Primary Site >> Colorectal Cancer
Gene >> TNFSF10
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Ref: Carcinoembryonic antigen (CEA). A prospective clinical trail in patients with gastrointestinal cancer. PMID: 1064149 |
Ref: [Pelvic recurrence after abdomino-perineal resection for carcinoma of the rectum (author's transl)]. PMID: 6256878 |
Ref: Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11. PMID: 10626806 Ref: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for treatment of prostate cancer: first results and review of the literature. PMID: 12497168 |
Ref: The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. PMID: 10933923 Ref: Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene. PMID: 11027498 Ref: NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal cancer cells. PMID: 11045427 Ref: The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. PMID: 11103780 Ref: Expression and function of death receptors and their natural ligands in the intestine. PMID: 11193573 |
Ref: p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. PMID: 11139340 Ref: Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. PMID: 11245478 Ref: Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. PMID: 11290766 Ref: Sensitization of human colon cancer cells to TRAIL-mediated apoptosis. PMID: 11309649 Ref: Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells. PMID: 11313891 Ref: The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. PMID: 11439335 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 Ref: Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis. PMID: 11490359 Ref: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. PMID: 11513873 Ref: Interferon-gamma modulates TRAIL-mediated apoptosis in human colon carcinoma cells. PMID: 11911240 |
Ref: Electroporation-mediated tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L gene therapy for hepatocellular carcinoma. PMID: 11812283 Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections. PMID: 11874999 Ref: Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. PMID: 11875499 Ref: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). PMID: 11912124 Ref: Distinct intracellular signaling in tumor necrosis factor-related apoptosis-inducing ligand- and CD95 ligand-mediated apoptosis. PMID: 11980895 Ref: [Action of apoptosis-induced ligand gene in relation to tumor necrosis factor on human colon cancer cell line HT29]. PMID: 12015033 Ref: Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors. PMID: 12032863 Ref: Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. PMID: 12140294 Ref: Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro. PMID: 12168112 Ref: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. PMID: 12174820 Ref: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. PMID: 12203115 Ref: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. PMID: 12208739 Ref: Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. PMID: 12215894 Ref: Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. PMID: 12384541 Ref: Defining characteristics of Types I and II apoptotic cells in response to TRAIL. PMID: 12407450 Ref: Therapeutics targeting signal transduction for patients with colorectal carcinoma. PMID: 12421735 Ref: Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL. PMID: 12429913 Ref: Heat shock protects HCT116 and H460 cells from TRAIL-induced apoptosis. PMID: 12460647 Ref: Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter. PMID: 12473583 Ref: Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis. PMID: 12478469 Ref: [Phase III clinical study of a new anticancer drug atofluding]. PMID: 12520746 |
Ref: Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. PMID: 12566305 Ref: Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. PMID: 12660816 Ref: Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells. PMID: 12675269 Ref: Macrophages from cancer patients: analysis of TRAIL, TRAIL receptors, and colon tumor cell apoptosis. PMID: 12697854 Ref: Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29. PMID: 12717839 Ref: Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis. PMID: 12730681 Ref: Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene. PMID: 12738989 Ref: Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480. PMID: 12800232 Ref: Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. PMID: 12845629 Ref: Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines. PMID: 12865931 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: [Synergistic effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and doxorubicin on human colon cancer SW480 cells]. PMID: 12917026 Ref: NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. PMID: 12934082 Ref: Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. PMID: 12941843 Ref: Colon polyps and cytokines: emerging immunological mechanisms. PMID: 14502322 Ref: Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. PMID: 14519785 Ref: Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. PMID: 14645705 Ref: Quantum dot-based cell motility assay. PMID: 14686951 Ref: Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis. PMID: 14713105 |
Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. PMID: 14749540 Ref: AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression. PMID: 14999225 Ref: Quantification of tumor tissue populations by multispectral analysis. PMID: 15004796 Ref: Interferon-gamma and TRAIL in human breast tumor cells. PMID: 15110183 Ref: Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. PMID: 15120327 Ref: Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. PMID: 15142888 Ref: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. PMID: 15155747 Ref: Suppressing orthotopic pancreatic tumor growth with a fiber-modified adenovector expressing the TRAIL gene from the human telomerase reverse transcriptase promoter. PMID: 15161713 Ref: Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. PMID: 15177310 Ref: Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. PMID: 15205314 Ref: Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. PMID: 15226295 Ref: Tissue distribution, stability, and pharmacokinetics of Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in human colon carcinoma COLO205 tumor-bearing nude mice. PMID: 15282212 Ref: Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. PMID: 15374982 Ref: Laparoscopic versus open total mesorectal excision with anal sphincter preservation for low rectal cancer. PMID: 15457380 Ref: Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. PMID: 15480430 Ref: Gene therapy in colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter. PMID: 15517918 Ref: Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis. PMID: 15527805 Ref: [Adenoviral vector expressing the TRAIL gene driven by the hTERT promoter]. PMID: 15592959 Ref: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. PMID: 15604280 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 Ref: Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy. PMID: 15790545 Ref: (99m)Tc-Labeled lexatumumab PMID: 20641185 Ref: (99m)Tc-Labeled mapatumumab PMID: 20641397 Ref: (111)In-Labeled mapatumumab PMID: 20641403 Ref: (111)In-Labeled lexatumumab PMID: 20641892 |
Ref: Impaired activation of caspases and prevention of mitochondrial dysfunction in the metastatic colon carcinoma CC531s-m2 cell line. PMID: 15652237 Ref: Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis. PMID: 15685228 Ref: Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines. PMID: 15688023 Ref: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. PMID: 15757891 Ref: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. PMID: 15767553 Ref: Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. PMID: 15771956 Ref: Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor {alpha}-related apoptosis-inducing ligand/anticancer drug combinations. PMID: 15837763 Ref: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PMID: 15846298 Ref: Expression of tumour necrosis factor-related apoptosis-inducing ligand death receptors in sporadic and hereditary colorectal tumours: potential targets for apoptosis induction. PMID: 15911244 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: AKT activation and response to interferon-beta in human cancer cells. PMID: 15970687 Ref: 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines. PMID: 15993848 Ref: Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line. PMID: 16036110 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Bcl-xL/Bax ratio is altered by IFNgamma in TNFalpha- but not in TRAIL-induced apoptosis in colon cancer cell line. PMID: 16085058 Ref: Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. PMID: 16103097 Ref: Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). PMID: 16153452 Ref: TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. PMID: 16157217 Ref: Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. PMID: 16170023 Ref: Bioluminescent imaging of TRAIL-induced apoptosis through detection of caspase activation following cleavage of DEVD-aminoluciferin. PMID: 16177559 Ref: Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. PMID: 16199534 Ref: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. PMID: 16227396 Ref: Non-invasive fluorescence imaging of cell death in fresh human colon epithelia treated with 5-Fluorouracil, CPT-11 and/or TRAIL. PMID: 16251801 Ref: Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment. PMID: 16294025 Ref: Osteoprotegerin is expressed in colon carcinoma cells. PMID: 16309167 Ref: Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. PMID: 16357153 Ref: Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. PMID: 16373718 Ref: The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis. PMID: 16382051 Ref: TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH. PMID: 16387703 Ref: [Study of a multivariate statistical 5-ALA-based discrimination method for fluorescence spectra of colonic tissue of SD rats]. PMID: 16544499 |
