Literatures

Primary Site >> Biliary tract Cancer

Gene >> AKT1

1.
Journal:	Hokkaido Igaku Zasshi. 2003 Mar;78(2):159-71.
Title:	[Activated serine/threonine kinase AKT enhances the radioresistancy in human cholangiocarcinoma].
Author:	Yanagawa, Nobuyuki
PMID:	12704859

2.
Journal:	Am J Pathol. 2003 Jul;163(1):217-29.
Title:	Identification of novel cellular targets in biliary tract cancers using global gene expression technology.
Author:	Hansel, Donna E\|Rahman, Ayman\|Hidalgo, Manuel\|Thuluvath, Paul J\|Lillemoe, Keith D\|Schulick, Richard\|Ku, Ja-Lok\|Park, Jae-Gahb\|Miyazaki, Kohje\|Ashfaq, Raheela\|Wistuba, Ignacio I\|Varma, Ram\|Hawthorne, Lesleyann\|Geradts, Joseph\|Argani, Pedram\|Maitra, Anirban
PMID:	12819026

3.
Journal:	Hepatology. 2004 Apr;39(4):1028-37.
Title:	Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation.
Author:	Zhang, Zichen\|Lai, Guan-Hua\|Sirica, Alphonse E
PMID:	15057907

4.
Journal:	Cancer Res. 2004 May 15;64(10):3486-90.
Title:	Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
Author:	Tanno, Satoshi\|Yanagawa, Nobuyuki\|Habiro, Atsuya\|Koizumi, Kazuya\|Nakano, Yasuhiro\|Osanai, Manabu\|Mizukami, Yusuke\|Okumura, Toshikatsu\|Testa, Joseph R\|Kohgo, Yutaka
PMID:	15150102

5.
Journal:	Liver Int. 2004 Dec;24(6):687-95.
Title:	Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells.
Author:	Chiorean, Mihnea V\|Guicciardi, Maria Eugenia\|Yoon, Jung-Hwan\|Bronk, Steven F\|Kaufmanns, Scott H\|Gores, Gregory J
PMID:	15566522

6.
Journal:	Gastroenterology. 2005 Jun;128(7):2054-65.
Title:	Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Author:	Kobayashi, Shogo\|Werneburg, Nathan W\|Bronk, Steven F\|Kaufmann, Scott H\|Gores, Gregory J
PMID:	15940637

7.
Journal:	Gastroenterology. 2005 Dec;129(6):2047-57.
Title:	erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.
Author:	Lai, Guan-Hua\|Zhang, Zichen\|Shen, Xue-Ning\|Ward, Deanna J\|Dewitt, Jennifer L\|Holt, Shawn E\|Rozich, Rebecca A\|Hixson, Douglas C\|Sirica, Alphonse E
PMID:	16344070

8.
Journal:	Int J Oncol. 2006 Apr;28(4):915-21.
Title:	The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines.
Author:	Miyata, Hideki\|Sasaki, Tamito\|Kuwahara, Kenichi\|Serikawa, Masahiro\|Chayama, Kazuaki
PMID:	16525641

9.
Journal:	Clin Cancer Res. 2006 Mar 15;12(6):1680-5.
Title:	Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma.
Author:	Leone, Francesco\|Cavalloni, Giuliana\|Pignochino, Ymera\|Sarotto, Ivana\|Ferraris, Renato\|Piacibello, Wanda\|Venesio, Tiziana\|Capussotti, Lorenzo\|Risio, Mauro\|Aglietta, Massimo
PMID:	16551849

10.
Journal:	J Clin Invest. 2006 Jul;116(7):1843-52. Epub 2006 Jun 8.
Title:	Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Author:	Xu, Xiaoling\|Kobayashi, Shogo\|Qiao, Wenhui\|Li, Cuiling\|Xiao, Cuiying\|Radaeva, Svetlana\|Stiles, Bangyan\|Wang, Rui-Hong\|Ohara, Nobuya\|Yoshino, Tadashi\|LeRoith, Derek\|Torbenson, Michael S\|Gores, Gregory J\|Wu, Hong\|Gao, Bin\|Deng, Chu-Xia
PMID:	16767220

11.
Journal:	Anticancer Drugs. 2006 Aug;17(7):783-95.
Title:	Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib.
Author:	Wiedmann, Marcus\|Feisthammel, Jurgen\|Bluthner, Thilo\|Tannapfel, Andrea\|Kamenz, Thomas\|Kluge, Annett\|Mossner, Joachim\|Caca, Karel
PMID:	16926628

12.
Journal:	J Gastroenterol Hepatol. 2006 Nov;21(11):1744-51.
Title:	Akt expression may predict favorable prognosis in cholangiocarcinoma.
Author:	Javle, Milind M\|Yu, Jihnhee\|Khoury, Thaer\|Chadha, Krishdeep S\|Iyer, Renuka V\|Foster, Jason\|Kuvshinoff, Boris W\|Gibbs, John F\|Geradts, Joseph\|Black, Jennifer D\|Brattain, Michael G
PMID:	16984600

13.
Journal:	Cancer Res. 2007 Apr 15;67(8):3794-800.
Title:	Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model.
Author:	Wu, Qi\|Kiguchi, Kaoru\|Kawamoto, Toru\|Ajiki, Tetsuo\|Traag, Jeanine\|Carbajal, Steve\|Ruffino, Lynnsie\|Thames, Howard\|Wistuba, Ignacio\|Thomas, Melanie\|Vasquez, Karen M\|DiGiovanni, John
PMID:	17440093

14.
Journal:	World J Gastroenterol. 2007 Mar 14;13(10):1561-8.
Title:	Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
Author:	Leelawat, Kawin\|Leelawat, Surang\|Narong, Siriluck\|Hongeng, Suradej
PMID:	17461449

15.
Journal:	Mol Cancer Ther. 2007 Jun;6(6):1709-17.
Title:	Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice.
Author:	Kiguchi, Kaoru\|Ruffino, Lynnsie\|Kawamoto, Toru\|Franco, Eugenia\|Kurakata, Shin-ichi\|Fujiwara, Kosaku\|Hanai, Masaharu\|Rumi, Mohammad\|DiGiovanni, John
PMID:	17575102

16.
Journal:	Hepatogastroenterology. 2007 Jul-Aug;54(77):1339-44.
Title:	Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma.
Author:	Ailawadhi, Sikander\|Nagase, Hiroki\|Khoury, Thaer\|Yu, Jihnhee\|Tan, Dongfeng\|Black, Jennifer\|Brattain, Michael\|Javle, Milind
PMID:	17708250

17.
Journal:	World J Gastroenterol. 2007 Dec 28;13(48):6470-7.
Title:	AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.
Author:	Schmitz, K J\|Lang, H\|Wohlschlaeger, J\|Sotiropoulos, G C\|Reis, H\|Schmid, K W\|Baba, H A
PMID:	18161916

18.
Journal:	Hepatology. 2008 Apr;47(4):1178-90.
Title:	A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines.
Author:	Sirica, Alphonse E\|Zhang, Zichen\|Lai, Guan-Hua\|Asano, Toru\|Shen, Xue-Ning\|Ward, Deanna J\|Mahatme, Arvind\|Dewitt, Jennifer L
PMID:	18081149

19.
Journal:	Genes Chromosomes Cancer. 2008 May;47(5):363-7.
Title:	Rare PIK3CA hotspot mutations in carcinomas of the biliary tract.
Author:	Riener, Marc-Oliver\|Bawohl, Marion\|Clavien, Pierre-Alain\|Jochum, Wolfram
PMID:	18181165

20.
Journal:	Eur J Cancer. 2008 May;44(7):1048-56.
Title:	MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications.
Author:	Miyahara, Naoki\|Shoda, Junichi\|Ishige, Kazunori\|Kawamoto, Toru\|Ueda, Tetsuya\|Taki, Ryuuichi\|Ohkohchi, Nobuhiro\|Hyodo, Ichinosuke\|Thomas, Melanie B\|Krishnamurthy, Savitri\|Carraway, Kermit L\|Irimura, Tatsuro
PMID:	18397823

21.
Journal:	Clin Cancer Res. 2009 Jan 15;15(2):660-7.
Title:	The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Author:	Chung, Joon-Yong\|Hong, Seung-Mo\|Choi, Byeong Yeob\|Cho, Hyungjun\|Yu, Eunsil\|Hewitt, Stephen M
PMID:	19147772

22.
Journal:	Clin Cancer Res. 2009 Feb 15;15(4):1288-96.
Title:	Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin.
Author:	Pawar, Pritish\|Ma, Liping\|Byon, Chang Hyun\|Liu, Hui\|Ahn, Eun-Young\|Jhala, Nirag\|Arnoletti, Juan P\|McDonald, Jay M\|Chen, Yabing
PMID:	19228732

23.
Journal:	Gastroenterology. 2009 Sep;137(3):1138-50, 1150.e1-9.
Title:	ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma.
Author:	Lee, Mi-Jin\|Yu, Gyung-Ran\|Yoo, Hee-Jung\|Kim, Jong-Hyun\|Yoon, Byung-Il\|Choi, Yang-Kyu\|Kim, Dae-Ghon
PMID:	19376120

