Primary Site >> Pancreatic Cancer
Gene >> TNF
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Ref: [Antitumor effect of the tumor necrosis factor against various types of human cancer cells]. PMID: 4062318 |
Ref: Antiproliferative effects exerted by recombinant human tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human pancreatic tumor cell lines. PMID: 3131759 |
Ref: [Low sensitivity of choriocarcinoma cell lines to tumor necrosis factor (TNF)-alpha]. PMID: 2504846 Ref: [Clinical efficacy of intratumoral administration of BRM in advanced cancer and their mechanism of actions]. PMID: 2782888 |
Ref: Binding and biological effects of tumor necrosis factor and gamma interferon in human pancreatic carcinoma cells. PMID: 2111548 |
Ref: Upregulation of interferon-gamma binding by tumor necrosis factor and lymphotoxin: disparate potencies of the cytokines and modulation of their effects by phorbol ester. PMID: 1903142 Ref: Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells. PMID: 1906154 |
Ref: [Effect of lipid A on the production of tumor necrosis factor (TNF) and antitumor activity against pancreatic cancer cells: preliminary report]. PMID: 1508144 Ref: Activity of a recombinant transforming growth factor-alpha-Pseudomonas exotoxin hybrid protein against primary human tumor colony-forming units. PMID: 1607249 |
Ref: Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium. PMID: 7687590 Ref: De novo expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in pancreas cancer. PMID: 8093883 Ref: Inverse regulation of human ERBB2 and epidermal growth factor receptors by tumor necrosis factor alpha. PMID: 8105469 Ref: Anti-proliferative effect of combined tumour necrosis factor-alpha and interferon-alpha on human pancreatic cancer in vitro and in vivo. PMID: 8239528 Ref: Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. PMID: 8430098 Ref: The expression and biological activity of IL-2 receptor on a human pancreas cancer cell line. PMID: 8507543 |
Ref: The MHC class-II and CD44 molecules are involved in the induction of tumour necrosis factor (TNF) gene expression by human monocytes stimulated with tumour cells. PMID: 7508890 Ref: Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. PMID: 7512810 Ref: [Molecular mechanism in hematogenous metastasis of pancreas carcinoma--possible implication of tumor-derived cytokine in a cell-to-cell interaction of pancreas carcinoma and vascular endothelial cells]. PMID: 7525435 Ref: Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. PMID: 7804431 Ref: Response of adenosquamous carcinoma of the pancreas to interferon-alpha, tumor necrosis factor-alpha and 5-fluorouracil combined treatment. PMID: 7872711 Ref: Recombinant human tumor necrosis factor causes regression in patients with advanced malignancies. PMID: 8208522 |
Ref: E-selectin expression induced by pancreas-carcinoma-derived interleukin-1 alpha results in enhanced adhesion of pancreas-carcinoma cells to endothelial cells. PMID: 7532161 Ref: Characterization of a novel human tumor necrosis factor-alpha mutant with increased cytotoxic activity. PMID: 7737913 Ref: Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production. PMID: 7882388 Ref: Tumor-associated lymphocytes (TAL) are competent to produce higher levels of cytokines in neoplastic pleural and peritoneal effusions than those found in sera and are able to release into culture higher levels of IL-2 and IL-6 than those released by PBMC. PMID: 8528743 |
Ref: Effects of a new synthetic lipid A on endogenous tumor necrosis factor production and antitumor activity against human pancreatic cancer cells. PMID: 8830332 Ref: Augmented antitumor effects of killer cells induced by tumor necrosis factor gene-transduced autologous tumor cells from gastrointestinal cancer patients. PMID: 8894681 Ref: Endogenous tumor necrosis factor inhibits the cytotoxicity of exogenous tumor necrosis factor and adriamycin in pancreatic carcinoma cells. PMID: 8899800 Ref: Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms. PMID: 8915489 Ref: Elevated serum interleukin-6 and decreased thyroid hormone levels in postoperative patients and effects of IL-6 on thyroid cell function in vitro. PMID: 9001195 Ref: Synthetic lipid A produces antitumor effect in a hamster pancreatic carcinoma model through production of tumor necrosis factor from activated macrophages. PMID: 9023454 |
