Primary Site >> Stomach Cancer
Gene >> TFF1
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Ref: Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. PMID: 2311759 |
Ref: pS2 protein in gastric carcinoma and normal gastric mucosa: association with clincopathological parameters and patient survival. PMID: 8158455 |
Ref: Expression pattern of breast-cancer-associated protein pS2/BCEI in colorectal tumors. PMID: 7505265 |
Ref: pS2 protein expression in gastric carcinoma. An immunohistochemical and immunoradiometric study. PMID: 8911122 Ref: [Expression of trefoil group antigen pS2 in human gastric cancer]. PMID: 8921704 Ref: Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. PMID: 9043862 |
Ref: Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer. PMID: 9187350 |
Ref: Loss of pS2 protein expression is an early event of intestinal-type gastric cancer. PMID: 9600121 Ref: Osmotic changes and ethanol modify TFF gene expression in gastrointestinal cell lines. PMID: 9849902 |
Ref: The trefoil peptide TFF1 inhibits the growth of the human gastric adenocarcinoma cell line AGS. PMID: 10419601 |
Ref: Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6). PMID: 10699992 Ref: DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis. PMID: 10737716 Ref: Genetic and epigenetic alterations in multistep carcinogenesis of the stomach. PMID: 10779229 Ref: Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers. PMID: 10974401 Ref: Somatic mutations of the trefoil factor family 1 gene in gastric cancer. PMID: 10982763 |
Ref: Aspirin promotes TFF2 gene activation in human gastric cancer cell lines. PMID: 11163773 Ref: Prognostic significance of cytosolic pS2 protein content in gastric cancer. PMID: 11288953 Ref: Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium. PMID: 11310832 Ref: Expression of WNT10A in human cancer. PMID: 11605000 |
Ref: The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis. PMID: 12034770 Ref: Expression of TFF1, TFF2 and TFF3 in gastric cancer. PMID: 12168114 Ref: Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues. PMID: 12210076 Ref: Trefoil factor 1 (TFF1/pS2) deficiency activates the unfolded protein response. PMID: 12359958 Ref: Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma. PMID: 12379766 Ref: Coordinate late expression of trefoil peptide genes (pS2/TFF1 and ITF/TFF3) in human breast, colon, and gastric tumor cells exposed to X-rays. PMID: 12477053 |
Ref: Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice. PMID: 12768581 Ref: Trefoil factors and human gastric cancer (review). PMID: 12792801 Ref: Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. PMID: 12891554 Ref: Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma. PMID: 14563942 Ref: Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas. PMID: 14601088 |
Ref: Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. PMID: 14699500 Ref: Highly specific marker genes for detecting minimal gastric cancer cells in cytology negative peritoneal washings. PMID: 14706632 Ref: [The expression of trefoil factor 1 and trefoil factor 2 in gastric cancer and precancer]. PMID: 15059374 Ref: Differentiation pathways in duodenal and ampullary carcinomas: a comparative study on mucin and trefoil peptide expression, including gastric and colon carcinomas. PMID: 15071739 Ref: Promoter selection for the cytosine deaminase suicide gene constructs in gastric cancer. PMID: 15095854 Ref: Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression. PMID: 15298601 Ref: Indometacin up-regulates TFF2 expression in gastric epithelial cells. PMID: 15298624 |
Ref: Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer. PMID: 15760920 Ref: Relationship between trefoil factor 1 expression and gastric mucosa injuries and gastric cancer. PMID: 15849833 Ref: Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. PMID: 15924415 Ref: Gastric achlorhydria in H/K-ATPase-deficient (Atp4a(-/-)) mice causes severe hyperplasia, mucocystic metaplasia and upregulation of growth factors. PMID: 16048577 Ref: Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. PMID: 16049341 Ref: [Association of trefoil factor 1 expression with gastric mucosa injuries and gastric cancer]. PMID: 16174594 Ref: [Trefoil factor 1 (pS2/TFF1), a peptide with numerous functions]. PMID: 16203267 Ref: Gene expression profiling of gastric cancer by microarray combined with laser capture microdissection. PMID: 16437709 |
Ref: Overexpression of CEBPbeta correlates with decreased TFF1 in gastric cancer. PMID: 16247479 Ref: Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas. PMID: 16452188 Ref: Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. PMID: 16474375 Ref: Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. PMID: 16697734 Ref: Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer. PMID: 16718800 Ref: Detection of lymph node micrometastasis in pN0 early gastric cancer: efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer. PMID: 16820924 Ref: [Molecular forms of TFF1 in normal gastric mucosa and its relationship with canceration]. PMID: 16939928 Ref: Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues. PMID: 17143957 |
Ref: Differentiation of the Gastric Mucosa IV. Role of trefoil peptides and IL-6 cytokine family signaling in gastric homeostasis. PMID: 16935852 Ref: Detection of minimal gastric cancer cells in peritoneal washings by focused microarray analysis with multiple markers: clinical implications. PMID: 17294072 Ref: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. PMID: 17376510 Ref: Up-regulation of TFF1 (pS2) expression by TNF-alpha in gastric epithelial cells. PMID: 17565651 |
Ref: Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. PMID: 18593995 Ref: Induction of follistatin precedes gastric transformation in gastrin deficient mice. PMID: 18804092 Ref: Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells. PMID: 18938748 |
