Primary Site >> Pancreatic Cancer
Gene >> STAT3
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Ref: Interferon-mediated activation of the STAT signaling pathway in a human carcinoid tumor. PMID: 9831114 |
Ref: Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-(kappa)B and STAT3. PMID: 11259367 |
Ref: Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. PMID: 12454861 |
Ref: Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. PMID: 12545153 Ref: Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. PMID: 12949733 Ref: Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. PMID: 14580692 Ref: Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. PMID: 14586404 |
Ref: Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein. PMID: 15015587 |
Ref: A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models. PMID: 15640156 Ref: Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions. PMID: 15714203 Ref: Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenograf PMID: 15735038 Ref: Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases. PMID: 15805288 Ref: mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. PMID: 15851011 |
Ref: Transcriptional anti-angiogenesis therapy of human pancreatic cancer. PMID: 16516532 Ref: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. PMID: 16546976 Ref: Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. PMID: 16751181 Ref: Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells. PMID: 16871430 Ref: RP101 improves the efficacy of chemotherapy in pancreas carcinoma cell lines and pancreatic cancer patients. PMID: 17001178 Ref: Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. PMID: 17054436 Ref: [Inhibitory effect of AG490 on invasion and metastasis of human pancreatic cancer cells in vitro]. PMID: 17533737 |
Ref: STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). PMID: 17203201 Ref: Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. PMID: 17332938 Ref: ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib. PMID: 17457047 Ref: RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. PMID: 17459060 Ref: Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion. PMID: 17726369 Ref: Inhibition of proliferation by omega-3 fatty acids in chemoresistant pancreatic cancer cells. PMID: 17896154 Ref: Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotop PMID: 17975158 |
Ref: Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis. PMID: 18254976 Ref: Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis. PMID: 18445520 Ref: Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. PMID: 18519681 Ref: STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. PMID: 18566225 Ref: Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes. PMID: 19001434 Ref: Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. PMID: 19010822 Ref: [Effect of RNAi-mediated STAT3 gene inhibition on metastasis of human pancreatic cancer cells]. PMID: 19035205 |
Ref: Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models. PMID: 18924149 Ref: The fungal secondary metabolite trichodimerol inhibits TGF-beta dependent cellular effects and tube formation of MDA-MB-231 cells. PMID: 19009233 Ref: Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. PMID: 19424602 Ref: Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein. PMID: 19523441 Ref: Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. PMID: 19605406 Ref: Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion. PMID: 19673016 Ref: Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells. PMID: 19712481 Ref: LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells. PMID: 19724917 Ref: Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. PMID: 19724924 |
Ref: G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. PMID: 19755960 Ref: Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. PMID: 19816711 Ref: A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. PMID: 20067773 Ref: Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. PMID: 20100905 Ref: Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression. PMID: 20121547 Ref: ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. PMID: 20160059 Ref: Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling. PMID: 20182390 Ref: Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells. PMID: 20197401 Ref: Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro. PMID: 20482858 Ref: MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells. PMID: 20583868 Ref: Suppression of cell death by the secretory form of N-terminal ERC/mesothelin. PMID: 20596597 Ref: PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation. PMID: 20667852 Ref: Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. PMID: 20682659 Ref: Breaking the NF-kappaB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis. PMID: 20978116 Ref: Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer. PMID: 21779469 |
Ref: Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. PMID: 21174186 Ref: Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies. PMID: 21243039 Ref: Chemosensitization of tumors by resveratrol. PMID: 21261654 Ref: Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth. PMID: 21266529 Ref: Targeting STAT3 signaling in pancreatic cancer promotes antiapoptotic gene expression. PMID: 21311318 Ref: STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo. PMID: 21479358 Ref: Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. PMID: 21481788 Ref: A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells. PMID: 21573184 Ref: Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer. PMID: 21593197 Ref: LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells. PMID: 21737619 Ref: The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro. PMID: 21744993 Ref: Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth. PMID: 21799645 Ref: STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice. PMID: 21991388 Ref: Molecular pathogenesis of pancreatic cancer and clinical perspectives. PMID: 22116519 |