Ref: Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer. PMID: 9164211 Ref: Biliary interleukin-6 and tumor necrosis factor-alpha in patients undergoing endoscopic retrograde cholangiopancreatography. PMID: 9201097 Ref: [Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]. PMID: 9276872 Ref: Endogenous tumor necrosis factor functions as a resistant factor against hyperthermic cytotoxicity in pancreatic carcinoma cells via enhancement of the heart shock element-binding activity of heart shock factor 1. PMID: 9395854 Ref: TNF-alpha induction of A1 expression in human cancer cells. PMID: 9563010 Ref: [The inhibitory effect of combined treatment of TNF alpha and antisense oligodeoxynucleotides on the growth of human pancreatic carcinoma cell line cells]. PMID: 10374336 Ref: Experimental study of the effect of IL-6 on cancer cachexia. PMID: 21590167 |
Ref: Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes. PMID: 9485028 Ref: Albumin synthesis rates are not decreased in hypoalbuminemic cachectic cancer patients with an ongoing acute-phase protein response. PMID: 9488524 Ref: An apoptosis-inducing gene therapy for pancreatic cancer with a combination of 55-kDa tumor necrosis factor (TNF) receptor gene transfection and mutein TNF administration. PMID: 9563482 Ref: The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. PMID: 9781666 |
Ref: Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase. PMID: 9989930 Ref: Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells. PMID: 10210643 Ref: Neopterin serum levels in pancreatic adenocarcinoma. PMID: 10211419 Ref: Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cells. PMID: 10231843 Ref: Hollow-spheres: a new model for analyses of differentiation of pancreatic duct epithelial cells. PMID: 10415853 Ref: Growth factors and cytokines in pancreatic carcinogenesis. PMID: 10415856 Ref: Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells. PMID: 10455908 Ref: Two polymorphisms of the tumour necrosis factor gene do not influence survival in pancreatic cancer. PMID: 10469042 Ref: Tumor size and lymph-node status in pancreatic carcinoma - is there a correlation to the preoperative immune function? PMID: 10552294 |
Ref: C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells. PMID: 10672841 Ref: Transforming growth factor-beta1 acts as a potent inhibitor of complement C3 biosynthesis in human pancreatic cancer cell lines. PMID: 10707928 Ref: Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. PMID: 10760829 Ref: Enhanced expression of Silencer of death domains (SODD/BAG-4) in pancreatic cancer. PMID: 10799310 Ref: The expression of chemokine genes correlates with nuclear factor-kappaB activation in human pancreatic cancer cell lines. PMID: 10881930 Ref: Dynamics of diurnal changes in serum concentration of TNF-alpha soluble receptors in gastrointestinal cancer patients. PMID: 11037054 |
Ref: Dynamics of circadian fluctuations in serum concentration of cortisol and TNF-alpha soluble receptors in gastrointestinal cancer patients. PMID: 11115600 Ref: Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines. PMID: 11169257 Ref: Loss of skeletal muscle in cancer: biochemical mechanisms. PMID: 11171557 Ref: Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients. PMID: 11396212 Ref: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. PMID: 11513873 Ref: Augmented adriamycin sensitivity in cells transduced with an antisense tumor necrosis factor gene is mediated by caspase-3 downstream from reactive oxygen species. PMID: 11572767 Ref: Antioxidants inhibit cytokine production and suppress NF-kappaB activation in CAPAN-1 and CAPAN-2 cell lines. PMID: 11768272 Ref: PI-3' kinase and NF-kappaB cross-signaling in human pancreatic cancer cells. PMID: 12086898 |
Ref: The role of oxygen-derived free radicals and nitric oxide in cytokine-induced antiproliferation of pancreatic cancer cells. PMID: 11854621 Ref: Laparoscopic gatrojejunostomy for palliation of gastric outlet obstruction in unresectable gastric cancer. PMID: 12073005 Ref: Large-scale expansion of CD3(+)CD56(+) lymphocytes capable of lysing autologous tumor cells with cytokine-rich supernatants. PMID: 12202905 Ref: Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. PMID: 12239630 Ref: Resection of pancreatic cancer normalizes the preoperative increase of tumor necrosis factor alpha gene expression. PMID: 12378118 Ref: Endogenous tumor necrosis factor promotes resistance to cellular stresses by inducing the metallothionein-1A gene. PMID: 12553033 |
