Primary Site >> Pancreatic Cancer
Gene >> TGFBR2
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Ref: Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression. PMID: 8389240 |
Ref: Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: identification of a I-cM region of common allelic loss. PMID: 8913725 |
Ref: Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. PMID: 9307274 Ref: Presence of two signaling TGF-beta receptors in human pancreatic cancer correlates with advanced tumor stage. PMID: 9365135 |
Ref: Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells. PMID: 9516449 Ref: Novel mutations in the polyadenine tract of the transforming growth factor beta type II receptor gene are found in a subpopulation of human pancreatic adenocarcinomas. PMID: 9598801 Ref: Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer. PMID: 9754660 Ref: Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. PMID: 9850059 |
Ref: The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. PMID: 10498890 Ref: Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer. PMID: 10505717 Ref: Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer. PMID: 10547197 |
Ref: Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta. PMID: 11114730 Ref: Molecular genetics of ductal pancreatic neoplasia. PMID: 17031113 |
Ref: Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. PMID: 11306499 Ref: Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas. PMID: 11408925 Ref: Soluble type II transforming growth factor-beta (TGF-beta) receptor inhibits TGF-beta signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation. PMID: 11555612 Ref: [Detection of the expression of Smad4, transforming growth factor beta(1) and beta receptor II proteins in paraffin-embedded human pancreatic cancer tissues]. PMID: 11866987 |
Ref: Establishment and characterization of four human pancreatic carcinoma cell lines. Genetic alterations in the TGFBR2 gene but not in the MADH4 gene. PMID: 12037578 Ref: Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2. PMID: 12420225 |
Ref: Rap1 reverses transcriptional repression of TGF-beta type II receptor by a mechanism involving AP-1 in the human pancreatic cancer cell line, UK Pan-1. PMID: 12447993 Ref: Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. PMID: 12615714 Ref: Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. PMID: 12750289 |
Ref: Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. PMID: 15647279 |
Ref: A microRNA expression signature of human solid tumors defines cancer gene targets. PMID: 16461460 |
Ref: PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. PMID: 20684793 |
Ref: Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. PMID: 22156295 Ref: Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer. PMID: 22523087 Ref: Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer. PMID: 22761868 Ref: Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. PMID: 23103869 |
Ref: Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer. PMID: 23237571 Ref: Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals. PMID: 23378339 |
Ref: Identification of biomarkers for the prognosis of pancreatic ductal adenocarcinoma with miRNA microarray data. PMID: 25791160 Ref: Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. PMID: 26255562 |
Ref: Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. PMID: 26279302 |
Ref: Mutant p53 Together with TGFbeta Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer. PMID: 27637888 Ref: miR-202 Diminishes TGFbeta Receptors and Attenuates TGFbeta1-Induced EMT in Pancreatic Cancer. PMID: 28373289 Ref: Elucidation of Novel Chromosomal Abnormalities in Pancreatic Cancer: Conventional and Molecular Cytogenetic Characterization of 16 Pancreatic Cell Lines. PMID: 28809762 |
Ref: Endoglin (CD105) and SMAD4 regulate spheroid formation and the suppression of the invasive ability of human pancreatic cancer cells. PMID: 29393426 Ref: Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway. PMID: 29899418 |