Primary Site >> Colorectal Cancer
Gene >> TP73
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Ref: Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. PMID: 9664127 |
Ref: p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. PMID: 10023682 Ref: Infrequent somatic mutations of the p73 gene in various human cancers. PMID: 10218465 Ref: Identification and classification of p53-regulated genes. PMID: 10588737 |
Ref: Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients. PMID: 11228544 |
Ref: p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells. PMID: 11327702 Ref: Loss of p27 expression predicts poor prognosis in patients with Dukes' B stage or proximal colorectal cancer. PMID: 11408921 Ref: Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. PMID: 11571580 Ref: Expression of p73 in colorectal carcinoma: clinicopathological relevance. PMID: 11675903 |
Ref: p73 overexpression is a prognostic factor in patients with colorectal adenocarcinoma. PMID: 11801554 Ref: Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. PMID: 12023887 Ref: No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese. PMID: 12430182 Ref: Differential expression of p63 isoforms in normal tissues and neoplastic cells. PMID: 12434410 |
Ref: p73 Overexpression and angiogenesis in human colorectal carcinoma. PMID: 12865464 |
Ref: Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal carcinomas. PMID: 14732927 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: Polymorphism of the p73 gene in relation to colorectal cancer risk and survival. PMID: 15485994 Ref: The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. PMID: 16181796 |
Ref: c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. PMID: 16505115 Ref: Questioning the oncogenic role of DeltaNp73alpha in different cell lines expressing p53 or not. PMID: 16721041 Ref: Expression of the p73 protein in rectal cancers with or without preoperative radiotherapy. PMID: 16750334 Ref: Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. PMID: 16835297 Ref: The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal carcinomas. PMID: 17029218 Ref: Regulating p73 isoforms in human tumours. PMID: 17044134 |
Ref: In vivo evaluation of the role of DNp73alpha protein in regulating the p53-dependent apoptotic pathway after treatment with cytotoxic drugs. PMID: 17096333 |
Ref: Wild-type p53 and p73 negatively regulate expression of proliferation related genes. PMID: 17982488 Ref: Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy. PMID: 18271923 Ref: E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. PMID: 18521084 Ref: p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis. PMID: 18546269 Ref: Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. PMID: 18922894 Ref: Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73. PMID: 19106635 |
Ref: p73 expression and its clinical significance in colorectal cancer. PMID: 19016816 Ref: Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73. PMID: 19558638 Ref: Significance of an exon 2 G4C14-to-A4T14 polymorphism in the p73 gene on survival in rectal cancer patients with or without preoperative radiotherapy. PMID: 19581013 Ref: Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer. PMID: 19609961 Ref: Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. PMID: 19690970 Ref: [P73 gene expression in colorectal adenocarcinoma: a prognostic or etiopathogenetic factor?]. PMID: 19835284 Ref: The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells. PMID: 19923910 |
Ref: The prognostic value of p73 overexpression in colorectal carcinoma: a clinicopathologic, immunohistochemical, and statistical study of 204 patients. PMID: 19956069 Ref: Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells. PMID: 20133503 Ref: TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status. PMID: 20146801 Ref: Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. PMID: 20442318 Ref: Association of a p73 exon 2 GC/AT polymorphism with colorectal cancer risk and survival in Tunisian patients. PMID: 20644956 Ref: Relationship between p73 polymorphism and the immunohistochemical profile of the full-length (TAp73) and NH2-truncated (DeltaNp73) isoforms in Tunisian patients. PMID: 20733477 Ref: p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival. PMID: 20845513 |
Ref: Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. PMID: 20812030 Ref: Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients. PMID: 21109973 Ref: CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer. PMID: 21344162 Ref: Endosialin expression in relation to clinicopathological and biological variables in rectal cancers with a Swedish clinical trial of preoperative radiotherapy. PMID: 21362178 Ref: p73 G4C14-A4T14 polymorphism and cancer risk: a meta-analysis based on 27 case-control studies. PMID: 21502193 Ref: Relationship between TP73 polymorphism (G4C14-A4T14) and cancer risk: a meta-analysis based on literatures. PMID: 21672615 Ref: Prognostic impact of DeltaTAp73 isoform levels and their target genes in colon cancer patients. PMID: 21807636 Ref: Expression of NF-kappaB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy. PMID: 22933966 |
Ref: Combined analysis of the association between p73 G4C14-to-A4T14 polymorphisms and cancer risk. PMID: 21617940 Ref: Effects of DeltaNp73beta on cisplatin treatment in colon cancer cells. PMID: 21837762 Ref: Association between the p73 exon 2 G4C14-to-A4T14 polymorphism and cancer risk: a meta-analysis. PMID: 22011187 Ref: Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. PMID: 22076304 Ref: Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. PMID: 22450763 Ref: STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death. PMID: 22462553 Ref: Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. PMID: 22643064 |
Ref: Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. PMID: 23373735 Ref: The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh] (R=Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways. PMID: 23850666 Ref: The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. PMID: 24163370 |
Ref: Differential expression of p53 family proteins in colorectal adenomas and carcinomas: Prognostic and predictive values. PMID: 23996743 Ref: Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. PMID: 24052409 Ref: Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53. PMID: 24247721 Ref: T-oligo as an anticancer agent in colorectal cancer. PMID: 24632202 Ref: Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland. PMID: 25539561 |
Ref: Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC 6H 4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-kappaB activation pathway and ubiquitination. PMID: 26003312 Ref: beta-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through DeltaNP73 Negative Regulation in Colon Cancer. PMID: 26023082 Ref: Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells. PMID: 26030884 Ref: Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines. PMID: 26043026 Ref: Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. PMID: 26294215 |
Ref: Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated DeltaNp73 Inhibition and p73 Activation. PMID: 26759239 Ref: Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. PMID: 27622714 Ref: Decreased expression of p73 in colorectal cancer. PMID: 27654017 |
Ref: Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). PMID: 28236663 Ref: [Application of PLA Method for Detection of p53/p63/p73 Complexes in Situ in Tumour Cells and Tumour Tissue]. PMID: 28471195 Ref: The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells. PMID: 28710427 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells. PMID: 29138581 Ref: Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador. PMID: 29258490 |
Ref: TAp73 inhibits cell invasion and migration by directly activating KAI1 expression in colorectal carcinoma. PMID: 29222041 Ref: Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. PMID: 29755130 Ref: A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer. PMID: 29896290 Ref: Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. PMID: 29945573 Ref: Long non-coding RNA TP73-AS1 sponges miR-194 to promote colorectal cancer cell proliferation, migration and invasion via up-regulating TGFalpha. PMID: 30010111 Ref: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer. PMID: 30191522 |