Primary Site >> Colorectal Cancer
Gene >> TNFRSF10B
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Ref: Frontiers in carcinoma of the colorectum from carcinogenesis to adjuvant therapy. PMID: 7369627 |
Ref: Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors. PMID: 2989604 Ref: Lymphokine-activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer. PMID: 3871657 |
Ref: Cancer patterns in Canada. PMID: 3942929 |
Ref: Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. PMID: 2437198 |
Ref: Ex vivo activation of killer monocytes (AKM) and their application to the treatment of human cancer. PMID: 3135291 Ref: The National Mortality Survey of China: implications for cancer control and prevention. PMID: 3242826 |
Ref: Inhibition of lymphokine-activated killer cell generation by cultured tumor cell lines in vitro. PMID: 2462468 Ref: Cytostatic and cytotoxic activity of lymphokine-activated killer cell supernatants. PMID: 2480843 Ref: Interleukin-2 and lymphokine-activated killer cell therapy of solid tumors: analysis of toxicity and management guidelines. PMID: 2647914 |
Ref: Substance P increases in vitro lymphokine-activated-killer (LAK) cell cytotoxicity against fresh colorectal cancer cells. PMID: 1279274 Ref: Resistance of different tumor cells to lysis by lymphokine activated killer cells can be mediated by distinct mechanisms. PMID: 1398742 |
Ref: Synergetic effect of interleukin-2 and cellular cytotoxicity against a novel tumor-associated carbohydrate antigen Le(a)/Le(a) (dimeric Le(a)) mediated by monoclonal antibody NCC-ST-421 in adoptive immunization using SCID mice. PMID: 8348564 |
Ref: Alteration in lymphocyte phenotype associated with administration of adjuvant levamisole and 5-fluorouracil. PMID: 7515770 Ref: Adenosine inhibits the adhesion of anti-CD3-activated killer lymphocytes to adenocarcinoma cells through an A3 receptor. PMID: 8012976 Ref: Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction. PMID: 8124689 |
Ref: Tumor-associated glycoantigen, sialyl Lewis(a) as a target for bispecific antibody-directed adoptive tumor immunotherapy. PMID: 7721341 |
Ref: Myocardial infarction. The number one killer of women. PMID: 9444172 Ref: Effects of thymic peptides, in vitro, on the impaired immunocytotoxicity of peripheral blood mononuclear cells from tumor patients. PMID: 21533400 |
Ref: Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. PMID: 10072170 Ref: Effectiveness and cost-effectiveness of colorectal cancer screening: Selecting the ideal strategy. PMID: 28976679 |
Ref: Combined antitumour activity of mitomycin C, 5-fluorouracil and interleukin-2 against human colon cancer cells. PMID: 10226560 |
Ref: Colorectal cancer: still a major killer despite progress on many fronts. PMID: 10751231 Ref: The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. PMID: 10933923 Ref: Cytokines secreted by lymphokine-activated killer cells induce endogenous nitric oxide synthesis and apoptosis in DLD-1 colon cancer cells. PMID: 11006006 Ref: [Locoregional immunotherapy of malignant effusions for colorectal cancer using OK-432 and its acting mechanisms--possibility of molecular diagnosis using TCRCDR 3 sequence]. PMID: 11086433 Ref: Cure of metastatic human colonic cancer in mice with radiolabeled monoclonal antibody fragments. PMID: 11156250 |
Ref: p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. PMID: 11139340 Ref: Colorectal cancer screening: the old and the new. PMID: 11233058 Ref: Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. PMID: 11245478 Ref: Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells. PMID: 11313891 Ref: p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. PMID: 11313989 Ref: Investigating the role of immunomodulation for colon cancer prevention: results of an in vivo dose escalation trial of levamisole with immunologic endpoints. PMID: 11341354 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 Ref: Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. PMID: 11526513 |
Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections. PMID: 11874999 Ref: Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. PMID: 11875499 Ref: Prognosis and response to therapy in colorectal cancer. PMID: 11978512 Ref: Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors. PMID: 12032863 Ref: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. PMID: 12174820 Ref: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. PMID: 12203115 Ref: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. PMID: 12208739 Ref: Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. PMID: 12384541 Ref: Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter. PMID: 12473583 |
Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: Macrophages from cancer patients: analysis of TRAIL, TRAIL receptors, and colon tumor cell apoptosis. PMID: 12697854 Ref: Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis. PMID: 12730681 Ref: Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. PMID: 12845629 Ref: Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines. PMID: 12865931 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. PMID: 14645705 |
Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: The importance of improving awareness of colorectal cancer. PMID: 15119130 Ref: Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. PMID: 15142888 Ref: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. PMID: 15155747 Ref: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. PMID: 15322075 Ref: Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. PMID: 15374982 Ref: Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. PMID: 15480430 Ref: Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy. PMID: 15790545 Ref: (99m)Tc-Labeled lexatumumab PMID: 20641185 Ref: (99m)Tc-Labeled mapatumumab PMID: 20641397 Ref: (111)In-Labeled mapatumumab PMID: 20641403 Ref: (111)In-Labeled lexatumumab PMID: 20641892 |
Ref: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. PMID: 15757891 Ref: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PMID: 15846298 Ref: Expression of tumour necrosis factor-related apoptosis-inducing ligand death receptors in sporadic and hereditary colorectal tumours: potential targets for apoptosis induction. PMID: 15911244 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. PMID: 16227396 Ref: Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. PMID: 16357153 Ref: Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. PMID: 16373718 |