Ref: Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. PMID: 12490654 Ref: Experimental studies of serum cytokine concentration following pancreatic electrolytic ablation. PMID: 12552236 Ref: Site-dependent angiogenic cytokine production in human tumor xenografts. PMID: 12670449 Ref: Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. PMID: 12712434 Ref: Circadian fluctuations of melatonin, tumor necrosis factor-alpha and its soluble receptors in the circulation of patients with advanced gastrointestinal cancer. PMID: 12866566 Ref: Diverse responses between human pancreatic cancer cell lines to native alpha 1-antitrypsin and its C-terminal fragment. PMID: 12894502 Ref: Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis. PMID: 14560157 |
Ref: The lack of a systemic inflammatory response syndrome supports the safety of pancreatic electrolysis: experimental studies. PMID: 14732357 Ref: A bispecific antibody to enhance radiotherapy by tumor necrosis factor-alpha in human CEA-expressing digestive tumors. PMID: 14751531 Ref: Prevention and reversal of tumor cell-induced monocyte deactivation by cytokines, purified protein derivative (PPD), and anti-IL-10 antibody. PMID: 15327279 Ref: [A case report of metastatic pancreatic cancer that responded remarkably to the combination of thalidomide, celecoxib and irinotecan]. PMID: 15446566 Ref: Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis. PMID: 15454338 Ref: [The repetitive immune cell transfer therapy combining non-myelosuppressive chemotherapy for patients with advanced and refractory cancer]. PMID: 15553672 Ref: [Study on acute pancreatitis-associated lung injury induced by L-arginine in mice]. PMID: 15573769 |
Ref: Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: low-dose ifosfamide and local tumor irradiation. PMID: 15455374 Ref: Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. PMID: 15753541 Ref: Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. PMID: 15781649 Ref: Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-kappaB inhibitor. PMID: 16211219 Ref: Phase I study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: expression analysis of genes related to outcome. PMID: 16314628 Ref: Insulinotropic and anti-inflammatory effects of rosiglitazone in experimental autoimmune diabetes. PMID: 17491689 |
Ref: Beneficial effect of resveratrol on cholecystokinin-induced experimental pancreatitis. PMID: 16499907 Ref: Radiation recall phenomenon secondary to capecitabine: possible role of thymidine phosphorylase. PMID: 16552574 Ref: Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. PMID: 16614115 Ref: The expression of adhesion molecules and the influence of inflammatory cytokines on the adhesion of human pancreatic carcinoma cells to mesothelial monolayers. PMID: 16670622 Ref: Clinical monitoring of innate cellular immunity of monocytes/macrophages by tumor necrosis factor alpha productivity in whole blood stimulated by lipopolysaccharide in patients with pancreatic cancer. PMID: 16804410 Ref: Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma. PMID: 16982746 |
Ref: Impact of interferon-alpha in combined chemoradioimmunotherapy for pancreatic adenocarcinoma (CapRI): first data from the immunomonitoring. PMID: 17198089 Ref: Systemic immune dysfunction in pancreatic cancer patients. PMID: 17235586 Ref: G2/M cell-cycle arrest and apoptosis by n-3 fatty acids in a pancreatic cancer model. PMID: 17291531 Ref: Effects of thalidomide in experimental models of post-endoscopic retrograde cholangiopancreatography pancreatitis. PMID: 17295769 Ref: Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. PMID: 17332938 Ref: Synthetic serine protease inhibitor, gabexate mesilate, prevents nuclear factor-kappaB activation and increases TNF-alpha-mediated apoptosis in human pancreatic cancer cells. PMID: 17357832 Ref: Induction of interleukin-8 (CXCL-8) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells: Impact of CXCL-8 as an autocrine growth factor. PMID: 17671691 Ref: Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase. PMID: 17762760 |
Ref: The immunocytokine scFv23/TNF targeting HER-2/neu induces synergistic cytotoxic effects with 5-fluorouracil in TNF-resistant pancreatic cancer cell lines. PMID: 18082672 Ref: Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. PMID: 18316608 Ref: Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. PMID: 18383873 Ref: Period is involved in the proliferation of human pancreatic MIA-PaCa2 cancer cells by TNF-alpha. PMID: 18480551 Ref: Claudin-1 expression is induced by tumor necrosis factor-alpha in human pancreatic cancer cells. PMID: 18949385 Ref: [Molecular mechanisms and its clinical impact in cancer cachexia]. PMID: 19053008 |