24.
Journal:	J Exp Clin Cancer Res. 2009 May 18;28:65.
Title:	Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
Author:	Li, Qinglong\|Yang, Zhulin
PMID:	19445727

25.
Journal:	Pathol Oncol Res. 2010 Sep;16(3):413-20.
Title:	Arsenic trioxide inhibits cholangiocarcinoma cell growth and induces apoptosis.
Author:	Zhong, Fei\|Zhang, Shineng\|Shao, Chunkui\|Yang, Jing\|Wu, Xiangyuan
PMID:	20012722

26.
Journal:	World J Gastroenterol. 2010 Jan 14;16(2):156-66.
Title:	Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance.
Author:	Wolf, Samuel\|Lorenz, Jana\|Mossner, Joachim\|Wiedmann, Marcus
PMID:	20066734

27.
Journal:	Cancer Invest. 2010 Feb;28(2):120-6.
Title:	T-cadherin modulates tumor-associated molecules in gallbladder cancer cells.
Author:	Adachi, Yoshihiro\|Takeuchi, Tamotsu\|Nagayama, Tomoko\|Furihata, Mutsuo
PMID:	20121546

28.
Journal:	World J Gastroenterol. 2010 Feb 14;16(6):713-22.
Title:	Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion.
Author:	Menakongka, Apaporn\|Suthiphongchai, Tuangporn
PMID:	20135719

29.
Journal:	J Cancer Res Clin Oncol. 2010 Oct;136(10):1537-44.
Title:	Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells.
Author:	Leelawat, Kawin\|Udomchaiprasertkul, Wandee\|Narong, Siriluck\|Leelawat, Surang
PMID:	20145951

30.
Journal:	Cancer Lett. 2010 Sep 28;295(2):252-9.
Title:	Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells.
Author:	Quan, Zhiwei\|Gu, Jun\|Dong, Ping\|Lu, Jianhua\|Wu, Xiangsong\|Wu, Wenguang\|Fei, Xiaozhou\|Li, Songgang\|Wang, Yong\|Wang, Jianwei\|Liu, Yingbin
PMID:	20359814

31.
Journal:	World J Gastroenterol. 2010 Aug 28;16(32):4047-54.
Title:	High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K.
Author:	Treekitkarnmongkol, Warapen\|Suthiphongchai, Tuangporn
PMID:	20731018

32.
Journal:	Ann Surg Oncol. 2011 Apr;18(4):1175-84.
Title:	Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells.
Author:	Okabe, Hirohisa\|Beppu, Toru\|Hayashi, Hiromitsu\|Ishiko, Takatoshi\|Masuda, Toshiro\|Otao, Ryu\|Horlad, Hasita\|Jono, Hirohumi\|Ueda, Mitsuharu\|Shinriki, Satoru\|Ando, Yukio\|Baba, Hideo
PMID:	21042948

33.
Journal:	J Gastroenterol. 2011 May;46(5):664-75.
Title:	Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
Author:	Namwat, N\|Puetkasichonpasutha, J\|Loilome, W\|Yongvanit, P\|Techasen, A\|Puapairoj, A\|Sripa, B\|Tassaneeyakul, W\|Khuntikeo, N\|Wongkham, S
PMID:	21076843

34.
Journal:	Biochem Biophys Res Commun. 2011 Feb 18;405(3):333-7.
Title:	Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2.
Author:	Yoon, Hyunho\|Min, Jeong-Ki\|Lee, Jung Whoi\|Kim, Dae-Ghon\|Hong, Hyo Jeong
PMID:	21130731

35.
Journal:	Oncol Rep. 2011 Apr;25(4):945-52.
Title:	The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo.
Author:	Jung, Juyeon\|Son, Yeon Sung\|Park, Hongryeol\|Jeon, Seong Kook\|Lee, Jung Whoi\|Choi, Song-Yi\|Kim, Jin-Man\|Kwon, Young-Guen\|Hong, Hyo Jeong\|Min, Jeong-Ki
PMID:	21318226

36.
Journal:	Carcinogenesis. 2011 Sep;32(9):1372-80.
Title:	Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.
Author:	Prakobwong, Suksanti\|Gupta, Subash C\|Kim, Ji Hye\|Sung, Bokyung\|Pinlaor, Porntip\|Hiraku, Yusuke\|Wongkham, Sopit\|Sripa, Banchob\|Pinlaor, Somchai\|Aggarwal, Bharat B
PMID:	21325634

37.
Journal:	Gastroenterology. 2011 Jun;140(7):2084-94.
Title:	Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression.
Author:	Lu, Dongdong\|Han, Chang\|Wu, Tong
PMID:	21354147

38.
Journal:	J Ethnopharmacol. 2011 Oct 11;137(3):1373-80.
Title:	Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin.
Author:	Dong, Ping\|Zhang, Yong\|Gu, Jun\|Wu, Wenguang\|Li, Maolan\|Yang, Jiahua\|Zhang, Lin\|Lu, Jianhua\|Mu, Jiasheng\|Chen, Lei\|Li, Songgang\|Wang, Jianwei\|Liu, Yingbin
PMID:	21855619

39.
Journal:	Anticancer Res. 2011 Oct;31(10):3289-99.
Title:	Polo-like kinase 1 inhibition as a new therapeutic modality in therapy of cholangiocarcinoma.
Author:	Thrum, Stephan\|Lorenz, Jana\|Mossner, Joachim\|Wiedmann, Marcus
PMID:	21965739

40.
Journal:	Parasitol Int. 2012 Mar;61(1):155-61.
Title:	Secreted Opisthorchis viverrini glutathione S-transferase regulates cell proliferation through AKT and ERK pathways in cholangiocarcinoma.
Author:	Daorueang, Daoyot\|Thuwajit, Peti\|Roitrakul, Sittiruk\|Laha, Thewarach\|Kaewkes, Sasithorn\|Endo, Yaeta\|Thuwajit, Chanitra
PMID:	21782971

41.
Journal:	Mod Pathol. 2012 Jan;25(1):131-9.
Title:	The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.
Author:	Lee, Dakeun\|Do, In-Gu\|Choi, Kyusam\|Sung, Chang Ohk\|Jang, Kee-Taek\|Choi, Dongwook\|Heo, Jin Seok\|Choi, Seoung Ho\|Kim, Jongmin\|Park, Jin Young\|Cha, Hyung Jin\|Joh, Jae-Won\|Choi, Kwan Yong\|Kim, Dae Shick
PMID:	21874010

42.
Journal:	Cancer Sci. 2012 Feb;103(2):252-61.
Title:	Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.
Author:	Ohashi, Hirokazu\|Adachi, Yasushi\|Yamamoto, Hiroyuki\|Taniguchi, Hiroaki\|Nosho, Katsuhiko\|Suzuki, Hiromu\|Arimura, Yoshiaki\|Imai, Kohzoh\|Carbone, David P\|Shinomura, Yasuhisa
PMID:	22044563

43.
Journal:	Gut. 2012 Feb;61(2):268-77.
Title:	Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism.
Author:	Frampton, Gabriel\|Invernizzi, Pietro\|Bernuzzi, Francesca\|Pae, Hae Yong\|Quinn, Matthew\|Horvat, Darijana\|Galindo, Cheryl\|Huang, Li\|McMillin, Matthew\|Cooper, Brandon\|Rimassa, Lorenza\|DeMorrow, Sharon
PMID:	22068162

44.
Journal:	Cancer Lett. 2012 Mar;316(1):70-6.
Title:	L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells.
Author:	Yoon, Hyunho\|Min, Jeong-Ki\|Lee, Dong Gwang\|Kim, Dae-Ghon\|Koh, Sang Seok\|Hong, Hyo Jeong
PMID:	22088438

45.
Journal:	Oncologist. 2012;17(1):72-9.
Title:	Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
Author:	Borger, Darrell R\|Tanabe, Kenneth K\|Fan, Kenneth C\|Lopez, Hector U\|Fantin, Valeria R\|Straley, Kimberly S\|Schenkein, David P\|Hezel, Aram F\|Ancukiewicz, Marek\|Liebman, Hannah M\|Kwak, Eunice L\|Clark, Jeffrey W\|Ryan, David P\|Deshpande, Vikram\|Dias-Santagata,
PMID:	22180306

46.
Journal:	Hepatology. 2012 Jun;55(6):1820-9.
Title:	Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways.
Author:	Chen, Qiang\|Li, Wenjiao\|Wan, Yunyan\|Xia, Xiaochun\|Wu, Qiao\|Chen, Yanling\|Lai, Zhide\|Yu, Chundong\|Li, Wengang
PMID:	22213475

47.
Journal:	Neoplasma. 2012;59(4):409-15.
Title:	Overexpression of ECM1 contributes to migration and invasion in cholangiocarcinoma cell.
Author:	Xiong, G P\|Zhang, J X\|Gu, S P\|Wu, Y B\|Liu, J F
PMID:	22489696

48.
Journal:	J Hepatol. 2012 Oct;57(4):813-20.
Title:	Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma.
Author:	Gentilini, Alessandra\|Rombouts, Krista\|Galastri, Sara\|Caligiuri, Alessandra\|Mingarelli, Eleonora\|Mello, Tommaso\|Marra, Fabio\|Mantero, Stefano\|Roncalli, Massimo\|Invernizzi, Pietro\|Pinzani, Massimo
PMID:	22727731

