Primary Site >> Colorectal Cancer
Gene >> ADAM17
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line. PMID: 15180185 |
Ref: IL-6 signaling promotes tumor growth in colorectal cancer. PMID: 15655344 Ref: Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells. PMID: 16041691 Ref: Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. PMID: 16213893 |
Ref: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. PMID: 16597643 |
Ref: Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. PMID: 17220428 |
Ref: TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. PMID: 18281553 Ref: Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL. PMID: 18922903 Ref: TACE of liver metastases from colorectal cancer adopting irinotecan-eluting beads: beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects. PMID: 19260480 |
Ref: Nuclear signalling by tumour-associated antigen EpCAM. PMID: 19136966 Ref: Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent. PMID: 19276250 Ref: Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma. PMID: 19380613 Ref: Drug-eluting bead therapy in primary and metastatic disease of the liver. PMID: 20495705 |
Ref: MicroRNA-145 targets YES and STAT1 in colon cancer cells. PMID: 20098684 Ref: Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation. PMID: 20334513 Ref: Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer. PMID: 20570921 Ref: ADAM-17: a target to increase chemotherapeutic efficacy in colorectal cancer? PMID: 20570925 |
Ref: The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. PMID: 21145125 Ref: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17. PMID: 21148749 Ref: Expression of the antiapoptotic protein survivin in colon cancer. PMID: 21855041 |
Ref: [alpha-fetoprotein producing rectal cancer]. PMID: 22504700 Ref: The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and gamma-secretase, enhances cell proliferation and migration in colon cancer cells. PMID: 22665490 Ref: MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17. PMID: 22677042 Ref: First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI). PMID: 22842404 Ref: ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. PMID: 23251384 |
Ref: Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. PMID: 23375636 |
Ref: Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acids. PMID: 24520077 Ref: ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer. PMID: 24931611 Ref: The power of genes: a case of unusually severe systemic toxicity after localized hepatic chemoembolization with irinotecan-eluted microspheres for metastatic colon cancer. PMID: 25202035 |
Ref: Claudin-7 promotes the epithelial-mesenchymal transition in human colorectal cancer. PMID: 25514462 Ref: Trans-Arterial Chemoembolization with Irinotecan-Loaded Drug-Eluting Beads (DEBIRI) and Capecitabine in Refractory Liver Prevalent Colorectal Metastases: A Phase II Single-Center Study. PMID: 25799948 |
Ref: A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. PMID: 26744411 Ref: Expression of Migration-Related Genes in Human Colorectal Cancer and Activity of a Disintegrin and Metalloproteinase 17. PMID: 27110571 Ref: A novel approach to inoperable or recurrent rectal cancer by chemoembolization: A new arrow in our quiver? PMID: 27303924 Ref: [A Case of Rectal Neuroendocrine Carcinoma with Metachronous Liver Metastasis Treated with Multimodality Therapy]. PMID: 27539046 Ref: Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway. PMID: 27874952 |
Ref: ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. PMID: 27489286 Ref: TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production. PMID: 27837433 Ref: 2-Deoxy-D-glucose suppresses the migration and reverses the drug resistance of colon cancer cells through ADAM expression regulation. PMID: 28059830 Ref: ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer. PMID: 28349819 Ref: Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency. PMID: 29029414 Ref: Long-term survival in a patient with low-level inflammatory markers and liver metastasis, converted resectable by TACE. PMID: 29032738 Ref: Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients. PMID: 29254295 Ref: Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the Apc(Min) model of colorectal cancer. PMID: 29312533 |
Ref: Insulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17. PMID: 28819788 Ref: ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. PMID: 29472497 Ref: Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation. PMID: 29964008 Ref: A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo. PMID: 30069943 |