Primary Site >> Colorectal Cancer

Gene >> ADAM17

Journal: Scand J Gastroenterol. 2004 May;39(5):464-9.
Title: Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line.
Author: Fan, C W|Chan, C C|Chao, C C K|Fan, H A|Sheu, D L|Chan, E C
PMID: 15180185
Journal: Cell Cycle. 2005 Feb;4(2):217-20. Epub 2005 Feb 3.
Title: IL-6 signaling promotes tumor growth in colorectal cancer.
Author: Becker, C|Fantini, M C|Wirtz, S|Nikolaev, A|Lehr, H A|Galle, P R|Rose-John, S|Neurath, M F
PMID: 15655344
Journal: J Pathol. 2005 Oct;207(2):156-63.
Title: Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells.
Author: Blanchot-Jossic, Frederique|Jarry, Anne|Masson, Damien|Bach-Ngohou, Kalyane|Paineau, Jacques|Denis, Marc G|Laboisse, Christian L|Mosnier, Jean-Francois
PMID: 16041691
Journal: Surgery. 2005 Sep;138(3):415-21.
Title: Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.
Author: Merchant, Nipun B|Rogers, Christopher M|Trivedi, Bakula|Morrow, Jason|Coffey, Robert J
PMID: 16213893
Journal: Carcinogenesis. 2006 Jul;27(7):1507-15. Epub 2006 Apr 5.
Title: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line.
Author: Fenton, Jenifer I|Hursting, Stephen D|Perkins, Susan N|Hord, Norman G
PMID: 16597643
Journal: J Pharmacol Exp Ther. 2007 Apr;321(1):84-97.
Title: Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling.
Author: Forsyth, C B|Banan, A|Farhadi, A|Fields, J Z|Tang, Y|Shaikh, M|Zhang, L J|Engen, P A|Keshavarzian, A
PMID: 17220428
Journal: Clin Cancer Res. 2008 Feb 15;14(4):1182-91.
Title: TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer.
Author: Merchant, Nipun B|Voskresensky, Igor|Rogers, Christopher M|Lafleur, Bonnie|Dempsey, Peter J|Graves-Deal, Ramona|Revetta, Frank|Foutch, A Coe|Rothenberg, Mace L|Washington, Mary K|Coffey, Robert J
PMID: 18281553
Journal: Cancer Res. 2008 Oct 15;68(20):8312-21.
Title: Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL.
Author: Van Schaeybroeck, Sandra|Kelly, Donal M|Kyula, Joan|Stokesberry, Susan|Fennell, Dean A|Johnston, Patrick G|Longley, Daniel B
PMID: 18922903
Journal: Hepatogastroenterology. 2008 Nov-Dec;55(88):2077-82.
Title: TACE of liver metastases from colorectal cancer adopting irinotecan-eluting beads: beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects.
Author: Fiorentini, Giammaria|Aliberti, Camillo|Benea, Giorgio|Montagnani, Francesco|Mambrini, Andrea|Ballardini, Pier Luigi|Cantore, Maurizio
PMID: 19260480
Journal: Hypertension. 2009 Jun;53(6):1077-82.
Title: Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma.
Author: Cousin, Christelle|Bracquart, Diane|Contrepas, Aurelie|Corvol, Pierre|Muller, Laurent|Nguyen, Genevieve
PMID: 19380613
Journal: HPB (Oxford). 2009 Nov;11(7):541-50.
Title: Drug-eluting bead therapy in primary and metastatic disease of the liver.
Author: Carter, Stewart|Martin Ii, Robert C G
PMID: 20495705
Journal: Clin Cancer Res. 2009 Apr 1;15(7):2397-405.
Title: Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent.
Author: Mutsaers, Anthony J|Francia, Giulio|Man, Shan|Lee, Christina R|Ebos, John M L|Wu, Yan|Witte, Larry|Berry, Scott|Moore, Malcolm|Kerbel, Robert S
PMID: 19276250
Journal: Nat Cell Biol. 2009 Feb;11(2):162-71.
Title: Nuclear signalling by tumour-associated antigen EpCAM.
Author: Maetzel, Dorothea|Denzel, Sabine|Mack, Brigitte|Canis, Martin|Went, Philip|Benk, Michael|Kieu, Cuong|Papior, Peer|Baeuerle, Patrick A|Munz, Markus|Gires, Olivier
PMID: 19136966
Journal: PLoS One. 2010 Jan 21;5(1):e8836.