49.
Journal:	Tumour Biol. 2012 Oct;33(5):1785-802.
Title:	Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinoma.
Author:	Boonjaraspinyo, Sirintip\|Boonmars, Thidarut\|Wu, Zhiliang\|Loilome, Watcharin\|Sithithaworn, Paiboon\|Nagano, Isao\|Pinlaor, Somchai\|Yongvanit, Puangrat\|Nielsen, Phuangphaka Sadee\|Pairojkul, Chawalit\|Khuntikeo, Narong
PMID:	22733151

50.
Journal:	Int J Oncol. 2012 Sep;41(3):1110-8.
Title:	Periostin activates integrin alpha5beta1 through a PI3K/AKTdependent pathway in invasion of cholangiocarcinoma.
Author:	Utispan, Kusumawadee\|Sonongbua, Jumaporn\|Thuwajit, Peti\|Chau-In, Siri\|Pairojkul, Chawalit\|Wongkham, Sopit\|Thuwajit, Chanitra
PMID:	22735632

51.
Journal:	Cancer. 2013 Jan 15;119(2):293-303.
Title:	Gene expression-based chemical genomics identifies heat-shock protein 90 inhibitors as potential therapeutic drugs in cholangiocarcinoma.
Author:	Chen, Ming-Huang\|Lin, Kun-Ju\|Yang, Wu-Lung R\|Kao, Ya-Wen\|Chen, Tsung-Wen\|Chao, Shu-Chaou\|Chang, Peter Mu-Hsin\|Liu, Chun-Yu\|Tzeng, Cheng-Hwai\|Chao, Yee\|Chen, Ming-Han\|Yeh, Chun-Nan\|Huang, Chi-Ying F
PMID:	22810956

52.
Journal:	Clin Exp Metastasis. 2013 Feb;30(2):177-87.
Title:	Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma.
Author:	Hong, Sun Mi\|Park, Chang Wook\|Cha, Hyung Jin\|Kwon, Jung Hee\|Yun, Young Sung\|Lee, Nam Gyu\|Kim, Dae-Ghon\|Nam, Hong Gil\|Choi, Kwan Yong
PMID:	22875246

53.
Journal:	Int J Oncol. 2013 Feb;42(2):690-8.
Title:	Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma.
Author:	Yang, Wei\|Wang, Xiaoyuan\|Zheng, Wei\|Li, Kedong\|Liu, Haofeng\|Sun, Yueming
PMID:	23254774

54.
Journal:	Dig Dis Sci. 2013 Jun;58(6):1627-35.
Title:	A high level of integrin alpha6 expression in human intrahepatic cholangiocarcinoma cells is associated with a migratory and invasive phenotype.
Author:	Ding, Yan-bing\|Deng, Bin\|Huang, You-sheng\|Xiao, Wei-ming\|Wu, Jian\|Zhang, Yan-qing\|Wang, Yuan-zhi\|Wu, Da-cheng\|Lu, Guo-tao\|Wu, Ke-yan
PMID:	23306848

55.
Journal:	Dig Dis Sci. 2013 Jun;58(6):1636-43.
Title:	NK4 gene therapy inhibits HGF/Met-induced growth of human cholangiocarcinoma cells.
Author:	Ge, Xianxiu\|Wang, Youli\|Wang, Yun\|Li, Quanpeng\|Yu, Hong\|Miao, Lin
PMID:	23314853

56.
Journal:	Hepatology. 2013 Jun;57(6):2248-60.
Title:	Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis.
Author:	Cui, Xiang-Dan\|Lee, Mi-Jin\|Kim, Jong-Hyun\|Hao, Pei-Pei\|Liu, Lan\|Yu, Goung-Ran\|Kim, Dae-Ghon
PMID:	23315987

57.
Journal:	Gastroenterology. 2013 May;144(5):1055-65.
Title:	Akt and mTORC1 have different roles during liver tumorigenesis in mice.
Author:	Kenerson, Heidi L\|Yeh, Matthew M\|Kazami, Machiko\|Jiang, Xiuyun\|Riehle, Kimberly J\|McIntyre, Rebecca L\|Park, James O\|Kwon, Steve\|Campbell, Jean S\|Yeung, Raymond S
PMID:	23376645

58.
Journal:	Int J Cancer. 2013 Nov;133(9):2065-76.
Title:	Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma.
Author:	Ewald, Florian\|Grabinski, Nicole\|Grottke, Astrid\|Windhorst, Sabine\|Norz, Dominik\|Carstensen, Lisa\|Staufer, Katharina\|Hofmann, Bianca T\|Diehl, Frank\|David, Kerstin\|Schumacher, Udo\|Nashan, Bjorn\|Jucker, Manfred
PMID:	23588885

59.
Journal:	Anticancer Res. 2013 May;33(5):1861-6.
Title:	Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells.
Author:	Ono, Misaki\|Higuchi, Takako\|Takeshima, Mikako\|Chen, Chen\|Nakano, Shuji
PMID:	23645731

60.
Journal:	PLoS One. 2013 Apr 30;8(4):e62844.
Title:	Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling.
Author:	Liu, Juan\|Han, Guoqing\|Liu, Hui\|Qin, Chengyong
PMID:	23646150

61.
Journal:	Mol Cell Biol. 2013 Sep;33(17):3416-25.
Title:	Oncogenic activity of retinoic acid receptor gamma is exhibited through activation of the Akt/NF-kappaB and Wnt/beta-catenin pathways in cholangiocarcinoma.
Author:	Huang, Gui-Li\|Luo, Qi\|Rui, Gang\|Zhang, Wei\|Zhang, Qiu-Yan\|Chen, Qing-Xi\|Shen, Dong-Yan
PMID:	23798555

62.
Journal:	Tumour Biol. 2013 Dec;34(6):3519-28.
Title:	Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment.
Author:	Dokduang, Hasaya\|Juntana, Sirinun\|Techasen, Anchalee\|Namwat, Nisana\|Yongvanit, Puangrat\|Khuntikeo, Narong\|Riggins, Gregory J\|Loilome, Watcharin
PMID:	23812726

63.
Journal:	Tumour Biol. 2013 Dec;34(6):3637-48.
Title:	Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy.
Author:	Yothaisong, Supak\|Dokduang, Hasaya\|Techasen, Anchalee\|Namwat, Nisana\|Yongvanit, Puangrat\|Bhudhisawasdi, Vajarabhongsa\|Puapairoj, Anucha\|Riggins, Gregory J\|Loilome, Watcharin
PMID:	23832540

64.
Journal:	Onco Targets Ther. 2013 Oct 3;6:1373-84.
Title:	AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines.
Author:	Leal, Pamela\|Garcia, Patricia\|Sandoval, Alejandra\|Buchegger, Kurt\|Weber, Helga\|Tapia, Oscar\|Roa, Juan C
PMID:	24124380

65.
Journal:	PLoS One. 2013 Nov 28;8(11):e81347.
Title:	Down-regulation of Gab1 inhibits cell proliferation and migration in hilar cholangiocarcinoma.
Author:	Sang, Haiquan\|Li, Tingting\|Li, Hangyu\|Liu, Jingang
PMID:	24312291

66.
Journal:	Ann Surg Oncol. 2014 Feb;21(2):487-500.
Title:	Prognostic biomarkers in patients with resected cholangiocarcinoma: a systematic review and meta-analysis.
Author:	Ruys, Anthony T\|Groot Koerkamp, Bas\|Wiggers, Jimme K\|Klumpen, Heinz-Josef\|ten Kate, Fiebo J\|van Gulik, Thomas M
PMID:	24081803

67.
Journal:	Oncogene. 2014 Oct 16;33(42):4997-5005.
Title:	GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.
Author:	Chen, W-T\|Zhu, G\|Pfaffenbach, K\|Kanel, G\|Stiles, B\|Lee, A S
PMID:	24141775

68.
Journal:	Mod Pathol. 2014 May;27(5):665-74.
Title:	Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
Author:	Mikhitarian, Kaidi\|Pollen, Maressa\|Zhao, Zhiguo\|Shyr, Yu\|Merchant, Nipun B\|Parikh, Alexander\|Revetta, Frank\|Washington, M Kay\|Vnencak-Jones, Cindy\|Shi, Chanjuan
PMID:	24186143

69.
Journal:	Carcinogenesis. 2014 Mar;35(3):597-605.
Title:	CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils.
Author:	Zhou, Shao-Lai\|Dai, Zhi\|Zhou, Zheng-Jun\|Chen, Qing\|Wang, Zheng\|Xiao, Yong-Sheng\|Hu, Zhi-Qiang\|Huang, Xiao-Yong\|Yang, Guo-Huan\|Shi, Ying-Hong\|Qiu, Shuang-Jian\|Fan, Jia\|Zhou, Jian
PMID:	24293410

70.
Journal:	Cancer Res. 2014 Feb 15;74(4):1005-10.
Title:	Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma.
Author:	Guest, Rachel V\|Boulter, Luke\|Kendall, Timothy J\|Minnis-Lyons, Sarah E\|Walker, Robert\|Wigmore, Stephen J\|Sansom, Owen J\|Forbes, Stuart J
PMID:	24310400