Ref: c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. PMID: 16247474 Ref: Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. PMID: 16554294 Ref: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. PMID: 16619034 Ref: Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. PMID: 16688727 Ref: Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. PMID: 16835297 Ref: Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. PMID: 17145853 |
Ref: Update on colorectal cancer imaging. PMID: 17157625 Ref: Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. PMID: 17273769 Ref: [Mechanism study of antisense cyclin B1 in tumorigenesis inhibition using proteomic technique]. PMID: 17355788 Ref: Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. PMID: 17510406 Ref: Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo. PMID: 17551494 Ref: c-FLIP: a key regulator of colorectal cancer cell death. PMID: 17575142 Ref: Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand. PMID: 17579120 Ref: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. PMID: 17638911 Ref: Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. PMID: 17645780 Ref: The potential of death receptor 4- and 5-directed therapies in the treatment of lung cancer. PMID: 17681093 Ref: Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. PMID: 17785559 Ref: Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. PMID: 17876056 Ref: Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4. PMID: 17881904 Ref: Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo. PMID: 17982666 Ref: Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. PMID: 17982676 |
Ref: 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. PMID: 17957723 Ref: Colonography by CT, MRI and PET/CT combined with conventional colonoscopy in colorectal cancer screening and staging. PMID: 18240342 Ref: Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. PMID: 18245490 Ref: DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. PMID: 18245494 Ref: A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes. PMID: 18304965 Ref: Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. PMID: 18377873 Ref: Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11. PMID: 18381960 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. PMID: 18460448 Ref: [Frequency of cancer at older ages]. PMID: 18511360 Ref: Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. PMID: 18590575 Ref: Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. PMID: 18593893 Ref: Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. PMID: 18680719 Ref: Synergism of CPT-11 and Apo2L/TRAIL against two differentially sensitive human colon tumor xenografts. PMID: 18714167 Ref: Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. PMID: 18726190 Ref: 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. PMID: 18852146 Ref: Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. PMID: 18974136 Ref: Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73. PMID: 19106635 Ref: Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. PMID: 19568915 |
Ref: Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. PMID: 19219602 Ref: Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade. PMID: 19224142 Ref: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. PMID: 19264955 Ref: Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. PMID: 19352384 Ref: Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin. PMID: 19424623 Ref: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. PMID: 19426686 Ref: Stem cells are resistant to TRAIL receptor-mediated apoptosis. PMID: 19604313 Ref: TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors. PMID: 19637313 Ref: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. PMID: 19638488 Ref: Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. PMID: 19654295 Ref: [Discovery of a new type of human regulatory T cell lines, HOZOTs, and their clinical application]]. PMID: 19721342 Ref: Phosphorothioate-modified TLR9 ligands protect cancer cells against TRAIL-induced apoptosis. PMID: 19734228 Ref: Smac deficiency affects endoplasmic reticulum stress-induced apoptosis in human colon cancer cells. PMID: 20209078 Ref: Sulindac Sulfide Differentially Induces Apoptosis in Smac-Proficient and -Deficient Human Colon Cancer Cells. PMID: 20419043 |
Ref: Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. PMID: 19577358 Ref: Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism. PMID: 20018172 Ref: Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. PMID: 20087343 Ref: Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity. PMID: 20103630 Ref: Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. PMID: 20150762 Ref: Synthetic constrained peptide selectively binds and antagonizes death receptor 5. PMID: 20156289 Ref: beta-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent upregulation of DR5 and downregulation of NF-kappaB activity. PMID: 20354117 Ref: Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. PMID: 20371690 Ref: Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC). PMID: 20399639 Ref: High-throughput SNP/CGH approaches for the analysis of genomic instability in colorectal cancer. PMID: 20416328 Ref: Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. PMID: 20428773 Ref: Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer. PMID: 20570920 Ref: Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations. PMID: 20673328 Ref: Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines. PMID: 20811726 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: A first-in-human study of conatumumab in adult patients with advanced solid tumors. PMID: 20947515 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 20978316 Ref: Implication of NF-kappaB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. PMID: 21713362 |
Ref: Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. PMID: 21037225 Ref: ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. PMID: 21127198 Ref: Hedgehog signaling drives cellular survival in human colon carcinoma cells. PMID: 21135115 Ref: Death receptor 5-mediated TNFR family signaling pathways modulate gamma-humulene-induced apoptosis in human colorectal cancer HT29 cells. PMID: 21152878 Ref: Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. PMID: 21156789 Ref: Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. PMID: 21195543 Ref: Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5. PMID: 21272366 Ref: Adeno-associated virus-mediated anti-DR5 chimeric antibody expression suppresses human tumor growth in nude mice. PMID: 21306822 Ref: Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. PMID: 21362627 Ref: Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity. PMID: 21486277 Ref: High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde. PMID: 21513580 Ref: Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells. PMID: 21519792 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 21538027 Ref: Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells. PMID: 21550977 Ref: Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation. PMID: 21653830 Ref: The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo. PMID: 21709442 Ref: Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance. PMID: 21738740 Ref: Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. PMID: 21779837 Ref: Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: correlation with advanced stages. PMID: 21805040 Ref: 2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression. PMID: 21817114 Ref: Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma. PMID: 21978492 Ref: GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. PMID: 22027835 |