Title: MicroRNA-145 targets YES and STAT1 in colon cancer cells.
Author: Gregersen, Lea H|Jacobsen, Anders B|Frankel, Lisa B|Wen, Jiayu|Krogh, Anders|Lund, Anders H
PMID: 20098684
Journal: Radiat Res. 2010 Apr;173(4):418-25.
Title: Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation.
Author: Matsumura, Satoko|Demaria, Sandra
PMID: 20334513
Journal: Clin Cancer Res. 2010 Jul 1;16(13):3378-89.
Title: Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer.
Author: Kyula, Joan N|Van Schaeybroeck, Sandra|Doherty, Joanne|Fenning, Catherine S|Longley, Daniel B|Johnston, Patrick G
PMID: 20570921
Journal: Clin Cancer Res. 2010 Jul 1;16(13):3319-21.
Title: ADAM-17: a target to increase chemotherapeutic efficacy in colorectal cancer?
Author: Lee, Adam M|Diasio, Robert B
PMID: 20570925
Journal: Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94.
Title: The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.
Author: Chalaris, Athena|Garbers, Christoph|Rabe, Bjorn|Rose-John, Stefan|Scheller, Jurgen
PMID: 21145125
Journal: Cancer Res. 2011 Feb 1;71(3):1071-80.
Title: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.
Author: Van Schaeybroeck, Sandra|Kyula, Joan N|Fenton, Audrey|Fenning, Catherine S|Sasazuki, Takehiko|Shirasawa, Senji|Longley, Daniel B|Johnston, Patrick G
PMID: 21148749
Journal: Clin Colorectal Cancer. 2011 Sep;10(3):188-93.
Title: Expression of the antiapoptotic protein survivin in colon cancer.
Author: Hernandez, Jonathan M|Farma, Jeffrey M|Coppola, Domenico|Hakam, Ardeshir|Fulp, William J|Chen, Dung-Tsa|Siegel, Erin M|Yeatman, Timothy J|Shibata, David
PMID: 21855041
Journal: PLoS One. 2012;7(12):e50791.
Title: ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.
Author: Das, Sudipta|Czarnek, Maria|Bzowska, Monika|Mezyk-Kopec, Renata|Stalinska, Krystyna|Wyroba, Barbara|Sroka, Jolanta|Jucha, Jaroslaw|Deneka, Dawid|Stoklosa, Paulina|Ogonek, Justyna|Swartz, Melody A|Madeja, Zbigniew|Bereta, Joanna
PMID: 23251384
Journal: Int J Oncol. 2012 Oct;41(4):1213-20.
Title: First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI).
Author: Eichler, K|Zangos, S|Mack, M G|Hammerstingl, R|Gruber-Rouh, T|Gallus, C|Vogl, T J
PMID: 22842404
Journal: J Biol Chem. 2012 Jul 20;287(30):25001-9.
Title: The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and gamma-secretase, enhances cell proliferation and migration in colon cancer cells.
Author: Na, Hye-Won|Shin, Won-Sik|Ludwig, Andreas|Lee, Seung-Taek
PMID: 22665490
Journal: Gan To Kagaku Ryoho. 2012 Apr;39(4):671-4.
Title: [alpha-fetoprotein producing rectal cancer].
Author: Nakagawa, Kan|Koike, Shoichiro|Matsumura, Hideyasu|Yokoi, Kenta|Kitamura, Hiroshi
PMID: 22504700
Journal: Exp Cell Res. 2012 Oct 15;318(17):2168-77.
Title: MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17.
Author: Xu, Ke|Liang, Xin|Shen, Ke|Sun, Liyun|Cui, Daling|Zhao, Yuxia|Tian, Jianhui|Ni, Lei|Liu, Jianwen
PMID: 22677042
Journal: Cancer Cell. 2013 Feb 11;23(2):171-85.
Title: Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.
Author: Lu, Jia|Ye, Xiangcang|Fan, Fan|Xia, Ling|Bhattacharya, Rajat|Bellister, Seth|Tozzi, Federico|Sceusi, Eric|Zhou, Yunfei|Tachibana, Isamu|Maru, Dipen M|Hawke, David H|Rak, Janusz|Mani, Sendurai A|Zweidler-McKay, Patrick|Ellis, Lee M
PMID: 23375636
Journal: Cancer Res. 2014 Apr 1;74(7):2062-72.
