Primary Site >> Colorectal Cancer
Gene >> TNFRSF10A
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Ref: p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. PMID: 10694497 Ref: Expression and function of death receptors and their natural ligands in the intestine. PMID: 11193573 |
Ref: Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. PMID: 11245478 Ref: Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. PMID: 11290766 Ref: Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells. PMID: 11313891 Ref: p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. PMID: 11313989 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 |
Ref: TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections. PMID: 11874999 Ref: Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. PMID: 12140294 Ref: Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. PMID: 12384541 Ref: Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter. PMID: 12473583 |
Ref: Macrophages from cancer patients: analysis of TRAIL, TRAIL receptors, and colon tumor cell apoptosis. PMID: 12697854 Ref: Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. PMID: 12845629 Ref: Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines. PMID: 12865931 |
Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. PMID: 15142888 Ref: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. PMID: 15155747 Ref: Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. PMID: 15480430 Ref: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. PMID: 15604280 Ref: Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy. PMID: 15790545 Ref: (99m)Tc-Labeled lexatumumab PMID: 20641185 Ref: (99m)Tc-Labeled mapatumumab PMID: 20641397 Ref: (111)In-Labeled mapatumumab PMID: 20641403 |
Ref: Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis. PMID: 15685228 Ref: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. PMID: 15757891 Ref: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PMID: 15846298 Ref: Expression of tumour necrosis factor-related apoptosis-inducing ligand death receptors in sporadic and hereditary colorectal tumours: potential targets for apoptosis induction. PMID: 15911244 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. PMID: 16227396 Ref: Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. PMID: 16373718 |
Ref: Death receptor 4 variants and colorectal cancer risk. PMID: 17035413 |
Ref: c-FLIP: a key regulator of colorectal cancer cell death. PMID: 17575142 Ref: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. PMID: 17638911 Ref: The potential of death receptor 4- and 5-directed therapies in the treatment of lung cancer. PMID: 17681093 Ref: Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. PMID: 17785559 Ref: Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. PMID: 17876056 |
Ref: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. PMID: 18202809 Ref: DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. PMID: 18245494 Ref: Gene profiling of colonic serrated adenomas by using oligonucleotide microarray. PMID: 18305945 Ref: Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. PMID: 18590575 Ref: Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. PMID: 18680719 Ref: Prognostic significance of TRAIL-R1 and TRAIL-R3 expression in metastatic colorectal carcinomas. PMID: 18755584 |
Ref: Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade. PMID: 19224142 Ref: Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. PMID: 19352384 Ref: Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin. PMID: 19424623 Ref: Stem cells are resistant to TRAIL receptor-mediated apoptosis. PMID: 19604313 Ref: TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors. PMID: 19637313 Ref: Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. PMID: 19654295 |
Ref: Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. PMID: 19577358 Ref: Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism. PMID: 20018172 Ref: Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. PMID: 20068564 Ref: Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. PMID: 20087343 Ref: Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. PMID: 20150762 Ref: Synthetic constrained peptide selectively binds and antagonizes death receptor 5. PMID: 20156289 Ref: Tumour-mediated TRAIL-Receptor expression indicates effective apoptotic depletion of infiltrating CD8+ immune cells in clinical colorectal cancer. PMID: 20580220 Ref: Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations. PMID: 20673328 Ref: Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines. PMID: 20811726 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 20978316 Ref: Implication of NF-kappaB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. PMID: 21713362 |
Ref: Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. PMID: 21037225 Ref: ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. PMID: 21127198 Ref: Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity. PMID: 21486277 Ref: Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. PMID: 21538027 Ref: Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation. PMID: 21653830 Ref: Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. PMID: 21779837 Ref: GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. PMID: 22027835 |
Ref: Hyperthermia-enhanced TRAIL- and mapatumumab-induced apoptotic death is mediated through mitochondria in human colon cancer cells. PMID: 22174016 Ref: Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PMID: 22389673 Ref: Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. PMID: 22495350 Ref: The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells. PMID: 22555452 Ref: Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. PMID: 22922338 Ref: The synergistic effects of low-dose irinotecan and TRAIL on TRAIL-resistant HT-29 colon carcinoma in vitro and in vivo. PMID: 22922573 Ref: A magnetic switch for the control of cell death signalling in in vitro and in vivo systems. PMID: 23042417 Ref: The role of Bcl-xL in synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia on human colon cancer. PMID: 23051936 |
Ref: Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. PMID: 23135489 Ref: Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects. PMID: 23429289 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells. PMID: 24013390 Ref: Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. PMID: 24118446 Ref: The prognostic value of the apoptosis pathway in colorectal cancer: a review of the literature on biomarkers identified by immunohistochemistry. PMID: 24179395 |
Ref: Regulation of TRAIL receptor expression by beta-catenin in colorectal tumours. PMID: 24379239 Ref: Laminarin-induced apoptosis in human colon cancer LoVo cells. PMID: 24765209 Ref: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. PMID: 24930757 |
Ref: Functional characterization of the tumor-suppressor MARCKS in colorectal cancer and its association with survival. PMID: 24662837 Ref: Antimicrobial peptide m2163 or m2386 identified from Lactobacillus casei ATCC 334 can trigger apoptosis in the human colorectal cancer cell line SW480. PMID: 25557887 Ref: TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol. PMID: 25704023 Ref: Genetic variants in the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and death receptor (DR4) genes contribute to susceptibility to colorectal cancer in pakistani population. PMID: 26518902 Ref: Editorial. PMID: 26520390 Ref: Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B. PMID: 26561202 |
Ref: The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. PMID: 26771233 Ref: Bakuchiol sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins. PMID: 27033605 Ref: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. PMID: 27629794 Ref: BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-kappaB. PMID: 27721019 Ref: Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. PMID: 27827395 |
Ref: Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway. PMID: 27603596 Ref: Anticancer activity of Nelumbo nucifera stamen extract in human colon cancer HCT-116 cells in vitro. PMID: 28454279 Ref: TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors. PMID: 28994313 |
Ref: DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus. PMID: 29446085 Ref: Effects of Recombinant Circularly Permuted Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) (Recombinant Mutant Human TRAIL) in Combination with 5-Fluorouracil in Human Colorectal Cancer Cell Lines HCT116 and SW480. PMID: 29695684 Ref: Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations. PMID: 29731264 Ref: Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo. PMID: 29970185 Ref: Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5. PMID: 30160785 Ref: Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK-mediated DR5 regulation in colorectal cancer. PMID: 30221676 |