| Title: | MiR-194 deregulation contributes to colorectal carcinogenesis via targeting AKT2 pathway. | ||||||||||
| Author: | Zhao, Hui-Jun|Ren, Lin-Lin|Wang, Zhen-Hua|Sun, Tian-Tian|Yu, Ya-Nan|Wang, Ying-Chao|Yan, Ting-Ting|Zou, Weiping|He, Jie|Zhang, Yaou|Hong, Jie|Fang, Jing-Yuan | ||||||||||
| PMID: | 25285168 | ||||||||||
| 21. | |||||||||||
| Journal: | PLoS One. 2014 Apr 23;9(4):e94621. | ||||||||||
| Title: | Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. | ||||||||||
| Author: | Sahlberg, Sara Haggblad|Spiegelberg, Diana|Glimelius, Bengt|Stenerlow, Bo|Nestor, Marika | ||||||||||
| PMID: | 24760019 | ||||||||||
| 22. | |||||||||||
| Journal: | Cell Biochem Biophys. 2015 Jan;71(1):383-8. | ||||||||||
| Title: | Knockdown of Akt2 expression by shRNA inhibits proliferation, enhances apoptosis, and increases chemosensitivity to paclitaxel in human colorectal cancer cells. | ||||||||||
| Author: | Ding, Zhongyang|Xu, Fei|Li, Gan|Tang, Jiandong|Tang, Zhangfeng|Jiang, Panqiang|Wu, Haotian | ||||||||||
| PMID: | 25134663 | ||||||||||
| 23. | |||||||||||
| Journal: | Hum Pathol. 2015 Apr;46(4):507-13. | ||||||||||
| Title: | Novel molecular insights from routine genotyping of colorectal carcinomas. | ||||||||||
| Author: | Stachler, Matthew D|Rinehart, Elizabeth|Lindeman, Neal|Odze, Robert|Srivastava, Amitabh | ||||||||||
| PMID: | 25683705 | ||||||||||
| 24. | |||||||||||
| Journal: | Cell Death Dis. 2015 Jul 9;6:e1808. | ||||||||||
| Title: | miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. | ||||||||||
| Author: | Sheng, L|He, P|Yang, X|Zhou, M|Feng, Q | ||||||||||
| PMID: | 26158514 | ||||||||||
| 25. | |||||||||||
| Journal: | Oncogene. 2016 Jun 16;35(24):3151-62. | ||||||||||
| Title: | Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial-mesenchymal transition. | ||||||||||
| Author: | Zhang, Q|Wei, T|Shim, K|Wright, K|Xu, K|Palka-Hamblin, H L|Jurkevich, A|Khare, S | ||||||||||
| PMID: | 26434583 | ||||||||||
| 26. | |||||||||||
| Journal: | Exp Neurol. 2016 Jan;275 Pt 1:11-6. | ||||||||||
| Title: | Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion. | ||||||||||
| Author: | Jiang, Shu-Ping|Zhang, Zhen-Dong|Kang, Lu-Mei|Wang, Qing-Hua|Zhang, Lei|Chen, Hong-Ping | ||||||||||
| PMID: | 26546510 | ||||||||||
| 27. | |||||||||||
| Journal: | Oncotarget. 2016 Apr 5;7(14):17970-85. | ||||||||||
| Title: | Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways. | ||||||||||
| Author: | Li, Gang|Ying, Li|Wang, Hong|Wei, Si-Si|Chen, Jie|Chen, Yi-He|Xu, Wei-Ping|Jie, Qi-Qiang|Zhou, Qing|Li, Yi-Gang|Wei, Yi-Dong|Wang, Yue-Peng | ||||||||||
| PMID: | 26918455 | ||||||||||
| 28. | |||||||||||
| Journal: | Int J Oncol. 2017 Jan;50(1):5-14. | ||||||||||
| Title: | Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells. | ||||||||||
| Author: | Haggblad Sahlberg, Sara|Mortensen, Anja C|Haglof, Jakob|Engskog, Mikael K R|Arvidsson, Torbjorn|Pettersson, Curt|Glimelius, Bengt|Stenerlow, Bo|Nestor, Marika | ||||||||||
