Primary Site >> Stomach Cancer
Gene >> TYMS
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Ref: [Thymidylate synthase inhibition in malignant tumors after oral administration of UFT]. PMID: 3099031 |
Ref: 5-Fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase. PMID: 2495166 |
Ref: [High-dose leucovorin and 5-FU]. PMID: 1626951 |
Ref: [UFT/CDDP preoperative chemotherapy for progressive gastric cancer--histological antitumor effects and thymidylate synthase inhibition rate]. PMID: 7487125 |
Ref: Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. PMID: 8558194 Ref: Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy. PMID: 8740793 |
Ref: Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum. PMID: 9626464 Ref: [The intratumoral levels of thymidylate synthetase and folate in gastric and colon cancer]. PMID: 9679579 |
Ref: Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection. PMID: 11161374 Ref: Gastric cancer with Virchow's and multiple lung metastases showing a remarkable response to preoperative chemotherapy: report of a case. PMID: 11321346 Ref: Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. PMID: 11445849 |
Ref: Synergistic cytotoxic effect between serine-threonine phosphatase inhibitors and 5-fluorouracil: a novel concept for modulation of cytotoxic effect. PMID: 11862424 Ref: Human colorectal malignancy and oral UFT. PMID: 12017314 Ref: Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer. PMID: 12530000 |
Ref: Differential alternative splicing expressions of thymidylate synthase isoforms. PMID: 12706868 |
Ref: Phase II clinical trial of parenteral hydroxyurea in combination with fluorouracil, interferon and filgrastim in the treatment of advanced pancreatic, gastric and neuroendocrine tumors. PMID: 14704829 Ref: Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU. PMID: 15224198 Ref: Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking. PMID: 15244514 Ref: Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma. PMID: 15330198 Ref: Association of thymidylate synthase polymorphisms with gastric cancer susceptibility. PMID: 15386366 Ref: [The association of expression and gene polymorphism of the thymidylate synthase gene with 5-fluoro-5'-deoxyuridine sensitivity in gastric cancer cell lines]. PMID: 15446554 |
Ref: [Assessment of dihydropyrimidine dehydrogenase and thymidylate synthase expression in gastric carcinoma and colonic carcinoma]. PMID: 15751630 Ref: Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy. PMID: 15897576 Ref: Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis. PMID: 15930032 Ref: [Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer]. PMID: 16030402 Ref: Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with irinotecan and cisplatin. PMID: 16303791 |
Ref: Polymorphism in the 3'-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy. PMID: 16424979 Ref: Determinants of chemosensitivity in gastric cancer. PMID: 16777480 Ref: Intratumoral heterogeneous expression of thymidylate synthase in gastric cancer. PMID: 16795992 Ref: [Combination chemotherapy of S-1 and docetaxel on advanced and recurrent gastric cancer]. PMID: 16897978 Ref: Prediction of clinical outcome of fluoropyrimidine-based chemotherapy for gastric cancer patients, in terms of the 5-fluorouracil metabolic pathway. PMID: 16952032 Ref: Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs. PMID: 16969485 |
Ref: Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil. PMID: 17609664 Ref: Expression of a molecular marker panel as a prognostic tool in gastric cancer patients treated postoperatively with docetaxel and irinotecan. A study of the Hellenic Cooperative Oncology Group. PMID: 17695481 |
Ref: ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen. PMID: 18362936 Ref: Challenges in predicting the clinical outcome in S-1-based chemotherapy for gastric cancer patients. PMID: 18553229 Ref: Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer. PMID: 18652704 Ref: The discrepancy in thymidylate synthase and dihydropyrimidine dehydrogenase expression depending on measurement methodologies in stage 4 gastric cancer. PMID: 19102414 |
Ref: Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions and gastric cancer. PMID: 18989779 Ref: Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer PMID: 19513514 Ref: Pharmacogenetics of fluoropyrimidine and cisplatin. A future application to gastric cancer treatment. PMID: 19638079 |
Ref: Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. PMID: 20047592 Ref: BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin. PMID: 20331623 Ref: The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells. PMID: 20372793 Ref: Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer. PMID: 20447923 Ref: Polymorphisms of thymidylate synthase gene 5'- and 3'-untranslated region and risk of gastric cancer in Koreans. PMID: 20651387 Ref: Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity. PMID: 20714149 |
Ref: Clinicopathologic significance of ERCC1, thymidylate synthase and glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy. PMID: 21133646 Ref: Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins. PMID: 21453385 Ref: Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells. PMID: 21561529 Ref: Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PMID: 21931799 Ref: Antitumour activity of S-1 in combination with cetuximab on human gastric cancer cell lines in vivo. PMID: 22110188 |
Ref: Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells. PMID: 22444164 Ref: 2R of thymidylate synthase 5'-untranslated enhanced region contributes to gastric cancer risk: a meta-analysis. PMID: 22901148 Ref: Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile. PMID: 22929309 Ref: 3R variant of thymidylate synthase 5'-untranslated enhanced region contributes to colorectal cancer risk: a meta-analysis. PMID: 22938428 |
Ref: An integrated analysis of the association between Ts gene polymorphisms and clinical outcome in gastric and colorectal cancer patients treated with 5-FU-based regimens. PMID: 23645036 Ref: Impact of excision repair cross-complementing gene 1 (ERCC1) on the outcomes of patients with advanced gastric cancer: correlative study in Japan Clinical Oncology Group Trial JCOG9912. PMID: 23884439 |
Ref: Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase. PMID: 23494117 Ref: Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment. PMID: 24415354 Ref: [Synergistic interaction between melittin and chemotherapeutic agents and their possible mechanisms: an experimental research]. PMID: 24672950 Ref: Correlation between expression of thymidylate synthase and clinical outcome of advanced gastric cancer treated with capecitabine alone chemotherapy. PMID: 25185651 Ref: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients. PMID: 25223338 Ref: Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers. PMID: 25232828 |
Ref: Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer. PMID: 24756984 Ref: Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer. PMID: 25112781 Ref: Retraction note: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients. PMID: 25888862 Ref: Delimiting Allelic Imbalance of TYMS by Allele-Specific Analysis. PMID: 26166093 Ref: Delineation of gastric cancer subtypes by co-regulated expression of receptor tyrosine kinases and chemosensitivity genes. PMID: 26396673 |
Ref: High/positive expression of 5-fluorouracil metabolic enzymes predicts better response to S-1 in patients with gastric cancer: a meta-analysis. PMID: 27012156 Ref: Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood. PMID: 27123139 Ref: The Significant Role of Cyclin D1 in the Synergistic Growth-inhibitory Effect of Combined Therapy of Vandetanib with 5-Fluorouracil for Gastric Cancer. PMID: 27798882 Ref: Tumor profiling of co-regulated receptor tyrosine kinase and chemoresistant genes reveal different targeting options for lung and gastroesophageal cancers. PMID: 28078044 |
Ref: Pharmacogenetic variants associated with outcome in patients with advanced gastric cancer treated with fluoropyrimidine and platinum-based triplet combinations: a pooled analysis of three prospective studies. PMID: 27995989 Ref: Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer. PMID: 28056823 Ref: Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. PMID: 28222070 Ref: Analysis of 12 variants in the development of gastric and colorectal cancers. PMID: 29358861 |
Ref: Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma. PMID: 28722177 Ref: Methods and significance of the combined detection of HER2 gene amplification and chemosensitivity in gastric cancer. PMID: 29125480 Ref: TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A gene mutation in Mexican colorectal cancer patients. PMID: 29906295 Ref: The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells. PMID: 30276573 |