Title: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids.
Author: Nagathihalli, Nagaraj S|Beesetty, Yugandhar|Lee, Wooin|Washington, M Kay|Chen, Xi|Lockhart, A Craig|Merchant, Nipun B
PMID: 24520077
Journal: Cell Rep. 2014 Jun 26;7(6):1940-55.
Title: ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.
Author: Van Schaeybroeck, Sandra|Kalimutho, Murugan|Dunne, Philip D|Carson, Robbie|Allen, Wendy|Jithesh, Puthen V|Redmond, Keara L|Sasazuki, Takehiko|Shirasawa, Senji|Blayney, Jaine|Michieli, Paolo|Fenning, Cathy|Lenz, Heinz-Josef|Lawler, Mark|Longley, Daniel B|J
PMID: 24931611
Journal: Ann Pharmacother. 2014 Dec;48(12):1646-50.
Title: The power of genes: a case of unusually severe systemic toxicity after localized hepatic chemoembolization with irinotecan-eluted microspheres for metastatic colon cancer.
Author: Cruz, Joseph E|Saksena, Rujuta|Jabbour, Salma K|Nosher, John L|Hermes-DeSantis, Evelyn|Moss, Rebecca A
PMID: 25202035
Journal: Oncotarget. 2015 Feb 10;6(4):2046-63.
Title: Claudin-7 promotes the epithelial-mesenchymal transition in human colorectal cancer.
Author: Philip, Rahel|Heiler, Sarah|Mu, Wei|Buchler, Markus W|Zoller, Margot|Thuma, Florian
PMID: 25514462
Journal: Cardiovasc Intervent Radiol. 2015 Dec;38(6):1523-31.
Title: Trans-Arterial Chemoembolization with Irinotecan-Loaded Drug-Eluting Beads (DEBIRI) and Capecitabine in Refractory Liver Prevalent Colorectal Metastases: A Phase II Single-Center Study.
Author: Iezzi, Roberto|Marsico, Valentina Angela|Guerra, Alessandra|Cerchiaro, Eleonora|Cassano, Alessandra|Basso, Michele|Devicienti, Ersilia|Rodolfino, Elena|Barone, Carlo|Bonomo, Lorenzo
PMID: 25799948
Journal: Eur Rev Med Pharmacol Sci. 2016 Nov;20(21):4474-4481.
Title: Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway.
Author: Wang, H-P|Wang, X|Gong, L-F|Chen, W-J|Hao, Z|Feng, S-W|Wu, Y-B|Ye, T|Cai, Y-K
PMID: 27874952
Journal: Gan To Kagaku Ryoho. 2016 Aug;43(8):1009-13.
Title: [A Case of Rectal Neuroendocrine Carcinoma with Metachronous Liver Metastasis Treated with Multimodality Therapy].
Author: Miyamae, Yohei|Shimizu, Hisashi|Naganuma, Atsushi|Aiba, Masaaki|Tanaka, Toshiyuki|Ogawa, Tetsushi|Ogawa, Akira|Osamura, Yoshiyuki
PMID: 27539046
Journal: Oncotarget. 2016 Jul 19;7(29):45275-45282.
Title: A novel approach to inoperable or recurrent rectal cancer by chemoembolization: A new arrow in our quiver?
Author: Bini, Roberto|Comelli, Simone|Leli, Renzo|Vaudano, Giacomo Paolo|Savio, Daniele|Viora, Tiziana|Addeo, Alfredo
PMID: 27303924
Journal: Biomed Res Int. 2016;2016:8208904.
Title: Expression of Migration-Related Genes in Human Colorectal Cancer and Activity of a Disintegrin and Metalloproteinase 17.
Author: Walkiewicz, Katarzyna|Koziel, Pawel|Bednarczyk, Martyna|Blazelonis, Adam|Mazurek, Urszula|Muc-Wierzgon, Malgorzata
PMID: 27110571
Journal: Stem Cells Transl Med. 2016 Mar;5(3):331-8.
Title: A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
Author: Wang, Rui|Ye, Xiangcang|Bhattacharya, Rajat|Boulbes, Delphine R|Fan, Fan|Xia, Ling|Ellis, Lee M
PMID: 26744411
Journal: Clin Cancer Res. 2017 Jan 15;23(2):549-561.
