Primary Site >> Colorectal Cancer
Gene >> YAP1
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Ref: YAP1 increases organ size and expands undifferentiated progenitor cells. PMID: 17980593 |
Ref: Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. PMID: 18922894 |
Ref: Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. PMID: 22042863 |
Ref: Wnt/beta-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. PMID: 22337891 Ref: YAP oncogene overexpression supercharges colon cancer proliferation. PMID: 22356765 Ref: Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis. PMID: 22710434 Ref: A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. PMID: 22778133 |
Ref: Restriction of intestinal stem cell expansion and the regenerative response by YAP. PMID: 23178811 Ref: TAZ expression as a prognostic indicator in colorectal cancer. PMID: 23372686 Ref: Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. PMID: 23419361 Ref: Clinical and prognostic significance of Yes-associated protein in colorectal cancer. PMID: 23558963 Ref: Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells. PMID: 23762387 Ref: Regulation of YAP through an Akt-dependent process by 3, 3'-diindolylmethane in human colon cancer cells. PMID: 24100865 Ref: Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. PMID: 24356468 Ref: E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells. PMID: 24369055 |
Ref: Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. PMID: 24323901 Ref: Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. PMID: 24470239 Ref: Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. PMID: 24892549 Ref: KRAS and YAP1 converge to regulate EMT and tumor survival. PMID: 24954536 Ref: Expression of hippo pathway in colorectal cancer. PMID: 24976283 Ref: Methylationassociated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma. PMID: 25270913 Ref: Reprogramming cellular phenotype by soft collagen gels. PMID: 25284029 |
Ref: Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients. PMID: 25388162 Ref: Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway. PMID: 25446534 Ref: FGF8 promotes colorectal cancer growth and metastasis by activating YAP1. PMID: 25473897 Ref: NDR functions as a physiological YAP1 kinase in the intestinal epithelium. PMID: 25601544 Ref: The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. PMID: 25728681 Ref: A gp130-Src-YAP module links inflammation to epithelial regeneration. PMID: 25731159 Ref: Crosstalk between Hippo and TGFbeta: Subcellular Localization of YAP/TAZ/Smad Complexes. PMID: 25937570 Ref: Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. PMID: 26039999 Ref: The Hippo pathway in colorectal cancer. PMID: 26160682 Ref: Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression. PMID: 26344692 Ref: Wnt activated beta-catenin and YAP proteins enhance the expression of non-coding RNA component of RNase MRP in colon cancer cells. PMID: 26415221 Ref: Proteostasis trumps YAP in colon cancer. PMID: 26443703 Ref: Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. PMID: 26443705 Ref: Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. PMID: 26503053 |
Ref: Germline polymorphisms in genes involved in the Hippo pathway as recurrence biomarkers in stages II/III colon cancer. PMID: 26370619 Ref: Non-Photoinduced Biological Properties of Verteporfin. PMID: 26980565 Ref: Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. PMID: 27225772 Ref: Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. PMID: 27292189 Ref: RARgamma Downregulation Contributes to Colorectal Tumorigenesis and Metastasis by Derepressing the Hippo-Yap Pathway. PMID: 27325643 Ref: IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes. PMID: 27337954 Ref: Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. PMID: 27383277 Ref: The clinical significance of forkhead box protein A1 and its role in colorectal cancer. PMID: 27484093 Ref: G-protein-coupled receptors mediate omega-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway. PMID: 27506947 Ref: RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells. PMID: 27520449 Ref: Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse. PMID: 27527859 Ref: NHERF1/EBP50 Suppresses Wnt-beta-Catenin Pathway-Driven Intestinal Neoplasia. PMID: 27566107 Ref: Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway. PMID: 27779692 |
