Primary Site >> Colorectal Cancer
Gene >> TSC2
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Ref: Characterizing mutations in samples with low-level mosaicism by collection and analysis of DHPLC fractionated heteroduplexes. PMID: 12552557 |
Ref: Malignant perivascular epithelioid cell tumor of the colon: report of a case with molecular analysis. PMID: 16398680 |
Ref: Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. PMID: 17390011 Ref: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. PMID: 17671177 |
Ref: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. PMID: 20530489 Ref: Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. PMID: 20622004 |
Ref: mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. PMID: 21177869 Ref: Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment. PMID: 21999454 |
Ref: Fluorinated N,N'-diarylureas as AMPK activators. PMID: 23414799 Ref: Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. PMID: 24061475 |
Ref: Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. PMID: 24858802 |
Ref: Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway. PMID: 25936523 Ref: Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway. PMID: 26735435 Ref: PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. PMID: 26844273 Ref: PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. PMID: 28958491 |
Ref: Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer. PMID: 26975632 Ref: Curcumin targets the TFEB-lysosome pathway for induction of autophagy. PMID: 27689333 |
Ref: Expanding the Spectrum of Colonic Manifestations in Tuberous Sclerosis: L-Cell Neuroendocrine Tumor Arising in the Background of Rectal PEComa. PMID: 28733877 Ref: Osteopontin-integrin engagement induces HIF-1alpha-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. PMID: 29435158 Ref: Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling. PMID: 29800814 |