Primary Site >> Colorectal Cancer
Gene >> TERT
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Ref: Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids. PMID: 8201595 |
Ref: Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance. PMID: 7887982 |
Ref: Isolation, purification and biological activity of major docetaxel metabolites from human feces. PMID: 8781781 |
Ref: Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections. PMID: 10102626 |
Ref: [Expression of telomerase genes in human tumors]. PMID: 11866885 |
Ref: Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells. PMID: 11243466 Ref: Quantitative analysis of hTERT mRNA expression in colorectal cancer. PMID: 11419845 Ref: Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas. PMID: 11420670 Ref: Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity. PMID: 11461757 Ref: Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: an in vitro study. PMID: 11518543 Ref: Telomerase activity and expression of telomerase RNA component and catalytic subunits in precancerous and cancerous colorectal lesions. PMID: 11786731 |
Ref: Clinical utility of telomerase in cancer. PMID: 11850791 Ref: Methylation status and expression of human telomerase reverse transcriptase mRNA in relation to hypermethylation of the p16 gene in colorectal cancers as analyzed by bisulfite PCR-SSCP. PMID: 11932355 Ref: Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer. PMID: 12119560 Ref: Evaluation of telomerase mRNA (hTERT) in colon cancer. PMID: 12168091 Ref: Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. PMID: 12168115 Ref: Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. PMID: 12196919 Ref: Prognostic potential of the telomerase subunit human telomerase reverse transcriptase in tumor tissue and nontumorous mucosa from patients with colorectal carcinoma. PMID: 12412163 |
Ref: Activity and expression of human telomerase in normal and malignant cells in gastric and colon cancer patients. PMID: 12544698 Ref: Telomere length and hTERT expression in patients with colorectal carcinoma. PMID: 12790332 Ref: Changes in telomerase activity, expression and splicing in response to differentiation of normal and carcinoma colon cells. PMID: 12820429 Ref: Telomerase activity and cell apoptosis in colon cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide. PMID: 12970889 Ref: Development of a highly sensitive RT-PCR luminometric hybridization assay for human telomerase reverse-transcriptase beta-plus transcript. PMID: 14981931 |
Ref: Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines. PMID: 14654914 Ref: Regulation of telomerase and its hTERT messenger in colorectal cancer. PMID: 14719074 Ref: Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. PMID: 15143073 Ref: Suppressing orthotopic pancreatic tumor growth with a fiber-modified adenovector expressing the TRAIL gene from the human telomerase reverse transcriptase promoter. PMID: 15161713 Ref: Telomerase as a diagnostic and predictive marker in colorectal carcinoma. PMID: 15190417 Ref: Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats. PMID: 15200164 Ref: Real time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA in patients with colorectal cancer. PMID: 15206965 Ref: Colon cancer: genomics and apoptotic events. PMID: 15255176 Ref: Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinoma. PMID: 15292707 Ref: Cytotoxic T-cell immunity against telomerase reverse transcriptase in colorectal cancer patients. PMID: 15375515 Ref: Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. PMID: 15375555 Ref: Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation. PMID: 15481329 Ref: Gene therapy in colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter. PMID: 15517918 Ref: [Clinical significance of human telomerase reverse transcriptase in patients with colon cancer]. PMID: 15566667 Ref: [Adenoviral vector expressing the TRAIL gene driven by the hTERT promoter]. PMID: 15592959 |
Ref: hTERT antagonizes p53-induced apoptosis independently of telomerase activity. PMID: 15608686 Ref: Experimental study of the killing effects of oxymatrine on human colon cancer cell line SW1116. PMID: 15667553 Ref: Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line. PMID: 15682468 Ref: Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells. PMID: 15781646 Ref: Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription. PMID: 15817155 Ref: hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer. PMID: 15818616 Ref: Expression pattern of telomerase reverse transcriptase in rectal carcinoma predicts tumor radiosensitivity, local recurrence and disease-free survival. PMID: 16001613 Ref: 1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols. PMID: 16018609 Ref: Clinical usefulness of telomerase for the detection of colon cancer in ulcerative colitis patients. PMID: 16174077 Ref: Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway. PMID: 16205109 |