Ref: Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo. PMID: 18772349 Ref: Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy. PMID: 18974777 Ref: AMT: preclinical pharmacology studies. PMID: 19360346 Ref: Interleukin-32 expression in the pancreas. PMID: 19386602 Ref: Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. PMID: 19405118 Ref: Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. PMID: 19405981 Ref: Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers. PMID: 19444302 Ref: Combination of human tumor necrosis factor-alpha (hTNF-alpha) gene delivery with gemcitabine is effective in models of pancreatic cancer. PMID: 19444305 Ref: CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha. PMID: 19577543 Ref: Surgical resection after TNFerade therapy for locally advanced pancreatic cancer. PMID: 19734632 Ref: Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. PMID: 19768141 Ref: Blood monocytes stimulate migration of human pancreatic carcinoma cells in vitro: the role of tumour necrosis factor - alpha. PMID: 19782426 Ref: Effects of conjugated linoleic acid on myogenic and inflammatory responses in a human primary muscle and tumor coculture model. PMID: 19838943 Ref: Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma. PMID: 20196789 |
Ref: Effects of carbon monoxide releasing molecule-liberated CO on severe acute pancreatitis in rats. PMID: 19900821 Ref: Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis. PMID: 20065943 Ref: Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells. PMID: 20197756 Ref: Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. PMID: 20331621 Ref: NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. PMID: 20350779 Ref: Protective effect of cyclosporin A on brain injury in rats with acute necrotic pancreatitis. PMID: 20561905 Ref: Digestive Disease Week 2010. Turning Science into Medicine--part 2. PMID: 20582861 Ref: Effects of Qingyi Huaji decoction on serum levels of interleukin-6, interleukin-8 and tumor necrosis factor-alpha in nude mice bearing pancreatic tumors. PMID: 20619142 Ref: Nuclear expression of interleukin-33 in pancreatic stellate cells. PMID: 20689058 Ref: Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. PMID: 20808857 Ref: Association between EGF, TGF-{beta}1, TNF-{alpha} gene polymorphisms and cancer of the pancreatic head. PMID: 21187523 |
Ref: PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKalpha and sustained activation of the NF-kappaB pathway. PMID: 21376459 Ref: Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer. PMID: 21457003 Ref: Combination treatment using adenovirus vector-mediated tumor necrosis factor-alpha gene transfer and a NF-kappaB inhibitor for pancreatic cancer in mice. PMID: 21482023 Ref: Dendritic cell-based vaccination of patients with advanced pancreatic carcinoma: results of a pilot study. PMID: 21547597 Ref: Involvement of COX-2/PGE(2) Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer. PMID: 21760774 Ref: Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression. PMID: 21880146 Ref: Induction of monocyte antitumor response by human cancer cells transduced with TNF-GFP fusion gene: possible implications for immunotherapy of cancer. PMID: 22038233 Ref: Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice. PMID: 22056382 |
Ref: Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway. PMID: 22004570 Ref: Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. PMID: 22246854 Ref: EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study. PMID: 22248601 Ref: Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells. PMID: 22293948 Ref: Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-alpha and TSGF after cryosurgery in pancreatic cancer patients. PMID: 22456901 Ref: [Protective effects and possible mechanism of lipoxin A(4) analogue in rats with acute pancreatitis]. PMID: 22781577 Ref: New tools and novel approaches in treating locally advanced pancreatic adenocarcinoma. PMID: 22797388 Ref: Effect of high-dose intravenous vitamin C on inflammation in cancer patients. PMID: 22963460 Ref: Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis. PMID: 22982349 Ref: Single nucleotide polymorphisms of genes for EGF, TGF-beta and TNF-alpha in patients with pancreatic carcinoma. PMID: 22990108 Ref: In vitro cytokine profiles and viability of different human cells treated with whole cell lysate of Mycobacterium avium subsp. paratuberculosis. PMID: 23006537 Ref: The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. PMID: 23086953 Ref: Desensitization of NFkappaB for overcoming chemoresistance of pancreatic cancer cells to TNF-alpha or paclitaxel. PMID: 23155247 |