71.
Journal:	Int J Clin Exp Pathol. 2014 Jan 15;7(2):521-8. eCollection 2014.
Title:	Potential biomarkers for sensitivity of gallbladder cancer cells to gemcitabine.
Author:	Yang, Chao\|Xu, Ming\|Shen, Huo-Jian\|Zhu, Hong-Yi\|Li, Fu\|He, Min\|Chen, Tao\|Wang, Jian\|Shi, Wei-Jin\|Ji, Fu
PMID:	24551272

72.
Journal:	World J Gastroenterol. 2014 Jan 21;20(3):755-73.
Title:	Epidermal growth factor upregulates Skp2/Cks1 and p27(kip1) in human extrahepatic cholangiocarcinoma cells.
Author:	Kim, Ja-Yeon\|Kim, Hong Joo\|Park, Jung Ho\|Park, Dong Il\|Cho, Yong Kyun\|Sohn, Chong Il\|Jeon, Woo Kyu\|Kim, Byung Ik\|Kim, Dong Hoon\|Chae, Seoung Wan\|Sohn, Jin Hee
PMID:	24574749

73.
Journal:	Oncol Rep. 2014 May;31(5):2063-70.
Title:	Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-kappaB pathways in human cholangiocarcinomas both in vitro and in vivo.
Author:	Xu, Dongsheng\|Ma, Yong\|Zhao, Baolei\|Li, Shuai\|Zhang, Yu\|Pan, Shangha\|Wu, Yaohua\|Wang, Jizhou\|Wang, Dawei\|Pan, Huayang\|Liu, Lianxin\|Jiang, Hongchi
PMID:	24603952

74.
Journal:	Oncotarget. 2014 Feb 28;5(4):894-900.
Title:	Role of aberrant PI3K pathway activation in gallbladder tumorigenesis.
Author:	Lunardi, Andrea\|Webster, Kaitlyn A\|Papa, Antonella\|Padmani, Bhavik\|Clohessy, John G\|Bronson, Roderick T\|Pandolfi, Pier Paolo
PMID:	24658595

75.
Journal:	Int J Mol Med. 2014 Jun;33(6):1431-40.
Title:	TNF-alpha promotes gallbladder cancer cell growth and invasion through autocrine mechanisms.
Author:	Zhu, Guangwei\|Du, Qiang\|Wang, Xiaoqian\|Tang, Nanhong\|She, Feifei\|Chen, Yanling
PMID:	24676340

76.
Journal:	Hepatology. 2014 Sep;60(3):908-18.
Title:	Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2.
Author:	Liu, Runping\|Zhao, Renping\|Zhou, Xiqiao\|Liang, Xiuyin\|Campbell, Deanna J W\|Zhang, Xiaoxuan\|Zhang, Luyong\|Shi, Ruihua\|Wang, Guangji\|Pandak, William M\|Sirica, Alphonse E\|Hylemon, Phillip B\|Zhou, Huiping
PMID:	24700501

77.
Journal:	Mol Cancer. 2014 Apr 13;13:82.
Title:	Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo.
Author:	Weng, Mingzhe\|Gong, Wei\|Ma, Mingzhe\|Chu, Bingfeng\|Qin, Yiyu\|Zhang, Mingdi\|Lun, Xueqing\|McFadden, Grant\|Forsyth, Peter\|Yang, Yong\|Quan, Zhiwei
PMID:	24725816

78.
Journal:	Oncotarget. 2014 May 15;5(9):2372-89.
Title:	Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma.
Author:	Chen, Ming-Huang\|Chiang, Kun-Chun\|Cheng, Chi-Tung\|Huang, Shih-Chiang\|Chen, Yeng-Yang\|Chen, Tsung-Wen\|Yeh, Ta-Sen\|Jan, Yi-Yin\|Wang, Hsi-Ming\|Weng, Jiang-Jie\|Chang, Peter Mu-Hsin\|Liu, Chun-Yu\|Li, Chung-Pin\|Chao, Yee\|Chen, Ming-Han\|Huang, Chi-Ying F\|Yeh, Chu
PMID:	24796583

79.
Journal:	J Clin Invest. 2014 Jul;124(7):3241-51.
Title:	Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
Author:	Li, Jun\|Razumilava, Nataliya\|Gores, Gregory J\|Walters, Stephanie\|Mizuochi, Tatsuki\|Mourya, Reena\|Bessho, Kazuhiko\|Wang, Yui-Hsi\|Glaser, Shannon S\|Shivakumar, Pranavkumar\|Bezerra, Jorge A
PMID:	24892809

80.
Journal:	J Hepatobiliary Pancreat Sci. 2014 Oct;21(10):754-60.
Title:	Molecular mechanism of cholangiocarcinoma carcinogenesis.
Author:	Maemura, Kosei\|Natsugoe, Shoji\|Takao, Sonshin
PMID:	24895231

81.
Journal:	Cell Biochem Biophys. 2014 Nov;70(2):1337-42.
Title:	Phenoxodiol enhances the antitumor activity of gemcitabine in gallbladder cancer through suppressing Akt/mTOR pathway.
Author:	Li, Yu\|Huang, Xiaoqiang\|Huang, Zhiqiang\|Feng, Jian
PMID:	24902539

82.
Journal:	Invest New Drugs. 2014 Dec;32(6):1144-54.
Title:	Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors.
Author:	Ewald, Florian\|Norz, Dominik\|Grottke, Astrid\|Hofmann, Bianca T\|Nashan, Bjorn\|Jucker, Manfred
PMID:	25152244

83.
Journal:	Oncol Rep. 2014 Nov;32(5):1796-802.
Title:	Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications.
Author:	Miyahara, Naoki\|Shoda, Junichi\|Kawamoto, Toru\|Ishida, Hiroyasu\|Ueda, Tetsuya\|Akimoto, Yoshihiro\|Kawakami, Hayato\|Irimura, Tatsuro
PMID:	25174601

84.
Journal:	Semin Liver Dis. 2014 Nov;34(4):456-64.
Title:	Cholangiocarcinoma: molecular pathways and therapeutic opportunities.
Author:	Rizvi, Sumera\|Borad, Mitesh J\|Patel, Tushar\|Gores, Gregory J
PMID:	25369307

85.
Journal:	Exp Mol Pathol. 2014 Dec;97(3):515-24.
Title:	Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.
Author:	Sirica, Alphonse E\|Almenara, Jorge A\|Li, Chao
PMID:	25446840

86.
Journal:	Dig Liver Dis. 2015 Jan;47(1):62-7.
Title:	Recruited metastasis suppressor NM23-H2 attenuates expression and activity of peroxisome proliferator-activated receptor delta (PPARdelta) in human cholangiocarcinoma.
Author:	He, Fang\|York, J Philippe\|Burroughs, Sherilyn Gordon\|Qin, Lidong\|Xia, Jintang\|Chen, De\|Quigley, Eamonn M\|Webb, Paul\|LeSage, Gene D\|Xia, Xuefeng
PMID:	25277864

87.
Journal:	Hepatology. 2015 May;61(5):1627-42.
Title:	IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism.
Author:	Yamada, Daisaku\|Rizvi, Sumera\|Razumilava, Nataliya\|Bronk, Steven F\|Davila, Jaime I\|Champion, Mia D\|Borad, Mitesh J\|Bezerra, Jorge A\|Chen, Xin\|Gores, Gregory J
PMID:	25580681

88.
Journal:	Mol Cancer. 2015 Jan 27;14:12.
Title:	SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway.
Author:	Shu, Yi-Jun\|Weng, Hao\|Ye, Yuan-Yuan\|Hu, Yun-Ping\|Bao, Run-Fa\|Cao, Yang\|Wang, Xu-An\|Zhang, Fei\|Xiang, Shan-Shan\|Li, Huai-Feng\|Wu, Xiang-Song\|Li, Mao-Lan\|Jiang, Lin\|Lu, Wei\|Han, Bao-San\|Jie, Zhi-Gang\|Liu, Ying-Bin
PMID:	25623055

89.
Journal:	Cancer Treat Rev. 2015 Mar;41(3):222-34.
Title:	Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy.
Author:	Bizama, Carolina\|Garcia, Patricia\|Espinoza, Jaime A\|Weber, Helga\|Leal, Pamela\|Nervi, Bruno\|Roa, Juan Carlos
PMID:	25639632

90.
Journal:	Cancer Lett. 2015 May 1;360(2):141-50.
Title:	Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer.
Author:	Cao, Yang\|Liu, Xiyong\|Lu, Wei\|Chen, Yuanyuan\|Wu, Xiangsong\|Li, Maolan\|Wang, Xu-An\|Zhang, Fei\|Jiang, Lin\|Zhang, Yijian\|Hu, Yunping\|Xiang, Shanshan\|Shu, Yijun\|Bao, Runfa\|Li, Huaifeng\|Wu, Wenguang\|Weng, Hao\|Yen, Yun\|Liu, Yingbin
PMID:	25657110

91.
Journal:	Br J Cancer. 2015 Mar 17;112(6):1042-51.
Title:	Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer.
Author:	Zuo, M\|Rashid, A\|Churi, C\|Vauthey, J-N\|Chang, P\|Li, Y\|Hung, M-C\|Li, D\|Javle, M
PMID:	25742482

