Primary Site >> Colorectal Cancer
Gene >> TCF7L2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. PMID: 9065402 |
Ref: Identification of c-MYC as a target of the APC pathway. PMID: 9727977 Ref: [beta-catenin overexpression in metastasized colorectal carcinoma--an important mechanism in progression of the disease?]. PMID: 14518265 |
Ref: Identification of Tcf4 residues involved in high-affinity beta-catenin binding. PMID: 10080941 |
Ref: Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation. PMID: 10918391 Ref: Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. PMID: 10987283 Ref: Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. PMID: 11035789 Ref: [beta-Catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma]. PMID: 11217438 |
Ref: A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. PMID: 11221869 Ref: Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. PMID: 11222711 Ref: Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation. PMID: 11289158 Ref: Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. PMID: 11326276 Ref: Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma. PMID: 11572874 Ref: Tcf4 can specifically recognize beta-catenin using alternative conformations. PMID: 11713475 Ref: Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. PMID: 11939410 |
Ref: Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability. PMID: 11746989 Ref: Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. PMID: 11774242 Ref: Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability. PMID: 11980438 Ref: Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer. PMID: 11996796 Ref: Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein. PMID: 11997022 Ref: Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. PMID: 12384519 Ref: The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. PMID: 12447697 Ref: Short chain fatty acids and colon cancer. PMID: 12468628 |
Ref: Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy. PMID: 12533679 Ref: Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. PMID: 12566320 Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. PMID: 12584607 Ref: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. PMID: 12622871 Ref: The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. PMID: 12651860 Ref: Synergistic cooperation between the beta-catenin signaling pathway and steroidogenic factor 1 in the activation of the Mullerian inhibiting substance type II receptor. PMID: 12724325 Ref: Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. PMID: 12776180 Ref: Wnt signaling during development of the gastrointestinal tract. PMID: 12871700 Ref: Overexpression of the beta-catenin binding domain of cadherin selectively kills colorectal cancer cells. PMID: 12949799 Ref: Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex. PMID: 14559787 |
Ref: Wnt breakers in colon cancer. PMID: 14749120 Ref: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. PMID: 14770182 Ref: [Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer]. PMID: 15067728 Ref: Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. PMID: 15141037 Ref: [Indomethacin induces apoptosis through inhibition of survivin regulated by beta-catenin/TCF4 in human colorectal cancer cells]. PMID: 15248904 |
Ref: beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. PMID: 15558022 Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 Ref: Expression of T cell factor-4 in non-small-cell lung cancer. PMID: 15667799 Ref: Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3). PMID: 15695391 Ref: Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. PMID: 15793302 Ref: The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. PMID: 15853773 Ref: Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer. PMID: 15899904 Ref: HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. PMID: 15928669 Ref: Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expression. PMID: 15935729 Ref: Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. PMID: 15940626 Ref: Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PMID: 15940627 Ref: The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. PMID: 15972967 Ref: EphB receptor activity suppresses colorectal cancer progression. PMID: 15973414 |
Ref: Genetic and cellular characterizations of human TCF4 with microsatellite instability in colon cancer and leukemia cell lines. PMID: 15905022 Ref: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. PMID: 16421660 Ref: APC inhibits ERK pathway activation and cellular proliferation induced by RAS. PMID: 16478791 Ref: SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. PMID: 16489032 Ref: Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. PMID: 16569639 Ref: Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. PMID: 16885356 Ref: Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. PMID: 16954380 Ref: Colorectal cancer and genetic alterations in the Wnt pathway. PMID: 17143297 |
Ref: An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. PMID: 17121828 Ref: The Intestinal Wnt/TCF Signature. PMID: 17320548 Ref: Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. PMID: 17360646 Ref: Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. PMID: 17383426 Ref: CBP/p300 are bimodal regulators of Wnt signaling. PMID: 17410209 Ref: Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. PMID: 17634137 Ref: EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. PMID: 17906625 |