Ref: PKCdelta-mediated regulation of FLIP expression in human colon cancer cells. PMID: 16052516 Ref: Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. PMID: 16082389 Ref: c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. PMID: 16247474 Ref: TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors. PMID: 16331624 Ref: Immunomodulation with low dose levamisole in patients with colonic polyps. PMID: 16458451 Ref: [Activity of the TNF-related apoptosis-inducing ligand gene expressed from the hTERT promoter on colon cancer cell line HT-29]. PMID: 16470920 Ref: [Security of dual cancer-specific targeting vector and its cytotoxic effect when harbored]. PMID: 16613667 Ref: Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy. PMID: 16618754 Ref: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. PMID: 16619034 Ref: KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand. PMID: 16707468 Ref: The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer. PMID: 16799468 Ref: Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. PMID: 16835297 Ref: TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. PMID: 16857810 Ref: Anti-idiotype antibody induced cellular immunity in mice transgenic for human carcinoembryonic antigen. PMID: 16895556 Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 Ref: Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines. PMID: 17012835 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 Ref: [Study on the effects of mitochondrial pathways on apoptosis in colon carcinoma cells induced by tumor necrosis factor related apoptosis inducing ligand]. PMID: 17143800 Ref: Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. PMID: 17145853 Ref: Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies. PMID: 17148761 Ref: [Study of the methods of wavelet feature extraction and neural network classification of fluorescence spectra to improve the diagnostic rate of colonic earlier stage cancer]. PMID: 17260761 |
Ref: Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver. PMID: 16478647 Ref: Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB. PMID: 16645643 Ref: TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. PMID: 17210702 Ref: Effect of hyperthermia on TRAIL-induced apoptotic death in human colon cancer cells: development of a novel strategy for regional therapy. PMID: 17212362 Ref: Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. PMID: 17234778 Ref: Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers. PMID: 17270019 Ref: Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. PMID: 17273769 Ref: Monoclonal antibodies in the treatment of non-Hodgkin's lymphoma. PMID: 17335294 Ref: Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells. PMID: 17431792 Ref: Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. PMID: 17434926 Ref: Expression of anti-apoptotic factors modulates Apo2L/TRAIL resistance in colon carcinoma cells. PMID: 17440816 Ref: 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. PMID: 17513605 Ref: Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo. PMID: 17551494 Ref: c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications. PMID: 17559541 Ref: Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand. PMID: 17579120 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Clearing the TRAIL for Cancer Therapy. PMID: 17613431 Ref: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. PMID: 17638911 Ref: Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. PMID: 17645780 Ref: The potential of death receptor 4- and 5-directed therapies in the treatment of lung cancer. PMID: 17681093 Ref: Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas. PMID: 17726263 Ref: Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. PMID: 17785559 Ref: Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. PMID: 17876056 Ref: Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4. PMID: 17881904 Ref: Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo. PMID: 17982666 Ref: Synergistic effects in apoptosis induction by taurolidine and TRAIL in HCT-15 colon carcinoma cells. PMID: 18097875 Ref: [The anti-diabetic drug troglitazone sensitizes colon cancer cells to TRAIL-induced apoptosis by down-regulating FLIP]. PMID: 18314627 |
Ref: Effect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells. PMID: 17520700 Ref: MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release. PMID: 17653087 Ref: Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis. PMID: 18060504 Ref: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. PMID: 18202809 Ref: BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity. PMID: 18204076 Ref: DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. PMID: 18245494 Ref: Effect of UV irradiation on colorectal cancer cells with acquired TRAIL resistance. PMID: 18247342 Ref: P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. PMID: 18345033 Ref: Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11. PMID: 18381960 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein. PMID: 18590777 Ref: Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. PMID: 18609706 Ref: OPG is regulated by beta-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer. PMID: 18676739 Ref: Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. PMID: 18680719 Ref: Synergism of CPT-11 and Apo2L/TRAIL against two differentially sensitive human colon tumor xenografts. PMID: 18714167 Ref: Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. PMID: 18726190 Ref: Prognostic significance of TRAIL-R1 and TRAIL-R3 expression in metastatic colorectal carcinomas. PMID: 18755584 Ref: [Overcoming acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand by Bcl-XL small interfering RNA in human colon cancer]. PMID: 18788624 Ref: CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer. PMID: 18830416 Ref: 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. PMID: 18852146 Ref: Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL. PMID: 18922903 Ref: Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. PMID: 18974136 Ref: TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. PMID: 19106633 Ref: Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. PMID: 19568915 |
