Primary Site >> Colorectal Cancer
Gene >> UGCG
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Ref: MRP1 and glucosylceramide are coordinately over expressed and enriched in rafts during multidrug resistance acquisition in colon cancer cells. PMID: 15122583 Ref: Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. PMID: 15141021 |
Ref: Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. PMID: 20540746 |
Ref: DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. PMID: 22349266 Ref: GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells. PMID: 22424291 |
Ref: Expression and significance of glucosylceramide synthase in colorectal carcinoma tissues. PMID: 25535133 |
Ref: AT7867 Inhibits Human Colorectal Cancer Cells via AKT-Dependent and AKT-Independent Mechanisms. PMID: 28081222 |