Primary Site >> Biliary tract Cancer
Gene >> AKT1
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Ref: [Activated serine/threonine kinase AKT enhances the radioresistancy in human cholangiocarcinoma]. PMID: 12704859 Ref: Identification of novel cellular targets in biliary tract cancers using global gene expression technology. PMID: 12819026 |
Ref: Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. PMID: 15057907 Ref: Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance. PMID: 15150102 Ref: Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells. PMID: 15566522 |
Ref: Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. PMID: 15940637 Ref: erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. PMID: 16344070 |
Ref: The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. PMID: 16525641 Ref: Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma. PMID: 16551849 Ref: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. PMID: 16767220 Ref: Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. PMID: 16926628 Ref: Akt expression may predict favorable prognosis in cholangiocarcinoma. PMID: 16984600 |
Ref: Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. PMID: 17440093 Ref: Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. PMID: 17461449 Ref: Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. PMID: 17575102 Ref: Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. PMID: 17708250 Ref: AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma. PMID: 18161916 |
Ref: A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. PMID: 18081149 Ref: Rare PIK3CA hotspot mutations in carcinomas of the biliary tract. PMID: 18181165 Ref: MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. PMID: 18397823 |
Ref: The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. PMID: 19147772 Ref: Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin. PMID: 19228732 Ref: ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma. PMID: 19376120 Ref: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. PMID: 19445727 |
Ref: Arsenic trioxide inhibits cholangiocarcinoma cell growth and induces apoptosis. PMID: 20012722 Ref: Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance. PMID: 20066734 Ref: T-cadherin modulates tumor-associated molecules in gallbladder cancer cells. PMID: 20121546 Ref: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion. PMID: 20135719 Ref: Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells. PMID: 20145951 Ref: Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells. PMID: 20359814 Ref: High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K. PMID: 20731018 |
Ref: Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells. PMID: 21042948 Ref: Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases. PMID: 21076843 Ref: Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. PMID: 21130731 Ref: The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo. PMID: 21318226 Ref: Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. PMID: 21325634 Ref: Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression. PMID: 21354147 Ref: Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. PMID: 21855619 Ref: Polo-like kinase 1 inhibition as a new therapeutic modality in therapy of cholangiocarcinoma. PMID: 21965739 |
Ref: Secreted Opisthorchis viverrini glutathione S-transferase regulates cell proliferation through AKT and ERK pathways in cholangiocarcinoma. PMID: 21782971 Ref: The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. PMID: 21874010 Ref: Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. PMID: 22044563 Ref: Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. PMID: 22068162 Ref: L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells. PMID: 22088438 Ref: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. PMID: 22180306 Ref: Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways. PMID: 22213475 Ref: Overexpression of ECM1 contributes to migration and invasion in cholangiocarcinoma cell. PMID: 22489696 Ref: Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma. PMID: 22727731 Ref: Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinoma. PMID: 22733151 Ref: Periostin activates integrin alpha5beta1 through a PI3K/AKTdependent pathway in invasion of cholangiocarcinoma. PMID: 22735632 |
Ref: Gene expression-based chemical genomics identifies heat-shock protein 90 inhibitors as potential therapeutic drugs in cholangiocarcinoma. PMID: 22810956 Ref: Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma. PMID: 22875246 Ref: Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma. PMID: 23254774 Ref: A high level of integrin alpha6 expression in human intrahepatic cholangiocarcinoma cells is associated with a migratory and invasive phenotype. PMID: 23306848 Ref: NK4 gene therapy inhibits HGF/Met-induced growth of human cholangiocarcinoma cells. PMID: 23314853 Ref: Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis. PMID: 23315987 Ref: Akt and mTORC1 have different roles during liver tumorigenesis in mice. PMID: 23376645 Ref: Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma. PMID: 23588885 Ref: Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells. PMID: 23645731 Ref: Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling. PMID: 23646150 Ref: Oncogenic activity of retinoic acid receptor gamma is exhibited through activation of the Akt/NF-kappaB and Wnt/beta-catenin pathways in cholangiocarcinoma. PMID: 23798555 Ref: Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment. PMID: 23812726 Ref: Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. PMID: 23832540 Ref: AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines. PMID: 24124380 Ref: Down-regulation of Gab1 inhibits cell proliferation and migration in hilar cholangiocarcinoma. PMID: 24312291 |