Ref: Immunosensitization with a Bcl-2 small molecule inhibitor. PMID: 18807035 Ref: Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro. PMID: 19034449 Ref: Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. PMID: 19137010 Ref: Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade. PMID: 19224142 Ref: Targeting apoptosis as an approach for gastrointestinal cancer therapy. PMID: 19278896 Ref: Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. PMID: 19352384 Ref: Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. PMID: 19361506 Ref: Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin. PMID: 19424623 Ref: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. PMID: 19426686 Ref: Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. PMID: 19438509 Ref: Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes. PMID: 19454726 Ref: Fucose is on the TRAIL of colon cancer. PMID: 19482107 Ref: Stem cells are resistant to TRAIL receptor-mediated apoptosis. PMID: 19604313 Ref: TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors. PMID: 19637313 Ref: Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. PMID: 19654295 Ref: Colorectal cancer: Irinotecan therapy-following a trail of breadcrumbs? PMID: 19713983 Ref: Enhanced radiosensitivity of SW480 cells via TRAIL up-regulation mediated by Egr-1 promoter. PMID: 19724854 Ref: Phosphorothioate-modified TLR9 ligands protect cancer cells against TRAIL-induced apoptosis. PMID: 19734228 Ref: Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). PMID: 19734940 Ref: Cyclooxygenase 2 modulates killing of cytotoxic T lymphocytes by colon cancer cells. PMID: 19794924 Ref: Clinical application of sentinel lymph node biopsy for staging, treatment and prognosis of colon and gastric cancer. PMID: 20214202 Ref: [Comparison of oncological outcomes between laparoscopic and open procedures in non-metastazing colonic carcinomas]. PMID: 20662437 |
Ref: Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence. PMID: 19508388 Ref: Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. PMID: 19577358 Ref: Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol. PMID: 19916747 Ref: Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism. PMID: 20018172 Ref: Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. PMID: 20068564 Ref: Tumor suppressor XIAP-Associated factor 1 (XAF1) cooperates with tumor necrosis factor-related apoptosis-inducing ligand to suppress colon cancer growth and trigger tumor regression. PMID: 20082449 Ref: Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. PMID: 20087343 Ref: Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity. PMID: 20103630 Ref: Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo. PMID: 20137855 Ref: Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. PMID: 20150762 Ref: Synthetic constrained peptide selectively binds and antagonizes death receptor 5. PMID: 20156289 Ref: Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab. PMID: 20179215 Ref: TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer. PMID: 20182517 Ref: Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells. PMID: 20188103 Ref: beta-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent upregulation of DR5 and downregulation of NF-kappaB activity. PMID: 20354117 Ref: Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. PMID: 20388793 Ref: Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. PMID: 20424169 Ref: Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. PMID: 20428773 Ref: Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. PMID: 20544795 Ref: Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer. PMID: 20570920 Ref: Tumour-mediated TRAIL-Receptor expression indicates effective apoptotic depletion of infiltrating CD8+ immune cells in clinical colorectal cancer. PMID: 20580220 Ref: Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells. PMID: 20661477 Ref: Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations. PMID: 20673328 Ref: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. PMID: 20682650 Ref: Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines. PMID: 20811726 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: Colorectal cancer chemoprevention: the potential of a selective approach. PMID: 20942626 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 20978316 Ref: Implication of NF-kappaB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. PMID: 21713362 |
