Primary Site >> Liver Cancer
Gene >> UGT1A1
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Ref: Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. PMID: 9230212 |
Ref: Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. PMID: 10706110 |
Ref: Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. PMID: 15057901 |
Ref: Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. PMID: 15682470 |
Ref: Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. PMID: 16204462 |
Ref: Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines. PMID: 18248513 Ref: Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability. PMID: 18491077 Ref: The three-dimensional cultivation of the carcinoma cell line HepG2 in a perfused chip system leads to a more differentiated phenotype of the cells compared to monolayer culture. PMID: 18765895 |
Ref: Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach. PMID: 20600030 |
Ref: Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans. PMID: 21171088 Ref: Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. PMID: 21656528 Ref: Safety and Efficacy of Sorafenib in Patients with Hepatocellular Carcinoma (HCC) and Child-Pugh A versus B Cirrhosis. PMID: 21673874 |
Ref: Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates. PMID: 22447115 Ref: Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells. PMID: 22749127 |
Ref: Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PMID: 23382909 Ref: High-dose FOLFIRI, surgery, and radiofrequency ablation for patients with unresectable liver metastases from colorectal cancer. PMID: 23564804 Ref: Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells. PMID: 23726867 |
Ref: Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched pericarcinomatous tissues determined using an isotope label-free UPLC-MS/MS method. PMID: 25288013 Ref: Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients. PMID: 26010150 Ref: Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania. PMID: 26125716 |
Ref: High Resectability Rate of Initially Unresectable Colorectal Liver Metastases After UGT1A1-Adapted High-Dose Irinotecan Combined with LV5FU2 and Cetuximab: A Multicenter Phase II Study (ERBIFORT). PMID: 26739304 Ref: CUL4B, NEDD4, and UGT1As involve in the TGF-beta signalling in hepatocellular carcinoma. PMID: 27236156 Ref: Polymorphisms in SLCO1B1 and UGT1A1 are associated with sorafenib-induced toxicity. PMID: 27533851 |
Ref: UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population. PMID: 28294511 |