Primary Site >> Colorectal Cancer

Gene >> XPO1

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Ref: Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover.
PMID: 10980707
Ref: Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm.
PMID: 11035805
 Ref: Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.
PMID: 11375905
Ref: Suppressor of fused negatively regulates beta-catenin signaling.
PMID: 11477086
 Ref: Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1.
PMID: 11986304
 Ref: Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression.
PMID: 12468543
 Ref: Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.
PMID: 15678162
 Ref: Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.
PMID: 16378739
 Ref: Nuclear export is essential for the tumor-promoting activity of survivin.
PMID: 17099069
 Ref: SUMOylation regulates nuclear localization of Kruppel-like factor 5.
PMID: 18782761
 Ref: Nuclear APC.
PMID: 19928349
 Ref: Inhibition of beta-catenin signaling by nongenomic action of orphan nuclear receptor Nur77.
PMID: 21986938
 Ref: Novel reversible selective inhibitor of nuclear export shows that CRM1 is a target in colorectal cancer cells.
PMID: 25996664
 Ref: XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer.
PMID: 26603256
Ref: RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
PMID: 26864624
Ref: Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4.
PMID: 27033953
Ref: [Radiation response enhanced by inhibition of XPO1 in preclinical rectal cancer models].
PMID: 27757501
 Ref: Nuclear Export of Ubiquitinated Proteins Determines the Sensitivity of Colorectal Cancer to Proteasome Inhibitor.
PMID: 27903750
Ref: Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer.
PMID: 28761359
Ref: L290P/V mutations increase ERK3's cytoplasmic localization and migration/invasion-promoting capability in cancer cells.
PMID: 29101390