Primary Site >> Colorectal Cancer
Gene >> STK11
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. PMID: 9605748 Ref: The genetics of hereditary common cancers. PMID: 9690990 Ref: Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. PMID: 9708796 Ref: Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer. PMID: 9731485 Ref: STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer. PMID: 9809980 Ref: Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. PMID: 9850045 |
Ref: LKB1 somatic mutations in sporadic tumors. PMID: 10079245 Ref: Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. PMID: 10201537 Ref: Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. PMID: 10398133 Ref: Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability. PMID: 10429655 |
Ref: Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. PMID: 10644993 Ref: No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. PMID: 10676634 Ref: 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. PMID: 10896921 |
Ref: Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. PMID: 11215281 Ref: CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers. PMID: 11355940 Ref: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. PMID: 11751682 |
Ref: Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis. PMID: 12051537 |
Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: [Hereditary colorectal cancer]. PMID: 15725711 Ref: Mutations in the human LKB1/STK11 gene. PMID: 16110486 |
Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 |
Ref: Genetic testing in colorectal cancer: who, when, how and why. PMID: 17392593 Ref: LKB1 catalytically deficient mutants enhance cyclin D1 expression. PMID: 17575127 Ref: National study of colorectal cancer genetics. PMID: 17895893 Ref: Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. PMID: 17921699 |
Ref: In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation. PMID: 18524847 Ref: Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. PMID: 18716850 Ref: LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. PMID: 18794113 |
Ref: Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology. PMID: 19892662 |
Ref: LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. PMID: 20400510 Ref: Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. PMID: 20622004 |
Ref: German national case collection for familial pancreatic cancer (FaPaCa): ten years experience. PMID: 21207249 Ref: A novel mutation in STK11 gene is associated with Peutz-Jeghers syndrome in Chinese patients. PMID: 22168747 |
Ref: [Coexistence of Peutz-Jeghers' syndrome and Lynch's syndrome in the same patient]. PMID: 22516349 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions. PMID: 22788692 |
Ref: Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. PMID: 22735569 Ref: Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. PMID: 22986809 Ref: 20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx. PMID: 23318138 Ref: Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients. PMID: 23544471 Ref: MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. PMID: 23886157 Ref: Adiponectin and metformin additively attenuate IL1beta-induced malignant potential of colon cancer. PMID: 24157941 Ref: Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. PMID: 24289550 |
Ref: The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study. PMID: 24700299 Ref: Genetic variations in STK11, PRKAA1, and TSC1 associated with prognosis for patients with colorectal cancer. PMID: 24770722 Ref: LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. PMID: 24879590 Ref: Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab. PMID: 24892446 Ref: Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality. PMID: 24959314 Ref: [Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: focus on the Peutz-Jeghers]. PMID: 25036236 |
Ref: Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice. PMID: 24838344 Ref: Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. PMID: 25238946 Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma. PMID: 25973293 Ref: The Mendelian colorectal cancer syndromes. PMID: 26169059 |
Ref: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies. PMID: 26350096 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer. PMID: 27150059 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. PMID: 27622015 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 |
Ref: Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. PMID: 26239883 Ref: Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway. PMID: 27908725 Ref: High expression of partitioning defective 3-like protein is associated with malignancy in colorectal cancer. PMID: 28443499 Ref: Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp. PMID: 28487883 Ref: Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer. PMID: 28492544 Ref: Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer. PMID: 28918830 Ref: Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient. PMID: 29141581 |
Ref: Clinical manifestations and STK11 germline mutations in Taiwanese patients with Peutz-Jeghers syndrome. PMID: 28869103 Ref: APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas. PMID: 29525853 Ref: Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner. PMID: 29963200 Ref: Optimization of the diagnosis of inherited colorectal cancer using NGS and capture of exonic and intronic sequences of panel genes. PMID: 29967336 Ref: Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice. PMID: 30359174 Ref: Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling. PMID: 30362049 |