Ref: The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer. PMID: 18722547 Ref: Comparative analysis of protein expressions in primary and metastatic gastric carcinomas. PMID: 18835621 Ref: Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells. PMID: 19281788 Ref: Cytokine signalling via gp130 in gastric cancer. PMID: 19665497 |
Ref: Mouse models demonstrating the role of stem/progenitor cells in gastric carcinogenesis. PMID: 20036835 Ref: C/EBP alpha expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis. PMID: 20386538 Ref: Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. PMID: 20801119 Ref: Epstein-Barr virus-specific methylation of human genes in gastric cancer cells. PMID: 21194482 |
Ref: Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. PMID: 21111741 Ref: Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas. PMID: 21185829 Ref: The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk. PMID: 21455714 Ref: Loss of TFF1 is associated with activation of NF-kappaB-mediated inflammation and gastric neoplasia in mice and humans. PMID: 21490402 Ref: Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening. PMID: 21699780 Ref: Gastric cancer: basic aspects. PMID: 21896084 |
Ref: Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner. PMID: 21870107 Ref: Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. PMID: 22034055 Ref: Polymorphism of estrogen response element in TFF1 gene promoter is associated with an increased susceptibility to gastric cancer. PMID: 22093877 Ref: Analysis for the combination expression of CK20, FABP1 and MUC2 is sensitive for the prediction of peritoneal recurrence in gastric cancer. PMID: 22172348 Ref: TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro. PMID: 22642590 Ref: Role of trefoil factor 1 in gastric cancer and relationship between trefoil factor 1 and gastrokine 1. PMID: 22842654 Ref: [Expression and significance of trefoil factor 1 protein and serum pepsinogen in benign and malignant gastric ulcers]. PMID: 22944057 |
Ref: Influence of Helicobacter pylori status and eradication on the serum levels of trefoil factors and pepsinogen test: serum trefoil factor 3 is a stable biomarker. PMID: 22907485 Ref: A set of specific miRNAs is connected with murine and human gastric cancer. PMID: 23124995 Ref: Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer. PMID: 23291975 Ref: Reduced expression of TFF1 and increased expression of TFF3 in gastric cancer: correlation with clinicopathological parameters and prognosis. PMID: 23329884 Ref: Activation of the NF-kB pathway downregulates TFF-1 in gastric carcinogenesis. PMID: 23942618 Ref: Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. PMID: 23993973 Ref: COX-2, TFF1, and Src define better prognosis in young patients with gastric cancer. PMID: 24037722 Ref: Mouse models of gastric cancer. PMID: 24216700 Ref: Copper promotes TFF1-mediated Helicobacter pylori colonization. PMID: 24236136 Ref: Trefoil factor 1 gene alternations and expression in colorectal carcinomas. PMID: 24503794 |
Ref: DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma. PMID: 24190027 Ref: Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis. PMID: 24408014 Ref: miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. PMID: 24486742 Ref: Slow overmethylation of housekeeping genes in the body mucosa is associated with the risk for gastric cancer. PMID: 24654229 Ref: Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: a monocentric cohort study in China. PMID: 24720760 Ref: Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro. PMID: 24798994 Ref: TFF1 activates p53 through down-regulation of miR-504 in gastric cancer. PMID: 25015107 |
Ref: Activation of beta-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. PMID: 25107557 Ref: miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner. PMID: 25652124 Ref: Loss of TFF1 promotes Helicobacter pylori-induced beta-catenin activation and gastric tumorigenesis. PMID: 25980439 Ref: Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population. PMID: 26240479 Ref: Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer. PMID: 26265233 Ref: Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis. PMID: 26372254 Ref: Wnt/beta-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. PMID: 26417932 Ref: Trefoil factor 1 elevates the malignant phenotype of mucinous ovarian cancer cell through Wnt/beta-catenin signaling. PMID: 26617749 |
Ref: Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. PMID: 26837764 Ref: C/EBPbeta regulates homeostatic and oncogenic gastric cell proliferation. PMID: 27522676 Ref: Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer. PMID: 27598141 |
Ref: Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells. PMID: 28150071 Ref: Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia. PMID: 28281307 Ref: Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection. PMID: 28512631 Ref: Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma: A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry. PMID: 28691258 Ref: Loss of Tff1 Promotes Pro-Inflammatory Phenotype with Increase in the Levels of RORgammat+ T Lymphocytes and Il-17 in Mouse Gastric Neoplasia. PMID: 28900479 |
Ref: TFF1 antagonizes TIMP-1 mediated proliferative functions in gastric cancer. PMID: 28977972 Ref: Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells. PMID: 29453320 Ref: TFF1 antagonizes TIMP-1 mediated proliferative functions in gastric cancer. PMID: 30035371 Ref: Effect of Helicobacter pylori Infection on GATA-5 and TFF1 Regulation, Comparison Between Pediatric and Adult Patients. PMID: 30083861 Ref: Three types of metaplasia models through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium. PMID: 30168144 |