Ref: The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. PMID: 22082308 Ref: High level interleukin-6 in the medium of human pancreatic cancer cell culture suppresses production of neurotransmitters by PC12 cell line. PMID: 22109853 Ref: IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines. PMID: 22273698 Ref: Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-kappaB signaling pathways. PMID: 22322442 Ref: Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. PMID: 22342309 Ref: EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer. PMID: 22348037 Ref: Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo. PMID: 22450950 Ref: The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. PMID: 22509024 Ref: AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway. PMID: 22722139 Ref: YM155 induces EGFR suppression in pancreatic cancer cells. PMID: 22723871 Ref: CD24 controls Src/STAT3 activity in human tumors. PMID: 22760497 Ref: EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. PMID: 22975375 Ref: Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. PMID: 23023703 Ref: Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. PMID: 23027619 Ref: Total synthesis and biological activity of the proposed structure of phaeosphaeride A. PMID: 23050677 Ref: XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. PMID: 23056374 Ref: Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration. PMID: 23061049 Ref: APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival. PMID: 23094050 Ref: Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer. PMID: 23170143 Ref: Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. PMID: 23185240 Ref: MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway. PMID: 23519249 |
Ref: Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. PMID: 22614008 Ref: Requirement of NEMO/IKKgamma for effective expansion of KRAS-induced precancerous lesions in the pancreas. PMID: 22751123 Ref: Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. PMID: 23206899 Ref: Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. PMID: 23221383 Ref: Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling. PMID: 23288783 Ref: Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. PMID: 23416191 Ref: Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation. PMID: 23482563 Ref: Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. PMID: 23514705 Ref: Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae. PMID: 23613993 Ref: Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PMID: 23650499 Ref: Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1. PMID: 23817566 Ref: Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. PMID: 23845849 Ref: Reg3beta deficiency impairs pancreatic tumor growth by skewing macrophage polarization. PMID: 23867474 Ref: PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells. PMID: 24002598 Ref: Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism. PMID: 24015205 Ref: Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer. PMID: 24025152 Ref: MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3. PMID: 24040078 Ref: Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment. PMID: 24073373 Ref: HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s. PMID: 24132924 Ref: A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice. PMID: 24204197 Ref: STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. PMID: 25364701 |
Ref: Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy? PMID: 24163144 Ref: Phosphorylation of STAT3 correlates with HER2 status, but not with survival in pancreatic ductal adenocarcinoma. PMID: 24164699 Ref: Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression. PMID: 24293409 Ref: Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle. PMID: 24404136 Ref: A perylene derivative regulates HIF-1alpha and Stat3 signaling pathways. PMID: 24485121 Ref: MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression. PMID: 24491408 Ref: Antitumor efficacy of alpha-solanine against pancreatic cancer in vitro and in vivo. PMID: 24505326 Ref: Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. PMID: 24520038 Ref: Combined targeting of STAT3/NF-kappaB/COX-2/EP4 for effective management of pancreatic cancer. PMID: 24520096 Ref: Interleukin-6 in inflammatory and malignant diseases of the pancreas. PMID: 24572992 Ref: Pancreatic cancer-induced cachexia is Jak2-dependent in mice. PMID: 24648112 Ref: Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. PMID: 24652403 Ref: Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells. PMID: 24676538 Ref: Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. PMID: 24694735 Ref: SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression. PMID: 24726914 Ref: Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. PMID: 24785258 Ref: PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling. PMID: 24788754 Ref: STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth. PMID: 24796733 Ref: Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: an under-appreciated symbiotic relationship. PMID: 24821201 Ref: Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. PMID: 24889936 Ref: Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). PMID: 24904966 Ref: Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer. PMID: 24953430 Ref: SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer. PMID: 24996521 Ref: Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. PMID: 25128650 Ref: Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization. PMID: 25157817 Ref: Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer. PMID: 25193856 Ref: MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2. PMID: 25220761 Ref: Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme. PMID: 25326645 |
