Primary Site >> Colorectal Cancer

Gene >> SUZ12

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Ref: Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
PMID: 15231737
 Ref: Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium.
PMID: 17365822
 Ref: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.
PMID: 21862635
 Ref: Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.
PMID: 23001792
Ref: Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.
PMID: 23588203
 Ref: Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer.
PMID: 25243792
 Ref: Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer.
PMID: 25326896
Ref: Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer.
PMID: 25652097
Ref: Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer.
PMID: 25653233
Ref: Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells.
PMID: 26407907
 Ref: PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer.
PMID: 26567139
Ref: Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer.
PMID: 26930714
Ref: Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling.
PMID: 27622053
 Ref: Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor.
PMID: 28418861
Ref: tRF/miR-1280 Suppresses Stem Cell-like Cells and Metastasis in Colorectal Cancer.
PMID: 28446464
Ref: STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.
PMID: 28827371
Ref: Deregulated expression of microRNA-200b/c and SUZ12, a Polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells.
PMID: 28966728
 Ref: Tumor-suppressive miR-145 co-repressed by TCF4-beta-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer.
PMID: 28921929