Ref: Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. PMID: 17828298 Ref: Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. PMID: 18268006 Ref: Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study. PMID: 18268068 Ref: Transcription factor 7-like 2 polymorphism and colon cancer. PMID: 18398040 Ref: Regulation of Wnt signaling by the nuclear pore complex. PMID: 18439914 Ref: Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk. PMID: 18478343 Ref: The ubiquitin-proteasome system in colorectal cancer. PMID: 18619533 Ref: A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. PMID: 18621708 Ref: A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. PMID: 18852287 Ref: KLF4 regulation in intestinal epithelial cell maturation. PMID: 18977346 Ref: Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells. PMID: 18983819 Ref: Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. PMID: 18992165 Ref: Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine. PMID: 19075513 |
Ref: p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors. PMID: 18951899 Ref: Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. PMID: 18992263 Ref: A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. PMID: 19037088 Ref: The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells. PMID: 19124064 Ref: Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. PMID: 19190323 Ref: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. PMID: 19421758 Ref: MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. PMID: 19443654 Ref: The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. PMID: 19561604 Ref: The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. PMID: 19561607 Ref: Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. PMID: 19602482 Ref: c-Rel is a transcriptional repressor of EPHB2 in colorectal cancer. PMID: 19621336 Ref: Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. PMID: 19760027 Ref: The kinase TNIK is an essential activator of Wnt target genes. PMID: 19816403 Ref: Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PMID: 19924301 |
Ref: Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. PMID: 19784072 Ref: Recent insights into the pathogenesis of colorectal cancer. PMID: 19786869 Ref: KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. PMID: 19901072 Ref: Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription. PMID: 20405066 Ref: Effects of potential calcium sensing receptor inducers on promoting chemosensitivity of human colon carcinoma cells. PMID: 20428782 Ref: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. PMID: 20454513 Ref: The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. PMID: 20459822 Ref: Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq. PMID: 20460455 Ref: Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. PMID: 20530691 Ref: Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation. PMID: 20566648 Ref: Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo. PMID: 20640398 Ref: TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. PMID: 20696899 Ref: NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer. PMID: 20705583 Ref: Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. PMID: 20711340 Ref: LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer. PMID: 21092222 Ref: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis. PMID: 21103407 |
Ref: beta-Catenin and NF-kappaB cooperate to regulate the uPA/uPAR system in cancer cells. PMID: 20473943 Ref: Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. PMID: 20938052 Ref: A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis. PMID: 21321609 Ref: T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. PMID: 21383188 Ref: Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet. PMID: 21406606 Ref: A gene signature distinguishing CD133hi from CD133- colorectal cancer cells: essential role for EGR1 and downstream factors. PMID: 21436631 Ref: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4). PMID: 21454679 Ref: The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways. PMID: 21473864 Ref: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. PMID: 21668942 Ref: Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. PMID: 21892161 Ref: Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. PMID: 21983179 Ref: beta-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. PMID: 22080605 Ref: [Effects of sodium selenite on the expressions of beta-catenin and its target cyclin D1 in colorectal cancer cells HCT 116 and SW480]. PMID: 22509550 |
Ref: The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. PMID: 21873734 Ref: Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer. PMID: 21956205 Ref: Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes. PMID: 21963845 Ref: DIF-1 inhibits the Wnt/beta-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines. PMID: 22005519 Ref: beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. PMID: 22082586 Ref: P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth. PMID: 22100495 Ref: VDR/RXR and TCF4/beta-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. PMID: 22108803 Ref: beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. PMID: 22155184 Ref: Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction. PMID: 22224445 Ref: Design, synthesis, and biological evaluation of new diaminoquinazolines as beta-catenin/Tcf4 pathway inhibitors. PMID: 22229647 Ref: Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk. PMID: 22419714 Ref: Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583. PMID: 22429595 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: Wnt signaling, stem cells, and cancer of the gastrointestinal tract. PMID: 22474007 Ref: Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. PMID: 22617424 Ref: Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism. PMID: 22637725 Ref: Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. PMID: 22851508 Ref: Recurrent R-spondin fusions in colon cancer. PMID: 22895193 Ref: The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway. PMID: 22935447 Ref: Activating mutations in beta-catenin in colon cancer cells alter their interaction with macrophages; the role of snail. PMID: 23029025 Ref: Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PMID: 23251453 |