Ref: Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma. PMID: 16444744 Ref: [Activity of the TNF-related apoptosis-inducing ligand gene expressed from the hTERT promoter on colon cancer cell line HT-29]. PMID: 16470920 Ref: Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma. PMID: 16489651 Ref: Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells. PMID: 16547498 Ref: Telomerase subunit immunoreactivity and recurrence in colorectal cancer. PMID: 16608021 Ref: hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. PMID: 16619047 Ref: Molecular detection of circulating tumor cells in the peripheral blood of patients with colorectal cancer using RT-PCR: significance of the prediction of postoperative metastasis. PMID: 16736329 Ref: Influence of neoadjuvant radiochemotherapy combined with hyperthermia on the quality of life in rectum cancer patients. PMID: 16754351 Ref: [Insulin-like growth factor receptor, hepatocyte-derived growth factor receptor and telomerase expression in ulcerative colitis]. PMID: 17066600 Ref: Suppression of colorectal tumor growth by regulated survivin targeting. PMID: 17077982 |
Ref: hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. PMID: 17210699 Ref: Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment. PMID: 17321502 Ref: Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. PMID: 17383428 Ref: Multiple molecular markers as predictors of colorectal cancer in patients with normal perioperative serum carcinoembryonic antigen levels. PMID: 17406027 Ref: Identification of a new hTERT-derived HLA-A*0201 restricted, naturally processed CTL epitope. PMID: 17464507 Ref: Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. PMID: 17510425 Ref: Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. PMID: 17641414 Ref: Site-specific methylation of CpG nucleotides in the hTERT promoter region can control the expression of hTERT during malignant progression of colorectal carcinoma. PMID: 17673177 |
Ref: Real-time PCR quantification of human telomerase reverse transcriptase (hTERT) in colorectal cancer. PMID: 18038311 Ref: hTERT-targeted RNA interference inhibits tumorigenicity and motility of HCT116 cells. PMID: 18059183 Ref: Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. PMID: 18061431 Ref: Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model. PMID: 18172280 Ref: Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin. PMID: 18189140 Ref: A novel method to quantify local CpG methylation density by regional methylation elongation assay on microarray. PMID: 18237388 Ref: hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features. PMID: 18322660 Ref: Adenovirus-mediated expression of SSAT inhibits colorectal cancer cell growth in vitro. PMID: 18430370 Ref: siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells. PMID: 18694522 Ref: Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis. PMID: 18938767 Ref: Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease. PMID: 19010861 Ref: Preventive vaccination with telomerase controls tumor growth in genetically engineered and carcinogen-induced mouse models of cancer. PMID: 19047167 Ref: Telomerase activity of blood samples and recurrence of colorectal cancer. PMID: 19102333 |
Ref: Downregulation of human telomerase reverse transcriptase through anti-C-myc siRNA in human colon cancer Colo 320 cells. PMID: 19116866 Ref: Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression. PMID: 19287963 Ref: Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. PMID: 19360348 Ref: Suppression of cancer growth in mice by adeno-associated virus vector-mediated IFN-beta expression driven by hTERT promoter. PMID: 19564073 Ref: Retraction: siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells. PMID: 19607687 Ref: Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial. PMID: 19690194 Ref: [Effects of matrine on proliferation and telomerase activity of colon cancer SW1116 cells]. PMID: 19764331 Ref: Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. PMID: 19903789 Ref: [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality]. PMID: 19958622 Ref: Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. PMID: 20032382 |
Ref: 4-hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity. PMID: 19733043 Ref: Targeted antitumor effect induced by hTERT promoter mediated ODC antisense adenovirus. PMID: 19876766 Ref: Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. PMID: 19886748 Ref: PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. PMID: 19912441 Ref: TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. PMID: 19914212 Ref: Enhanced expression of proproliferative and antiapoptotic genes in ulcerative colitis-associated neoplasia. PMID: 20027603 Ref: Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. PMID: 20096072 Ref: New insights into susceptibility to glioma. PMID: 20212223 Ref: Telomerase mRNA expression and immunohistochemical detection as a biomarker of malignant transformation in patients with inflammatory bowel disease. PMID: 20334955 Ref: New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. PMID: 20452226 Ref: Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: synthesis, structure, biological efficacy and QSAR studies. PMID: 20553814 Ref: No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. PMID: 20570912 Ref: Human telomerase reverse transcriptase expression in colorectal tumors: correlations with immunohistochemical expression and clinicopathologic features. PMID: 21074689 |
