Primary Site >> Colorectal Cancer
Gene >> TP53BP1
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Ref: Cancer-specific gene therapy. PMID: 16096014 |
Ref: Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. PMID: 18804090 |
Ref: MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. PMID: 21285347 Ref: Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. PMID: 21382167 |
Ref: Alteration of the DNA damage response in colorectal tumor progression. PMID: 23332927 Ref: MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PMID: 23724141 Ref: Kruppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. PMID: 23919723 |
Ref: PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule. PMID: 24502970 Ref: Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. PMID: 24956373 |
Ref: Targeting BRG1 chromatin remodeler via its bromodomain for enhanced tumor cell radiosensitivity in vitro and in vivo. PMID: 25504753 Ref: Icotinib hydrochloride enhances the effect of radiotherapy by affecting DNA repair in colorectal cancer cells. PMID: 25572529 Ref: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. PMID: 26132569 Ref: Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer. PMID: 26261485 Ref: The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. PMID: 26383618 Ref: A prospective study on histone gamma-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome. PMID: 26541290 |
Ref: Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair. PMID: 26756216 Ref: RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. PMID: 26864624 Ref: Absent in melanoma 2 proteins in the development of cancer. PMID: 27328971 Ref: Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer. PMID: 27499037 Ref: Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. PMID: 27788492 Ref: Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein. PMID: 28082821 |
Ref: 53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway. PMID: 27838786 Ref: Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. PMID: 28219770 Ref: A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PMID: 28806777 |
Ref: Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers. PMID: 28803425 Ref: 53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells. PMID: 29388453 Ref: LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer. PMID: 30144787 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 |