Title: ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer.
Author: Mustafi, Reba|Dougherty, Urszula|Mustafi, Devkumar|Ayaloglu-Butun, Fatma|Fletcher, Michelle|Adhikari, Sarbani|Sadiq, Farhana|Meckel, Katherine|Haider, Haider I|Khalil, Abdurahman|Pekow, Joel|Konda, Vani|Joseph, Loren|Hart, John|Fichera, Alessandro|Li, Yan
PMID: 27489286
Journal: Mol Cell Biochem. 2017 Jan;425(1-2):191-202.
Title: TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production.
Author: Park, Ga Bin|Kim, Daejin
PMID: 27837433
Journal: Anticancer Drugs. 2017 Apr;28(4):410-420.
Title: 2-Deoxy-D-glucose suppresses the migration and reverses the drug resistance of colon cancer cells through ADAM expression regulation.
Author: Park, Ga B|Chung, Yoon H|Kim, Daejin
PMID: 28059830
Journal: Tumour Biol. 2017 Mar;39(3):1010428317695024.
Title: ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer.
Author: Verset, Laurine|Tommelein, Joke|Decaestecker, Christine|De Vlieghere, Elly|Bracke, Marc|Salmon, Isabelle|De Wever, Olivier|Demetter, Pieter
PMID: 28349819
Journal: Oncotarget. 2017 May 10;8(39):65090-65099.
Title: Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.
Author: Dosch, Joseph|Ziemke, Elizabeth|Wan, Shanshan|Luker, Kathryn|Welling, Theodore|Hardiman, Karin|Fearon, Eric|Thomas, Suneetha|Flynn, Matthew|Rios-Doria, Jonathan|Hollingsworth, Robert|Herbst, Ronald|Hurt, Elaine|Sebolt-Leopold, Judith
PMID: 29029414
Journal: Immunotherapy. 2017 Oct;9(13):1067-1069.
Title: Long-term survival in a patient with low-level inflammatory markers and liver metastasis, converted resectable by TACE.
Author: Mizandari, Malkhaz|Paksashvili, Natela|Kikodze, Nino|Azrumelashvili, Tamta|Pantsulaia, Ia|Shanava, Koba|Janikashvili, Nona|Chikovani, Tinatin
PMID: 29032738
Journal: J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):929-934.
Title: Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients.
Author: Walkiewicz, K|Nowakowska-Zajdel, E|Strzelczyk, J|Dziegielewska-Gesiak, S|Muc-Wierzgon, M
PMID: 29254295
Journal: Oncotarget. 2017 Nov 26;8(65):108303-108315.
Title: Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the Apc(Min) model of colorectal cancer.
Author: Dombernowsky, Sarah L|Schwarz, Jeanette|Samsoe-Petersen, Jacob|Albrechtsen, Reidar|Jensen, Kim B|Thomas, Gary|Kveiborg, Marie
PMID: 29312533
Journal: Mol Cell Biochem. 2018 Feb;439(1-2):199-211.
Title: Insulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17.
Author: Park, Ga Bin|Kim, Daejin
PMID: 28819788
Journal: J Exp Med. 2018 Apr 2;215(4):1205-1225.
Title: ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Author: Schmidt, Stefanie|Schumacher, Neele|Schwarz, Jeanette|Tangermann, Simone|Kenner, Lukas|Schlederer, Michaela|Sibilia, Maria|Linder, Markus|Altendorf-Hofmann, Annelore|Knosel, Thomas|Gruber, Elisabeth S|Oberhuber, Georg|Bolik, Julia|Rehman, Ateequr|Sinha, A
PMID: 29472497
Journal: Biochem Biophys Res Commun. 2018 Sep 18;503(4):2333-2339.
Title: Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation.
Author: Zhang, Qi|Wang, Changyou|Han, Xuechao|Yang, Guanghua|Ge, Zhipeng|Zhang, Guozhi
PMID: 29964008
Journal: Cell Prolif. 2018 Oct;51(5):e12480.
Title: A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo.
Author: Li, Dan-Dan|Zhao, Chang-Hao|Ding, Huai-Wei|Wu, Qiong|Ren, Tian-Shu|Wang, Jian|Chen, Cong-Qin|Zhao, Qing-Chun
PMID: 30069943