Primary Site >> Biliary tract Cancer

Gene >> TIMP2

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Ref: Expression of MMP-2,TIMP-2 protein and the ratio of MMP-2/TIMP-2 in gallbladder carcinoma and their significance.
PMID: 12439941
 Ref: Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of cholangiocarcinoma.
PMID: 14687144
Ref: [The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism].
PMID: 15312360
Ref: The ratio of MMP-2 to TIMP-2 in hilar cholangiocarcinoma: a semi-quantitative study.
PMID: 15567754
Ref: Immunohistochemical study of characteristics of bile duct dysplasia evaluated on the basis of expression of metastasis/invasion-related factors and p53.
PMID: 15619017
Ref: A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice.
PMID: 15743030
 Ref: Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells.
PMID: 15832413
 Ref: [Effects of norcantharidin on angiogenesis of human gallbladder carcinoma and its anti-angiogenic mechanisms].
PMID: 16681930
Ref: [Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo].
PMID: 16784656
 Ref: Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma.
PMID: 21935919
Ref: Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.
PMID: 22200632
 Ref: Contribution of the PI3K/MMPs/Ln-5gamma2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.
PMID: 23588386
 Ref: Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5gamma2 signaling pathway.
PMID: 24628713
 Ref: Norcantharidin enhances TIMP2 antivasculogenic mimicry activity for human gallbladder cancers through downregulating MMP2 and MT1MMP.
PMID: 25405519