Ref: Prognostic biomarkers in patients with resected cholangiocarcinoma: a systematic review and meta-analysis. PMID: 24081803 Ref: GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. PMID: 24141775 Ref: Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. PMID: 24186143 Ref: CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils. PMID: 24293410 Ref: Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. PMID: 24310400 Ref: Potential biomarkers for sensitivity of gallbladder cancer cells to gemcitabine. PMID: 24551272 Ref: Epidermal growth factor upregulates Skp2/Cks1 and p27(kip1) in human extrahepatic cholangiocarcinoma cells. PMID: 24574749 Ref: Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-kappaB pathways in human cholangiocarcinomas both in vitro and in vivo. PMID: 24603952 Ref: Role of aberrant PI3K pathway activation in gallbladder tumorigenesis. PMID: 24658595 Ref: TNF-alpha promotes gallbladder cancer cell growth and invasion through autocrine mechanisms. PMID: 24676340 Ref: Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. PMID: 24700501 Ref: Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo. PMID: 24725816 Ref: Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. PMID: 24796583 Ref: Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. PMID: 24892809 Ref: Molecular mechanism of cholangiocarcinoma carcinogenesis. PMID: 24895231 Ref: Phenoxodiol enhances the antitumor activity of gemcitabine in gallbladder cancer through suppressing Akt/mTOR pathway. PMID: 24902539 Ref: Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors. PMID: 25152244 Ref: Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications. PMID: 25174601 Ref: Cholangiocarcinoma: molecular pathways and therapeutic opportunities. PMID: 25369307 Ref: Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications. PMID: 25446840 |
Ref: Recruited metastasis suppressor NM23-H2 attenuates expression and activity of peroxisome proliferator-activated receptor delta (PPARdelta) in human cholangiocarcinoma. PMID: 25277864 Ref: IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism. PMID: 25580681 Ref: SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway. PMID: 25623055 Ref: Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy. PMID: 25639632 Ref: Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer. PMID: 25657110 Ref: Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer. PMID: 25742482 Ref: Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer. PMID: 25895131 Ref: Gab1 regulates proliferation and migration through the PI3K/Akt signaling pathway in intrahepatic cholangiocarcinoma. PMID: 26014518 Ref: Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma. PMID: 26028364 Ref: Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. PMID: 26090720 Ref: Zinc finger X-chromosomal protein (ZFX) is a significant prognostic indicator and promotes cellular malignant potential in gallbladder cancer. PMID: 26230915 Ref: MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma. PMID: 26255969 Ref: Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. PMID: 26287365 Ref: Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer. PMID: 26294099 Ref: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44nu is an indicator for recurrence in advanced cancer. PMID: 26572077 Ref: Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells. PMID: 26770369 Ref: Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway. PMID: 26823715 |
Ref: Lupeol induces apoptosis and inhibits invasion in gallbladder carcinoma GBC-SD cells by suppression of EGFR/MMP-9 signaling pathway. PMID: 25037728 Ref: LTbetaR signalling preferentially accelerates oncogenic AKT-initiated liver tumours. PMID: 26206664 Ref: Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells. PMID: 26470769 Ref: YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma. PMID: 26781979 Ref: LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway. PMID: 26797416 Ref: Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice. PMID: 26877611 Ref: Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. PMID: 26910791 Ref: CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation. PMID: 26910892 Ref: Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines. PMID: 26935541 Ref: Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer: Additional Options for an Orphan Cancer. PMID: 26947513 Ref: A novel PI3K/AKT signaling axis mediates Nectin-4-induced gallbladder cancer cell proliferation, metastasis