Ref: Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. PMID: 27864128 Ref: VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. PMID: 28051067 Ref: YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. PMID: 28130546 Ref: Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways. PMID: 28241877 Ref: Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. PMID: 28249901 Ref: Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer. PMID: 28356122 Ref: TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. PMID: 28416184 Ref: MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. PMID: 28433598 Ref: The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer. PMID: 28435452 Ref: Inhibitory effect and mechanism of exogenous mammalian sterile 20-like kinase 1 on the growth of human colorectal cancer. PMID: 28454447 Ref: A TIAM Double Hit to Oppose YAP/TAZ. PMID: 28486099 Ref: SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner. PMID: 28618450 Ref: Angiomotin Family Members: Oncogenes or Tumor Suppressors? PMID: 28656002 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. PMID: 28848049 Ref: MiR-590-3p promotes proliferation and metastasis of colorectal cancer via Hippo pathway. PMID: 28938537 Ref: YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer. PMID: 29037225 Ref: Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway. PMID: 29039607 Ref: Upregulation of Yes-associated protein and transcriptional co-activator with PDZ-binding motif influences the behavior of LOVO human colon adenocarcinoma cells. PMID: 29042987 Ref: Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells. PMID: 29049318 Ref: Dual roles of yes-associated protein (YAP) in colorectal cancer. PMID: 29088905 Ref: YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways. PMID: 29241219 Ref: Small-sized colorectal cancer cells harbor metastatic tumor-initiating cells. PMID: 29296212 Ref: Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells. PMID: 29312609 |
Ref: Significant expression of tafazzin (TAZ) protein in colon cancer cells and its downregulation by radiation. PMID: 29099643 Ref: TEAD4 promotes colorectal tumorigenesis via transcriptionally targeting YAP1. PMID: 29157094 Ref: Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells. PMID: 29316729 Ref: ARRDC3 suppresses colorectal cancer progression through destabilizing the oncoprotein YAP. PMID: 29364502 Ref: Modified miR-15a has therapeutic potential for improving treatment of advanced stage colorectal cancer through inhibition of BCL2, BMI1, YAP1 and DCLK1. PMID: 29416778 Ref: Corrigendum to "MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer", [Canc. Lett. 399 (2017) 53-63]. PMID: 29429755 Ref: REGgamma Controls Hippo Signaling and Reciprocal NF-kappaB-YAP Regulation to Promote Colon Cancer. PMID: 29437787 Ref: Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells. PMID: 29510994 Ref: Suppression of YAP by DDP disrupts colon tumor progression. PMID: 29512779 Ref: Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis. PMID: 29766649 Ref: Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer. PMID: 29770434 Ref: YAP-dependent ubiquitination and degradation of beta-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer. PMID: 29789528 Ref: miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP. PMID: 29844307 Ref: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway. PMID: 29872721 Ref: MicroRNA-590-5p Inhibits Intestinal Inflammation by Targeting YAP. PMID: 29912317 Ref: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. PMID: 29967145 Ref: VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs. PMID: 30034932 Ref: RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer. PMID: 30037330 Ref: Deletion of cadherin-17 enhances intestinal permeability and susceptibility to intestinal tumour formation. PMID: 30047135 Ref: Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer. PMID: 30074279 Ref: Long noncoding RNA kcna3 inhibits the progression of colorectal carcinoma through down-regulating YAP1 expression. PMID: 30099342 Ref: Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells. PMID: 30106444 Ref: Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. PMID: 30143543 Ref: Verteporfin enhances the sensitivity of LOVO/TAX cells to taxol via YAP inhibition. PMID: 30210616 Ref: SCC-S2 Facilitates Tumor Proliferation and Invasion via Activating Wnt Signaling and Depressing Hippo Signaling in Colorectal Cancer Cells and Predicts Poor Prognosis of Patients. PMID: 30216108 Ref: Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells. PMID: 30218452 Ref: Curcumin Induces Autophagy via Inhibition of Yes-Associated Protein (YAP) in Human Colon Cancer Cells. PMID: 30281585 Ref: Association between PPP2CA expression and colorectal cancer prognosis tumor marker prognostic study. PMID: 30296597 Ref: Loss of HACE1 promotes colorectal cancer cell migration via upregulation of YAP1. PMID: 30362561 |