Ref: Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells. PMID: 25047070 Ref: STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells. PMID: 25411359 Ref: MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer. PMID: 25444909 Ref: A preclinical evaluation of SKLB261, a multikinase inhibitor of EGFR/Src/VEGFR2, as a therapeutic agent against pancreatic cancer. PMID: 25519702 Ref: Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion. PMID: 25561562 Ref: LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1alpha and Stat3 Signaling. PMID: 25655308 Ref: Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors. PMID: 25698618 Ref: TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis. PMID: 25762644 Ref: REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. PMID: 25779676 Ref: Metformin suppresses pancreatic tumor growth with inhibition of NFkappaB/STAT3 inflammatory signaling. PMID: 25875801 Ref: LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy. PMID: 25883212 Ref: A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion. PMID: 25915428 Ref: Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. PMID: 25948792 Ref: Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells. PMID: 25961376 Ref: Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis. PMID: 26024373 Ref: Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. PMID: 26032425 Ref: Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. PMID: 26056043 Ref: Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis. PMID: 26182900 Ref: The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer. PMID: 26211581 Ref: Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. PMID: 26255562 Ref: IL17 Functions through the Novel REG3beta-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. PMID: 26404002 Ref: Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway. PMID: 26459366 Ref: Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth. PMID: 26510913 Ref: A New Scalpel for the Treatment of Pancreatic Cancer: Targeting Stromal-Derived STAT3 Signaling. PMID: 26526714 Ref: Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial-mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells. PMID: 26527884 Ref: Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. PMID: 26530532 Ref: Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. PMID: 26575024 Ref: Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. PMID: 26641266 |
Ref: p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. PMID: 26546043 Ref: Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib. PMID: 26682870 Ref: Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. PMID: 26719042 Ref: Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition. PMID: 26781210 Ref: GSK-3beta Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression. PMID: 26823495 Ref: Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis. PMID: 26847351 Ref: Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. PMID: 26873728 Ref: Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling. PMID: 26887043 Ref: Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment. PMID: 26909608 Ref: Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis. PMID: 26959884 Ref: Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. PMID: 27003603 Ref: A natural food sweetener with anti-pancreatic cancer properties. PMID: 27065453 Ref: Src/STAT3 signaling pathways are involved in KAI1-induced downregulation of VEGF-C expression in pancreatic cancer. PMID: 27082851 Ref: HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer. PMID: 27085461 Ref: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. PMID: 27089513 Ref: Targeting inflammation in pancreatic cancer: Clinical translation. PMID: 27096033 Ref: YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. PMID: 27215660 Ref: Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-kappaB Regulation. PMID: 27242913 Ref: LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo. PMID: 27278358 Ref: Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells. PMID: 27333990 Ref: Interleukin-32alpha inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial-mesenchymal transition, invasion, and metastasis in pancreatic cancer cells. PMID: 27471397 Ref: Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow. PMID: 27489361 Ref: Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation. PMID: 27496707 Ref: Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer. PMID: 27528027 Ref: Regulation of HIF1alpha under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models. PMID: 27535970 Ref: Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. PMID: 27535971 Ref: In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFkappaB signaling in pancreatic cancer cells. PMID: 27539371 Ref: Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling. PMID: 27556697 Ref: Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-kappaB/STAT3 signaling cascade. PMID: 27576197 Ref: A single nucleotide polymorphism in the 3'-UTR of STAT3 regulates its expression and reduces risk of pancreatic cancer in a Chinese population. PMID: 27577070 Ref: Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells. PMID: 27602757 Ref: Gemcitabine reduces MDSCs, tregs and TGFbeta-1 while restoring the teff/treg ratio in patients with pancreatic cancer. PMID: 27687804 Ref: STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. PMID: 27748818 Ref: Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer. PMID: 27875298 |