92.
Journal:	Oncotarget. 2015 Aug 7;6(22):19148-62.
Title:	Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer.
Author:	Qiu, Yinghe\|Li, Xiaoya\|Yi, Bin\|Zheng, Junnian\|Peng, Zhangxiao\|Zhang, Zhihan\|Wu, Mengchao\|Shen, Feng\|Su, Changqing
PMID:	25895131

93.
Journal:	Tumour Biol. 2015 Nov;36(11):8367-77.
Title:	Gab1 regulates proliferation and migration through the PI3K/Akt signaling pathway in intrahepatic cholangiocarcinoma.
Author:	Sang, Haiquan\|Li, Tingting\|Li, Hangyu\|Liu, Jingang
PMID:	26014518

94.
Journal:	Cell Host Microbe. 2015 Jun 10;17(6):763-74.
Title:	Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.
Author:	Scanu, Tiziana\|Spaapen, Robbert M\|Bakker, Jeroen M\|Pratap, Chandra Bhan\|Wu, Lin-en\|Hofland, Ingrid\|Broeks, Annegien\|Shukla, Vijay Kumar\|Kumar, Mohan\|Janssen, Hans\|Song, Ji-Ying\|Neefjes-Borst, E Andra\|te Riele, Hein\|Holden, David W\|Nath, Gopal\|Neefjes, Jac
PMID:	26028364

95.
Journal:	Oncotarget. 2015 Sep 15;6(27):23594-608.
Title:	Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma.
Author:	Chen, Ming-Huang\|Yen, Chueh-Chuan\|Cheng, Chi-Tung\|Wu, Ren-Chin\|Huang, Shih-Chiang\|Yu, Chung-Shan\|Chung, Yi-Hsiu\|Liu, Chun-Yu\|Chang, Peter Mu-Hsin\|Chao, Yee\|Chen, Ming-Han\|Chen, Yu-Fen\|Chiang, Kun-Chun\|Yeh, Ta-Sen\|Chen, Tzu Chi\|Huang, Chi-Ying F\|Yeh, Chun-
PMID:	26090720

96.
Journal:	Cancer Biol Ther. 2015;16(10):1462-70.
Title:	Zinc finger X-chromosomal protein (ZFX) is a significant prognostic indicator and promotes cellular malignant potential in gallbladder cancer.
Author:	Weng, Hao\|Wang, Xu'an\|Li, Maolan\|Wu, Xiangsong\|Wang, Zheng\|Wu, Wenguang\|Zhang, Zhou\|Zhang, Yijian\|Zhao, Shuai\|Liu, Shibo\|Mu, Jiasheng\|Cao, Yang\|Shu, Yijun\|Bao, Runfa\|Zhou, Jian\|Lu, Jianhua\|Dong, Ping\|Gu, Jun\|Liu, Yingbin
PMID:	26230915

97.
Journal:	Biochem Biophys Res Commun. 2015 Sep 18;465(2):262-9.
Title:	MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.
Author:	Xiong, Xinkui\|Sun, Daoyi\|Chai, Hao\|Shan, Wengang\|Yu, Yue\|Pu, Liyong\|Cheng, Feng
PMID:	26255969

98.
Journal:	PLoS One. 2015 Aug 19;10(8):e0136193.
Title:	Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling.
Author:	Zhang, Peng\|Guo, Zhiyong\|Wu, Ying\|Hu, Ronglin\|Du, Jun\|He, Xiaoshun\|Jiao, Xingyuan\|Zhu, Xiaofeng
PMID:	26287365

99.
Journal:	Diagn Pathol. 2015 Aug 21;10:148.
Title:	Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer.
Author:	Roa, Ivan\|de Toro, Gonzalo\|Fernandez, Fernanda\|Game, Anakaren\|Munoz, Sergio\|de Aretxabala, Xabier\|Javle, Milind
PMID:	26294099

100.
Journal:	BMC Cancer. 2015 Nov 16;15:903.
Title:	Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer.
Author:	Wu, Cheng-Lin\|Chao, Ying-Jui\|Yang, Ta-Ming\|Chen, Yi-Ling\|Chang, Kung-Chao\|Hsu, Hui-Ping\|Shan, Yan-Shen\|Lai, Ming-Derg
PMID:	26572077

101.
Journal:	Int J Clin Exp Med. 2015 Oct 15;8(10):17781-8. eCollection 2015.
Title:	Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells.
Author:	Chen, Yueguang\|Lian, Peilong\|Liu, Yanfeng\|Xu, Kesen
PMID:	26770369

102.
Journal:	Int J Clin Exp Pathol. 2015 Nov 1;8(11):14028-33. eCollection 2015.
Title:	Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.
Author:	Xie, Kun\|Nian, Jianze\|Zhu, Xingyang\|Geng, Xiaoping\|Liu, Fubao
PMID:	26823715

103.
Journal:	Cytotechnology. 2016 Jan;68(1):123-33.
Title:	Lupeol induces apoptosis and inhibits invasion in gallbladder carcinoma GBC-SD cells by suppression of EGFR/MMP-9 signaling pathway.
Author:	Liu, Yan\|Bi, Tingting\|Shen, Genhai\|Li, Zhimin\|Wu, Guoliang\|Wang, Zheng\|Qian, Liqiang\|Gao, Quangen
PMID:	25037728

104.
Journal:	Gut. 2016 Oct;65(10):1765-75.
Title:	LTbetaR signalling preferentially accelerates oncogenic AKT-initiated liver tumours.
Author:	Scarzello, Anthony J\|Jiang, Qun\|Back, Timothy\|Dang, Hien\|Hodge, Deborah\|Hanson, Charlotte\|Subleski, Jeffrey\|Weiss, Jonathan M\|Stauffer, Jimmy K\|Chaisaingmongkol, Jitti\|Rabibhadana, Siritida\|Ruchirawat, Mathuros\|Ortaldo, John\|Wang, Xin Wei\|Norris, Paula S\|
PMID:	26206664

105.
Journal:	Gut Liver. 2016 Mar;10(2):310-7.
Title:	Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells.
Author:	Lee, Jin\|Hong, Eun Mi\|Jang, Ju Ah\|Park, Se Woo\|Koh, Dong Hee\|Choi, Min Ho\|Jang, Hyun Joo\|Kae, Sea Hyub
PMID:	26470769

106.
Journal:	Tumour Biol. 2016 Jul;37(7):9451-63.
Title:	YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma.
Author:	Thongsom, Sunisa\|Chaocharoen, Wethaka\|Silsirivanit, Atit\|Wongkham, Sopit\|Sripa, Banchob\|Choe, Han\|Suginta, Wipa\|Talabnin, Chutima
PMID:	26781979

107.
Journal:	Cancer Lett. 2016 Mar 28;372(2):239-50.
Title:	LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway.
Author:	Li, ZhiZhen\|Chen, YuanYuan\|Wang, XuAn\|Zhang, HongChen\|Zhang, Yijian\|Gao, YaoHui\|Weng, Mingzhe\|Wang, Lei\|Liang, HaiBin\|Li, MaoLan\|Zhang, Fei\|Zhao, Shuai\|Liu, Shibo\|Cao, Yang\|Shu, Yijun\|Bao, Runfa\|Zhou, Jian\|Liu, Xiyong\|Yan, Yun\|Zhen, Lei\|Dong, Qian\|Liu, Yi
PMID:	26797416

108.
Journal:	World J Gastroenterol. 2016 Feb 14;22(6):2071-80.
Title:	Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
Author:	Ding, Ning\|Che, Li\|Li, Xiao-Lei\|Liu, Yan\|Jiang, Li-Jie\|Fan, Biao\|Tao, Jun-Yan\|Chen, Xin\|Ji, Jia-Fu
PMID:	26877611

109.
Journal:	Hepatology. 2016 Jun;63(6):1900-13.
Title:	Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.
Author:	Li, Lei\|Che, Li\|Tharp, Kevin M\|Park, Hyo-Min\|Pilo, Maria G\|Cao, Dan\|Cigliano, Antonio\|Latte, Gavinella\|Xu, Zhong\|Ribback, Silvia\|Dombrowski, Frank\|Evert, Matthias\|Gores, Gregory J\|Stahl, Andreas\|Calvisi, Diego F\|Chen, Xin
PMID:	26910791

110.
Journal:	Oncotarget. 2016 Apr 5;7(14):17751-9.
Title:	CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation.
Author:	Li, Chen\|Wang, Cong\|Xing, Yang\|Zhen, Jiaojiao\|Ai, Zhilong
PMID:	26910892

111.
Journal:	Int J Oncol. 2016 May;48(5):2025-34.
Title:	Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Author:	Muller, Alena\|Barat, Samarpita\|Chen, Xi\|Bui, Khac Cuong\|Bozko, Przemyslaw\|Malek, Nisar P\|Plentz, Ruben R
PMID:	26935541

112.
Journal:	J Mol Diagn. 2016 May;18(3):388-394.
Title:	Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer: Additional Options for an Orphan Cancer.
Author:	Roa, Ivan\|Garcia, Hernan\|Game, Anakaren\|de Toro, Gonzalo\|de Aretxabala, Xabier\|Javle, Milind
PMID:	26947513

