Primary Site >> Colorectal Cancer
Gene >> UGT1A6
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Ref: Tissue-specific 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of human UDP-glucuronosyltransferase UGT1A6. PMID: 8914852 |
Ref: Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6. PMID: 9466822 Ref: AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. PMID: 9762354 |
Ref: Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. PMID: 10220484 |
Ref: Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid. PMID: 10688250 Ref: Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7. PMID: 10901286 |
Ref: CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk. PMID: 11325819 |
Ref: Tissue-specific regulation of canine intestinal and hepatic phenol and morphine UDP-glucuronosyltransferases by beta-naphthoflavone in comparison with humans. PMID: 12007571 |
Ref: Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. PMID: 15319294 |
Ref: The effects of coffee on conjugation reactions in human colon carcinoma cells. PMID: 15684482 Ref: UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. PMID: 15709193 Ref: No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. PMID: 16141797 |
Ref: Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. PMID: 16797247 Ref: Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. PMID: 16819192 |
Ref: The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells. PMID: 18694909 |
Ref: No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. PMID: 19437564 |
Ref: Expression of UDP-glucuronosyltransferase 1A6 isoform in Caco-2 cells stimulated with lipopolysaccharide. PMID: 19710100 Ref: UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. PMID: 19831498 |
Ref: Association between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk. PMID: 22901212 |
Ref: Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry. PMID: 24677636 |
Ref: Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial. PMID: 25927723 Ref: Biomarkers of erlotinib response in non-small cell lung cancer tumors that do not harbor the more common epidermal growth factor receptor mutations. PMID: 26045797 Ref: Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial. PMID: 26697360 |
Ref: Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228). PMID: 28817838 Ref: Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study. PMID: 29282011 |
Ref: Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations. PMID: 29425227 |