Ref: Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes. PMID: 22402060 Ref: Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. PMID: 23232060 Ref: Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/beta-catenin pathway in colorectal cancer. PMID: 23319804 Ref: ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. PMID: 23340304 Ref: Crosstalk between Wnt Signaling and RNA Processing in Colorectal Cancer. PMID: 23386908 Ref: Generation of high quality chromatin immunoprecipitation DNA template for high-throughput sequencing (ChIP-seq). PMID: 23629434 Ref: Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis. PMID: 23722564 Ref: CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. PMID: 23796952 Ref: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer. PMID: 23803691 Ref: Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with beta-catenin/TCF4 interaction in colorectal cancer cells. PMID: 23844215 Ref: Association between TCF7L2 gene polymorphism and cancer risk: a meta-analysis. PMID: 23951231 Ref: Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations. PMID: 24317174 Ref: Modulation of beta-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways. PMID: 24324366 Ref: Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population. PMID: 24338422 |
Ref: Association of common gene variants in the WNT/beta-catenin pathway with colon cancer recurrence. PMID: 23817222 Ref: EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and beta-catenin activation. PMID: 24056964 Ref: Regulation of TRAIL receptor expression by beta-catenin in colorectal tumours. PMID: 24379239 Ref: Revealing the molecular mechanism of colorectal cancer by establishing LGALS3-related protein-protein interaction network and identifying signaling pathways. PMID: 24398765 Ref: Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. PMID: 24413017 Ref: Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PMID: 24466159 Ref: A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients. PMID: 24470513 Ref: Stimulation of beta-catenin and colon cancer cell growth by the KDM4B histone demethylase. PMID: 24481461 Ref: Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. PMID: 24532795 Ref: High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants. PMID: 24608966 Ref: DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice. PMID: 24670930 Ref: Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells. PMID: 24716727 Ref: Plumbagin downregulates Wnt signaling independent of p53 in human colorectal cancer cells. PMID: 24828199 Ref: Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. PMID: 24836286 Ref: ITF2 prevents activation of the beta-catenin-TCF4 complex in colon cancer cells and levels decrease with tumor progression. PMID: 24846398 Ref: TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common chemotherapeutic drug. PMID: 24869759 Ref: MiR-29b downregulates canonical Wnt signaling by suppressing coactivators of beta-catenin in human colorectal cancer cells. PMID: 24913975 Ref: Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. PMID: 24943349 Ref: Oncogenicity of LHX4 in colorectal cancer through Wnt/beta-catenin/TCF4 cascade. PMID: 25034524 Ref: Histone deacetylase inhibitors induce attenuation of Wnt signaling and TCF7L2 depletion in colorectal carcinoma cells. PMID: 25050608 Ref: A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding. PMID: 25131200 Ref: Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. PMID: 25205133 Ref: Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data. PMID: 25469308 |
Ref: Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells. PMID: 24619956 Ref: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775 Ref: Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma. PMID: 25399296 Ref: Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. PMID: 25500543 Ref: A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas. PMID: 25617745 Ref: A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. PMID: 25659031 Ref: Kruppel-like factor 5 incorporates into the beta-catenin/TCF complex in response to LPA in colon cancer cells. PMID: 25683913 Ref: Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial. PMID: 25927723 Ref: TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer. PMID: 25961950 Ref: Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy. PMID: 26060019 Ref: An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/beta-catenin-elicited promotion of the cancer stem cell phenotype. PMID: 26075748 Ref: Differential Effects of Hepatocyte Nuclear Factor 4alpha Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. PMID: 26240283 Ref: Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer. PMID: 26243311 Ref: Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer. PMID: 26311743 Ref: The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated beta-catenin by sequestering TCF4 to the nuclear membrane. PMID: 26350900 Ref: ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression. PMID: 26387539 Ref: Mechanism of Chemoprevention against Colon Cancer Cells Using Combined Gelam Honey and Ginger Extract via mTOR and Wnt/beta-catenin Pathways. PMID: 26434873 Ref: Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications. PMID: 26447334 Ref: Novel RNA variants in colorectal cancers. PMID: 26474385 Ref: Rock2 stabilizes beta-catenin to promote tumor invasion and metastasis in colorectal cancer. PMID: 26505794 Ref: Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer. PMID: 26542362 Ref: [T Cell Factor 4, beta-catenin and SFRP1 Expression of Wnt Signaling Pathway in Colorectal Carcinoma and the Prognosis]. PMID: 26710459 |