Ref: Downregulation of STAT3/NF-kappaB potentiates gemcitabine activity in pancreatic cancer cells. PMID: 27208550 Ref: Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. PMID: 27750041 Ref: SRI36160 is a specific inhibitor of Wnt/beta-catenin signaling in human pancreatic and colorectal cancer cells. PMID: 28043913 Ref: Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer. PMID: 28053127 Ref: A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. PMID: 28067673 Ref: Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer. PMID: 28075464 Ref: The G Protein-Coupled Receptor RAI3 Is an Independent Prognostic Factor for Pancreatic Cancer Survival and Regulates Proliferation via STAT3 Phosphorylation. PMID: 28114355 Ref: MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. PMID: 28121485 Ref: The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions. PMID: 28179300 Ref: Immunosuppressive CD14(+)HLA-DR(lo/neg) monocytes are elevated in pancreatic cancer and "primed" by tumor-derived exosomes. PMID: 28197368 Ref: Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer. PMID: 28254412 Ref: miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer. PMID: 28321160 Ref: Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells. PMID: 28322306 Ref: PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk. PMID: 28386018 Ref: EGFR-induced phosphorylation of type Igamma phosphatidylinositol phosphate kinase promotes pancreatic cancer progression. PMID: 28388589 Ref: JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer. PMID: 28405527 Ref: OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling. PMID: 28418923 Ref: Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-kappab/Stat3/Bcl-2 signaling pathway. PMID: 28455228 Ref: Tumour-associated macrophages activate migration and STAT3 in pancreatic ductal adenocarcinoma cells in co-cultures. PMID: 28476581 Ref: Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo. PMID: 28496202 Ref: BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling. PMID: 28602977 Ref: Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma. PMID: 28619758 Ref: MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway. PMID: 28677798 Ref: Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNgamma signaling. PMID: 28680757 Ref: Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. PMID: 28692035 Ref: Pim-3 Regulates Stemness of Pancreatic Cancer Cells via Activating STAT3 Signaling Pathway. PMID: 28775772 Ref: Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles. PMID: 28849098 Ref: Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression. PMID: 28880262 Ref: Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. PMID: 29026320 Ref: [Interleukin-9 promotes pancreatic cancer cell proliferation and migration via activation of STAT3 pathway]. PMID: 29089082 Ref: Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells. PMID: 29100320 Ref: Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells. PMID: 29130098 Ref: Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth. PMID: 29156726 Ref: Apolipoprotein A-I mimetic peptide 4F suppresses tumor-associated macrophages and pancreatic cancer progression. PMID: 29245934 Ref: CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway. PMID: 29255366 Ref: Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. PMID: 29262554 Ref: TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration. PMID: 29371911 Ref: Disorders noticed during development of pancreatic cancer: potential opportunities for early and effective diagnostics and therapy. PMID: 29472816 |
Ref: Kruppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. PMID: 29248441 Ref: LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker. PMID: 29269518 Ref: Luteolin inhibits pancreatitisinduced acinarductal metaplasia, proliferation and epithelialmesenchymal transition of acinar cells. PMID: 29286098 Ref: Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition. PMID: 29308316 Ref: MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer. PMID: 29337110 Ref: Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. PMID: 29393444 Ref: Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway. PMID: 29393456 Ref: MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. PMID: 29408481 Ref: Genistein induced anticancer effects on pancreatic cancer cell lines involves mitochondrial apoptosis, G0/G1cell cycle arrest and regulation of STAT3 signalling pathway. PMID: 29433670 Ref: Celecoxib suppresses proliferation and metastasis of pancreatic cancer cells by down-regulating STAT3 / NF-kB and L1CAM activities. PMID: 29525378 Ref: IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer. PMID: 29572224 Ref: A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer. PMID: 29605512 Ref: L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway. PMID: 29606890 Ref: TAM Infiltration Differences in "Tumor-First" and " ZHENG-First" Models and the Underlying Inflammatory Molecular Mechanism in Pancreatic Cancer. PMID: 29681184 Ref: A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. PMID: 29683208 Ref: MiR-221 inhibits proliferation of pancreatic cancer cells via down regulation of SOCS3. PMID: 29687843 Ref: Blocking IL-6/GP130 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity in human pancreatic cancer cells. PMID: 29714141 Ref: Matrine suppresses KRAS-driven pancreatic cancer growth by inhibiting autophagy-mediated energy metabolism. PMID: 29791786 Ref: Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42. PMID: 29853638 Ref: miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-kappaB Signaling Pathways. PMID: 29858050 Ref: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. PMID: 29923200 Ref: Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-beta/STAT3 Pathway. PMID: 29953970 Ref: TGF-betaRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727. PMID: 30065235 Ref: Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor kappaB and STAT3 in vitro and in vivo. PMID: 30078206 Ref: Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine. PMID: 30083262 Ref: EGFR may participate in immune evasion through regulation of B7H5 expression in nonsmall cell lung carcinoma. PMID: 30106102 Ref: STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis. PMID: 30135074 Ref: Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. PMID: 30154150 Ref: L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression. PMID: 30171263 Ref: Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathway PMID: 30273298 Ref: Resistin effects on pancreatic cancer progression and chemoresistance are mediated through its receptors CAP1 and TLR4. PMID: 30317640 Ref: Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. PMID: 30321984 |