Ref: The role of mesothelin in tumor progression and targeted therapy. PMID: 22721387 Ref: Detection of Legionella pneumophila serogroup 1 in blood cultures from a patient treated with tumor necrosis factor-alpha inhibitor. PMID: 22911089 Ref: Inhibition of nuclear factor kappa-B enhances the antitumor effect of combination treatment with tumor necrosis factor-alpha gene therapy and gemcitabine for pancreatic cancer in mice. PMID: 23219147 Ref: Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway. PMID: 23394575 Ref: Disrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease. PMID: 23429495 Ref: Targeting the NF-kappaB and mTOR pathways with a quinoxaline urea analog that inhibits IKKbeta for pancreas cancer therapy. PMID: 23444213 Ref: Inflammatory plasma markers and pancreatic cancer risk: a prospective study of five U.S. cohorts. PMID: 23462920 Ref: Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. PMID: 23590467 Ref: Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl1 and TCTP and increases that of TNF-alpha and Bax in BxPC3 pancreatic carcinoma cells. PMID: 23652631 Ref: Role of Peroxisome Proliferator-Activated Receptor beta/delta and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells. PMID: 23737761 Ref: Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-kappaB and MMPs. PMID: 23918941 Ref: Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer. PMID: 23940742 Ref: Proteome variations in pancreatic stellate cells upon stimulation with proinflammatory factors. PMID: 24089530 Ref: Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PMID: 24098720 Ref: Digitoflavone inhibits IkappaBalpha kinase and enhances apoptosis induced by TNFalpha through downregulation of expression of nuclear factor kappaB-regulated gene products in human pancreatic cancer cells. PMID: 24146961 Ref: Novel mechanism of cytokine-induced disruption of epithelial barriers: Janus kinase and protein kinase D-dependent downregulation of junction protein expression. PMID: 24665409 |
Ref: Depression, cytokines, and pancreatic cancer. PMID: 24136882 Ref: Apigenin potentiates the growth inhibitory effects by IKK-beta-mediated NF-kappaB activation in pancreatic cancer cells. PMID: 24148603 Ref: Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy? PMID: 24163144 Ref: Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-alpha gene therapy for pancreatic cancer. PMID: 24289533 Ref: Quantitative glycoproteomics analysis reveals changes in N-glycosylation level associated with pancreatic ductal adenocarcinoma. PMID: 24471499 Ref: The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. PMID: 24567526 Ref: Contribution of environment and genetics to pancreatic cancer susceptibility. PMID: 24651674 Ref: Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell-Cell Contact and Secreted Factors. PMID: 24995006 Ref: Targeted nanogel conjugate for improved stability and cellular permeability of curcumin: synthesis, pharmacokinetics, and tumor growth inhibition. PMID: 25072100 Ref: Genetic polymorphisms of inflammatory response gene TNF-alpha and its influence on sporadic pancreatic neuroendocrine tumors predisposition risk. PMID: 25213764 Ref: Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction. PMID: 25274283 Ref: Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203. PMID: 25290620 Ref: [Pancreas and biliary tract: recent developments]. PMID: 25294273 Ref: Serum adiponectin relates to shortened overall survival in men with squamous cell esophageal cancer treated with preoperative concurrent chemoradiotherapy: a pilot study. PMID: 25408239 Ref: Metabolomics evaluation of serum markers for cachexia and their intra-day variation in patients with advanced pancreatic cancer. PMID: 25411961 Ref: Epigallocatechin gallate prevents inflammation by reducing macrophage infiltration and inhibiting tumor necrosis factor-alpha signaling in the pancreas of rats on a high-fat diet. PMID: 25453543 |
