Primary Site >> Liver Cancer
Gene >> TERT
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Antitumor effect and structure-activity relationship of asterriquinone analogs. PMID: 7152200 |
Ref: Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants. PMID: 3899519 |
Ref: Dose-response relationship in multistage carcinogenesis: promoters. PMID: 8187717 |
Ref: Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion. PMID: 8620494 |
Ref: Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. PMID: 9425903 |
Ref: NF-kappa B regulates transcription of the mouse telomerase catalytic subunit. PMID: 10970902 |
Ref: [Reversing malignant phenotypes of liver cancer cell lines with antisense gene to human telomerase reverse transcriptase]. PMID: 11983122 |
Ref: Telomerase-dependent oncolytic adenovirus for cancer treatment. PMID: 12858189 Ref: Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402. PMID: 12877588 |
Ref: Protein kinase A inhibits lysophosphatidic acid induction of serum response factor via alterations in the actin cytoskeleton. PMID: 15240009 Ref: [Expression and clinical significance of telomerase hTRT in primary hepatocellular carcinoma]. PMID: 15329219 |
Ref: Preoperative human-telomerase reverse transcriptase mRNA in peripheral blood and tumor recurrence in living-related liver transplantation for hepatocellular carcinoma. PMID: 16201066 |
Ref: In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors. PMID: 16465377 Ref: Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice. PMID: 16497559 Ref: [A preliminary study on anti-liver cancer immunity of the virus-like particulate peptide-nucleic acid vaccine]. PMID: 16635296 Ref: [Expressions of h-TERT, c-myc, PCNA and cell apoptosis in liver carcinogenesis]. PMID: 16793609 Ref: A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. PMID: 17087938 Ref: Comparison between human-telomerase reverse transcriptase mRNA and alpha-fetoprotein mRNA as a predictive value for recurrence of hepatocellular carcinoma in living donor liver transplantation. PMID: 17175353 |
Ref: The oncolytic adenovirus targeting to TERT and RB pathway induced specific and potent anti-tumor efficacy in vitro and in vivo for hepatocellular carcinoma. PMID: 18281783 |
Ref: Syntheses and cytotoxicities of the analogues of the taxoid brevifoliol. PMID: 17950495 |
Ref: Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. PMID: 19903789 |
Ref: Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. PMID: 19886748 Ref: Nuclear translocation of telomerase reverse transcriptase: a critical process in chemical induced hepatocellular carcinogenesis. PMID: 20353272 Ref: beta-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy. PMID: 20811694 Ref: [The role and significance of Wnt/beta-catenin signaling pathway regulating the signaling molecules in hepatocellular carcinoma]. PMID: 20943078 |
Ref: Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma. PMID: 21199526 Ref: Combinational RNAi gene therapy of hepatocellular carcinoma by targeting human EGFR and TERT. PMID: 21238587 Ref: Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy. PMID: 21275467 Ref: Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. PMID: 21527554 Ref: Tumor-specific expression of microRNA-26a suppresses human hepatocellular carcinoma growth via cyclin-dependent and -independent pathways. PMID: 21610700 Ref: [The relationship between gene polymorphism of telomerase reverse transcriptase and susceptibility to hepatocellular carcinoma]. PMID: 22041560 |
Ref: Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. PMID: 22634754 Ref: Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. PMID: 22634756 Ref: Anticancer effect of tert-butyl-2(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxy l-2)-pyrrolidine-1-carboxylic ester on human hepatoma HepG2 cell line. PMID: 22704995 Ref: Dyskerin overexpression in human hepatocellular carcinoma is associated with advanced clinical stage and poor patient prognosis. PMID: 22912812 |
Ref: Telomerase-specific oncolytic adenoviral therapy for orthotopic hepatocellular carcinoma in HBx transgenic mice. PMID: 22886913 Ref: The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling. PMID: 23109092 Ref: Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations. PMID: 23276797 Ref: Highly recurrent TERT promoter mutations in human melanoma. PMID: 23348506 Ref: TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. PMID: 23530248 Ref: Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing "stemness"-related markers. PMID: 23685049 Ref: HIVID: an efficient method to detect HBV integration using low coverage sequencing. PMID: 23867110 Ref: TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. PMID: 24101484 |