Ref: Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells. PMID: 25777538 Ref: New Wnt/beta-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals. PMID: 26156959 Ref: Wnt/beta-catenin signaling regulated SATB1 promotes colorectal cancer tumorigenesis and progression. PMID: 26165840 Ref: OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. PMID: 26619963 Ref: Topoisomerase IIalpha mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. PMID: 26947016 Ref: Time course analysis based on gene expression profile and identification of target molecules for colorectal cancer. PMID: 27013928 Ref: Genomic Landscape of Colorectal Mucosa and Adenomas. PMID: 27221540 Ref: A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate. PMID: 27292638 Ref: A recellularized human colon model identifies cancer driver genes. PMID: 27398792 Ref: Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. PMID: 27504909 Ref: The Role of the C-Clamp in Wnt-Related Colorectal Cancers. PMID: 27527215 Ref: Wnt-beta-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer. PMID: 27709738 Ref: TCF7L2 and CCND1 polymorphisms and its association with colorectal cancer in Mexican patients. PMID: 27755946 Ref: Association between the TCF7L2 polymorphism and colorectal cancer does not differ by diabetes and obesity statuses. PMID: 27792933 |
Ref: Differential expression of LEF1/TCFs family members in colonic carcinogenesis. PMID: 27433921 Ref: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. PMID: 27793841 Ref: Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer. PMID: 28002797 Ref: 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications. PMID: 28060743 Ref: Identification of FERM domain-containing protein 5 as a novel target of beta-catenin/TCF7L2 complex. PMID: 28117551 Ref: Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORbeta. PMID: 28137278 Ref: ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. PMID: 28143522 Ref: USP39 promotes colorectal cancer growth and metastasis through the Wnt/beta-catenin pathway. PMID: 28259917 Ref: Transcription-dependent radial distribution of TCF7L2 regulated genes in chromosome territories. PMID: 28343235 Ref: The genetic basis of obesity complications. PMID: 28362475 Ref: TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells. PMID: 28450117 Ref: The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/beta-Catenin Signaling Pathway. PMID: 28472810 Ref: Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/beta-catenin Signaling. PMID: 28811361 Ref: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. PMID: 28870200 Ref: A Small Molecule Inhibitor of the beta-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo. PMID: 29033371 Ref: Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway. PMID: 29050326 Ref: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. PMID: 29118424 Ref: Gene expression profiling demonstrates WNT/beta-catenin pathway genes alteration in Mexican patients with colorectal cancer and diabetes mellitus. PMID: 29135090 Ref: Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/beta-Catenin Pathways via miR-130a. PMID: 29225578 Ref: Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/beta-catenin signaling confers anti-apoptotic properties to colorectal cancer cells. PMID: 29245969 Ref: Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis. PMID: 29254234 |
Ref: Cumulative evidence for relationships between multiple variants in the VTI1A and TCF7L2 genes and cancer incidence. PMID: 28949031 Ref: Proteomic Characterization of Transcription and Splicing Factors Associated with a Metastatic Phenotype in Colorectal Cancer. PMID: 29131639 Ref: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition. PMID: 29298515 Ref: Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells. PMID: 29301589 Ref: Beta-catenin cleavage enhances transcriptional activation. PMID: 29330435 Ref: RNF6 Promotes Colorectal Cancer by Activating the Wnt/beta-Catenin Pathway via Ubiquitination of TLE3. PMID: 29374067 Ref: Molecular dynamics of interaction of Sesamin and related compounds with the cancer marker beta-catenin: an in silico study. PMID: 29455637 Ref: Modulation of the colon cancer cell phenotype by pro-inflammatory macrophages: A preclinical model of surgery-associated inflammation and tumor recurrence. PMID: 29462209 Ref: Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study. PMID: 29511559 Ref: beta-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. PMID: 29551770 Ref: Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells. PMID: 29554905 Ref: Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. PMID: 29802748 Ref: The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2. PMID: 29975781 Ref: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. PMID: 30017821 Ref: A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer. PMID: 30026326 Ref: Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer. PMID: 30032163 Ref: Interaction between Tumor-Associated Dendritic Cells and Colon Cancer Cells Contributes to Tumor Progression via CXCL1. PMID: 30115896 Ref: Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1. PMID: 30131849 Ref: MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/beta-catenin positive feedback loop. PMID: 30253791 Ref: Colorectal cancer susceptibility loci and influence on survival. PMID: 30350386 Ref: Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. PMID: 30380024 |