113.
Journal:	Cancer Lett. 2016 May 28;375(1):179-89.
Title:	A novel PI3K/AKT signaling axis mediates Nectin-4-induced gallbladder cancer cell proliferation, metastasis and tumor growth.
Author:	Zhang, Yijian\|Liu, Shibo\|Wang, Lei\|Wu, Yaoshi\|Hao, Jiaqi\|Wang, Zheng\|Lu, Wei\|Wang, Xu-An\|Zhang, Fei\|Cao, Yang\|Liang, Haibin\|Li, Huaifeng\|Ye, Yuanyuan\|Ma, Qiang\|Zhao, Shuai\|Shu, Yijun\|Bao, Runfa\|Jiang, Lin\|Hu, Yunping\|Zhou, Jian\|Chen, Lei\|Liu, Yingbin
PMID:	26949052

114.
Journal:	Oncotarget. 2016 Mar 29;7(13):17220-9.
Title:	Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma.
Author:	Peng, Hong\|Zhang, Qiuyang\|Li, Jiali\|Zhang, Ning\|Hua, Yunpeng\|Xu, Lixia\|Deng, Yubin\|Lai, Jiaming\|Peng, Zhenwei\|Peng, Baogang\|Chen, Minhu\|Peng, Sui\|Kuang, Ming
PMID:	26967384

115.
Journal:	Pathology. 2016 Jan;48(1):35-40.
Title:	EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma.
Author:	Moon, Ahrim\|Chin, Susie\|Kim, Hee Kyung\|Kwak, Jeong Ja\|Koh, Eun Suk\|Kim, Youn Wha\|Jang, Kee-Taek
PMID:	27020207

116.
Journal:	Cancer Lett. 2016 Jun 28;376(1):197-198.
Title:	Corrigendum to .
Author:	Li, ZhiZhen\|Chen, YuanYuan\|Wang, XuAn\|Zhang, HongChen\|Zhang, Yijian\|Gao, YaoHui\|Weng, Mingzhe\|Wang, Lei\|Liang, HaiBin\|Li, MaoLan\|Zhang, Fei\|Zhao, Shuai\|Liu, Shibo\|Cao, Yang\|Shu, Yijun\|Bao, Runfa\|Zhou, Jian\|Liu, Xiyong\|Yan, Yun\|Zhen, Lei\|Dong, Qian\|Liu, Yi
PMID:	27125425

117.
Journal:	J Exp Clin Cancer Res. 2016 Jun 18;35(1):97.
Title:	The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Author:	Zhao, Shuai\|Cao, Yang\|Liu, Shi-Bo\|Wang, Xu-An\|Bao, Run-Fa\|Shu, Yi-Jun\|Hu, Yun-Ping\|Zhang, Yi-Jian\|Jiang, Lin\|Zhang, Fei\|Liang, Hai-Bin\|Li, Huai-Feng\|Ma, Qiang\|Xu, Yi\|Wang, Zheng\|Zhang, Yi-Chi\|Chen, Lei\|Zhou, Jian\|Liu, Ying-Bin
PMID:	27317099

118.
Journal:	Epigenetics. 2016 Nov;11(11):780-790. Epub 2016 Sep 3.
Title:	Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma.
Author:	Goeppert, Benjamin\|Ernst, Christina\|Baer, Constance\|Roessler, Stephanie\|Renner, Marcus\|Mehrabi, Arianeb\|Hafezi, Mohammadreza\|Pathil, Anita\|Warth, Arne\|Stenzinger, Albrecht\|Weichert, Wilko\|Bahr, Marion\|Will, Rainer\|Schirmacher, Peter\|Plass, Christoph\|Weich
PMID:	27593557

119.
Journal:	Onco Targets Ther. 2016 Aug 24;9:5297-305.
Title:	Knockdown of Sall4 inhibits intrahepatic cholangiocarcinoma cell migration and invasion in ICC-9810 cells.
Author:	Zhu, Lei\|Huang, Feizhou\|Deng, Gang\|Nie, Wanpin\|Huang, Wei\|Xu, Hongbo\|Zheng, Shaopeng\|Yi, Zhongjie\|Wan, Tao
PMID:	27601921

120.
Journal:	PLoS One. 2016 Sep 14;11(9):e0162594.
Title:	Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation.
Author:	Hall, Terence G\|Yu, Yi\|Eathiraj, Sudharshan\|Wang, Yunxia\|Savage, Ronald E\|Lapierre, Jean-Marc\|Schwartz, Brian\|Abbadessa, Giovanni
PMID:	27627808

121.
Journal:	Oncotarget. 2016 Nov 8;7(45):72833-72844.
Title:	Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway.
Author:	Shen, Sheng\|Liu, Han\|Wang, Yueqi\|Wang, Jiwen\|Ni, Xiaolin\|Ai, Zhilong\|Pan, Hongtao\|Liu, Houbao\|Shao, Yebo
PMID:	27637083

122.
Journal:	Oncotarget. 2016 Nov 15;7(46):75210-75220.
Title:	Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway.
Author:	Liu, Long-Zi\|He, Yi-Zhou\|Dong, Ping-Ping\|Ma, Li-Jie\|Wang, Zhi-Chao\|Liu, Xin-Yang\|Duan, Meng\|Yang, Liu-Xiao\|Shi, Jie-Yi\|Zhou, Jian\|Fan, Jia\|Gao, Qiang\|Wang, Xiao-Ying
PMID:	27655691

123.
Journal:	Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12250-12255. Epub 2016 Oct 10.
Title:	Notch3 drives development and progression of cholangiocarcinoma.
Author:	Guest, Rachel V\|Boulter, Luke\|Dwyer, Benjamin J\|Kendall, Timothy J\|Man, Tak-Yung\|Minnis-Lyons, Sarah E\|Lu, Wei-Yu\|Robson, Andrew J\|Gonzalez, Sofia Ferreira\|Raven, Alexander\|Wojtacha, Davina\|Morton, Jennifer P\|Komuta, Mina\|Roskams, Tania\|Wigmore, Stephen J
PMID:	27791012

124.
Journal:	Am J Transl Res. 2016 Oct 15;8(10):4068-4081. eCollection 2016.
Title:	Upregulation of long non-coding RNA LINC00152 by SP1 contributes to gallbladder cancer cell growth and tumor metastasis via PI3K/AKT pathway.
Author:	Cai, Qiang\|Wang, Zhen-Qiang\|Wang, Shou-Hua\|Li, Chen\|Zhu, Zheng-Gang\|Quan, Zhi-Wei\|Zhang, Wen-Jie
PMID:	27829993

125.
Journal:	Oncogenesis. 2016 Dec 5;5(12):e274.
Title:	Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans.
Author:	Che, L\|Fan, B\|Pilo, M G\|Xu, Z\|Liu, Y\|Cigliano, A\|Cossu, A\|Palmieri, G\|Pascale, R M\|Porcu, A\|Vidili, G\|Serra, M\|Dombrowski, F\|Ribback, S\|Calvisi, D F\|Chen, X
PMID:	27918553

126.
Journal:	Mol Cancer Ther. 2017 Feb;16(2):344-356.
Title:	Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Author:	Talbert, Erin E\|Yang, Jennifer\|Mace, Thomas A\|Farren, Matthew R\|Farris, Alton B\|Young, Gregory S\|Elnaggar, Omar\|Che, Zheng\|Timmers, Cynthia D\|Rajasekera, Priyani\|Maskarinec, Jennifer M\|Bloomston, Mark\|Bekaii-Saab, Tanios\|Guttridge, Denis C\|Lesinski, Grego
PMID:	27811010

127.
Journal:	Oncotarget. 2017 Jan 17;8(3):5349-5360.
Title:	Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing.
Author:	Feng, Feiling\|Cheng, Qingbao\|Yang, Liang\|Zhang, Dadong\|Ji, Shunlong\|Zhang, Qiangzu\|Lin, Yihui\|Li, Fugen\|Xiong, Lei\|Liu, Chen\|Jiang, Xiaoqing
PMID:	28029662

128.
Journal:	Biol Pharm Bull. 2017 Apr 1;40(4):495-503.
Title:	Growth Inhibition of Refractory Human Gallbladder Cancer Cells by Retinol, and Its Mechanism of Action.
Author:	Li, Chuan\|Imai, Masahiko\|Hasegawa, Shinya\|Yamasaki, Masahiro\|Takahashi, Noriko
PMID:	28100868

129.
Journal:	Hepatology. 2017 Jun;65(6):2005-2018.
Title:	The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.
Author:	Wang, Yongqing\|Aoki, Hiroaki\|Yang, Jing\|Peng, Kesong\|Liu, Runping\|Li, Xiaojiaoyang\|Qiang, Xiaoyan\|Sun, Lixin\|Gurley, Emily C\|Lai, Guanhua\|Zhang, Luyong\|Liang, Guang\|Nagahashi, Masayuki\|Takabe, Kazuaki\|Pandak, William M\|Hylemon, Phillip B\|Zhou, Huiping
PMID:	28120434

130.
Journal:	Oncotarget. 2017 Feb 28;8(9):15775-15788.
Title:	Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.
Author:	Wang, Yueqi\|Gao, Zhihui\|Zhang, Dexiang\|Bo, Xiaobo\|Wang, Yaojie\|Wang, Jiwen\|Shen, Sheng\|Liu, Han\|Suo, Tao\|Pan, Hongtao\|Ai, Zhilong\|Liu, Houbao
PMID:	28178656

