Primary Site >> Colorectal Cancer
Gene >> TNKS
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Ref: Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. PMID: 18026951 |
Ref: Frameshift mutations of poly(adenosine diphosphate-ribose) polymerase genes in gastric and colorectal cancers with microsatellite instability. PMID: 21333322 |
Ref: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. PMID: 22440753 Ref: Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. PMID: 23050049 |
Ref: Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. PMID: 24294969 Ref: Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors. PMID: 24900633 |
Ref: Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes. PMID: 26124443 |
Ref: Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of beta-Catenin Degradation-Competent Axin Puncta. PMID: 26930278 Ref: The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the beta-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. PMID: 27068743 Ref: The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila. PMID: 27190037 Ref: The Discovery and Characterization of K-756, a Novel Wnt/beta-Catenin Pathway Inhibitor Targeting Tankyrase. PMID: 27196752 Ref: Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity. PMID: 27482906 |
Ref: Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and beta-Catenin Degradation. PMID: 28107521 Ref: Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. PMID: 28683851 |
Ref: TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer. PMID: 29222171 Ref: Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1. PMID: 30046848 Ref: In silico insights on Tankyrase protein: a potential target for colorectal cancer. PMID: 30204055 |