Primary Site >> Colorectal Cancer
Gene >> TNKS2
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Ref: Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. PMID: 18026951 |
Ref: Telomerase activation without shortening of telomeric 3'-overhang is a poor prognostic factor in human colorectal cancer. PMID: 21108695 Ref: Frameshift mutations of poly(adenosine diphosphate-ribose) polymerase genes in gastric and colorectal cancers with microsatellite instability. PMID: 21333322 |
Ref: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. PMID: 22440753 |
Ref: Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. PMID: 24294969 |
Ref: Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and beta-Catenin Degradation. PMID: 28107521 |
Ref: Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1. PMID: 30046848 Ref: In silico insights on Tankyrase protein: a potential target for colorectal cancer. PMID: 30204055 |