Ref: Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells. PMID: 24416313 Ref: Positive association of long telomeres with the invasive capacity of hepatocellular carcinoma cells. PMID: 24732358 Ref: Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. PMID: 24735922 Ref: TERT promoter mutations: gatekeeper and driver of hepatocellular carcinoma. PMID: 24859456 Ref: TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection. PMID: 24866078 Ref: [Expressions of TERT during the development of rat liver cancer under the interventions of oxymatrine and selenium enriched yeast]. PMID: 25016875 Ref: Human telomerase reverse transcriptase messenger RNA (TERT mRNA) as a tumour marker for early detection of hepatocellular carcinoma. PMID: 25097049 Ref: Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis. PMID: 25123086 Ref: The genomic landscape of hepatoblastoma and their progenies with HCC-like features. PMID: 25135868 Ref: Diverse modes of genomic alteration in hepatocellular carcinoma. PMID: 25159915 Ref: Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. PMID: 25229655 Ref: Frequency of TERT promoter mutations in primary tumors of the liver. PMID: 25267585 Ref: Polymorphisms of TERT and CLPTM1L and the risk of hepatocellular carcinoma in Chinese males. PMID: 25339005 Ref: Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. PMID: 25362482 Ref: Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. PMID: 25526364 |
Ref: Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration. PMID: 25043739 Ref: Reply to: "TERT promoter mutation during development of hepatoblastoma to hepatocellular carcinoma". PMID: 25450207 Ref: TERT promoter mutation during development of hepatoblastoma to hepatocellular carcinoma. PMID: 25450209 Ref: Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations. PMID: 25574106 Ref: Automated synthesis and PET evaluation of both enantiomers of [(1)(8)F]FMISO. PMID: 25595134 Ref: Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. PMID: 25636086 Ref: Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population. PMID: 25683523 Ref: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. PMID: 25822088 Ref: Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation. PMID: 25843513 Ref: Novel metronomic chemotherapy and cancer vaccine combinatorial strategy for hepatocellular carcinoma in a mouse model. PMID: 25944003 Ref: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells. PMID: 25973027 Ref: Frequency of TERT Promoter Mutations in Prostate Cancer. PMID: 25997473 Ref: Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. PMID: 26099527 Ref: New molecular therapies for hepatocellular carcinoma. PMID: 26206572 Ref: Comparative transcriptome analysis reveals that the extracellular matrix receptor interaction contributes to the venous metastases of hepatocellular carcinoma. PMID: 26271415 Ref: Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. PMID: 26301494 Ref: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. PMID: 26409325 Ref: CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc. PMID: 26513297 Ref: SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex. PMID: 26547749 Ref: Hepatocellular Carcinoma Arising in an HNF-1alpha-Mutated Adenoma in a 23-Year-Old Woman with Maturity-Onset Diabetes of the Young: A Case Report. PMID: 26676820 |
Ref: TERT promoter mutations in primary liver tumors. PMID: 26336998 Ref: Differential timing of oxidative DNA damage and telomere shortening in hepatitis C and B virus-related liver carcinogenesis. PMID: 26408804 Ref: TGF-beta1 pathway affects the protein expression of many signaling pathways, markers of liver cancer stem cells, cytokeratins, and TERT in liver cancer HepG2 cells. PMID: 26462837 Ref: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. PMID: 26553052 Ref: The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer. PMID: 26575952 Ref: MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12. PMID: 26646106 Ref: Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections. PMID: 26943571 Ref: Multiple beta-catenin mutations in hepatocellular lesions arising in Abernethy malformation. PMID: 27038679 Ref: Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinoma. PMID: 27056898 Ref: Novel fluorinated docetaxel analog for anti-hepatoma: Molecular docking and biological evaluation. PMID: 27058438 Ref: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. PMID: 27064257 Ref: Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR. PMID: 27167190 Ref: Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing. PMID: 27248174 Ref: New evidence of TERT rs2736098 polymorphism and cancer risk: an updated meta-analysis. PMID: 27273963 Ref: Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma. PMID: 27276713 Ref: Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma. PMID: 27308626 Ref: Inflammatory related gene IKKalpha, IKKbeta, IKKgamma cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. PMID: 27367027 Ref: Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID: 27403431 Ref: TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma. PMID: 27511114 Ref: A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma. PMID: 27563447 Ref: Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. PMID: 27643433 Ref: Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma. PMID: 27661004 Ref: Detecting Circulating Tumor DNA in Hepatocellular Carcinoma Patients Using Droplet Digital PCR Is Feasible and Reflects Intratumoral Heterogeneity. PMID: 27698932 Ref: [Studies on telomerase reverse transcriptase components and liver cancer]. PMID: 27784441 Ref: Integrated Multiple "-omics" Data Reveal Subtypes of Hepatocellular Carcinoma. PMID: 27806083 Ref: Envisaging Structural Insight of a Terminally Protected Proline Dipeptide by Raman Spectroscopy and Density Functional Theory Analyses. PMID: 27973793 |