Ref: Cytotoxicity and genotoxicity of capecitabine in head and neck cancer and normal cells. PMID: 21107724 Ref: A broad spectrum anticancer nucleoside with selective toxicity against human colon cells in vitro. PMID: 21288718 Ref: Molecular detection of persistent postoperative circulating tumour cells in stages II and III colon cancer patients via multiple blood sampling: prognostic significance of detection for early relapse. PMID: 21343933 Ref: MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer. PMID: 21422235 Ref: DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response. PMID: 21636528 Ref: Anti-cancer activity of nitrones and observations on mechanism of action. PMID: 21651461 Ref: The prognostic value of hTERT expression levels in advanced-stage colorectal cancer patients: a comparison between tissue and serum expression. PMID: 21680300 Ref: Telomerase-driven expression of the sodium iodide symporter (NIS) for in vivo radioiodide treatment of cancer: a new broad-spectrum NIS-mediated antitumor approach. PMID: 21697253 Ref: RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer. PMID: 21763315 Ref: Novel positron emission tomography tracer distinguishes normal from cancerous cells. PMID: 21832075 Ref: Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. PMID: 21936551 Ref: hTERT methylation is necessary but not sufficient for telomerase activity in colorectal cells. PMID: 22848298 |
Ref: Meta-analysis of new genome-wide association studies of colorectal cancer risk. PMID: 21761138 Ref: Overexpression of S100B, TM4SF4, and OLFM4 genes is correlated with liver metastasis in Taiwanese colorectal cancer patients. PMID: 22011044 Ref: Telomere-specific reverse transcriptase (hTERT) and cell-free RNA in plasma as predictors of pathologic tumor response in rectal cancer patients receiving neoadjuvant chemoradiotherapy. PMID: 22395986 Ref: Telomerase expression as a predictive marker of radiotherapy response in rectal cancer. PMID: 22406483 Ref: Association of genetic variants of human telomerase with colorectal polyps and colorectal cancer risk. PMID: 22495810 Ref: The TERT variant rs2736100 is associated with colorectal cancer risk. PMID: 22878375 Ref: Human telomerase reverse transcriptase (hTERT) is a target gene of beta-catenin in human colorectal tumors. PMID: 22894902 Ref: The relative roles of charge and a recognition peptide in luminal targeting of colorectal cancer by fluorescent polyacrylamide. PMID: 23022517 Ref: Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. PMID: 23050049 |
Ref: TERT's role in colorectal carcinogenesis. PMID: 22351525 Ref: Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase beta. PMID: 23266186 Ref: Tetraphenylporphyrin tethered chitosan based carriers for photochemical transfection. PMID: 23281854 Ref: Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trial. PMID: 23303903 Ref: Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer. PMID: 23322193 Ref: Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. PMID: 23517721 Ref: Overexpression of hTERT in potentially malignant colorectal laterally spreading tumors. PMID: 23525166 Ref: Synthesis, properties, and antitumor effects of a new mixed phosphine gold(I) compound in human colon cancer cells. PMID: 23632460 Ref: Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. PMID: 23756870 Ref: hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer. PMID: 23762817 Ref: Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. PMID: 24086482 Ref: Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway. PMID: 24152305 |
Ref: Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. PMID: 23946381 Ref: Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. PMID: 24295787 Ref: A comprehensive look at transcription factor gene expression changes in colorectal adenomas. PMID: 24472434 Ref: Telomeres, telomerase and colorectal cancer. PMID: 24616570 Ref: Reduced hTERT protein levels are associated with DNA aneuploidy in the colonic mucosa of patients suffering from longstanding ulcerative colitis. PMID: 24676865 Ref: A novel cancer vaccine strategy with combined IL-18 and HSV-TK gene therapy driven by the hTERT promoter in a murine colorectal cancer model. PMID: 25051201 Ref: Silencing of the hTERT gene by shRNA inhibits colon cancer SW480 cell growth in vitro and in vivo. PMID: 25207650 Ref: High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. PMID: 25500546 Ref: Effects of octreotide and insulin on colon cancer cellular proliferation and correlation with hTERT activity. PMID: 25594044 Ref: HCT116 colonospheres shows elevated expression of hTERT and beta-catenin protein - a short report. PMID: 25942340 |