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PMID: 27617958 Ref: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. PMID: 27629794 Ref: Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. PMID: 27648301 Ref: Colonic Lamina Propria Inflammatory Cells from Patients with IBD Induce the Nuclear Factor-E2 Related Factor-2 Thereby Leading to Greater Proteasome Activity and Apoptosis Protection in Human Colonocytes. PMID: 27661668 Ref: BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-kappaB. PMID: 27721019 Ref: High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer. PMID: 27725224 Ref: An HPLC method associated with a thermodynamic analysis to compare the binding of TRAIL and its nanovectorized form to death receptors DR4 and DR5 and their relationship to cytotoxicity. PMID: 27750195 Ref: Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. PMID: 27827395 Ref: Two-stage nanoparticle delivery of piperlongumine and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) anti-cancer therapy. PMID: 27853735 |
Ref: Oxaliplatin immunohybrid nanoparticles in vitro synergistic suppression evaluation in treatment of colorectal cancer. PMID: 26933919 Ref: Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway. PMID: 27603596 Ref: miR-20a-directed regulation of BID is associated with the TRAIL sensitivity in colorectal cancer. PMID: 28004114 Ref: Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex. PMID: 28423356 Ref: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia. PMID: 28486050 Ref: Novel Structurally Related Flavones Augment Cell Death Induced by rhsTRAIL. PMID: 28587286 Ref: [Comparison of two on-line risk calculators versus the detection of circulating prostate cells for the detection of high risk prostate cancer at first biopsy.] PMID: 28613202 Ref: MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis. PMID: 28686677 Ref: Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRbeta Enhances the in vivo Antitumor Effects of Human TRAIL. PMID: 28740549 Ref: Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors. PMID: 28767654 Ref: TRAIL enhances quinacrine-mediated apoptosis in breast cancer cells through induction of autophagy via modulation of p21 and DR5 interactions. PMID: 28936683 Ref: TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors. PMID: 28994313 Ref: TRAIL mutant membrane penetrating peptide alike (TMPPA) TRAILMu3 enhances the antitumor effects of TRAIL in vitro and in vivo. PMID: 29039511 Ref: Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model. PMID: 29039580 Ref: Synergism between alpha-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway. PMID: 29039600 Ref: N-myc downstream-regulated gene 1 promotes apoptosis in colorectal cancer via up-regulating death receptor 4. PMID: 29137287 Ref: A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase beta in colorectal cancer in vivo and in vitro. PMID: 29207641 Ref: Hsp90 inhibitor sensitizes TRAIL-mediated apoptosis via chop-dependent DR5 upregulation in colon cancer cells. PMID: 29218092 Ref: Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. PMID: 29383150 |
Ref: Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. PMID: 28846107 Ref: Improving sensitivity of magnetic resonance imaging by using a dual-targeted magnetic iron oxide nanoprobe. PMID: 29100127 Ref: Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms. PMID: 29357916 Ref: Validity of the CR-POSSUM model in surgery for colorectal cancer in Spain (CCR-CARESS study) and comparison with other models to predict operative mortality. PMID: 29378647 Ref: Correlation Between Baseline Osteoprotegerin Serum Levels and Prognosis of Advanced-Stage Colorectal Cancer Patients. PMID: 29402836 Ref: Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells. PMID: 29541416 Ref: Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes. PMID: 29643993 Ref: Effects of Recombinant Circularly Permuted Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) (Recombinant Mutant Human TRAIL) in Combination with 5-Fluorouracil in Human Colorectal Cancer Cell Lines HCT116 and SW480. PMID: 29695684 Ref: Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations. PMID: 29731264 Ref: Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo. PMID: 29970185 Ref: Modified PAMAM vehicles for effective TRAIL gene delivery to colon adenocarcinoma: in vitro and in vivo evaluation. PMID: 30095012 Ref: Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5. PMID: 30160785 Ref: Editor's Note: Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species. PMID: 30181307 Ref: Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK-mediated DR5 regulation in colorectal cancer. PMID: 30221676 Ref: miR-128 Targets the SIRT1/ROS/DR5 Pathway to Sensitize Colorectal Cancer to TRAIL-Induced Apoptosis. PMID: 30257253 Ref: Intestinal Inflammation and Dysregulated Immunity in Patients with Inherited Caspase-8 Deficiency. PMID: 30267714 Ref: Colon-specific eQTL analysis to inform on functional SNPs. PMID: 30283144 Ref: Ixazomib promotes CHOP-dependent DR5 induction and apoptosis in colorectal cancer cells. PMID: 30359552 |