Ref: Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer. PMID: 25344906 Ref: Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions. PMID: 25361845 Ref: 5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-alpha secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells. PMID: 25642980 Ref: Measuring sickness behavior in the context of pancreatic cancer. PMID: 25659492 Ref: Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro. PMID: 25847529 Ref: Orthotopic inflammation-related pancreatic carcinogenesis in a wild-type mouse induced by combined application of caerulein and dimethylbenzanthracene. PMID: 25916208 Ref: CD4(+) T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4(+) T cells in pancreatic cancer development. PMID: 26137395 Ref: Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. PMID: 26310895 Ref: A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer. PMID: 26314849 Ref: Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-kappaB Activity. PMID: 26336582 Ref: Prognostic nutritional index predicts survival and correlates with systemic inflammatory response in advanced pancreatic cancer. PMID: 26343824 Ref: Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. PMID: 26479921 Ref: Augmented IFN-gamma and TNF-alpha Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10. PMID: 26697005 |
Ref: Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study. PMID: 26413860 Ref: Subclinical Inflammation and Endothelial Dysfunction in Patients with Chronic Pancreatitis and Newly Diagnosed Pancreatic Cancer. PMID: 26597191 Ref: Expansion of Tumor-reactive T Cells From Patients With Pancreatic Cancer. PMID: 26849077 Ref: AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas. PMID: 26884209 Ref: Expression of tumor necrosis factor-alpha-induced protein 8 in stage III gastric cancer and the correlation with DcR3 and ERK1/2. PMID: 26998086 Ref: Thymoquinone Modulates Blood Coagulation in Vitro via Its Effects on Inflammatory and Coagulation Pathways. PMID: 27043539 Ref: Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution. PMID: 27133426 Ref: Irradiated human endothelial progenitor cells induce bystander killing in human non-small cell lung and pancreatic cancer cells. PMID: 27258472 Ref: Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. PMID: 27267809 Ref: Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cells. PMID: 27573419 Ref: Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma. PMID: 27835602 Ref: Hyperglycemia, tumorigenesis, and chronic inflammation. PMID: 27931833 |
Ref: Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors. PMID: 27864344 Ref: A predictive model of inflammatory markers and patient-reported symptoms for cachexia in newly diagnosed pancreatic cancer patients. PMID: 28111717 Ref: Dendritic cells engineered to secrete anti-DcR3 antibody augment cytotoxic T lymphocyte response against pancreatic cancer in vitro. PMID: 28223726 Ref: Effect of cigarette smoke exposure and mutant Kras overexpression on pancreatic cell proliferation. PMID: 28454347 Ref: The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand. PMID: 28476883 Ref: Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ss or TNF-alpha. PMID: 28482827 Ref: miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity. PMID: 28511795 Ref: Anticancer activity of salicin and fenofibrate. PMID: 28733879 Ref: NF-kappaB regulates GDF-15 to suppress macrophage surveillance during early tumor development. PMID: 28891811 Ref: SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. PMID: 28958848 Ref: CXCR5(+) CD8(+) T cells potently infiltrate pancreatic tumors and present high functionality. PMID: 28965867 Ref: Immunomodulation after radiofrequency ablation of locally advanced pancreatic cancer by monitoring the immune response in 10 patients. PMID: 29037917 Ref: Postoperative course and prognostic value of circulating angiogenic cytokines after pancreatic cancer resection. PMID: 29069789 Ref: The Diagnostic Roles of Cytokines in Hepatobiliary Cancers. PMID: 29410961 |
Ref: GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. PMID: 29092903 Ref: The predictive value and role of stromal tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma (PDAC). PMID: 29313457 Ref: The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells. PMID: 29609556 Ref: Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. PMID: 29618658 Ref: Transforming Growth Factor-beta and Tumor Necrosis Factor-alpha Reduce the Sensitivity of MiaPaCa2 Pancreatic Cancer Cells to Lysis by NK Cells. PMID: 29926278 Ref: Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer. PMID: 30011858 Ref: Human Surfactant Protein D Suppresses Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells by Downregulating TGF-beta. PMID: 30158928 Ref: Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells. PMID: 30167093 Ref: Anergic natural killer cells educated by tumor cells are associated with a poor prognosis in patients with advanced pancreatic ductal adenocarcinoma. PMID: 30167864 Ref: Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness. PMID: 30185628 |