Primary Site >> Colorectal Cancer
Gene >> AKT2
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Ref: Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. PMID: 11085546 |
Ref: Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyri din-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxami PMID: 15901852 Ref: Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs. PMID: 16128748 Ref: X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. PMID: 16278380 |
Ref: Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. PMID: 16772787 |
Ref: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. PMID: 17615082 |
Ref: A novel AKT3 mutation in melanoma tumours and cell lines. PMID: 18813315 Ref: Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. PMID: 19075230 |
Ref: Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs. PMID: 19433066 |
Ref: Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. PMID: 20133737 Ref: Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. PMID: 20421047 Ref: Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions. PMID: 20535615 |
Ref: Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. PMID: 21209368 Ref: miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. PMID: 21354697 Ref: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. PMID: 21425139 Ref: Functional specificity of Akt isoforms in cancer progression. PMID: 25962016 |
Ref: Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin alpha6beta4-dependent Akt, GSK-3beta, and HSF-1 in mesenchymal stem cells. PMID: 23538444 Ref: Cell survival and metastasis regulation by Akt signaling in colorectal cancer. PMID: 23603750 |
Ref: The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. PMID: 24338765 Ref: Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PMID: 24760019 Ref: MiR-194 deregulation contributes to colorectal carcinogenesis via targeting AKT2 pathway. PMID: 25285168 |
Ref: Knockdown of Akt2 expression by shRNA inhibits proliferation, enhances apoptosis, and increases chemosensitivity to paclitaxel in human colorectal cancer cells. PMID: 25134663 Ref: Novel molecular insights from routine genotyping of colorectal carcinomas. PMID: 25683705 Ref: miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. PMID: 26158514 |
Ref: Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial-mesenchymal transition. PMID: 26434583 Ref: Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion. PMID: 26546510 Ref: Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways. PMID: 26918455 |
Ref: Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells. PMID: 27878243 Ref: Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis. PMID: 28068324 Ref: AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells. PMID: 28837154 Ref: Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors. PMID: 28853539 Ref: Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer. PMID: 29258530 |
Ref: Identification of candidate genes and long non-coding RNAs associated with the effect of ATP5J in colorectal cancer. PMID: 29484395 Ref: Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2. PMID: 29933193 Ref: MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression. PMID: 29962093 Ref: Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. PMID: 30387805 |