| PMID: | 27878243 | ||||||||||
| 29. | |||||||||||
| Journal: | Oncogene. 2017 Jun 1;36(22):3104-3118. | ||||||||||
| Title: | Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis. | ||||||||||
| Author: | Agarwal, E|Robb, C M|Smith, L M|Brattain, M G|Wang, J|Black, J D|Chowdhury, S | ||||||||||
| PMID: | 28068324 | ||||||||||
| 30. | |||||||||||
| Journal: | Cell Death Dis. 2017 Aug 24;8(8):e3019. | ||||||||||
| Title: | AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells. | ||||||||||
| Author: | Seiwert, Nina|Neitzel, Carina|Stroh, Svenja|Frisan, Teresa|Audebert, Marc|Toulany, Mahmoud|Kaina, Bernd|Fahrer, Jorg | ||||||||||
| PMID: | 28837154 | ||||||||||
| 31. | |||||||||||
| Journal: | Anal Chem. 2017 Oct 3;89(19):10592-10600. | ||||||||||
| Title: | Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors. | ||||||||||
| Author: | Popp, Robert|Li, Huiyan|LeBlanc, Andre|Mohammed, Yassene|Aguilar-Mahecha, Adriana|Chambers, Andrew G|Lan, Cathy|Poetz, Oliver|Basik, Mark|Batist, Gerald|Borchers, Christoph H | ||||||||||
| PMID: | 28853539 | ||||||||||
| 32. | |||||||||||
| Journal: | J Transl Med. 2017 Dec 19;15(1):257. | ||||||||||
| Title: | Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer. | ||||||||||
| Author: | Lv, Zhenbing|Wei, Jinlai|You, Wenxian|Wang, Rong|Shang, Jingkun|Xiong, Yongfu|Yang, Hua|Yang, Xuanhua|Fu, Zhongxue | ||||||||||
| PMID: | 29258530 | ||||||||||
| 33. | |||||||||||
| Journal: | Int J Oncol. 2018 Apr;52(4):1129-1138. | ||||||||||
| Title: | Identification of candidate genes and long non-coding RNAs associated with the effect of ATP5J in colorectal cancer. | ||||||||||
| Author: | Bai, Bingjun|Xie, Binbin|Pan, Zongyou|Shan, Lina|Zhao, Jianpei|Zhu, Hongbo | ||||||||||
| PMID: | 29484395 | ||||||||||
| 34. | |||||||||||
| Journal: | Int Immunopharmacol. 2018 Aug;61:346-354. | ||||||||||
| Title: | Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2. | ||||||||||
| Author: | Deng, Shuangjiao|Wang, Hongfei|Fan, Heng|Zhang, Lijuan|Hu, Jianli|Tang, Qing|Shou, Zhexing|Liu, Xingxing|Zuo, Dongmei|Yang, Jia|Xu, Meng|Chen, Qianyun|Dong, Yalan|Nan, Zhen|Wu, Hui|Liu, Yujin | ||||||||||
| PMID: | 29933193 | ||||||||||
| 35. | |||||||||||
| Journal: | Genes Cells. 2018 Jul 2. | ||||||||||
| Title: | MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression. | ||||||||||
| Author: | Kokuda, Rie|Watanabe, Risayo|Okuzaki, Daisuke|Akamatsu, Hiroki|Oneyama, Chitose | ||||||||||
| PMID: | 29962093 | ||||||||||
| 36. | |||||||||||
| Journal: | Int J Mol Med. 2018 Nov 1. | ||||||||||
| Title: | Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. | ||||||||||
| Author: | Li, Dan|Wang, Gangcheng|Jin, Guoguo|Yao, Ke|Zhao, Zhenjiang|Bie, Liangyu|Guo, Yongjun|Li, Ning|Deng, Wenying|Chen, Xiaobin|Chen, Beibei|Liu, Yuanyuan|Luo, Suxia|Guo, Zhiping | ||||||||||
| PMID: | 30387805 | ||||||||||