Ref: MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation. PMID: 25603978 Ref: Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer. PMID: 25744732 Ref: Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer. PMID: 25845814 Ref: Recombinant lentivirus with enhanced expression of caudal-related homeobox protein 2 inhibits human colorectal cancer cell proliferation in vitro. PMID: 25847407 Ref: 6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells. PMID: 25875209 Ref: Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. PMID: 25923178 Ref: Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76,108 Cases and 134,215 Controls. PMID: 26042809 Ref: Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine. PMID: 26085010 Ref: Decreased expression of PinX1 protein predicts poor prognosis of colorectal cancer patients receiving 5-FU adjuvant chemotherapy. PMID: 26211574 Ref: POLE mutations in families predisposed to cutaneous melanoma. PMID: 26251183 Ref: Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells. PMID: 26418880 Ref: Telomerase Reverse Transcriptase (TERT) Gene Variations and Susceptibility of Colorectal Cancer. PMID: 26501986 Ref: A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells. PMID: 26512920 Ref: Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. PMID: 26621817 Ref: Genome editing through large insertion leads to the skipping of targeted exon. PMID: 26691863 Ref: Genetic variants within the hTERT gene and the risk of colorectal cancer in Lynch syndrome. PMID: 26807197 |
Ref: An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer. PMID: 26540342 Ref: Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. PMID: 26747605 Ref: Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. PMID: 26820603 Ref: Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer. PMID: 26913901 Ref: Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer. PMID: 27167335 Ref: Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality. PMID: 27186328 Ref: Trifluoroselenomethionine: A New Unnatural Amino Acid. PMID: 27383291 Ref: [Apoptotic endonuclease EndoG induces alternative splicing of telomerase catalytic subunit hTERT and death of tumor cells]. PMID: 27420614 Ref: Immunoprevalence and magnitude of HLA-DP4 versus HLA-DR-restricted spontaneous CD4(+) Th1 responses against telomerase in cancer patients. PMID: 27467955 Ref: Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps. PMID: 27584834 Ref: Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance. PMID: 27613840 Ref: Telomere Length, TERT, and miRNA Expression. PMID: 27627813 Ref: Bufalin Inhibits hTERT Expression and Colorectal Cancer Cell Growth by Targeting CPSF4. PMID: 27997899 |
Ref: Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. PMID: 27869826 Ref: Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization. PMID: 28245649 Ref: CDC5L Promotes hTERT Expression and Colorectal Tumor Growth. PMID: 28472785 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Differences in telomerase activity and the effects of AZT in aneuploid and euploid cells in colon cancer. PMID: 28627647 Ref: Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo. PMID: 28627695 Ref: Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappaB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells. PMID: 28676732 Ref: Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1. PMID: 28707774 Ref: Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. PMID: 28717007 Ref: Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth. PMID: 28749462 Ref: TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker. PMID: 28754720 Ref: Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer. PMID: 28781675 Ref: Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population. PMID: 28915643 Ref: GSK-3beta inhibitor 6-bromo-indirubin-3'-oxime promotes both adhesive activity and drug resistance in colorectal cancer cells. PMID: 29039496 Ref: Co-Delivery of Curcumin and Chrysin by Polymeric Nanoparticles Inhibit Synergistically Growth and hTERT Gene Expression in Human Colorectal Cancer Cells. PMID: 29083232 Ref: TERT rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis. PMID: 29221218 Ref: Study of the role of telomerase in colorectal cancer: preliminary report and literature review. PMID: 29280699 |
Ref: Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation. PMID: 28176652 Ref: Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line. PMID: 29294495 Ref: Correction: Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line. PMID: 29381880 Ref: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients. PMID: 29449673 Ref: Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AX. PMID: 29462394 Ref: Absence of TERT promoter mutations in colorectal precursor lesions and cancer. PMID: 29473934 Ref: A silyl andrographolide analogue suppresses Wnt/beta-catenin signaling pathway in colon cancer. PMID: 29501763 Ref: Blood free-circulating DNA testing by highly sensitive methylation assay to diagnose colorectal neoplasias. PMID: 29682198 Ref: Author Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients. PMID: 29780160 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PMID: 29870526 Ref: Apoptosis Induction and Antimigratory Activity of Andrographolide Analog (3A.1)-Incorporated Self-Assembled Nanoparticles in Cancer Cells. PMID: 30117042 Ref: Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. PMID: 30250641 Ref: Synthesis and biological evaluation of novel 5-chloro-N-(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors. PMID: 30288225 Ref: Blackberry Extract Inhibits Telomerase Activity in Human Colorectal Cancer Cells. PMID: 30372130 |