Ref: Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance. PMID: 27634656 Ref: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. PMID: 27939373 Ref: Malignant transformation of a beta-catenin inflammatory adenoma due to an S45 beta-catenin-activating mutation present 12 years before. PMID: 27984126 Ref: Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma. PMID: 28151853 Ref: HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression. PMID: 28258280 Ref: Gene expression profiling of circulating CD133(+) cells of hepatocellular carcinoma patients associated with HCV infection. PMID: 28258914 Ref: Constitutional and functional genetics of human alcohol-related hepatocellular carcinoma. PMID: 28296015 Ref: Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. PMID: 28302680 Ref: TERT promoter mutations in telomere biology. PMID: 28342451 Ref: BATVI: Fast, sensitive and accurate detection of virus integrations. PMID: 28361674 Ref: Recombinant adenovirus of SEA and CD80 genes driven by MMRE and mouse TERT promoter induce effective antitumor immune responses against different types of tumor cells in vitro and in vivo. PMID: 28393253 Ref: Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma. PMID: 28460432 Ref: Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma. PMID: 28529542 Ref: Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. PMID: 28532995 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. PMID: 28622513 Ref: Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma. PMID: 28813500 Ref: Quantification of six potential unspecific human biomarkers of 1-vinyl-2-pyrrolidone exposure in Sprague-Dawley rat urine using gas chromatography coupled with triple mass spectrometry. PMID: 28841759 Ref: Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma. PMID: 28843658 Ref: The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. PMID: 28854942 Ref: Clinical importance of TERT overexpression in hepatocellular carcinoma treated with curative surgical resection in HBV endemic area. PMID: 28947783 Ref: A validated, transitional and translational porcine model of hepatocellular carcinoma. PMID: 28969016 Ref: TERT-CLPTM1 locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma. PMID: 29042796 |
Ref: Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations. PMID: 29180252 Ref: Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival. PMID: 29354286 Ref: Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma. PMID: 29460642 Ref: Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features. PMID: 29556353 Ref: Molecular genomic landscapes of hepatobiliary cancer. PMID: 29573058 Ref: Inflammatory factor receptor Toll-like receptor 4 controls telomeres through heterochromatin protein 1 isoforms in liver cancer stem cell. PMID: 29602239 Ref: A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. PMID: 29628508 Ref: Telomerase reverse transcriptase suppression inhibits cell proliferation and promotes cell apoptosis in hepatocellular cancer. PMID: 29707886 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications. PMID: 29791027 Ref: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers. PMID: 29861854 Ref: Novel asymmetric 3,5-bis(arylidene)piperidin-4-one derivatives: synthesis, crystal structures and cytotoxicity. PMID: 29870000 Ref: Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors. PMID: 29881823 Ref: Coumarin Probe for Selective Detection of Fluoride Ions in Aqueous Solution and Its Bioimaging in Live Cells. PMID: 29949921 Ref: Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with RAS-Mutated Hepatocellular Carcinoma. PMID: 29950351 Ref: Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma. PMID: 29987895 Ref: Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma. PMID: 30017965 Ref: Androgen Receptor Enhances Hepatic TERT Transcription after Hepatitis B Virus Integration or Point Mutation in Promoter Region. PMID: 30070724 Ref: Host and Viral Genetic Variation in HBV-Related Hepatocellular Carcinoma. PMID: 30073017 Ref: Comprehensive review of Hepatitis B Virus-associated hepatocellular carcinoma research through text mining and big data analytics. PMID: 30105774 Ref: Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening. PMID: 30142445 Ref: Analysis of The Cancer Genome Atlas data to determine the correlation between PROX1 and TERT in hepatocellular carcinoma. PMID: 30246869 Ref: Molecular Scoring of Hepatocellular Carcinoma for Predicting Metastatic Recurrence and Requirements of Systemic Chemotherapy. PMID: 30274313 |