and tumor growth. PMID: 26949052 Ref: Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma. PMID: 26967384 Ref: EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma. PMID: 27020207 Ref: Corrigendum to PMID: 27125425 Ref: The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR. PMID: 27317099 Ref: Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma. PMID: 27593557 Ref: Knockdown of Sall4 inhibits intrahepatic cholangiocarcinoma cell migration and invasion in ICC-9810 cells. PMID: 27601921 Ref: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation. PMID: 27627808 Ref: Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway. PMID: 27637083 Ref: Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway. PMID: 27655691 Ref: Notch3 drives development and progression of cholangiocarcinoma. PMID: 27791012 Ref: Upregulation of long non-coding RNA LINC00152 by SP1 contributes to gallbladder cancer cell growth and tumor metastasis via PI3K/AKT pathway. PMID: 27829993 Ref: Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans. PMID: 27918553 |
Ref: Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. PMID: 27811010 Ref: Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing. PMID: 28029662 Ref: Growth Inhibition of Refractory Human Gallbladder Cancer Cells by Retinol, and Its Mechanism of Action. PMID: 28100868 Ref: The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. PMID: 28120434 Ref: Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling. PMID: 28178656 Ref: SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling. PMID: 28212545 Ref: Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition. PMID: 28223426 Ref: Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells. PMID: 28378944 Ref: Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer. PMID: 28412732 Ref: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. PMID: 28423362 Ref: Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo. PMID: 28454273 Ref: K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines. PMID: 28544747 Ref: EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway. PMID: 28594409 Ref: Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. PMID: 28609656 Ref: Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling. PMID: 28656003 Ref: Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkappaB pathways in cholangiocarcinoma cells. PMID: 28670110 Ref: Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation. PMID: 28694672 Ref: Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components. PMID: 28698100 Ref: Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice. PMID: 28733220 Ref: Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. PMID: 28766687 Ref: LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. PMID: 28887321 Ref: Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma. PMID: 28902342 Ref: Anti-tumor effects of NVP-BKM120 alone or in combination with MEK162 in biliary tract cancer. PMID: 29024814 Ref: Isolation and identification of tumor-initiating cell properties in human gallbladder cancer cell lines using the marker cluster of differentiation 133. PMID: 29344142 |
Ref: Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway. PMID: 29110119 Ref: Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway. PMID: 29170841 Ref: Clinical Outcome of Patients with Advanced Biliary Tract Cancer in a Dedicated Phase I Unit. PMID: 29224898 Ref: Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans. PMID: 29378174 Ref: STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma. PMID: 29413947 Ref: miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma. PMID: 29416013 Ref: Novel role of apatinib as a multi-target RTK inhibitor in the direct suppression of hepatocellular carcinoma cells. PMID: 29486282 Ref: Phase II study of everolimus (RAD001) monotherapy as first-line treatment in advanced biliary tract cancer with biomarker exploration: the RADiChol Study. PMID: 29527009 Ref: Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. PMID: 29545603 Ref: Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors. PMID: 29693152 Ref: Role of the overexpression of TRAF4 in predicting the prognosis of intrahepatic cholangiocarcinoma. PMID: 29749456 Ref: Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway. PMID: 29864908 Ref: Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis. PMID: 29954840 Ref: Anti-proliferative and anti-invasive effects of garcinol from Garcinia indica on gallbladder carcinoma cells. PMID: 30001777 Ref: Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma. PMID: 30084835 Ref: The clinical value of Fibulin-1 for prognosis and its prospective mechanism in intrahepatic cholangiocarcinoma. PMID: 30266493 Ref: CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer. PMID: 30276551 Ref: IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC. PMID: 30278918 Ref: Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer. PMID: 30282449 Ref: The chemosensory function of primary cilia regulates cholangiocyte migration, invasion and tumor growth. PMID: 30299561 Ref: MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner. PMID: 30322054 |