Ref: PNAS-4 expression and its relationship to p53 in colorectal cancer. PMID: 21556770 Ref: Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. PMID: 21797841 Ref: Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. PMID: 21927023 Ref: 2A peptide-based, lentivirus-mediated anti-death receptor 5 chimeric antibody expression prevents tumor growth in nude mice. PMID: 21934654 Ref: Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. PMID: 22018732 Ref: Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells. PMID: 22076304 Ref: Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. PMID: 22086925 Ref: Hyperthermia-enhanced TRAIL- and mapatumumab-induced apoptotic death is mediated through mitochondria in human colon cancer cells. PMID: 22174016 Ref: First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer-hybrid epitope long peptide of MAGE-A4 cancer antigen. PMID: 22221328 Ref: 3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells. PMID: 22359244 Ref: Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PMID: 22389673 Ref: Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. PMID: 22395735 Ref: An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. PMID: 22465431 Ref: Improved activation toward primary colorectal cancer cells by antigen-specific targeting autologous cytokine-induced killer cells. PMID: 22481963 Ref: Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. PMID: 22495350 Ref: The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells. PMID: 22555452 Ref: Snake venom toxin from Vipera lebetina turanica induces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression. PMID: 22681760 Ref: Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation. PMID: 22895172 Ref: Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. PMID: 22922338 Ref: The synergistic effects of low-dose irinotecan and TRAIL on TRAIL-resistant HT-29 colon carcinoma in vitro and in vivo. PMID: 22922573 Ref: [Hepatic intra-arterial infusion of biological response modifier (BRM)-activated killer immune lymphocytes to treat liver cancer]. PMID: 23267895 |
Ref: Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells. PMID: 23001792 Ref: Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. PMID: 23135489 Ref: Lung cancer chemoprevention: difficulties, promise and potential agents? PMID: 23167766 Ref: Enhanced antitumor activity of the photosensitizer meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles. PMID: 23327610 Ref: Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects. PMID: 23429289 Ref: Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins. PMID: 23435998 Ref: Study protocol for "Moving Bright, Eating Smart"- A phase 2 clinical trial on the acceptability and feasibility of a diet and physical activity intervention to prevent recurrence in colorectal cancer survivors. PMID: 23688320 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy. PMID: 23752617 Ref: Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model. PMID: 23754197 Ref: Chemotherapy sensitizes colon cancer initiating cells to Vgamma9Vdelta2 T cell-mediated cytotoxicity. PMID: 23762301 Ref: Targeting cancer with a bi-functional peptide: in vitro and in vivo results. PMID: 23812212 Ref: Efficacy of postoperative adjuvant transfusion of cytokine-induced killer cells combined with chemotherapy in patients with colorectal cancer. PMID: 23974720 Ref: Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation. PMID: 24002210 Ref: Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008. PMID: 24045184 Ref: Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. PMID: 24118446 Ref: TRAIL receptor agonist conatumumab with modified FOLFOX6 plus bevacizumab for first-line treatment of metastatic colorectal cancer: A randomized phase 1b/2 trial. PMID: 24122767 Ref: Comparison of population based cancer incidence rates among Circassians, Chechans and Arabs in Jordan (1996-2005). PMID: 24289621 Ref: The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. PMID: 24512730 |
Ref: The impact of personalized medicine on survival: comparisons of results in metastatic breast, colorectal and non-small-cell lung cancers. PMID: 24112813 Ref: Peroxisome proliferator-activated receptor gamma ligand troglitazone and TRAIL synergistically induce apoptosis. PMID: 24276615 Ref: Regulation of TRAIL receptor expression by beta-catenin in colorectal tumours. PMID: 24379239 Ref: Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells. PMID: 24530917 Ref: Laminarin-induced apoptosis in human colon cancer LoVo cells. PMID: 24765209 Ref: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. PMID: 24840647 Ref: Modification of chemokine receptor expression to enhance levels of trafficking receptors on autologous cytokine-induced killer cells derived from patients with colorectal cancer. PMID: 24855035 Ref: Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. PMID: 24905183 Ref: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. PMID: 24930757 Ref: Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-re PMID: 24939851 Ref: Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells. PMID: 25102912 Ref: Annona muricata leaves induce G(1) cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. PMID: 25195082 Ref: Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine. PMID: 25200008 Ref: Retrospective comparative study of the effects of dendritic cell vaccine and cytokine-induced killer cell immunotherapy with that of chemotherapy alone and in combination for colorectal cancer. PMID: 25210706 Ref: Virtual gastrointestinal colonoscopy in combination with large bowel endoscopy: clinical application. PMID: 25320519 Ref: Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction. PMID: 25484045 |
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