Primary Site >> Colorectal Cancer
Gene >> TYMP
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Ref: 5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression. PMID: 7627962 Ref: Thymidine phosphorylase mediates the sensitivity of human colon carcinoma cells to 5-fluorouracil. PMID: 7642571 |
Ref: Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. PMID: 8757190 Ref: Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells. PMID: 8757194 Ref: Differential expression of platelet-derived endothelial cell growth factor (thymidine phosphorylase) in nonpolypoid and polypoid lesions of the colon. PMID: 21544470 |
Ref: Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer. PMID: 9570376 |
Ref: Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. PMID: 9516932 Ref: Regulation of expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in human colon carcinoma cells. PMID: 9537263 Ref: Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression correlated with tumor angiogenesis and macrophage infiltration in colorectal cancer. PMID: 9652793 |
Ref: Thymidine phosphorylase expression in human colorectal mucosa, adenoma and carcinoma: role of p53 expression. PMID: 10469391 Ref: Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas. PMID: 10519420 |
Ref: Expression of platelet-derived endothelial cell growth factor correlates with good prognosis in patients with colorectal carcinoma. PMID: 10618604 Ref: Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. PMID: 10778957 Ref: Tissue concentration of platelet-derived endothelial cell growth factor in colorectal cancer. PMID: 10831266 |
Ref: [Thymidine phosphorylase expression in hepatic metastasis from colorectal carcinoma]. PMID: 11707969 Ref: Prognostic role of angiogenesis in colorectal cancer. PMID: 11908690 |
Ref: The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells. PMID: 12466967 |
Ref: Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma. PMID: 12457033 Ref: The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion. PMID: 12469136 Ref: Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells. PMID: 12565833 Ref: Effects of introduction of dThdPase cDNA on sensitivity to 5'-deoxy-5-fluorouridine and tumor angiogenesis. PMID: 12632076 Ref: Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease. PMID: 12673445 Ref: Platelet-derived endothelial cell growth factor mediates Rho-associated coiled-coil domain kinase messenger RNA expression and promotes cell motility. PMID: 12794027 |
Ref: Platelet-derived endothelial cell growth factor expression is an independent prognostic factor in colorectal cancer patients after curative surgery. PMID: 15028312 Ref: [Expression of thymidine phosphorylase in cancer]. PMID: 15312368 |
Ref: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. PMID: 15655543 Ref: Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells. PMID: 15711180 Ref: Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemorad PMID: 16160472 |
Ref: Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy. PMID: 16931962 |
Ref: The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. PMID: 17179993 Ref: Angiogenic effect of naive and 5-fluorouracil resistant colon carcinoma on endothelial cells in vitro. PMID: 17686575 Ref: Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients. PMID: 19090149 |
Ref: Neoadjuvant treatment of colorectal cancer with bevacizumab: the perioperative angiogenic balance is sensitive to systemic thrombospondin-1 levels. PMID: 18381946 Ref: Significance of thymidine phosphorylase expression in stromal cells around invasive front of rectal cancer. PMID: 19260474 |
Ref: The dual role of thymidine phosphorylase in cancer development and chemotherapy. PMID: 19434693 Ref: A review on the use of molecular markers of cytotoxic therapy for colorectal cancer, what have we learned? PMID: 19473832 |
Ref: Value of gene polymorphisms as markers of 5-FU therapy response in stage III colon carcinoma: a pilot study. PMID: 20665215 Ref: Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy. PMID: 20727737 |
Ref: Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro. PMID: 22132975 |
Ref: Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer. PMID: 22593457 Ref: Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer. PMID: 23115484 Ref: Predictive role of thymidine phosphorylase expression in patients with colorectal cancer and its association with angiogenesis-related proteins and extracellular matrix components. PMID: 23160694 |
Ref: Changes in thymidine phosphorylase gene expression related to treatment of rectal cancer. PMID: 23749894 Ref: [Expression of vascular growth factors in intestinal tissues in colorectal carcinoma patients with schistosomiasis japonica]. PMID: 24024441 Ref: Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines. PMID: 24167597 |
Ref: Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression. PMID: 25202077 |
Ref: Gene expression differences in primary colorectal tumors and matched liver metastases: chemotherapy related or tumoral heterogeneity? PMID: 25301403 |
Ref: Phase II Trial of Target-guided Personalized Chemotherapy in First-line Metastatic Colorectal Cancer. PMID: 24517959 Ref: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis. PMID: 26676887 Ref: Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer. PMID: 27127154 Ref: Effects of Platelet-Derived Endothelial Cell Growth Factor and Doppler Perfusion Index in Patients with Colorectal Hepatic Metastases. PMID: 27493949 |
Ref: Identification of new SNPs associated with severe toxicity to capecitabine. PMID: 28347776 |
Ref: Thymidine phosphorylase: the unforeseen driver in colorectal cancer treatment? PMID: 29701074 Ref: [The influence of Thymidine Phosphorylase genetic variation on clinical outcomes and safety of colorectal cancer patients received adjuvant chemotherapy after R0 resection]. PMID: 30220141 |