131.
Journal:	Oncotarget. 2017 Mar 21;8(12):19980-19996.
Title:	SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling.
Author:	Qin, Yiyu\|Meng, Li\|Fu, Yang\|Quan, Zhiwei\|Ma, Mingzhe\|Weng, Mingzhe\|Zhang, Zhengdong\|Gao, Cuixiang\|Shi, Xinghua\|Han, Koulan
PMID:	28212545

132.
Journal:	Mol Cancer Ther. 2017 Jun;16(6):1145-1154.
Title:	Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition.
Author:	Jin, Mei Hua\|Nam, Ah-Rong\|Park, Ji Eun\|Bang, Ju-Hee\|Bang, Yung-Jue\|Oh, Do-Youn
PMID:	28223426

133.
Journal:	Cancer Sci. 2017 Jun;108(6):1240-1252.
Title:	Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells.
Author:	Liu, Yongchen\|Wang, Zheng\|Li, Maolan\|Ye, Yuanyuan\|Xu, Yi\|Zhang, Yichi\|Yuan, Ruiyan\|Jin, Yunpeng\|Hao, Yajuan\|Jiang, Lin\|Hu, Yunping\|Chen, Shili\|Liu, Fatao\|Zhang, Yijian\|Wu, Wenguang\|Liu, Yingbin
PMID:	28378944

134.
Journal:	Oncotarget. 2017 Apr 18;8(16):26169-26184.
Title:	Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.
Author:	Weber, Helga\|Valbuena, Jose R\|Barbhuiya, Mustafa A\|Stein, Stefan\|Kunkel, Hana\|Garcia, Patricia\|Bizama, Carolina\|Riquelme, Ismael\|Espinoza, Jaime A\|Kurtz, Stephen E\|Tyner, Jeffrey W\|Calderon, Juan Francisco\|Corvalan, Alejandro H\|Grez, Manuel\|Pandey, Akhile
PMID:	28412732

135.
Journal:	Oncotarget. 2017 Jul 18;8(29):47052-47063.
Title:	TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.
Author:	Li, Xinxing\|Teng, Shifeng\|Zhang, Yanyan\|Zhang, Weigang\|Zhang, Xianwen\|Xu, Kai\|Yao, Houshan\|Yao, Jun\|Wang, Haolu\|Liang, Xiaowen\|Hu, Zhiqian
PMID:	28423362

136.
Journal:	Oncol Lett. 2017 Mar;13(3):1432-1436.
Title:	Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo.
Author:	Dana, Paweena\|Vaeteewoottacharn, Kulthida\|Kariya, Ryusho\|Matsuda, Kouki\|Wongkham, Sopit\|Okada, Seiji
PMID:	28454273

137.
Journal:	Mol Oncol. 2017 Sep;11(9):1130-1142.
Title:	K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
Author:	Yeung, Yvonne\|Lau, David K\|Chionh, Fiona\|Tran, Hoanh\|Tse, Janson W T\|Weickhardt, Andrew J\|Nikfarjam, Mehrdad\|Scott, Andrew M\|Tebbutt, Niall C\|Mariadason, John M
PMID:	28544747

138.
Journal:	Cell Death Dis. 2017 Jun 8;8(6):e2868.
Title:	EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway.
Author:	Zhang, Fei\|Xiang, Shanshan\|Cao, Yang\|Li, Maolan\|Ma, Qiang\|Liang, Haibin\|Li, Huaifeng\|Ye, Yuanyuan\|Zhang, Yijian\|Jiang, Lin\|Hu, Yunping\|Zhou, Jian\|Wang, Xuefeng\|Zhang, Yong\|Nie, Lei\|Liang, Xiao\|Gong, Wei\|Liu, Yingbin
PMID:	28594409

139.
Journal:	Cancer Cell. 2017 Jun 12;31(6):771-789.e6.
Title:	Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.
Author:	Yuan, Detian\|Huang, Shan\|Berger, Emanuel\|Liu, Lei\|Gross, Nina\|Heinzmann, Florian\|Ringelhan, Marc\|Connor, Tracy O\|Stadler, Mira\|Meister, Michael\|Weber, Julia\|Ollinger, Rupert\|Simonavicius, Nicole\|Reisinger, Florian\|Hartmann, Daniel\|Meyer, Rudiger\|Reich, Ma
PMID:	28609656

140.
Journal:	Int J Biol Sci. 2017 Jun 1;13(6):782-793.
Title:	Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling.
Author:	Song, Xiaoling\|Wang, Zheng\|Liang, Haibin\|Zhang, Wenjie\|Ye, Yuanyuan\|Li, HuaiFeng\|Hu, Yunping\|Zhang, Yijian\|Weng, Hao\|Lu, Jianhua\|Wang, Xuefeng\|Li, Maolan\|Liu, Yingbin\|Gu, Jun
PMID:	28656003

141.
Journal:	Drug Des Devel Ther. 2017 Jun 15;11:1753-1766.
Title:	Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkappaB pathways in cholangiocarcinoma cells.
Author:	Ke, Fayong\|Wang, Zheng\|Song, Xiaoling\|Ma, Qiang\|Hu, Yunping\|Jiang, Lin\|Zhang, Yijian\|Liu, Yingbin\|Zhang, Yong\|Gong, Wei
PMID:	28670110

142.
Journal:	World J Gastroenterol. 2017 Jun 21;23(23):4311-4316.
Title:	Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation.
Author:	Bian, Ji-Lai\|Wang, Mei-Mei\|Tong, En-Juan\|Sun, Jing\|Li, Ming\|Miao, Zhi-Bo\|Li, Yan-Lin\|Zhu, Bai-Hong\|Xu, Jia-Jia
PMID:	28694672

143.
Journal:	Pathol Res Pract. 2017 Aug;213(8):1010-1013.
Title:	Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components.
Author:	Galuppini, Francesca\|Salmaso, Roberta\|Valentini, Elisa\|Lanza, Cristiano\|Maretto, Isacco\|Nitti, Donato\|Rugge, Massimo\|Fassan, Matteo
PMID:	28698100

144.
Journal:	J Hepatol. 2017 Dec;67(6):1194-1203.
Title:	Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.
Author:	Zhang, Shanshan\|Song, Xinhua\|Cao, Dan\|Xu, Zhong\|Fan, Biao\|Che, Li\|Hu, Junjie\|Chen, Bin\|Dong, Mingjie\|Pilo, Maria G\|Cigliano, Antonio\|Evert, Katja\|Ribback, Silvia\|Dombrowski, Frank\|Pascale, Rosa M\|Cossu, Antonio\|Vidili, Gianpaolo\|Porcu, Alberto\|Simile, Mar
PMID:	28733220

145.
Journal:	Int J Oncol. 2017 Sep;51(3):823-831.
Title:	Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway.
Author:	Hao, Jiaqi\|Yang, Ziyi\|Wang, Lei\|Zhang, Yijian\|Shu, Yijun\|Jiang, Lin\|Hu, Yunping\|Lv, Wenjie\|Dong, Ping\|Liu, Yingbin
PMID:	28766687

146.
Journal:	EMBO Rep. 2017 Oct;18(10):1837-1853.
Title:	LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.
Author:	Wu, Xiang-Song\|Wang, Fang\|Li, Huai-Feng\|Hu, Yun-Ping\|Jiang, Lin\|Zhang, Fei\|Li, Mao-Lan\|Wang, Xu-An\|Jin, Yun-Peng\|Zhang, Yi-Jian\|Lu, Wei\|Wu, Wen-Guang\|Shu, Yi-Jun\|Weng, Hao\|Cao, Yang\|Bao, Run-Fa\|Liang, Hai-Bin\|Wang, Zheng\|Zhang, Yi-Chi\|Gong, Wei\|Zheng, Lei
PMID:	28887321

147.
Journal:	Int J Mol Med. 2017 Oct;40(4):1143-1151.
Title:	Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma.
Author:	Zhu, Xingyang\|Song, Xiaoling\|Xie, Kun\|Zhang, Xue\|He, Wei\|Liu, Fubao
PMID:	28902342

148.
Journal:	Cancer Lett. 2017 Dec 28;411:162-170.
Title:	Anti-tumor effects of NVP-BKM120 alone or in combination with MEK162 in biliary tract cancer.
Author:	Jin, Ling\|Jin, Mei-Hua\|Nam, Ah-Rong\|Park, Ji-Eun\|Bang, Ju-Hee\|Oh, Do-Youn\|Bang, Yung-Jue
PMID:	29024814

149.
Journal:	Oncol Lett. 2017 Dec;14(6):7111-7120.
Title:	Isolation and identification of tumor-initiating cell properties in human gallbladder cancer cell lines using the marker cluster of differentiation 133.
Author:	Yu, Jiwei\|Tang, Zhaohui\|Gong, Wei\|Zhang, Mingdi\|Quan, Zhiwei
PMID:	29344142

150.
Journal:	Cytotechnology. 2018 Feb;70(1):439-448.
Title:	Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway.
Author:	Bi, Tingting\|Zhu, Ao\|Yang, Xufeng\|Qiao, Huiying\|Tang, Jinmei\|Liu, Yan\|Lv, Rong
PMID:	29110119

151.
Journal:	Cytotechnology. 2018 Feb;70(1):83-94.
Title:	Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway.
Author:	Qian, Liqiang\|Li, Xiaqin\|Ye, Penghui\|Wang, Gang\|Dai, Wei\|Liu, Yan\|Gao, Quangen\|Shen, Genhai
PMID:	29170841

152.
Journal:	Clin Oncol (R Coll Radiol). 2018 Mar;30(3):185-191.
Title:	Clinical Outcome of Patients with Advanced Biliary Tract Cancer in a Dedicated Phase I Unit.
Author:	Sundar, R\|Custodio, A\|Petruckevich, A\|Chenard-Poirier, M\|Ameratunga, M\|Collins, D\|Lim, J\|Kaye, S B\|Tunariu, N\|Banerji, U\|de Bono, J\|Lopez, J
PMID:	29224898

153.
Journal:	Am J Pathol. 2018 Apr;188(4):995-1006.
Title:	Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.
Author:	Zhang, Shanshan\|Wang, Jingxiao\|Wang, Haichuan\|Fan, Lingling\|Fan, Biao\|Zeng, Billy\|Tao, Junyan\|Li, Xiaolei\|Che, Li\|Cigliano, Antonio\|Ribback, Silvia\|Dombrowski, Frank\|Chen, Bin\|Cong, Wenming\|Wei, Lixin\|Calvisi, Diego F\|Chen, Xin
PMID:	29378174

154.
Journal:	Int J Biochem Cell Biol. 2018 Apr;97:16-27.
Title:	STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
Author:	Hu, Yun-Ping\|Wu, Zeng-Bin\|Jiang, Lin\|Jin, Yun-Peng\|Li, Huai-Feng\|Zhang, Yi-Jian\|Ma, Qiang\|Ye, Yuan-Yuan\|Wang, Zheng\|Liu, Yong-Chen\|Chen, Hong-Zhuan\|Liu, Ying-Bin
PMID:	29413947

155.
Journal:	Cell Death Dis. 2018 Feb 7;9(2):182.
Title:	miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma.
Author:	Jin, Yun-Peng\|Hu, Yun-Ping\|Wu, Xiang-Song\|Wu, Yao-Shi\|Ye, Yuan-Yuan\|Li, Huai-Feng\|Liu, Yong-Chen\|Jiang, Lin\|Liu, Fa-Tao\|Zhang, Yi-Jian\|Hao, Ya-Juan\|Liu, Xi-Yong\|Liu, Ying-Bin
PMID:	29416013

156.
Journal:	Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1693-1701.
Title:	Novel role of apatinib as a multi-target RTK inhibitor in the direct suppression of hepatocellular carcinoma cells.
Author:	Li, Xiaojin\|Xu, Anjian\|Li, Huihui\|Zhang, Bei\|Cao, Bangwei\|Huang, Jian
PMID:	29486282

157.
Journal:	Br J Cancer. 2018 Apr;118(7):966-971.
Title:	Phase II study of everolimus (RAD001) monotherapy as first-line treatment in advanced biliary tract cancer with biomarker exploration: the RADiChol Study.
Author:	Lau, David K\|Tay, Rebecca Y\|Yeung, Yvonne H\|Chionh, Fiona\|Mooi, Jennifer\|Murone, Carmel\|Skrinos, Effie\|Price, Timothy J\|Mariadason, John M\|Tebbutt, Niall C
PMID:	29527009

158.
Journal:	Oncogene. 2018 Jun;37(24):3229-3242.
Title:	Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.
Author:	Wang, Jingxiao\|Dong, Mingjie\|Xu, Zhong\|Song, Xinhua\|Zhang, Shanshan\|Qiao, Yu\|Che, Li\|Gordan, John\|Hu, Kaiwen\|Liu, Yan\|Calvisi, Diego F\|Chen, Xin
PMID:	29545603

159.
Journal:	Int J Oncol. 2018 Jul;53(1):177-188.
Title:	Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors.
Author:	Tanjak, Pariyada\|Thiantanawat, Apinya\|Watcharasit, Piyajit\|Satayavivad, Jutamaad
PMID:	29693152

160.
Journal:	Int J Oncol. 2018 Jul;53(1):286-296.
Title:	Role of the overexpression of TRAF4 in predicting the prognosis of intrahepatic cholangiocarcinoma.
Author:	Kang, Qiang\|Zou, Hao\|Zhou, Lei\|Liu, Li-Xin\|Cai, Jia-Bin\|Xie, Nan\|Li, Wei-Hao\|Zhang, Chao\|Shi, Wan-Hong\|Wang, Lian-Min\|Zhang, Wei-Han\|Zhu, Hong\|Wang, Shu-Fen\|Zhang, Xiao-Wen
PMID:	29749456

161.
Journal:	Biomed Pharmacother. 2018 Jul;103:1272-1278.
Title:	Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway.
Author:	Li, Hui\|Zhang, Yu\|Hai, Jun\|Wang, Jixin\|Zhao, Bei\|Du, Lixue\|Geng, Xilin
PMID:	29864908

162.
Journal:	Gut. 2018 Jun 28. pii: gutjnl-2018-316039.
Title:	Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis.
Author:	Li, Maolan\|Liu, Fatao\|Zhang, Fei\|Zhou, Weiping\|Jiang, Xiaoqing\|Yang, Yuan\|Qu, Kai\|Wang, Yueqi\|Ma, Qiang\|Wang, Ting\|Bai, Lu\|Wang, Zheng\|Song, Xiaoling\|Zhu, Yidi\|Yuan, Ruiyan\|Gao, Yuan\|Liu, Yongchen\|Jin, Yunpeng\|Li, Huaifeng\|Xiang, Shanshan\|Ye, Yuanyuan\|Zha
PMID:	29954840

163.
Journal:	Pharmazie. 2018 Jul 1;73(7):413-417.
Title:	Anti-proliferative and anti-invasive effects of garcinol from Garcinia indica on gallbladder carcinoma cells.
Author:	Duan, Yi-Tao\|Yang, Xiao-Ang\|Fang, Lian-Ying\|Wang, Jin-Han\|Liu, Qiang
PMID:	30001777

164.
Journal:	Clin Cancer Res. 2018 Jul 3. pii: 1078-0432.CCR-18-0284.
Title:	Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma.
Author:	Song, Xinhua\|Liu, Xianqiong\|Wang, Haichuan\|Wang, Jingxiao\|Qiao, Yu\|Cigliano, Antonio\|Utpatel, Kirsten\|Ribback, Silvia\|Pilo, Maria G\|Serra, Marina\|Gordan, John D\|Che, Li\|Zhang, Shanshan\|Cossu, Antonio\|Porcu, Alberto\|Pascale, Rosa Maria\|Dombrowski, Frank\|Hu
PMID:	30084835

165.
Journal:	HPB (Oxford). 2018 Sep 25. pii: S1365-182X(18)33951-0.
Title:	The clinical value of Fibulin-1 for prognosis and its prospective mechanism in intrahepatic cholangiocarcinoma.
Author:	Jie, Yusheng\|Gong, Jiao\|Xiao, Cuicui\|Zheng, Jun\|Zhang, Zhiwei\|Li, Xinhua\|Gao, Zhiliang\|Hu, Bo\|Chong, Yutian
PMID:	30266493

166.
Journal:	Cell Oncol (Dordr). 2018 Oct 1. pii: 10.1007/s13402-018-0410-8.
Title:	CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer.
Author:	Zhou, Zhenyu\|Peng, Yaorong\|Wu, Xiaoying\|Meng, Shiyu\|Yu, Wei\|Zhao, Jinghua\|Zhang, Heyun\|Wang, Jie\|Li, Wenbin
PMID:	30276551

167.
Journal:	J Surg Res. 2018 Nov;231:116-125.
Title:	IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC.
Author:	Wang, Jian\|Zhang, Zhan-Guo\|Ding, Ze-Yang\|Dong, Wei\|Liang, Hui-Fang\|Chu, Liang\|Zhang, Bi-Xiang\|Chen, Xiao-Ping
PMID:	30278918

168.
Journal:	Cancer Res Treat. 2018 Oct 1. pii: crt.2018.375.
Title:	Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer.
Author:	Nam, Ah-Rong\|Kim, Ji-Won\|Park, Ji Eun\|Bang, Ju-Hee\|Jin, Mei Hua\|Oh, Do-Youn\|Bang, Yung-Jue
PMID:	30282449

169.
Journal:	Hepatology. 2018 Oct 9.
Title:	The chemosensory function of primary cilia regulates cholangiocyte migration, invasion and tumor growth.
Author:	Mansini, Adrian P\|Peixoto, Estanislao\|Jin, Sujeong\|Richard, Seth\|Gradilone, Sergio A
PMID:	30299561

170.
Journal:	Int J Mol Sci. 2018 Oct 12;19(10). pii: ijms19103141.
Title:	MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.
Author:	Miao, Wenyu\|Sakai, Katsuya\|Imamura, Ryu\|Ito, Kenichiro\|Suga, Hiroaki\|Sakuma, Tetsushi\|Yamamoto, Takashi\|Matsumoto, Kunio
PMID:	30322054